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Prevalence and Factors Associated with Low Back Pain among Healthcare Workers in Two Hospitals in Yaoundé-Cameroon: A Cross-Sectional Study

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第3期14卷 89-107页

作者： Brian Gweha Ahmadou Musa Jingi Baudelaire Fojo Talongong claude tayou Madeleine Singwé-Ngandeu Department of Clinical Sciences Faculty of Health Sciences The University of Bamenda Bamenda Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaound Yaound Cameroon The Rheumatology Unit The Yaound Central Hospital Yaound Cameroon The Hematology Laboratory The Yaound University Teaching Hospital Yaound Cameroon

Background: Low back pain (LBP) is a very common health problem amongst the general population and a major cause of disability that affects work performance and well-being. Healthcare workers (HCWs) are especially at risk of developing LBP because of physical and emotional factors. Little is known about the burden of LBP in Cameroon. Objective: To determine the prevalence of low back pain and identify its associated factors among healthcare workers. Methods: A cross-sectional study using a self-administered questionnaire was conducted among healthcare workers in the Yaound Central Hospital and the Yaound University Teaching Hospital. The questionnaire collected data regarding recent, past year and lifetime occurrences of LBP, socio-demographics and work conditions. Data were analysed using IBM Statistical Package for Social Sciences (SPSS) version 26. Results: A total number of 268 HCWs participated in the study, including 197 (73.5%) females and 71 (26.5%) males. The mean age of the study participants was 40.60 8.38 years (extremes of 20 and 65 years). The lifetime, annual, and point prevalences of LBP among the participants were 67.5% (CI: 61.6 - 73.1), 61.5% (CI: 55.6 - 67.1) and 35.7% (CI: 29.7 - 41.5) respectively. Multivariate analysis confirmed a moderate stress level, a sedentary lifestyle, working in the medicine and specialities department, lifting heavy objects and bending to work as associated factors to LBP. Most sufferers had a minimal functional disability (65.7%) while 34.3% had a moderate to severe disability. Conclusions: Healthcare providers have a considerably high prevalence of low back pain. Factors associated with LBP found in this study were similar to those widely recognized in the literature. A substantial proportion of healthcare providers are suffering from functional disability associated with low back pain, affecting their social and work lives. There is a need for multilevel interventions to prevent and control low back pain in this hi

关键词： Prevalence Associated Factors Low Back Pain Healthcare Workers Yaoundé

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Involvement of haptoglobin in disease development

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World Journal of Hematology 2024年第2期11卷 1-7页

作者： Romaric Tuono De Manfouo JosuéSimo Louokdom Bernard claude Chetcha Larissa Michelle BakamMagoua Prosper Cabral Biapa Nya Constant Anatole Pieme claude tayou Tagny Department of Microbiology ParasitologyHematologyand Infectious DiseasesHematology UnitFaculty of Medicine and Biomedical SciencesUniversity of Yaoundé1Yaoundé296Cameroon Higher Institute of Health Sciences Universitédes MontagnesBangangté296Cameroon Public Health and Biotechnology Research Laboratory(LAPHER-Biotech) Faculty of SciencesUniversity of Yaoundé1Yaoundé296Cameroon Faculty of Sciences Universitéde DschangDschang 296Cameroon Department of Biochemistry Faculty of Medicine and Biomedical SciencesUniversity of Yaoundé1Yaoundé296Cameroon

Haptoglobin(HP)is a liver glycoprotein that is actively synthesized during in-flammatory and hemolytic *** also has pro-oxidant and proinflam-matory properties,which are a function of its *** genetic polymorp-hism of the chains leads to synthesis of three phenotypes/proteins,which are related to the number and type of chains and their molecular weight,namely HP1-1,HP1-2 and *** with HP2-2 have more vascular complications,while those with HP1-1 have *** is involved in the worsening of diseases,such as HP2-2 in aggravation of vaso-occlusive crises in sickle cell disease,and worsening of the pathophysiology of other *** contrast,HP1-1 confers better protection against *** of this suggests that further studies should be conducted,including experimental and analytical studies focused on de-monstrating the influence of different HP genotypes on individual clinical and hematological *** would help in understanding the role played by this genetic polymorphism in the pathophysiology of diseases.

关键词： Haptoglobin Protein Properties Polymorphism Diseases

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HindIII and MseI in the Biomolecular Profile of Hemophilia in Cameroon: A Primer Study

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Journal of Biosciences and Medicines 2022年第6期10卷 8-19页

作者： Nsa’Amang Carolle Eyebe Eyebe Serge Eyebe Kengne Jean Paul Chedjou Tah Calvino Fomboh Aurélien Chendjou Verdiane Mabopda claude tayou Fon Wilfred Mbacham The Biotechnology Centre University of Yaounde I Yaounde Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Department of Biochemistry and Molecular Biology Faculty of Science University of Buea Buea Cameroon Department of Biochemistry Faculty of Science University of Yaounde I Yaounde Cameroon European Institute for Cooperation and Development Delegation Yaoude Cameroon The University Teaching Hospital Yaoude Cameroon

Numerous studies are being carried out on polymorphisms within the genes coding for factors VIII and IX due to their clinical relevance in the context of hereditary disorders. The quests for polymorphism can be used to screen for haemophilia through an affected family. In Cameroon, very few studies on factors VIII and IX gene polymorphisms have been conducted. Thus, this study was aimed at detecting HindIII SNP of the F8 gene and MseI SNP of the F9 gene by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RLFP) method and determining their involvement in the severity and complications of haemophilia. Fifty-five consented haemophilia patients from the Centre Hospitalier et Universitaire de Yaoundé (CHUY) were recruited for this study on a convenience sampling basis. Finger-prick blood was collected and spotted on filter papers from which DNA was extracted and then subjected to the PCR-RFLP. We were able to recruit 55 (37.16%) patients out of the 148 haemophilia patients registered at the CHUY until December 2018. The average age was 15 years. Of the 55 haemophilia patients, 42 (76.36%) had type A haemophilia and 13 (23.64%) had type B haemophilia, 41 patients (74.55%) had a severe form, 10 (18.18%) had a moderate form and 4 (7.27%) a mild form). Of the 55 patients recruited, 38 (69.09%) already had an osteoarticular complication and the remaining 17 (30.91%) had no complication. Fifty-three (96.36%) participants had HindIII SNP and a significant association was found with the severity of hemophilia (P = 0.00). No association (P = 0.56) was found with osteoarticular complications of haemophilia. On the other hand, 15 (27.27%) participants were diagnosed with MseI SNPs and no association was found with the severity (P = 0.89) or complications (P = 0.68) of haemophilia.

关键词： Haemophilia SNP HindIII SNP MseI PCR-RFLP Cameroon

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Hematobiological Profile of Patients with Chronic Myeloid Leukemia at the Diagnosis in Yaoundé: A Cross-Sectional Study

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Open Journal of Blood Diseases 2020年第4期10卷 110-123页

作者： Annie Prudence Bisso Ngono Prisca Angandji Tipane Sylvain Raoul Simeni Njonnou Aimée Tiodoung Timnou Anne Juliette Flora Sango Paul Ndom claude tayou Tagny Dora Mbanya Department of Microbiology Parasitology Hematology and Infectious Diseases Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Yaoundé Central Hospital Yaoundé Cameroon Yaoundé Jamot’s Hospital Yaoundé Cameroon Department of Internal Medicine and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Dschang District Hospital Dschang Cameroon Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Internal Medicine and Pediatrics Faculty of Health Sciences Medicine and Biomedical Sciences University of Buea Buea Cameroon Yaoundé General Hospital Yaoundé Cameroon Solidarité Chimiothérapie (SOCHIMIO) Yaoundé Cameroon Yaounde University Teaching Hospital Yaoundé Cameroon National Center for Blood Transfusion Yaoundé Cameroon

Background: Chronic Myeloid Leukemia (CML) is a myeloproliferative blood neoplasia, characterized by the presence of a translocation between chromosomes 9 and 22 leading to the formation of the Philadelphia chromosome. Data on the biological profile of patients with CML at diagnosis are still lacking in sub-Saharan Africa, particularly in Cameroon. Methods: A cross-sectional study was carried out from January 2001 to July 2016 among patients recently diagnosed with CML at the Yaounde University Teaching Hospital, the Yaoundé Central Hospital and the Yaoundé General Hospital. Analyzed variables included socio-demographic, clinical presentation, the diagnosis means, biological parameters (hematological and biochemical). Sampling was consecutive. Results: We included 132 (76 males) patients with CML with a median age of 39.2 years at diagnosis. The 31 - 45 years age group was the most represented, with 40.9% of the study population. A risk factor was found in only 5 (3.8%) of patients. Clinical manifestations were recorded in only 27 (20.45%) patients, with fatigue being the commonest (10.6%). Almost all patients (128, 96.9%) have performed the karyotype while 22 (16.7%) have performed fluorescence in situ hybridization (FISH) and 4 (3.0%) the PCR. At diagnosis, 66% of the patients were in the chronic phase (CP), 11.3% in accelerated phase (AP), and 22.7% in blast crisis (BC). All patients presented hyperleukocytosis, with a white blood cell mean of 128,362/mm3. Anemia was common (77.3%), usually moderate (61.4%). Thrombocytopenia was rare (8.3%), as far as basophilia (1.2%). Among those patients, mean values of creatinine, Glutamic pyruvate transaminase (GPT) and glycemia were normal while activated partial thromboplastin time (APTT), prothrombin time (PT), plasma uric acid level, gamma glutamic transferase (GGT), lactate dehydrogenase (LDH), and inflammatory paramete

关键词： Chronic Myeloid Leukemia Biological Clues at Diagnosis Sub-Saharan Africa

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Determination of Electron Collision Cross Sections Set for Tetramethysilane

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Plasma Science and Technology 2007年第6期9卷 756-759页

作者： Marie-claude BORDAGE Toulouse University LAPLACE UMR 5213 CNRS-UPSPaul Sabatier University118Route de Narbonne31062 Toulouse CedexFrance

A swarm analysis technique based on the solution of the Boltzmann equation is used to derive low energy electron collision cross sections for tetramethylsilane （TMS）. The calculated swarm parameters with this first available cross sections set is consistent with measured values of the swarm parameters. Calculations of transport parameters in mixtures of TMS with argon are also presented.

关键词： tetramethysilane electron cross section swarm parameters

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Advantages and Drawbacks of Quantum Mechanical Static and Dynamic Approaches to Modelling Infrared Spectra

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Chinese Journal of Chemical Physics 2009年第2期22卷 123-128页

作者： claude Pouchan Philippe Carbonniere Groupe Chimie Théorique et Réactivité ECP IPREM UMR CNRS 5254 Université de Pau et des Pays de I'Adour 2 Rue Jules Ferry F-54000 Pau France

We present quantum mechanical vibrational computations beyond the harmonic approximation from effective second order perturbative and variation perturbation treatments defined as static approaches, as well as vibrational analysis from density functional theory molecular dynamics trajectories at 300 and 600 K. The four schemes are compared in terms of prediction of fundamental transitions, and simulation of the corresponding medium infrared spectrum at the same level of theory using the B3LYP/6-31＋G（d,p） description of the electronic structure. We summarize conclusions about advantages and drawbacks of these two approaches and report the main results obtained for semi-rigid and flexible molecules.

关键词： Anharmonic vibrations Vibrational configuration interaction Perturbative approach Ab initio molecular dynamic treatment

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The synergy between the payloads on the ASO-S mission

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Research in Astronomy and Astrophysics 2019年第11期19卷 115-126页

作者： Jean-claude Vial Institut d’Astrophysique Spatiale University Paris-Sud

This paper addresses the improved science resulting from joint observations performed by the different instruments onboard the Advanced Space-based Solar Observatory(ASO-S)mission along with ancillary instruments on missions flying at the same *** first describes the three major instruments along with their stated *** it presents some basic science issues concerning jointly observed flares,coronal mass ejections(CMEs)and eruptive prominences(EPs).Each physical candidate(magnetic reconnection,instability,hard X-ray emission and magnetic coronal field topology)is discussed in terms of its signature and identification with ASO-S *** importance of Lyαdetection and non-LTE modeling is *** instrumental and science challenges are briefly discussed.

关键词： techniques imagery,polarimetry-Sun eruptions,flares,coronal mass ejections

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More constructions of APN and differentially 4-uniform functions by concatenation

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Science China Mathematics 2013年第7期56卷 1373-1384页

作者： CARLET claude LAGA University of Paris 13CNRS (UMR 7539)France Department of Mathematics University of Paris 8 2 rue de la liberté 93526 Saint-Denis Ced-exFrance

We study further the method of concatenating the outputs of two functions for designing an APN or a differentially 4-uniform (n, n)-function for every even n. We deduce several specific constructions of APN or differentially 4-uniform (n, n)-functions from APN and differentially 4-uniform (n/2, n/2)-functions. We also give a construction of quadratic APN functions which includes as particular cases a previous construction by the author and a more recent construction by Pott and Zhou.

关键词： block cipher vectorial function substitution box almost perfect nonlinear almost bent

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Biomechanics of transendothelial migration by cancer cells

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BIOCELL 2022年第11期46卷 2381-2386页

作者： claude VERDIER UniversitéGrenoble Alpes CNRSLIPhyGrenoble38000France

Cancer metastasis is still a major social issue with limited knowledge of the formation of tumors and their *** addition the formation of metastases is very difficult to understand,since it involves very complex physical mechanisms such as cellular interactions and cell rheology,which are *** studies investigated transendothelial migration using sophisticated techniques such as microfluidics,traction force microscopy(TFM)or Atomic Force Microscopy(AFM),combined with physical *** we summarize recent results and suggest new ways to investigate the precise mechanisms used by cancer cells to undergo transendothelial migration.

关键词： Rheology Deformation Forces Adhesion Biophysics

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Lanthanide-doped nanoscintillators

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Light(Science & Applications) 2022年第10期11卷 2264-2266页

作者： Jean-claude Georges Bünzli institute of Chemical Sciences and Engineering Swiss Federal Institute of TechnologyLausanne(EPFL)LausanneSwitzerland Department of Biomedical Engineering Southern University of Science and Technology(SUSTech)ShenzhenChina

Lanthanide-doped nanoscintillators are taking the lead in several important fields including radiation detection,biomedicine,both at the level of diagnosis and therapy,and information encoding.

关键词： diagnosis Lanthanide ill

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