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Importance of complementary data to histopathological image analysis of oral leukoplakia and carcinoma using deep neural networks

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Intelligent Medicine 2023年第4期3卷 258-266页

作者： Leandro Muniz de Lima Maria clara Falcão Ribeiro de Assis Júlia Pessini Soares Tânia Regina Grão-Velloso Liliana Aparecida Pimenta de Barros Danielle Resende Camisasca Renato Antonio Krohling Nature-inspired Computing Lab Federal University of Espirito SantoVitoriaBrazil Graduate Program in Computer Science Federal University of Espirito SantoVitoriaBrazil School of Dentistry Departamento de Clinica OdontologicaFederal University of Espirito SantoVitoriaBrazil Graduate Program in Clinical Dentistry Federal University of Espirito SantoVitoriaBrazil

Background Oral cancer is one of the most common types of cancer in men causing mortality if not *** recent years,computer-aided diagnosis(CAD)using artificial intelligence techniques,in particular,deepneural networks have been investigated and several approaches have been proposed to deal with the automateddetection of various pathologies using digital *** studies indicate that the fusion of images with thepatient’s clinical information is important for the final clinical *** such dataset does not yet exist fororal cancer,as far as the authors are aware,a new dataset was collected consisting of histopathological images,demographic and clinical *** study evaluated the importance of complementary data to histopathologicalimage analysis of oral leukoplakia and carcinoma for *** A new dataset(NDB-UFES)was collected from 2011 to 2021 consisting of histopathological imagesand *** 237 samples were curated and analyzed by oral pathologists generating the gold standardfor ***-of-the-art image fusion architectures and complementary data(Concatenation,MutualAttention,MetaBlock and MetaNet)using the latest deep learning backbones were investigated for 4 distincttasks to identify oral squamous cell carcinoma,leukoplakia with dysplasia and leukoplakia without *** evaluate them using balanced accuracy,precision,recall and area under the ROC curve *** Experimental results indicate that the best models present balanced accuracy of 83.24%using images,demographic and clinical information with MetaBlock fusion and ResNetV2 *** represents an improvement in performance of 30.68%(19.54 pp)in the task to differentiate samples diagnosed with oral squamous cellcarcinoma and leukoplakia with or without *** This study indicates that cured demographic and clinical data may positively influence the performance of artificial intelligence models in automated classification of

关键词： Leukoplakia Squamous carcinoma Pathology Deep learning Transfer learning

Urine-derived stem/progenitor cells:A focus on their characterization and potential

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World Journal of Stem Cells 2020年第10期12卷 1080-1096页

作者： Perrine Burdeyron Sébastien Giraud Thierry Hauet clara Steichen INSERM U1082 IRTOMIT CHU de PoitiersPoitiers 86021France Facultéde Médecine et Pharmacie Universite de PoitiersPoitiers 86021France

Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized *** the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(USCs)have aroused interest in the past *** display classical features of mesenchymal stem cells such as differentiation capacity and ***,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive ***,USCs can be differentiated into renal cell *** is of high interest for renal cell therapy-based regenerative *** review will firstly describe the isolation and characterization of *** will specifically present USC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation *** the second part of this review,we will present and discuss the main applications of *** include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of USCs for cell therapy approaches with a detailed analysis depending on the targeted organ or ***,we will also focus on the applications that rely on the use of USC-derived products such as microvesicles including exosomes,which is a strategy being increasingly *** the last section,we will discuss the remaining barriers and challenges in the field of USC-based regenerative medicine.

关键词： Urine-derived stem cells Urine progenitor cells Exosomes Cell therapy Kidney injury and repair Regenerative medicine

Inherited Fanconi syndrome

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World Journal of Pediatrics 2023年第7期19卷 619-634页

作者： Anna Luiza Braga Albuquerque Rafael dos Santos Borges Ana Flavia Conegundes Erika Emmylaine dos Santos Frederico Moreira Man Fu clara Tavares Araujo Pedro Alves Soares Vaz de Castrol Ana Cristina Simoes e Silva Interdisciplinary Laboratory of Medical Investigation Unit of Pediatric NephrologyFaculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteBrazil Department of Pediatrics Faculty of MedicineUFMGAlfredo Balena Avenue1902Nd FloorRoom#281Belo HorizonteMG 30130-100Brazil

Background Fanconi-Debré-de Toni syndrome(also known as Fanconi renotubular syndrome,or FRST)profoundly increased the understanding of the functions of the proximal convoluted tubule(PCT)and provided important insights into the pathophysiology of several kidney diseases and drug *** sources We searched Pubmed and Scopus databases to find relevant articles about *** review article focuses on the physiology of the PCT,as well as on the physiopathology of FRST in children,its diagnosis,and *** FRST encompasses a wide variety of inherited and acquired PCT alterations that lead to impairment of PCT *** children,FRST often presents as a secondary feature of systemic disorders that impair energy supply,such as Lowe's syndrome,Dent's disease,cystinosis,hereditary fructose intolerance,galactosemia,tyrosinemia,Alport syndrome,and Wilson's *** rare,congenital causes of FRST greatly impact the morbidity and mortality of patients and impose diagnostic ***,its treatment is diverse and considers the ability of the clinician to identify the correct etiology of the *** The early diagnosis and treatment of pediatric patients with FRST improve the prognosis and the quality of life.

关键词： Cystinosis Fanconi syndrome Fanconi renotubular syndrome Fanconi-Debre-de Toni syndrome Proximal tubule Renal tubular transport-Rickets

Liver metastases:The role of magnetic resonance imaging

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世界胃肠病学杂志:英文版 2023年第36期29卷 5180-5197页

作者： Cesare Maino Federica Vernuccio Roberto Cannella Francesco Cortese Paolo NiccolòFranco clara Gaetani Valentina Giannini Riccardo Inchingolo Davide Ippolito Arianna Defeudis Giulia Pilato Davide Tore Riccardo Faletti Marco Gatti Department of Radiology Fondazione IRCCS San Gerardo dei TintoriMonza 20900Italy University Hospital of Padova Institute of RadiologyPadova 35128Italy Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Unit of Interventional Radiology F Miulli HospitalAcquaviva delle Fonti 70021Italy Department of Surgical Sciences University of TurinTurin 10126Italy School of Medicine University of Milano BicoccaMilano 20100Italy

The liver is one of the organs most commonly involved in metastatic disease,especially due to its unique ***’s well known that liver metastases represent the most common hepatic malignant *** a practical point of view,it’s of utmost importance to evaluate the presence of liver metastases when staging oncologic patients,to select the best treatment possible,and finally to predict the overall *** the past few years,imaging techniques have gained a central role in identifying liver metastases,thanks to ultrasonography,contrast-enhanced computed tomography(CT),and magnetic resonance imaging(MRI).All these techniques,especially CT and MRI,can be considered the noninvasive reference standard techniques for the assessment of liver involvement by *** the other hand,the liver can be affected by different focal lesions,sometimes benign,and sometimes *** these bases,radiologists should face the differential diagnosis between benign and secondary lesions to correctly allocate patients to the best *** the above-mentioned principles,it’s extremely important to underline and refresh the broad spectrum of liver metastases features that can occur in everyday clinical *** review aims to summarize the most common imaging features of liver metastases,with a special focus on typical and atypical appearance,by using MRI.

关键词： Liver metastases Magnetic resonance imaging Gadolinium Gd-EOB-DTPA Gadoxetate disodium Liver specific contrast agents Hepatobiliary contrast agents

Clinical implications of endogenous testosterone density on prostate cancer progression in patients with very favorable low and intermediate risk treated with radical prostatectomy

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Asian Journal of Andrology 2023年第5期25卷 556-563页

作者： Antonio Benito Porcaro Alessandro Tafuri Andrea Panunzio clara Cerrato Alberto Bianchi Sebastian Gallina Stefano Vidiri Damiano D'Aietti Emanuele Serafin Giovanni Mazzucato Alessandro Princiotta Davide Brusa Matteo Brunelli Vincenzo Pagliarulo Maria Angela Cerruto AlessandroAntonelli Department of Urology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy Department of Urology Vito Fazzi HospitalLecce 73100Italy Department of Pathology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy

We tested the association between endogenous testosterone density(ETD;the ratio between endogenous testosterone[ET]and prostate volume)and prostate cancer(PCa)aggressiveness in very favorable low-and intermediate-risk PCa patients who underwent radical prostatectomy(RP).Only patients with prostate-specific antigen(PSA)within 10 ng ml^(-1),clinical stage T1c,and International Society of Urological Pathology(IsUP)grade group 1 or 2 were *** ET levels up to 350 ng dl^(-1)were classified as *** quantitation density factors were evaluated as the ratio between percentage of biopsy-positive cores and prostate volume(biopsy-positive cores density,BPCD)and the ratio between percentage of cancer invasion at final pathology and prostate weight(tumor load density,TLD).Disease upgrading was coded as ISUP grade group>2,and progression as recurrence(biochemical and/or local and/or distant).Risk associations were evaluated by multivariable Cox and logistic regression *** 320 patients,151(47.2%)had intermediate-risk ***(median:402.3 ng dl^(-1))resulted abnormal in 111(34.7%)cases(median ETD:9.8 ng dl^(-1)ml^(-1)).Upgrading and progression occurred in 109(34.1%)and 32(10.6%)cases,*** was predicted by ISUP grade group 2(hazard ratio[HR]:2.290;P=0.029)and upgrading(HR:3.098;P=0.003),which was associated with ISUP grade group 2(odds ratio[OR]:1.785;P=0.017)and TLD above the median(OR:2.261;P=0.001).After adjustment for PSAdensity and bodymass index(BMI),ETDabovethemedianwas positivelyassociatedwithBPCD(OR:3.404;P<0.001)and TLD(OR:5.238;P<0.001).Notably,subjects with abnormal ET were more likely to have higher BPCD(OR:5.566;P=0.002),as well as TLD(OR:14.998;P=0.016).Independently by routinely evaluated factors,as ETD increased,BPCD and TLD increased,but increments were higher for abnormal ET *** very favorable cohorts,ETD may further stratify the risk of aggressive PCa.

关键词： endogenous testosterone density prostate cancer radical prostatectomy tumor progression

Suitability and limitations of mesenchymal stem cells to elucidate human bone illness

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World Journal of Stem Cells 2019年第9期11卷 578-593页

作者： Izaskun Mitxitorena Arantza Infante Blanca Gener clara I Rodríguez Stem Cells and Cell Therapy Laboratory Biocruces Bizkaia Health Research InstituteCruces University HospitalBarakaldo 48903BizkaiaSpain Service of Genetics Biocruces Bizkaia Health Research InstituteCruces University HospitalBarakaldo 48903BizkaiaSpain Centre for Biomedical Network Research on Rare Diseases Instituto de Salud Carlos IIIMadrid 28005Spain

Functional impairment of mesenchymal stem cells(MSCs),osteoblast progenitor cells,has been proposed to be a pathological mechanism contributing to bone disorders,such as osteoporosis(the most common bone disease)and other rare inherited skeletal *** bone loss can be caused not only by an enhanced bone resorption activity but also by hampered osteogenic differentiation of *** majority of the current treatment options counteract bone loss,and therefore bone fragility by blocking bone *** socalled antiresorptive treatments,in spite of being effective at reducing fracture risk,cannot be administered for extended periods due to security ***,there is a real need to develop osteoanabolic therapies to promote bone *** MSCs emerge as a suitable tool to study the etiology of bone disorders at the cellular level as well as to be used for cell therapy purposes for bone *** review will focus on the most relevant findings using human MSCs as an in vitro cell model to unravel pathological bone mechanisms and the application and outcomes of human MSCs in cell therapy clinical trials for bone disease.

关键词： Mesenchymal stem cells Bone illness Osteoporosis Osteogenesis Osteoanabolic therapies In vitro cell models Cell therapy

“I Felt Defeated. I Felt Helpless”: Social Determinants of Health Influencing the Cancer Survivorship of a Young Latina Mother

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Journal of Cancer Therapy 2022年第7期13卷 440-449页

作者： Adriena Hernandez clara L. Reyes Isela Garcia Rebecca L. Palacios Department of Health Promotion Sciences The University of Arizona Tucson AZ USA Department of Public Health Sciences New Mexico State University Las Cruces NM USA

Social determinants of health (SDOH) contribute to cancer disparities among young Latina women (<50 years) residing in the counties along the US-Mexico border. These SDOH are particularly burdensome to young Latina mothers diagnosed with cancer while they are raising school-age children. Conexiones, a culturally adapted program designed to improve mother and child adjustment to maternal cancer, was piloted with diagnosed Latina mothers residing in border counties in New Mexico and Texas. The purpose of this case analysis was to highlight the SDOH affecting a young Latina mother’s cancer survivorship in the U.S.-Mexico border region. The participant’s Conexiones education sessions were recorded, transcribed, translated to English, back translated to Spanish to establish accuracy, and inductively coded. The participant’s baseline survey indicated she was a young (<50 years), married, Spanish-speaking Latina mother diagnosed with breast cancer while raising a teenage daughter. Seventeen SDOH themes affecting the participant’s cancer experience were identified in the cancer-related emotional triggers she reported across five Conexiones sessions. These themes were organized using Yanez’s conceptual model of determinants of cancer outcomes in Hispanics (i.e., socioeconomic, healthcare, cultural context, and psychosocial). Findings provide direction for cultural adaptations of evidence-based programs.

关键词： Cancer Survivors Latinas Social Determinants of Health U.S.-Mexico Border

Parallel Driving in CPSS:A Unified Approach for Transport Automation and Vehicle Intelligence

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 577-587页

作者： Fei-Yue Wang Nan-Ning Zheng Dongpu Cao clara Marina Martinez Li Li Teng Liu IEEE State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences Research Center for Military Computational Experiments and Parallel Systems Technology National University of Defense Technology Institute of Artificial Intelligence and Robotics Xi’an Jiaotong University Advanced Vehicle Engineering Center Cranfield University Department of Automation Tsinghua University State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences Qingdao Huituo Intelligent Machine Company

The emerging development of connected and automated vehicles imposes a significant challenge on current vehicle control and transportation systems. This paper proposes a novel unified approach, Parallel Driving, a cloud-based cyberphysical-social systems(CPSS) framework aiming at synergizing connected automated driving. This study first introduces the CPSS and ACP-based intelligent machine systems. Then the parallel driving is proposed in the cyber-physical-social space,considering interactions among vehicles, human drivers, and information. Within the framework, parallel testing, parallel learning and parallel reinforcement learning are developed and concisely reviewed. Development on intelligent horizon(iHorizon)and its applications are also presented towards parallel *** proposed parallel driving offers an ample solution for achieving a smooth, safe and efficient cooperation among connected automated vehicles with different levels of automation in future road transportation systems.

关键词： ACP theory connected automated driving cyber-physical-social systems(CPSS) iHorizon parallel driving parallel horizon parallel learning parallel reinforcement learning parallel testing

替代性食物体系治理策略研究——基于比利时鲁汶的治理经验与启示

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城市发展研究 2023年第4期30卷 41-52页

作者：李冬雪 clara Medina-García Xenia Katsigianni Pieter Van den Broeck 王兴平东南大学建筑学院比利时鲁汶大学工程科学学院西班牙马德里康普顿斯大学政治科学和社会学学院

替代性食物体系是应对传统工业化农业带来的环境与社会危机，促进城市碳中和转型的创新型食物系统模式，其出现为城市食物体系治理和土地供给提出了新要求。国内现有食物体系治理与规划的相关研究主要聚焦在传统食物体系层面，对致力于... 详细信息

替代性食物体系是应对传统工业化农业带来的环境与社会危机，促进城市碳中和转型的创新型食物系统模式，其出现为城市食物体系治理和土地供给提出了新要求。国内现有食物体系治理与规划的相关研究主要聚焦在传统食物体系层面，对致力于实现可持续发展和社会公平的替代性实践关注不足。结合全球范围内的已有替代性做法，从参与者网络和空间实体网络两个维度构建了替代性食物体系的治理框架。基于比利时鲁汶的替代性食物体系演变、治理转型和替代性实践项目经验，提出中国式替代性食物体系网络建设、多元化空间利用与创新型土地供给、包容性制度环境支持等建议，以促进具有中国特色的替代性食物体系发展。

关键词：替代性食物体系社区支持农业都市农业农业用地治理鲁汶