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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira Silva Mariana Santos Calmon cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Wafer-level vapor cells filled with laser-actuated hermetic seals for integrated atomic devices

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Microsystems & Nanoengineering 2022年第6期8卷 225-235页

作者： Vincent Maurice clément Carlé Shervin Keshavarzi Ravinder Chutani Samuel Queste Ludovic Gauthier-Manuel Jean-Marc Cote Rémy Vicarini Moustafa Abdel Hafiz Rodolphe Boudot Nicolas Passilly IEMN-Institut d’Electronique de Microélectronique et de Nanotechnologie UMR8520 CNRSUniversitéLilleCentrale LilleF-59000 LilleFrance FEMTO-ST Institute UMR6174 CNRSUniversitéBourgogne Franche-ComtéF-25030 BesançonFrance

Atomic devices such as atomic clocks and optically-pumped magnetometers rely on the interrogation of atoms contained in a cell whose inner content has to meet high standards of purity and ***-blowing techniques and craftsmanship have evolved over many decades to achieve such standards in macroscopic vapor *** the emergence of chip-scale atomic devices,the need for miniaturization and mass fabrication has led to the adoption of microfabrication techniques to make millimeter-scale vapor ***,many shortcomings remain and no process has been able to match the quality and versatility of glass-blown ***,we introduce a novel approach to structure,fill and seal microfabricated vapor cells inspired from the century-old approach of glass-blowing,through opening and closing single-use zero-leak microfabricated *** valves are actuated exclusively by laser,and operate in the same way as the“make-seals”and“break-seals”found in the filling apparatus of traditional *** structures are employed to fill cesium vapor cells at the *** make-seal structure consists of a glass membrane that can be locally heated and deflected to seal a *** break-seal is obtained by breaching a silicon wall between *** new approach allows adapting processes previously restricted to glass-blown *** can also be extended to vacuum microelectronics and vacuum-packaging of micro-electro-mechanical systems(MEMS)devices.

关键词： filled vacuum heated

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Study of disorder in pulsed laser deposited double perovskite oxides by first-principle structure prediction

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npj Computational Materials 2021年第1期7卷 826-833页

作者： Edoardo Fertitta Sujit Das Debalina Banerjee Farbod Ebrahimi clément Barraud Kai Du He Tian Chris J.Pickard Cedric Weber Ramamoorthy Ramesh Peter Littlewood David Dubbink Happy Electron Ltd. LondonUnited Kingdom Department of Materials Science and Engineering University of CaliforniaBerkeleyCAUSA Department of Physics King’s College LondonLondonUnited Kingdom Laboratoire Matériaux et Phénomènes Quantiques UMR 7162Universitéde ParisCNRSParisFrance Center of Electron Microscopy School of Materials Science and EngineeringZhejiang UniversityHangzhouChina Department of Materials Science and Metallurgy CambridgeUnited Kingdom Advanced Institute for Materials Research Tohoku UniversitySendaiJapan Department of Physics James Franck InstituteUniversity of ChicagoChicagoILUSA

Double perovskite oxides,with generalized formula A_(2)BB'O_(6),attract wide interest due to their multiferroic and charge transfer *** offer a wide range of potential applications such as spintronics and electrically tunable ***,great practical limitations are encountered,since a spontaneous order of the B-site cations is notoriously hard to *** this joint experimental-theoretical work,we focused on the characterization of double perovskites La2TiFeO6 and La_(2)VCuO_(6) films grown by pulsed laser deposition and interpretation of the observed B-site disorder and partial charge transfer between the B-site ions.A random structure sampling method was used to show that several phases compete due to their corresponding configurational *** order to capture a representative picture of the most relevant competing microstates in realistic experimental conditions,this search included the potential formation of non-stoichiometric phases as well,which could also be directly related to the observed partial charge *** optimized the information encapsulated in the potential energy landscape,captured via structure sampling,by evaluating both enthalpic and entropic *** terms were employed as a metric for the competition of different *** approach,applied herein specifically to La_(2)TiFeO_(6),highlights the presence of highly entropic phases above the ground state which can explain the disorder observed frequently in the broader class of double perovskite oxides.

关键词： laser double structure

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Investigation of charge interaction between fullerene derivatives and single-walled carbon nanotubes

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InfoMat 2019年第4期1卷 559-570页

作者： clément Delacou Il Jeon Keigo Otsuka Taiki Inoue Anton Anisimov Takenori Fujii Esko I.Kauppinen Shigeo Maruyama Yutaka Matsuo Department of Mechanical Engineering The University of TokyoTokyoJapan KU-KIST Green School Graduate School of Energy and Environment Korea UniversitySeoulSouth Korea Nanoscale Quantum Photonics Laboratory RIKENSaitamaJapan Canatu Ltd HelsinkiFinland Cryogenic Research Center The University of TokyoTokyoJapan Department of Applied Physics Aalto University School of ScienceAaltoFinland Energy NanoEngineering Laboratory National Institute of Advanced Industrial Science and Technology(AIST)TsukubaJapan Institutes of Innovation for Future Society Nagoya UniversityNagoyaJapan

The charge interaction and corresponding doping effect between single-walled carbonnanotubes (SWNTs) and various fullerene derivatives, namely, C60, phenyl-C61-butyricacid methyl ester (PC61BM), methano-indenefullerene (MIF), 10,100,40,400-tetrahydrodi[1,4]methanonaphthaleno[5,6]fullerene (ICBA), 1,4-bis(dimethylphenylsilylmethyl)[60]fullerene (SIMEF-1), and dimethyl(orthoanisyl) silylmethyl(dimethylphenylsilylmethyl)[60]fullerene (SIMEF-2), are investigated. A variety of analytical techniques,including field-effect transistors (FETs) made of horizontally aligned arrays ofSWNTs, is used as a means of investigation. Data from different measurements haveto be used to obtain a concrete evaluation for the fullerene-applied SWNTs. The datacollectively points toward the conclusion that fullerenes with high molecular orbitalenergy levels, namely, MIF, SIMEF-1, SIMEF-2, and PC61BM, induce p-type doping,while fullerenes with low molecular orbital energy levels, namely, ICBA and C60,induce n-type doping on the carbon nanotubes. Nevertheless, the SWNTs retained ptypecharacteristics because n-doping induced by the fullerenes are weak compared tothe p-doping of the water and oxygen on carbon nanotubes. This means that fullerenederivatives have the ability to fine-tune the energy levels of carbon nanotubes, whichcan play a crucial role in carbon nanotube-based electronics, such as solar cells, lightemittingdevices, and FETs.

关键词： doping field-effect transistors fullerene single-walled carbon nanotubes thin films

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Collagen proportionate area correlates to hepatic venous pressure gradient in non-abstinent cirrhotic patients with alcoholic liver disease

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World Journal of Hepatology 2018年第1期10卷 73-81页

作者： Sophie Restellini Nicolas Goossens Sophie clément Nicolas Lanthier Francesco Negro Laura Rubbia-Brandt Laurent Spahr Department of Medical Specialties Division of Gastroenterology and Hepatology Geneva University Hospitals and University of Geneva Department of Genetic and Laboratory Medicine Division of Clinical Pathology Geneva University Hospitals and University of Geneva Laboratory of Gastroenterology and Hepatology Institut de Recherche Expérimentale et Clinique Université catholique de Louvain

AIM To explore the relationship between collagen proportionate area(CPA) and portal hypertension-related clinical manifestations in alcoholic liver disease(ALD).METHODS Retrospective study with chart review of patients with ALD adressed to our center between January 2012 and December 2013 for a transjugular liver biopsy(TJLB) and hepatic hemodynamic study. Patients were included if they met the following criteria:(1) Medical indication for a liver biopsy in the setting of ALD;(2) recent(clinical, radiological, endoscopic and biological data available; and(3) estimated follow-up of at least 6 mo. Liver tissue from cirrhotic subjects obtained from transjugular liver biopsies was stained with Picro Sirius red and computer-assisted digital image analysis to determine fibrosis density using CPA was performed. RESULTS We included 61 patients with alcoholic ALD, subdivided in 41 active alcohol drinkers and 20 durably abstinent patients. Nine healthy liver donors served as controls. Mean CPA in patients with ALD was 7.1%, with no difference between active drinkers and abstinent patients(P = 0.17). Using a fibrosis density cutoff of 5%, we observed a positive correlation between high fibrosis density and the hepatic venous pressure gradient(HVPG) only in active drinkers(P = 0.02). At 12-mo of follow-up, in the group of active alcohol drinkers, patients reaching a composite outcome showed a higher HVPG value as compared to those who did not(18.5 mm Hg vs 14.5 mm Hg P clUSION In active alcoholic ALD, CPA correlates to portal pressure but only HVPG predicts clinical events, pointing to the role of alcohol as a modulator of portal hypertension.

关键词： Fibrosis Hepatic venous pressure gradient Cirrhosis Chronic advanced liver disease Collagen proportionate area

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Structural effects of reedbed grazing and its cessation on reed-nesting songbird densities

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Avian Research 2024年第2期15卷 238-248页

作者： Thomas Pagnon clemence Pechinot Lea Sgro Jeremie Demay Remi Jullian Regis Gallais Brigitte Poulin Cyril Marmoex Theria Ecologie 6 avenue des martyrs05400VeynesFrance UMR 6249 Chrono-Environnement CNRSUniversite de Franche-Comte16 route de Gray25000BesanconFrance Conservatoire d’Espaces Naturels d’Occitanie 26 alle de Mycenes34000MontpellierFrance Office Français de la Biodiversite 12 cours Lumiere94300VincennesFrance Tour du Valat Research Institute for the Conservation of Mediterranean Wetlands Le Sambuc13200ArlesFrance

Reedbeds are crucial breeding habitats for vulnerable songbird *** of their protection status,these habitats may be threatened by organic matter accumulation,progressively leading to structural homoge-nization and habitat succession towards *** prevent excessive litter build-up with various in-terventions opening-up the reedbeds,such as grazing,which may be detrimental or suitable for some reed bird *** assessed the effects of extensive grazing by horses and its cessation in the medium and long terms on reedbed structure,and the consequences on reed-nesting songbird densities in Estagnol Nature Reserve,a pro-tected wetland near the French Mediterranean *** compared reedbed structural features between grazed,newly ungrazed and old-ungrazed *** nine years,we censused four songbird species in spring and collected water level data in the same survey *** reduced reedbed extent,rejuvenated the vegetation with more short green stems on a thinner litter,and produced higher structural heterogeneity and discontinuity compared to long-lasting non *** ungrazed plot showed intermediate *** surveyed songbird total densities were similar among plots while species numbers and densities *** reedbed was more attractive to Moustached Warblers(Acrocephalus melanopogon)and Great Reed Warblers(Acrocephalus arundi-naceus),likely due to the large edges and the high vegetation structural ***,Moustached Warblers were more negatively affected by higher water level in grazed reedbed,presumably because flooding prevents litter *** newly ungrazed reedbed was not preferred by any *** warbler species were found under low density in the old-ungrazed reedbed,where Reed Buntings(Emberiza schoeniclus)were exclu-sively *** availability related to thick litter layer may explain this *** Reed Warblers(Acrocephalus scirpaceus)were found everywhere in similar

关键词： Bird conservation Edge complexity Fragmentation Habitat management Horse grazing Phragmites australis Reed passerine

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P0.05).CONclUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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诗歌,通用的语言——从唐诗说起

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扬子江文学评论 2024年第2期 21-25页

作者： [法]勒克莱齐奥施雪莹(译) 不详南京大学外国语学院

是否存在一种通用的诗歌语言?矛盾之处在于:诗歌不是放之四海而皆准的--它是与具体的文明、文化与语言紧密相连的表达。我曾与董强教授合作撰写过一本关于唐诗的书。董强教授始终强调,中国诗歌是与汉语联系在一起的。汉语的特殊性在于... 详细信息

是否存在一种通用的诗歌语言?矛盾之处在于:诗歌不是放之四海而皆准的--它是与具体的文明、文化与语言紧密相连的表达。我曾与董强教授合作撰写过一本关于唐诗的书。董强教授始终强调,中国诗歌是与汉语联系在一起的。汉语的特殊性在于它是一字一音节的语言,而中文诗就建立在这一特性之上。这也让中国诗歌的翻译变得格外困难,因为世界上大部分语言都是一词多音节的。法语中的一些词,特别是德语中有些词,长到需要用整一句话才能写完。而汉语是一种简短的语言。

关键词：诗歌语言唐诗合作撰写文化与语言一字一音诗歌的翻译紧密相连

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基于内聚损伤模型的微通道扁管换热器无模弯曲仿真研究

基于内聚损伤模型的微通道扁管换热器无模弯曲仿真研究

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作者： clément LABRUGERE 上海交通大学

学位级别：硕士

空调系统制造过程中的最大成本来源于换热器制造。传统的换热器制造中换热器装配主要依靠钎焊工艺进行,但钎焊有以下缺点:一方面由于需要依靠大型钎焊炉,从而钎焊过程耗能巨大,使得生产成本大幅增加;另一方面,由于钎焊过程需进行加热,... 详细信息

空调系统制造过程中的最大成本来源于换热器制造。传统的换热器制造中换热器装配主要依靠钎焊工艺进行,但钎焊有以下缺点:一方面由于需要依靠大型钎焊炉,从而钎焊过程耗能巨大,使得生产成本大幅增加;另一方面,由于钎焊过程需进行加热,这要求换热器材料在钎焊高温下不易变形。随着在汽车与航空领域越来越广泛的应用,粘接已经被证明能够克服焊接的缺点、高效、稳定地实现复杂系统装配中的不同材料的连接。本文探讨了一种新型的连接方式换热器的弯曲成形性能。采用汽车领域广泛使用的环氧基树脂粘接剂实现微通道换热器中的装配连接,并且该微通道换热器采用无模弯曲成形。本文基于Ls-Dyna显式动力求解器对微通道扁管换热器中的粘接层性能进行了有限元仿真,并采用内聚损伤模型来模拟粘接层材料的弹塑性性能与分层断裂现象。本文通过双悬臂梁试样的端部开口弯曲试验,建立和标定粘接层材料在内聚损伤模型。建立了平行流换热器无模弯曲有限元模型,有限元仿真结果显示所采用的粘接剂强度足够保证无模弯曲的进行,粘接层在微通道扁管换热器的弯曲过程中仅发生塑性变形而未发生失效,并且采用粘接能够很好的限制微通道扁管换热器无模弯曲过程中发生屈曲。本研究首次对粘接型换热器的弯曲成形性能进行了探讨今后需要开展更多的粘接性能试验与换热器弯曲实验。

关键词：折叠微通道扁管弯曲有限元仿真内聚损伤模型 LS-Dyna

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Unsupervised Segmentation Method of Multicomponent Images based on Fuzzy Connectivity Analysis in the Multidimensional Histograms

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Engineering（科研） 2011年第3期3卷 203-214页

作者： Sié Ouattara Georges Laussane Loum Alain clément 不详

Image segmentation denotes a process for partitioning an image into distinct regions, it plays an important role in interpretation and decision making. A large variety of segmentation methods has been developed;among them, multidimensional histogram methods have been investigated but their implementation stays difficult due to the big size of histograms. We present an original method for segmenting n-D (where n is the number of components in image) images or multidimensional images in an unsupervised way using a fuzzy neighbourhood model. It is based on the hierarchical analysis of full n-D compact histograms integrating a fuzzy connected components labelling algorithm that we have realized in this work. Each peak of the histo- gram constitutes a class kernel, as soon as it encloses a number of pixels greater than or equal to a secondary arbitrary threshold knowing that a first threshold was set to define the degree of binary fuzzy similarity be- tween pixels. The use of a lossless compact n-D histogram allows a drastic reduction of the memory space necessary for coding it. As a consequence, the segmentation can be achieved without reducing the colors population of images in the classification step. It is shown that using n-D compact histograms, instead of 1-D and 2-D ones, leads to better segmentation results. Various images were segmented;the evaluation of the quality of segmentation in supervised and unsupervised of segmentation method proposed compare to the classification method k-means gives better results. It thus highlights the relevance of our approach, which can be used for solving many problems of segmentation.

关键词： Multicomponent Images Unsupervised Segmentation n-D Histogram Fuzzy Connected Components Labelling n-D Compact Histogram Evaluation of Segmentation Quality

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