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Journal of Cancer Metastasis and Treatment 2019年第1期4卷 55-81页

作者： ciro isidoro Gianluca Gaidano Universitàdel Piemonte Orientale"A.Avogadro" Novara 28100Italy

Cancer remains a leading cause of death, despite the undeniable progress made in the last decades in thediagnosis and therapeutic treatments. Further improvements are only possible if we understand morein depth how cancer develops and metastasizes, and how it produces its damaging effects on the wholeorganisms, including immune-suppression and cachexia, that eventually lead to patient death. The goal ofthe International Workshop No-Cancer 2018 “understanding cancer cell biology to improve diagnosis andtherapy” held in 28-30 Oct, in Novara (Italy) is precisely to share the foremost updated knowledge on thebiology of cancer and the emerging technologies for early detection of cancer cells and the new “chemo-free”therapeutic options.

关键词： diagnosis Cancer cancer

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Meeting Abstracts

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 56-91页

作者： Dr.ciro isidoro Department of Health Sciences Universitàdel Piemonte Orientale“A.Avogadro”Novara 28100Italy

This Special Issue of Journal of Cancer Metastasis and Treatment is dedicated to the proceedings of the 2nd World Congress on Cancer 2018 held in Bologna(Italy)in July *** theme of the Conference Cancer-2018 was“Onco... 详细信息

关键词： Cancer Metastasis Bologna

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Epigenetic control of autophagy in women’s tumors:role of non-coding RNAs

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 49-68页

作者： Chiara Vidoni Letizia Vallino Alessandra Ferraresi Eleonora Secomandi Amreen Salwa Menaka Chinthakindi Alessandra Galetto Danny N Dhanasekaran ciro isidoro Laboratory of Molecular Pathology Department of Health SciencesUniversitàdel Piemonte Orientale“A.Avogadro”Novara 28100Italy Unit of Medical Oncology Department of Experimental and Translational MedicineUniversitàdel Piemonte OrientaleNovara 28100Italy Stephenson Cancer Center University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA

Cancer remains the second leading cause of death worldwide and a major public health and economic *** reduce the burden,new approaches are necessary to diagnose the disease at early stages and improve clinical outcomes of cancer patients,for which understanding the molecular mechanisms of carcinogenesis is *** is a pro-survival pathway that ensures the removal and renewal of cellular macromolecular structures,thus playing a crucial role in the maintenance of cellular *** of autophagy can favor chemoresistance and survival of dormant cancer cells,thus favoring cancer progression and *** studies report dysregulated expression of long non-coding RNAs and micro-RNAs acting as tumor suppressors or tumor promoters by targeting genes involved in the autophagy ***,we focus on the role played by non-coding RNAs-mediated regulation of autophagy in development and progression of cancers in *** how epigenetics can impact autophagy might open novel therapeutic strategies in the fight against cancers in women.

关键词： Autophagy cancer breast cancer ovarian cancer micro-RNAs long non-coding RNA cell metabolism,autophagy-related genes

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Resilience analysis of road tunnels subject to refurbishment work

Digital Transportation and Safety

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Digital Transportation and Safety 2023年第3期2卷 190-199页

作者： ciro Caliendo isidoro Russo Gianluca Genovese Department of Civil Engineering University of SalernoVia Giovanni Paolo II132-84084 FiscianoSAItaly

After some tragic fire events,Directive 2004/54/EC was issued to ensure a minimum safety level for tunnels belonging to the Trans-European Road Network longer than 500 ***,most of the Italian road tunnels are still not in compliance with the minimum safety requirements,thus refurbishment works are often *** developing a traffic macro-simulation model,this paper aims at assessing the resilience of an existing twin-tube motorway tunnel when one of its tubes is partially or completely closed due to planned *** scenarios were investigated,also considering the availability or not of an alternative itinerary in the surrounding transportation *** average vehicles’speed was used as a functionality parameter,while the resilience metrics were the resilience loss,the recovery speed,and the resilience *** findings showed higher resilience losses for complete closure rather than partial closure of the tube under planned refurbishment *** implementation of digital technologies,such as variable message signs,might reduce the resilience loss of the tunnel *** research might represent a reference for tunnel management agencies in the choice of the most appropriate traffic control strategy to improve tunnel resilience in the event of planned activities.

关键词： Road tunnels Resilience Refurbishment works Traffic simulation Digital technologies

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