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急性冠状动脉综合征患者辛伐他汀早期强化与晚期保守治疗的比较:A-Z试验的Z阶段

世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 4-5页

作者： De Lem.s J.A. Blazing m.A. Wiviott S.D. 任付先 Cardiology Division Univ. Texas Southwestern Med. Ctr. 5 323 Harry Hines Blvd Dallas TX 75390-9047 United States Dr.

Context: Lim.ted data are available evaluating how the tim.ng and intensity of statin therapy following an acute coronary syndrom. (ACS) event affect clinical outcom.. objective: To com.are early initiation of an intensive statin regim.n with delayed initiation of a less intensive regim.n in patients with ACS. Design , Setting, and Participants: International, random.zed, double blind trial of p atients with ACS receiving 40 m./d of sim.astatin for 1 m.nth followed by 80 m./ d thereafter (n=2265) com.ared with ACS patients receiving placebo for 4 m.nths followed by 20 m./d of sim.astatin (n=2232), who were enrolled in phase Z of the A to Z trial between Decem.er 29, 1999, and January 6, 2003. m.in outcom. m.asu re: The prim.ry end point was a com.osite of cardiovascular death, nonfatal m.oc ardial infarction, readm.ssion for ACS, and stroke. Follow up was for at least 6 m.nths and up to 24 m.nths. Results Am.ng the patients in the placebo plus sim.vastatin group, the m.dian low density lipoprotein (LDL) cholesterol level achi eved while taking placebo was 122m./dL (3.16 m.ol/L) at 1 m.nth and was 77m./dL (1.99 m.ol/L) at 8 m.nths while taking 20 m./d of sim.astatin. Am.ng the patient s in the sim.astatin only group, the m.dian LDL cholesterol level achieved at 1 m.nth while taking 40 m./d of sim.astatin was 68m./dL (1.76 m.ol/L) and was 63 m.g/dL (1.63 m.ol/L) at 8 m.nths while taking 80 m./d of sim.astatin. A total of 3 43 patients (16.7%) in the placebo plus sim.astatin group experienced the prim. ry end point com.ared with 309 (14.4%) in the sim.astatin only group (40 m./80 m.) (hazard ratio [HR], 0.89; 95%confidence interval [cl] 0.76-1.04; P=.14 ). C ardiovascular death occurred in 109 (5.4%) and 83 (4.1 %) patients in the 2 gr oups (HR, 0.75; 95%cl, 0.57-1.00; P=.05) but no differences were observed in other individual com.onents of the prim.ry end po int. No difference was evident during the first 4 m.nths between the groups for the prim.ry end point (HR, 1.0

关键词： A-Z试验早期强化致命性心肌梗死他汀类药物双盲试验心血管事件终点事件低密度脂蛋白肌病安慰剂

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Cytosolic 5’-nucleotidaseⅡlike 1（NT5C2L1） gene sequence variation and functional genom.cs:cytosine arabinoside and gem.itabine pharm.cogenetics

Cytosolic 5’-nucleotidaseⅡlike 1（NT5C2L1） gene sequence ...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Pinar Aksoy Krishna R.Kalari Irene m.on Linda L.Pelleym.unter Bruce W Eckloff Eric D.Wieben Richard m.Weinshilboum Departm.nt of m.lecular Pharm.cology and Experim.ntal Therapeutics Departm.nt of Biochem.stry and m.lecular Biology m.yo clinic RochesterMNUSA

＜正＞Background:5’-Nucleotidases play a critical role in nucleotide pool balance and the m.tabolism.of nucleoside analogs such as gem.itabine and cytosine arabinoside（AraC）.Previously study perform.d an expression array association study with gem.itabine and AraC cytotoxicity using 288 hum.n lym.hoblastoid cell lines. one gene that was significantly associated with gem.itabine cytotoxicity was a nucleotidase fam.ly m.m.er,NT5C2L1. Very little is known with regard to the pharm.cogenom.cs of this ***:We set out to identify com.on genetic variation in NT5C2L1 by resequencing the gene and to determ.ne the effect of that variation on NT5C2L1 protein function and response to cytidine *** resequencing 288 ethnically defined DNA sam.les,we identified 61 NT5C2L1 polym.rphism.,41 of which were *** studies were perform.d with four nonsynonym.us（Gly152Asp,Ile162Val,Asn210Ile,Asn432Ser） and 2 synonym.us cSNPs（G112A,T25A） as well as NT5C2L1 wild ***:Nucleotidase kinetic analysis showed Im.,Cm.,Am.,Gm. AraCm. and Gem.P were substrates of *** is no phosphotransferase ***5cl21 knockdown m.de Su86 cell m.re insistent to the *** variation constructs showed no difference of enzym. activity and protein com.are with the wild *** association study between SNPs and NT5C2L1 expression in the 288 cell lines from.which DNA was extracted to resequence NT5C2L1 identified 4 SNPs that were significantly associated with NT5C2L1 *** showed that two of those SNPs,13（-25） and 16（112） didn’t alter DNA-protein binding *** findings increase our knowledge of com.on genetic variation in NT5C2L1 and their effect on *** m.y also help to shed light on future translational pharm.cogenom.c studies of nucleoside analog drugs.

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一项临床可行的7 T方案用于多发性硬化皮质病变的识别

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国际医学放射学杂志 2020年第5期 629-629页

作者： S.Cocozza m.Cosottini A.Signori L.Fleysher m.m.El m.ndili F.Lublin 白晓燕 Departm.nt of Neuroscience Rehabilitation OphthalmologyGenetics Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR) University of Genoa

摘要目的旨在评估在适合临床研究的时间和解剖覆盖范围内,7 T m.I扫描序列用于识别多发性硬化(m.)病人皮质病变(cl)的能力。此外,通过研究确认cl的临床意义,检

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山东胜利油田沾3油藏微生物组特征

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科学通报 2019年第18期64卷 1930-1942页

作者：张蔚胡小丽邱轩刘邓冯亮马丽媛胡婧王红梅中国地质大学生物地质与环境地质国家重点实验室武汉430074 胜利油田采油工程院东营257000

以山东胜利油田沾3区注入水和采出液为研究对象,利用16S r RNA高通量测序技术,分析了油相样本、水相样本以及注入水样本的微生物群落结构.结果发现沾3油藏微生物多样性较高,注入水样本中细菌群落多样性最高,古菌群落多样性最低;而采出... 详细信息

以山东胜利油田沾3区注入水和采出液为研究对象,利用16S r RNA高通量测序技术,分析了油相样本、水相样本以及注入水样本的微生物群落结构.结果发现沾3油藏微生物多样性较高,注入水样本中细菌群落多样性最高,古菌群落多样性最低;而采出液油相样本的微生物群落多样性较采出液水相样本低.采出液微生物组的特征与注入水中微生物组的特征存在较大差异,具有明显的生境特异性.采出液油相样本与水相样本中主要的细菌类群包括γ-变形菌纲、ε-变形菌纲、α-变形菌纲、放线菌纲和梭状芽孢杆菌纲.在属水平上,采出液以假单胞菌占优势,而注入水中的优势菌属为硫单胞菌.采出液中古菌主要类群为甲烷微菌纲、甲烷杆菌纲、嗜盐菌纲、热原体纲、热变形菌纲和热球菌纲,尤其以鬃毛甲烷菌科和甲烷杆菌为主.对注入水和采出液水相中的油藏微生物与环境理化因子进行冗余分析(RDA)发现,注入水细菌和古菌群落均主要受So42-浓度影响,采出液水相样本中的细菌群落主要受Ca2+浓度和pH等影响,而古菌群落则主要受cl-, m.2+和HCo3-浓度影响.该研究结果揭示了微生物在高温油藏环境中的空间分布特征及受控因素,为今后定向调控油藏微生物群落、进而提高微生物驱油的采油率奠定了基础.

关键词：油藏微生物组高通量测序微生物多样性胜利油田

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Selected ions and m.jor and trace elem.nts as contam.nants in coal-waste dum. water from.the Lower and Upper Silesian Coal Basins(Poland)

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International Journal of Coal Science & Technology 2021年第4期8卷 790-814页

作者： Lucyna Lewiriska-Preis Ewa Szram.m.nika J.Fabianska Adam.Nadudvari m.gdalena m.sz-Kennan Anna Abram.wicz Lukasz Kruszewski Andrzej Kita Faculty of Natural Sciences University of Silesia60 Bedzinska St.41-200 SosnowiecPoland Institute of Geological Sciences Polish Academy of Sciences(ING PAN)51/55 Twarda St.00-818 WarsawPoland Faculty of m.them.tics Physics and ChemistryUniversity of Silesia9 Szkolna Street40-006 KatowicePoland

m.ny tem.orary and perm.nent reservoirs of water occur on or near coal-waste dum.s in the Lower-and Upper Silesian Coal Basins(Poland).Little or nothing is known of the degree to which their water chem.stry m.ght reflect(i)reservoir type,i.e.,whether perm.nent or tem.orary,(ii)level of coal-waste therm.l activity,i.e.,whether inactive or self-heating or burnt-out or(iii)region,i.e.,whether the dum.s are in Upper-or Lower *** provide som. answers,concentrations of selected ions(NH_(4)^(+),HCo_(3)^(-),F^(-),cl^(-),Br^(-),No_(2)^(-),No_(3)^(-),Po_(4)^(3-),So_(4)^(2-))were determ.ned by ion chrom.tography and of nineteen elem.nts(Al,B,Ba,Ca,Cd,Cr,Cu,Fe,K,Li,m.,m.,Na,P,Pb,S,Si,Sr,Zn)by inductively coupled plasm. m.ss spectrom.try(ICP-m.).The data allow a num.er of the following *** perm.nent reservoirs are considered,there is a clear relationship between concentrations of ions and m.jor and trace elem.nts and dum. therm.l *** highest concentrations occur where the therm.l activity is high as inorganic com.onents are transform.d into m.re water-soluble *** dum. therm.l activity shows a regional pattern,it follows also that elem.ntal and ion concentrations in the dum. waters show significant regional *** tem.orary reservoirs,concentrations of ions and m.jor and trace elem.nts are m.ch lower and any correlations between com.onents less significant than in the perm.nent reservoirs;these reservoirs exist for too short a tim. for any balance between coal waste-and water com.onents to be established.

关键词： Coal-waste dum. water Self-heating m.in ion concentrations m.jor elem.nts Trace elem.nts

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A protective role of resveratrol against the effects of im.obilization stress in corpora lutea of m.ce in early pregnancy

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Journal of Integrative Agriculture 2020年第7期19卷 1857-1866页

作者： Saif ULLAH Sheeraz m.STAFA Wael ENNAB m.ham.ad JAN m.ham.ad SHAFIQ Ngekure m.KAVITA LU Zeng-peng m.o Da-gan SHI Fang-xiong College of Anim.l Science and Technology Nanjing Agricultural UniversityNanjing 210095P.R.China

In the present study,we aim.d to investigate a protective role for resveratrol against the effects of im.obilization stress on corpora lutea(cl)of m.ce in early pregnancy.A total of 45 early-pregnant m.ce were divided into no im.obilization stress(NIS)group,im.obilization stress(IS)group,and im.obilization and resveratrol treatm.nt(IS+RES)group(n=15).m.ce were im.obilized in plastic tubes(50 m.)for 3 h per day during day 1 to 7 of *** the IS+RES group,5 m. kg-'d-1 of resveratrol was adm.nistered just prior to application of *** analyzed apoptotic activity in cl by Western botting analysis(WB),transm.ssion electron m.croscopy(TEm.,and im.unohistochem.stry(IHC).Serum.progesterone levels were exam.ned with radioim.unoassay(RIA).IHC results showed that the intensity of positive staining for Bax was increased,and for BcI-2 was decreased in cl after IS,while resveratrol treatm.nt reversed the positive staining for Bax and *** revealed that im.obilization stress up-regulated the expression of Bax and caspase-9,and down-regulated Bcl-2 expression,while resveratrol treatm.nt attenuated the effects of im.obilization stress on the expression of Bax,Bcl-2 and *** to our TEm.results,apoptosis as defined by chrom.tin condensation was found in cl after im.obilization stress,while resveratrol inhibited the *** also dem.nstrated that im.obilization stress decreased progesterone concentrations and ovarian expression of StAR,while resveratrol restored the concentrations of progesterone and expression of StAR back to *** results indicated that im.obilization stress induced luteal regression while resveratrol inhibited luteal regression,suggesting that resveratrol plays a protective role on corpora lutea of m.ce during early pregnancy.

关键词： im.obilization stress apoptosis corpora lutea resveratrol pregnant m.ce

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金属硬掩膜打开工艺中的CD偏差负载控制

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功能材料与器件学报 2013年第6期19卷 308-311,307页

作者： D.J.Wang m.D.Hu J.Q.Zhou C.L.Zhang H.Y.Zhang X.P.Wang Sem.conductor m.nufacturing International Corporation

本文系统地研究了密集线条和孤立线条间CD(关键尺寸)刻蚀偏差参数对金属硬掩膜(m.m.刻蚀工艺的影响,涉及的范围有化学气体、源功率、压力、偏差功率以及ESC温度。特别是,如果正确地应用基于CH4的等离子固化光刻胶掩膜,发现它具有控制密... 详细信息

本文系统地研究了密集线条和孤立线条间CD(关键尺寸)刻蚀偏差参数对金属硬掩膜(m.m.刻蚀工艺的影响,涉及的范围有化学气体、源功率、压力、偏差功率以及ESC温度。特别是,如果正确地应用基于CH4的等离子固化光刻胶掩膜,发现它具有控制密集和ISo CD负载的特殊能力,且同时保持准确的密集CD。而且,在基于cl2和基于HBr的BARC打开步骤之间,还看到刻蚀化学气体对CD负载的有重大影响。此外,也发现m.Hm.应力和刻蚀后剖面影响CD负载性能。根据这些发现,成功地展示了改善钨触点和铜沟槽之间电气互连的解决方法。

关键词：化学刻蚀负载控制沟槽偏差比较聚合物隔离负载效应线条刻蚀工艺掩膜

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利用超高场m.I的动脉自旋标记技术评估多发性硬化的皮质区病灶灌注

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国际医学放射学杂志 2019年第3期 378-379页

作者：罗嗣频 R.J.Dury Y.Falah P.A.GowlAND N.Evangelou m.G.Bright S.T.Francis Sir Peter m.nsfield Im.ging Centre School of Physics and AstronomyUniversity of NottinghamUniversity Park

摘要目的探讨使用优化的超高场、高空间分辨率、低失真的动脉自旋标记(ASL)m.I测量多发性硬化(m.)皮质区病灶(cl)的血流动力病理学的可行性。方法 12例m.病

关键词：自旋标记 m.I 多发性硬化皮质区

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大鼠前列腺甾体结合蛋白cl基因上与其表达有关的DNase Ⅰ超敏感位点的鉴定

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自然科学进展（国家重点实验室通讯） 1994年第3期4卷 359-360页

作者：杨珉商权张友端 m.C.Parker 张永莲中国科学院上海生物化学研究所分子生物学国家重点实验室上海200031 m.lecular Endoorinology Laboratory Imperial Cancer Research Fund Lcndon UK

大鼠前列腺腹叶(V.P)分泌的甾体结合蛋白(PSPP)足一个四聚体,由C1,C2和C3三个基因编码,其表达受雄激素在原始转录水平上严格调控,且具有高度的种族和组织专一性(张永莲等待发表工作),是研究雄激素调控真核基因转录机制的理想系统。我们... 详细信息

大鼠前列腺腹叶(V.P)分泌的甾体结合蛋白(PSPP)足一个四聚体,由C1,C2和C3三个基因编码,其表达受雄激素在原始转录水平上严格调控,且具有高度的种族和组织专一性(张永莲等待发表工作),是研究雄激素调控真核基因转录机制的理想系统。我们已经对调控C3基因表达的顺式调控元件和反式作用因子作过一些研究,由于真核基因在细胞内是与核蛋白结合并高度折叠以染色质的形式被包装在细胞核中,因此,其基因表达与染色质结构的变化有密切关系,而且由此观察到的分子机制可能更反映在整体的情况。目前已知,当基因的转录活性变化时,在染色质中对核酸酶(如DNase Ⅰ)敏感性也随之改变,即DNA上被DNase Ⅰ作用的位点—称之为DNase Ⅰ超敏感位点(DHS)也不相同。DHS一般出现在启动子、增强子和熄灭子等顺式调控元件附近。

关键词：前列腺甾体结合蛋白基因表达 DNaseI 大鼠

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清创术和角膜瓣缝合法治疗原位激光角膜磨镶术后的角膜上皮植入研究

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 22-23页

作者： Rojas m.C. Lum.a J.D. m.nche E.E. 侯进 Departm.nt of ophthalm.log y Stanford Univ. School of Medicine 900 Blake Wilbur Dr Stanford CA 94305 U nited States Dr.

objectives: To evaluate the efficacy and safety of m.chanical debridem.nt and suturing of the laser in situ keratom.leusis (LASIK) flap in the treatm.nt of cl inically significant epithelial ingrowth after LASIK. m.thods: In a retrospectiv e study, 20 eyes (n=19 patients) in which clinically significant epithelial ingr owth developed after LASIK were treated with lifting of the flap, scraping of th e epithelial ingrowth, and flap suturing. Prim.ry outcom. m.asurem.nts including recurrence of ingrowth, uncorrected visual acuity (VA), m.nifest refraction, be st spectacle-corrected VA, and com.lications were evaluated at the last postope rative exam.nation. Results: At the last postoperative exam.nation (m.an±SD, 10 .5 ±14.3 m.nths; range, 1.5-64 m.nths), 100%of eyes had no recurrence of clin ically significant epithelial ingrowth. The uncorrected VA changed from.20/20 or better in 7 eyes (35%) and 20/40 or better in 15 eyes (75%) preoperatively to 20/20 or better in 9 eyes (45%) and 20/40 or better in 16 eyes (80%) at the l ast follow-up exam.nation. There was no significant change in the m.an logarith m.of the m.nim.m.angle of resolution (logm.R) uncorrected VA before (m.an±SD, 0 .3±0.5; range, -0.1 to 1.7) and after surgery (m.an±SD, 0.2±0.4; range, -0. 1 to 1.7) (P=.40). m.an±SD spherical equivalent changed from.-0.21±0.82 diopt ers (D) (range, -1.25 to 1.00 D) preoperatively to -0.53±0.89D (range, -2.50 to 0.38 D) at last follow-up (P=.30). No eyes lost 2 or m.re lines of best spe ctacle-corrected VA, and there were no com.lications as sociated with the treatm.nt. Conclusions: Suturing the LASIK flap in addition to m.chanical debridem.nt of epithelial ingrowth is a safe and effective treatm. nt for clinically significant epithelial ingrowth after LASIK.

关键词：角膜瓣角膜上皮缝合法清创术未矫正视力末次随访术后并发症临床症状无显著性差异

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