Hematobiological Profile of Patients with Chronic Myeloid Leukemia at the Diagnosis in Yaoundé: A Cross-Sectional Study

作     者：Annie Prudence Bisso Ngono Prisca Angandji Tipane Sylvain Raoul Simeni Njonnou Aimée Tiodoung Timnou Anne Juliette Flora Sango Paul Ndom Claude Tayou Tagny Dora Mbanya Annie Prudence Bisso Ngono;Prisca Angandji Tipane;Sylvain Raoul Simeni Njonnou;Aimée Tiodoung Timnou;Anne Juliette Flora Sango;Paul Ndom;Claude Tayou Tagny;Dora Mbanya

作者机构：Department of Microbiology Parasitology Hematology and Infectious Diseases Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Yaoundé Central Hospital Yaoundé Cameroon Yaoundé Jamot’s Hospital Yaoundé Cameroon Department of Internal Medicine and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Dschang District Hospital Dschang Cameroon Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Internal Medicine and Pediatrics Faculty of Health Sciences Medicine and Biomedical Sciences University of Buea Buea Cameroon Yaoundé General Hospital Yaoundé Cameroon Solidarité Chimiothérapie (SOCHIMIO) Yaoundé Cameroon Yaounde University Teaching Hospital Yaoundé Cameroon National Center for Blood Transfusion Yaoundé Cameroon 

出 版 物：《Open Journal of Blood Diseases》 (血液病期刊（英文）)

年 卷 期：2020年第10卷第4期

页      面：110-123页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Chronic Myeloid Leukemia Biological Clues at Diagnosis Sub-Saharan Africa 

摘      要：Background: Chronic Myeloid Leukemia (CML) is a myeloproliferative blood neoplasia, characterized by the presence of a translocation between chromosomes 9 and 22 leading to the formation of the Philadelphia chromosome. Data on the biological profile of patients with CML at diagnosis are still lacking in sub-Saharan Africa, particularly in Cameroon. Methods: A cross-sectional study was carried out from January 2001 to July 2016 among patients recently diagnosed with CML at the Yaounde University Teaching Hospital, the Yaoundé Central Hospital and the Yaoundé General Hospital. Analyzed variables included socio-demographic, clinical presentation, the diagnosis means, biological parameters (hematological and biochemical). Sampling was consecutive. Results: We included 132 (76 males) patients with CML with a median age of 39.2 years at diagnosis. The 31 - 45 years age group was the most represented, with 40.9% of the study population. A risk factor was found in only 5 (3.8%) of patients. Clinical manifestations were recorded in only 27 (20.45%) patients, with fatigue being the commonest (10.6%). Almost all patients (128, 96.9%) have performed the karyotype while 22 (16.7%) have performed fluorescence in situ hybridization (FISH) and 4 (3.0%) the PCR. At diagnosis, 66% of the patients were in the chronic phase (CP), 11.3% in accelerated phase (AP), and 22.7% in blast crisis (BC). All patients presented hyperleukocytosis, with a white blood cell mean of 128,362/mm3. Anemia was common (77.3%), usually moderate (61.4%). Thrombocytopenia was rare (8.3%), as far as basophilia (1.2%). Among those patients, mean values of creatinine, Glutamic pyruvate transaminase (GPT) and glycemia were normal while activated partial thromboplastin time (APTT), prothrombin time (PT), plasma uric acid level, gamma glutamic transferase (GGT), lactate dehydrogenase (LDH), and inflammatory paramete