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Free Cyclic Actions on Surfaces and the Borsuk-Ulam Theorem

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Acta Mathematica Sinica,English Series 2022年第10期38卷 1803-1822页

作者： Daciberg lima GONCALVES John GUASCHI Vinicius Casteluber LAASS Departamento de Matematica IMEUniversidade de Sao PauloRua do Matao 1010 CEP:05508-090Sao Paulo-SPBrazil Normandie Univ. UNICAENCNRSLMNO14000 CaenFrance Universidade Federal da Bahia IMEDepartamento de MatematicaAv.Milton SantosS/N Ondina CEP:40170-110Salvador-BABrazil

Let M and N be topological spaces,let G be a group,and letτ:G×M→M be a proper free action of *** this paper,we define a Borsuk-Ulam-type property for homotopy classes of maps from M to N with respect to the pair(G,τ)that generalises the classical antipodal Borsuk-Ulam theorem of maps from the n-sphere S^(n) to R^(n).In the cases where M is a finite pathwise-connected CWcomplex,G is a finite,non-trivial Abelian group,τis a proper free cellular action,and N is either R^(2) or a compact surface without boundary different from S^(2) and RP^(2),we give an algebraic criterion involving braid groups to decide whether a free homotopy class β∈[M,N]has the Borsuk-Ulam *** an application of this criterion,we consider the case where M is a compact surface without boundary equipped with a free actionτof the finite cyclic group *** terms of the orient ability of the orbit space Mof M by the actionτ,the value of n modulo 4 and a certain algebraic condition involving the first homology group of M,we are able to determine if the single homotopy class of maps from M to R^(2) possesses the Borsuk-Ulam property with respect to(Z_(n),τ).Finally,we give some examples of surfaces on which the symmetric group acts,and for these cases,we obtain some partial results regarding the Borsuk-Ulam property for maps whose target is R^(2).

关键词： Borsuk-Ulam theorem cyclic groups braid groups surfaces

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全球蜂胶专利分布和市场分析

中国蜂业 2024年第5期75卷 49-51页

作者：罗照明(编译) 孟丽峰(编译) 中国蜂产品协会北京100050 中国农业科学院蜜蜂研究所北京100093

一、引言过去几年,由于消费者需求旺盛,基于蜂胶的新专利和天然产品逐步增加。目前,全球各大洲已有超过4500项注册的蜂胶专利。对于一个天然产品来说,这是相当大量的专利,尤其是考虑到全球范围内对此类专利的激励措施直到上世纪90年代... 详细信息

一、引言过去几年,由于消费者需求旺盛,基于蜂胶的新专利和天然产品逐步增加。目前,全球各大洲已有超过4500项注册的蜂胶专利。对于一个天然产品来说,这是相当大量的专利,尤其是考虑到全球范围内对此类专利的激励措施直到上世纪90年代末才开始出现。涉及蜂胶专利数量之多,不仅是因为市场增长所致,还与对这种天然产品的研究增加、生产和技术进步有关。

关键词：蜂胶激励措施专利分布全球范围专利数量消费者市场

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An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros lima Wu Hong Kwong Antonio José Goncalves Cruz Chemical Engineering Graduate Program Federal University of Sao Carlos Department of Chemical Engineering Department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

Regional validity of the parameters of a distributed runoff-erosion model in the semi-arid region of Brazil

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Science China(Technological Sciences) 2009年第11期52卷 3348-3356页

作者： SRINIVASAN Vajapeyam Srirangachar PAIVA Fernanda Maria de lima Federal University of Campina Grande Post-graduate programme in Civil and Environmental Engineering Campus I 58429-900 Campina Grande PB Brazil

The present paper examines the validity of the application of a distributed rainfall-runoff-erosion model on a regional basis in a semi-arid region of Brazil. The model tested is known as WESP (Water Erosion Simulation Program) developed by Lopes (1987). The model simulates the hydrograph and the sediment graph for individual events and thus, the model when properly calibrated can serve as a predictive tool for runoff and soil erosion on an individual or a continuous basis. The possibility of the existence of regionally applicable values for the parameters of the model WESP would be very interesting from the point of view of predictability of runoff and soil erosion from ungauged basins in the region. For this purpose, data collected in several experimental units in the experimental basin of Sumé as well as in the experimental basin of So Joo de Cariri have been used. The model was calibrated and validated in each of the experimental units (consisting of erosion plots and micro-basins) and the average value from all of the units for each of the parameters was considered to be the regional value. With these average values, all the events in all the experimental units were simulated. The results show that the runoff and erosion values simulated with this single parameter set were very good in all the units, being well within the acceptable deviations.

关键词： regional parameters model WESP experimental basins semi-arid region soil erosion

Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors

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World Journal of clinical Cases 2022年第31期10卷 11283-11291页

作者： Fabrício Freire de Melo Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho cláudio lima Souza Márcio Vasconcelos Oliveira Institution Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

Helicobacter pylori(***)is a Gram-negative bacterium that infects about half of the world's *** infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged *** *** this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene *** function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial *** discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of ***,including the oncoprotein ***,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of *** addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients *** that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of *** and the potential clinical repercussions of this modulation.

关键词： Helicobacter pylori Small regulatory RNAs Nickel-regulated small RNA Virulence factors Cytotoxin associated antigen A Gastric cancer

Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros lima Antonio Jose Goncalves Cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

Evaluation of parasitemia by qPCR in patients with chronic Chagas disease treated with benznidazole

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Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 565-572页

作者： Tycha bianca Sabaini Pavan Eros Antônio de Almeida Rodrigo Gonçalves de lima Jamiro da Silva Wanderley Luiz cláudio Martins Sandra Cecília Botelho Costa Gláucia Elisete Barbosa Marcon Departamento de clínica Médica Faculdade de Ciências MédicasUniversidade Estadual de Campinas(Unicamp)CampinasSão PauloBrasil Fundação Oswaldo Cruz Fiocruz Mato Grosso do SulCampo GrandeMSBrasil

Objective:To evaluate parasitemia by qPCR in patients undergoing etiological treatment and followed in a Brazilian reference ***:Parasite load was quantified by qPCR in 32 participants with chronic Chagas disease who were treated with *** analyses were performed before and after the treatment and parasite loads were compared prior and 12/18 months post the ***:Thirty-two participants were recruited and treated with benznidazole,and 20 were *** events(AE)were observed in 22 out of 29 participants that had safety data(76%),and dermatological alterations were the most frequently observed *** the 20 participants analyzed,13 and 7 completed 12 and 18 months follow-up after the treatment,respectively.12 Months after the final treatment,Trypanosoma cruzi was detectable in 3 patients by qPCR;18 months after the final treatment,Trypanosoma cruzi was detectable per qPCR in 4 of the 7 ***,between 12 and 18 months,7 participants of the 20 initial follow-up cases showed positive qPCR,indicating treatment ***:qPCR can be used as an alternative method for evaluating the effectiveness of the etiological treatment of CD,and can be applied to analyze early therapeutic *** study showed that benznidazole therapy had limited effectiveness in treating chronic CD patients,thus emphasizing the importance of conducting continued research for developing more effective therapies and diagnosis for CD.

关键词： Trypanosoma cruzi Chagas disease Antitrypanosomal therapy Benznidazole qPCR Therapeutic failure

Coconut oil:what do we really know about it so far?

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Food Quality and Safety 2019年第2期3卷 61-72页

作者： Renan da Silva lima Jane Mara Block Department of Food Science and Technology Federal University of Santa CatarinaFlorianópolisBrazil

In recent years,coconut oil has emerged as a potential‘miracle’*** media vehicles and health specialists assure that this fat is capable of promoting health benefits,such as weight reduction,cholesterol lowering,prevention of cardiovascular diseases,and anti-inflammatory effect,among *** claims are used to market the product and boost its sales by coconut oil ***,governmental regulatory agencies in many countries are still sceptical about the benefits obtained by the consumption of coconut oil due to its high-saturated fatty acid *** light of such controversy,this review focused on analysing the published literature on the alleged health claims,in order to investigate if there is enough scientific evidence to support *** was verified that the metabolism of lauric acid,the major fatty acid in coconut oil,remains *** studies reported that the product was not efficient in weight ***,it has been reported that the consumption of coconut oil increased low-density lipoprotein cholesterol,consequently increasing the risk of cardiovascular *** general,the studies present conflicting results and there is a lack of long-term human-based clinical ***,as a saturated fat,coconut oil should be consumed with moderation and the health allegations should not be used to market the product,once they are not scientifically proven so far.

关键词： lauric acid saturated fatty acids medium-chain triglycerides LDL cholesterol cardiovascular diseases

Modularity and specialization in bat-fly interaction networks are remarkably consistent across patches within urbanized landscapes and spatial scales

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Current Zoology 2021年第4期67卷 403-410页

作者： Gustavo lima Urbieta Gustavo Graciolli Jeferson Vizentin-Bugoimi Programa de Pós-Graduação em Ciencias Biológicas Departamento de Sistematica e EcologiaUniversidade Federal da ParaibaCidade Jardim Universitários/nCastelo BrancoJoão Pessoa 58051-900Brazil Programa de Pós-Graduação em Biologia Animal Laboratorio de SistematicaEcologia e Evoluqao(LSEE)Instituto de BiocienciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo Grande 79090-900Brazil Department of Natural Resources and Environmental Sciences University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Patterns of specialization and the structure of interactions between bats and ectoparasitic flies have been studied mostly on non-urban environments and at local ***,how anthropogenic disturbances influence species interactions and network structure in this system remain poorly ***,we investigated patterns of interaction between Phyllostomidae bats and ectoparasitic Streblidae flies,and variations in network specialization and structure across Cerrado patches within urbanized landscapes in Brazil and between local and regional *** found high similarity in the richness and composition of bat and fly species across communities,associated with low turnover of interactions between *** high specialization of bat-streblid interactions resulted in little connected and modular networks,with the emergence of modules containing subsets of species that interact exclusively or primarily with each *** similarities in species and interaction composition and network structure across communities and scales suggest that bat-fly interactions within Cerrado patches are little affected by the degree of human modification in the surrounding *** remarkable consistency is likely promoted by specific behaviors,the tolerance of Phyllostomidae bats to surrounding urbanized landscapes as well as by the specificity of the streblid-bat interactions shaped over evolutionary time.

关键词： Chiroptera ectoparasites host-parasite network neotropics Streblidae urbanization