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Reconciling individual and population levels of porcine reproductive and respiratory syndrome virus evolution

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Virologica Sinica 2017年第4期32卷 342-345页

作者： Giovanni Franzo claudia Maria Tucciarone Mattia Cecchinato Michele Drigo Department of Animal Medicine Production and Health(MAPS)University of PaduaViale dell’Università1635020LegnaroItaly

Porcine reproductive and respiratory syndrome virus（PRRSV）, a member of the family Arteriviridae, repre-sents one of the most challenging pathogens in the swineindustry, with serious economic impact. Unfortunately,despite widespread application, vaccination has not beensuccessful in effectively controlling the virus, mainlybecause of the limited cross-protection among differentstrains （Kimman et al., 2009）.

关键词：中国病毒学英文版

Genome-based nutrition:An intervention strategy for the prevention and treatment of obesity and nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2015年第12期21卷 3449-3461页

作者： Sonia Roman claudia Ojeda-Granados Omar Ramos-Lopez Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde"GuadalajaraJalisco Mexico and Health Sciences Center University of Guadalajara

Obesity and nonalcoholic steatohepatitis are increasing in westernized countries, regardless of their geographiclocation. In Latin America, most countries, including Mexico, have a heterogeneous admixture genome with Amerindian, European and African ancestries. However, certain high allelic frequencies of several nutrientrelated polymorphisms may have been achieved by past gene-nutrient interactions. Such interactions may have promoted the positive selection of variants adapted to regional food sources. At present, the unbalanced diet composition of the Mexicans has led the country to a 70% prevalence rate of overweightness and obesity due to substantial changes in food habits, among other factors. International guidelines and intervention strategies may not be adequate for all populations worldwide because they do not consider disparities in genetic and environmental factors, and thus there is a need for differential prevention and management strategies. Here, we provide the rationale for an intervention strategy for the prevention and management of obesity-related diseases such as nonalcoholic steatohepatitis based on a regionalized genome-based diet. The components required to design such a diet should focus on the specific ancestry of each population around the world and the convenience of consuming traditional ethnic food.

关键词： Latin America Mexico Gene-nutrient interactions Ev

The prognostic relevance of examined lymph nodes for accurate staging of resected pancreatic adenocarcinoma

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 632-635页

作者： claudia Zaharia Marcus Roalsø Kjetil Søreide Department of Pathology Stavanger University HospitalStavangerNorway Department of Gastrointestinal Surgery HPB UnitStavanger University HospitalStavangerNorway Department of Quality and Health Technology University of StavangerStavangerNorway Department of Clinical Medicine University of BergenBergenNorway

Pancreatic ductal adenocarcinoma(PDAC)is a disease with a particular aggressive cancer biology and,unfortunately,a very poor prognosis for most *** is no question about the lethality of pancreatic ***,the question why this malignancy is so deadly remains a biological puzzle both to investigators and caretakers *** of pancreatic cancer undergoing resection-while important to compare cohorts across studies and trials-also allows for a clinical clue about the progress of the disease.

关键词： adenocarcinoma cancer prognosis

Ammonia and greenhouse gas distribution in a dairy barn during warm periods

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Frontiers of Agricultural Science and Engineering 2024年第3期11卷 428-441页

作者： Provvidenza Rita D’URSO claudia ARCIDIACONO Giovanni CASCONE Department of Agriculture Food and EnvironmentUniversity of CataniaVia S.Sofia n.100Catania 95123Italy

This research aimed to quantify concentrations of ammonia(NH3),carbon dioxide(CO_(2))and methane(CH_(4)),estimate emissions,and analyze the factors influencing them during warm periods in an open dairy barn equipped with two cooling systems in a Mediterranean climate *** distribution within the barn was observed to vary both vertically and horizontally,with the highest gas concentrations observed in the central area of the ***_(3),CH_(4)and CO_(2)ranged in 1.7–7.4,7–18,560–724μg·g^(–1),*** ventilation through openings and the operation of cooling systems induced changes in indoor microclimate conditions,influencing cow behavior and,consequently,gas *** concentrations were the highest at air velocities below 0.5 m·s^(–1).The highest concentration of NH_(3)was observed when the temperature-humidity index(THI)was>72 and≤78;and CO_(2)and CH_(4)concentrations were the highest with THI≥72 and decreased with THI≤***_(3)concentrations when barn management included three daily milkings were higher than those measured when barn management was based on two daily milkings,and lower for CH_(4)and CO_(2).NH_(3)and CH_(4)emissions were the highest during barn cleaning,while the lowest NH_(3)emissions occurred during activity of the cows(i.e.,feeding,walking).

关键词： Ammonia greenhouse gas environmental monitoring cows’behavior barn management housing system climatic parameters

How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

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World Journal of Stem Cells 2023年第5期15卷 281-301页

作者： María Belén Novoa Díaz Pedro Carriere claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del SurBahía Blanca 8000Buenos AiresArgentina Instituto de Ciencias Biológicas y Biomédicas del Sur Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional del Sur(UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorectal cancer(CRC)remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant *** is well established that the appearance of distal metastasis in CRC patients is the cause of a poor prognosis and treatment ***,in the last decades,CRC aggressiveness and progression have been attributed to a specific cell population called CRC stem cells(CCSC)with features like tumor initiation capacity,self-renewal capacity,and acquired multidrug *** data highlight the concept of this cell subtype as a plastic entity that has a dynamic status and can be originated from different types of cells through genetic and epigenetic *** alterations are modulated by complex and dynamic crosstalk with environmental factors by paracrine *** is known that in the tumor niche,different cell types,structures,and biomolecules coexist and interact with cancer cells favoring cancer growth and ***,these components constitute the tumor microenvironment(TME).Most recently,researchers have also deepened the influence of the complex variety of microorganisms that inhabit the intestinal mucosa,collectively known as gut microbiota,on *** TME and microorganisms participate in inflammatory processes that can drive the initiation and evolution of *** in the last decade,crucial advances have been made concerning to the synergistic interaction among the TME and gut microorganisms that condition the identity of CCSC,the data exposed in this review could provide valuable insights into the biology of CRC and the development of new targeted therapies.

关键词： Colorectal cancer Colorectal cancer stem cells Tumor microenvironment factors Tumor stroma Gut microbiota Cancer progression

Exploratory analysis of structural diversity indicators at stand level in three Italian beech sites and implications for sustainable forest management

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Journal of Forestry Research 2019年第1期30卷 121-127页

作者： Giada Bertini claudia Becagli Ugo Chiavetta Fabrizio Ferretti Gianfranco Fabbio Luca Salvati CREA Research Centre for Forestry and Wood

The present study introduces an exploratory data analysis based on structural indicators with the aim to assess the effect of silvicultural practices on tree stand structure. The study was carried out in three Italian beech forests of different ages with stand structures that originated from dissimilar regeneration and cultivation techniques(Cansiglio, northern Italy, Chiarano, central Italy,and Mongiana, southern Italy). Ten structural indicators were considered when investigating the latent multivariate relationship between stand structure attributes before and after thinning operations by using a multiway factor analysis(MFA). The MFA results identified the older stand at Cansiglio as more homogeneous for cultivation regimes,and more stable to practices when compared with the younger sites(Chiarano and Mongiana). Heterogeneous stands were sensitive to silvicultural practice thus suggesting their possible impact on forest attributes. The proposed approach proved to be an operational tool to evaluate comprehensively the response of forest structure to planned interventions.

关键词： Forest diversity Multiway factor analysis Silviculture Structural diversity indicators Tree stand structure

Association of autoimmune hepatitis and systemic lupus erythematodes:A case series and review of the literature

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World Journal of Gastroenterology 2014年第35期20卷 12662-12667页

作者： claudia Beisel Christina Weiler-Normann Andreas Teufel Ansgar W Lohse Department of Internal Medicine University Medical Center Hamburg-Eppendorf Department of Internal Medicine Johannes Gutenberg Universit?t Mainz Department of Internal Medicine University Hospital Regensburg

Liver test abnormalities have been described in up to 60% of patients with systemic lupus erythematodes(SLE) at some point during the course of their *** treatment with potentially hepatotoxic drugs or viral hepatitis is commonly considered to be the main cause of liver disease in SLE ***,in rare cases elevated liver enzymes may be due to concurrent autoimmune hepatitis(AIH).To distinguish whether the patient has primary liver disease with associated autoimmune clinical and laboratory features resembling SLE- such as AIH- or the elevation of liver enzymes is a manifestation of SLE remains a difficult challenge for the treating ***,we present six female patients with complex autoimmune disorders and *** charts were reviewed in order to investigate the complex relationship between SLE and *** patients had coexisting autoimmune disease in their medical *** the time of diagnosis of AIH,patients presented with arthralgia,abdominal complaints,cutaneous involvement and fatigue as common *** patients fulfilled the current diagnostic criteria of both,AIH and *** of acute hepatitis was achieved in all cases after the initiation of immunosuppressive *** addition to this case study a literature review was conducted.

关键词： Systemic lupus erythematodes Elevated liver enzymes Autoimmune hepatitis

Impact of indoor air volume on thermal performance in social housing with mixed mode ventilation in three different climates

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Energy and Built Environment 2022年第4期3卷 433-443页

作者： claudia Eréndira Vázquez-Torres Adolfo Gómez-Amador Faculty of Architecture University of ColimaColima-Coquimatlán Km 9ColimaMexico

There are prototypes of social housing massively built in contrasting climatic conditions,generating thermal comfort needs that are difficult to satisfy by the users *** of indoor air volume in living spaces where the use of air conditioning and natural ventilation strategies provides elements to improve thermal comfort *** research shows the thermal performance located in a representative social housing according to Mexico’s National Housing *** temperature results from a benchmark case were compared to six Virtual Evaluation Models,using the Dynamic Thermal Simulation tool Design Builder®from the perspective of *** main objective was to determine the minimum use of active systems with different indoor air volumes and improve comfort conditions to promote sustainable living in social *** analysis was conducted under an adaptive comfort range according to three different climate conditions in Mexico adopting a Numerical Theoretical *** main findings can be divided into two parts:a)the impact of the indoor air volume on thermal performance was evidenced in a proportion of time in three representative climates of the central region of Mexico,and b)no relationship was found between indoor air volume and thermal comfort in sub-humid cold climate;in sub-humid temperate climate,the same number of comfort hours was found in two different models,and in sub-humid warm climate,an inversely proportional relationship was found between indoor air volume and the comfort *** findings implies a greater knowledge relative to what we know about sub-humid cold,temperate and warm climates.

关键词： Dynamic simulation Mixed mode ventilation Social housing Thermal comfort Passive systems

The prolactin receptor(PRLR)gene is linked to and associated with the comorbidity of depression and type 2 diabetes in Italian families

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Genes & Diseases 2024年第3期11卷 15-17页

作者： Mutaz Amin Rongling Wu Teodor T.Postolache claudia Gragnoli INSERM US14-OrphanetParis 75014France University of Paris Paris 75013France Department of Biochemistryand Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Department of Public Health Sciences Penn State College of MedicineHersheyPA 17033USA Department of Statistics Penn State College of MedicineHersheyPA 17033USA Mood and Anxiety Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mountain Mental Illness Research Education and Clinical Center(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO80246USA Mental illness Research Education and Clinical Center(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Molecular Biology Laboratory Bios Biotech Multi-Diagnostic Health CenterRome 00197Italy

Major depressive disorder(MDD)and type 2 diabetes(T2D)are two common complex multifactorial disorders that share several genetic and environmental risk factors such as hypercortisolism and related genes'riskvariants within the stress response and the neuroendocrine hypothalamicpituitary *** stress,the pituitary gland releases prolactin(PRL),whose effects are pleiotropic and include mood control and insulin secretion from the beta cells.1 Variations in the prolactin receptor(PRLR)gene are associated in rodent models with stress level,depressionlike behavior,2 and hepatic insulin sensitivity3 and in humans with maternal glucose homeostasis and gestational diabetes.

关键词： diabetes prolactin pituitary