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Affective responses to supervised 10-week programs of resistance exercise in older adults

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Journal of Sport and Health Science 2020年第6期9卷 604-613页

作者： Darren L.Richardson Michael J.Duncan Alfonso Jimenez Paul M.Juris Neil D.clarke Centre for Applied Biological&Exercise Sciences School of Life SciencesCoventry UniversityCoventry CV12DSUK Department of Kinesiology University of Massachusetts AmherstAmherstMA 01003USA

Background:Resistance exercise has numerous,well-documented benefits on the health and functional performance of older ***,little information exists on the affective responses to resistance exercise in this *** affective responses can predict continued exercise behavior,examining if and how they differ between resistance exercise intensities and frequencies in older adults may provide important data to improve resistance exercise ***:We monitored the affective responses of older adults when performing high-velocity,low-load(HVLL)or low-velocity,high-load(LVHL)resistance exercise once or twice weekly.A total of 40 moderately to highly active,but resistance-exercise naïve,older adults(60-79 years)completed 1 of 4 randomly assigned progressive resistance exercise conditions:HVLL once weekly(HVLL1:n=10),HVLL twice weekly(HVLL2:n=10),LVHL once weekly(LVHL1:n=10),or LVHL twice weekly(LVHL2:n=10).The Physical Activity Affect Scale,Felt Arousal Scale,Feeling Scale,rating of perceived exertion,Visual Analog Scale,and the Physical Activity Enjoyment Scale were used to assess enjoyment and affective ***:The results from Physical Activity Enjoyment Scale(out of 35)suggest that all exercise conditions were largely and similarly enjoyable to older adults(HVLL1:30.9±2.4;LVHL1:31.9±3.6;HVLL2:30.9±3.5;LVHL2:30.2±3.7)despite greater fatigue(p=0.033;ηp^2p=0.22)and perceived workload(p=0.042;ηp^2=0.20)in LVHL(results from Visual Analog Scale).Conclusion:Moderately to highly physically active older adults may tolerate higher intensities of resistance exercise performed once or twice weekly without experiencing a negative impact on ***,the role that supervision and social interaction played in shaping the participants’responses is unclear.

关键词： Aging Enjoyment Exercise affect Health education Older adults

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Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage

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Asian Journal of Andrology 2015年第4期17卷 681-685页

作者： Carol Coughlan Helen clarke Rachel Cutting Jane Saxton Sarah Waite William Ledger Tinchiu Li Allan A Pacey Department of Human Metabolism Academic Unit of Reproductive and Developmental Medicine University of Sheffield Level 4 The Jessop Wing Tree Root WalkSheffield S10 2SF UK Assisted Conception Unit Jessop Wing Tree Root Walk Sheffield S10 2SF UK Department of Obstetrics and Gynaecology School of Women'sand Children's Health University of New South Wales Royal Hospital for Women Sydney New South Wales Australia

Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage （RM）. To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure （RIF） following in vitro fertilization, 16 women diagnosed with RM and seven recent fathers （control） were examined. Sperm were examined pre- and post-density centrifugation by the sperm chromatin dispersion （SCD） test and the terminal deoxynucleotidyl transferase dUTP nick end labeling （TUNEL） assay. There were no significant differences in the age of either partner or sperm concentration, motility or morphology between three groups. Moreover, there were no obvious differences in sperm DNA fragmentation measured by either test. However, whilst on average sperm DNA fragmentation in all groups was statistically lower in prepared sperm when measured by the SCD test, this was not seen with the results from the TUNEL assay. These results do not support the hypothesis that sperm DNA fragmentation is an important cause of RIF or RM, or that sperm DNA integrity testing has value in such patients. It also highlights significant differences between test methodologies and sperm preparation methods in interpreting the data from sperm DNA fragmentation tests.

关键词： DNA recurrent implantation failure recurrent miscarriage sperm

基于RS/GIS的赣州市生态系统服务价值时空演变特征研究

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城市建筑 2023年第23期20卷 116-118页

作者：赵元凌鄢博 [美]Kethleen clarke 长江水利委员会长江科学院佛罗里达大学建筑城市规划学院

随着城市化进程的不断加速,生态系统服务价值(ESV)的动态变化成为评估区域可持续发展的重要指标。文章对中国赣州市2000年、2010年和2020年的土地利用数据及ESV进行时空分析,旨在揭示这一时期内ESV的时空变化及其与土地利用变化的关系... 详细信息

随着城市化进程的不断加速,生态系统服务价值(ESV)的动态变化成为评估区域可持续发展的重要指标。文章对中国赣州市2000年、2010年和2020年的土地利用数据及ESV进行时空分析,旨在揭示这一时期内ESV的时空变化及其与土地利用变化的关系。研究采用遥感(RS)和地理信息系统(GIS)技术,通过随机森林算法对土地利用类型进行分类,并结合本地化的ESV系数计算和分析地均ESV。结果表明,赣州市在20年间的ESV总价值轻微下降,从2000年的1669.21亿元减少至2020年的1 650.83亿元。在未来城市规划和土地管理决策中需要考虑生态系统服务保护和增强,以促进地方可持续发展和生态文明建设。

关键词：生态系统服务价值土地利用变化遥感地理信息系统

维普期刊数据库博看期刊

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一个英国救援队员的7天

三联生活周刊 2023年第9期 60-62页

作者： Andrew clarke(口述) 印柏同不详

把遇难者的遗体搬出来并不是我们的工作,这听上去有点残酷,但我们的首要任务是搜救幸存者。他们生活过的地方我是在英国时间2月6号早上7点收到前往土耳其救灾的志愿召集消息的。我是英格兰切斯特市的消防员,今年35岁,有15年的消防经验... 详细信息

把遇难者的遗体搬出来并不是我们的工作,这听上去有点残酷,但我们的首要任务是搜救幸存者。他们生活过的地方我是在英国时间2月6号早上7点收到前往土耳其救灾的志愿召集消息的。我是英格兰切斯特市的消防员,今年35岁,有15年的消防经验。过去,我营救过车祸后被困在车里的乘客,做过水上救援,还帮人开过门锁,将家里的病人送去医院。但我从来没有参与过地震现场的救援。

关键词：地震现场水上救援消防员救援队员切斯特幸存者土耳其遇难者

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局部无缝垂直参考基准面的建立方法研究

武汉大学学报（信息科学版） 2006年第5期31卷 448-450页

作者：赵建虎张红梅 John E Hughes clarke 武汉大学测绘学院武汉市珞喻路129号430079 武汉大学动力与机械学院武汉市东湖南路8号430072 新伯伦瑞克大学图形组

为在局域建立一个无缝垂直参考基准面,提出了两步转换的思想和方法,即从大地高到正高然后到海图高。利用该方法,构造了Saint John河高程转换模型,并在该河段建立了无缝垂直参考基准面,且得到了实际验证。

关键词：大地高正常高海图基准海图基准高程

Ultra high sensitivity Charde Coupled Devices（CCD）

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Ultra high sensitivity Charde Coupled Devices（CCD）

Accelerating material design with the generative toolkit for scientific discovery

中国物理学会光散射专业委员会成立十周年暨第六届学术会议

作者： John F clarke Spex Industries Inc Edison NJ USA B.Sc.Ph.D

＜正＞The SPEX Spectrum One CCD is a stats-of-the-art,Z-D detector that excels at very low-light level applications reaniring the utmost *** has the added advantage of enhanced red response making it ideal for

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npj Computational Materials 2023年第1期9卷 1649-1654页

作者： Matteo Manica Jannis Born Joris Cadow Dimitrios Christofidellis Ashish Dave Dean clarke Yves Gaetan Nana Teukam Giorgio Giannone Samuel C.Hoffman Matthew Buchan Vijil Chenthamarakshan Timothy Donovan Hsiang Han Hsu Federico Zipoli Oliver Schilter Akihiro Kishimoto Lisa Hamada Inkit Padhi Karl Wehden Lauren McHugh Alexy Khrabrov Payel Das Seiji Takeda John R.Smith IBM Research Europe-Zurich RüschlikonSwitzerland IBM Research-UK HursleyUK IBM Research-Yorktown Heights New YorkUSA IBM Research-Tokyo TokyoJapan IBM Research-Almaden San JoseUSA

With the growing availability of data within various scientific domains,generative models hold enormous potential to accelerate scientific *** harness powerful representations learned from datasets to speed up the formulation of novel hypotheses with the potential to impact material discovery *** present the Generative Toolkit for Scientific Discovery(GT4SD).This extensible open-source library enables scientists,developers,and researchers to train and use state-of-the-art generative models to accelerate scientific discovery focused on organic material design.

关键词： enable scientific formulation

Gastric per-oral endoscopic myotomy: Current status and future directions

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World Journal of Gastroenterology 2019年第21期25卷 2581-2590页

作者： Alexander Podboy Joo Ha Hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O clarke Division of Gastroenterology and Hepatology Stanford University School of Medicine

Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field.

关键词： Gastroparesis Gastric per-oral endoscopic myotomy Per-oral endoscopic pyloromyotomy Myotomy Endoscopic myotomy Peroral endoscopic myotomy Gastric emptying

Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores:evidence from the China Kadoorie Biobank

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Chinese Medical Journal 2023年第20期136卷 2476-2483页

作者： Songchun Yang Dong Sun Zhijia Sun Canqing Yu Yu Guo Jiahui Si Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona YMillwood Robin GWalters Yiping Chen Huaidong Du Zengchang Pang Dan Schmidt Rebecca Stevens Robert clarke Junshi Chen Zhengming Chen Jun Lv Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100730China Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Qingdao Center of Disease Control and Prevention QingdaoShandong 266033China China National Center for Food Safety Risk Assessment Beijing 100738China 不详

Background:Several studies have reported that polygenic risk scores(PRSs)can enhance risk prediction of coronary artery disease(CAD)in European ***,research on this topic is far from sufficient in non-European countries,including *** aimed to evaluate the potential of PRS for predicting CAD for primary prevention in the Chinese ***:Participants with genome-wide genotypic data from the China Kadoorie Biobank were divided into training(n=28,490)and testing sets(n=72,150).Ten previously developed PRSs were evaluated,and new ones were developed using clumping and thresholding or LDpred *** PRS showing the strongest association with CAD in the training set was selected to further evaluate its effects on improving the traditional CAD risk-prediction model in the testing *** risk was computed by summing the product of the weights and allele dosages across genome-wide single-nucleotide *** of the 10-year first CAD events was assessed using hazard ratios(HRs)and measures of model discrimination,calibration,and net reclassification improvement(NRI).Hard CAD(nonfatal I21-I23 and fatal I20-I25)and soft CAD(all fatal or nonfatal I20-I25)were analyzed ***:In the testing set,1214 hard and 7201 soft CAD cases were documented during a mean follow-up of 11.2 *** HR per standard deviation of the optimal PRS was 1.26(95%CI:1.19-1.33)for hard *** on a traditional CAD risk prediction model containing only non-laboratory-based information,the addition of PRS for hard CAD increased Harrell’s C index by 0.001(-0.001 to 0.003)in women and 0.003(0.001 to 0.005)in *** the different high-risk thresholds ranging from 1%to 10%,the highest categorical NRI was 3.2%(95%CI:0.4-6.0%)at a high-risk threshold of 10.0%in *** association of the PRS with soft CAD was much weaker than with hard CAD,leading to minimal or no improvement in the soft CAD ***:In this Chinese population sam

关键词： Coronary artery disease Polygenic risk score Risk prediction model Chinese population

维普期刊数据库