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Alternative therapeutic strategies in diabetes management

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World Journal of Diabetes 2024年第6期15卷 1142-1161页

作者： Alessia Annicchiarico Barbara Barile cinzia Buccoliero Grazia Paola nicchia Giacomina Brunetti Department of Biosciences Biotechnologies and EnvironmentUniversity of Bari Aldo MoroBari 70125Italy

Diabetes is a heterogeneous metabolic disease characterized by elevated blood glucose levels resulting from the destruction or malfunction of pancreaticβcells,insulin resistance in peripheral tissues,or both,and results in a non-sufficient production of *** adjust blood glucose levels,diabetic patients need exogenous insulin administration together with medical nutrition therapy and physical *** the aim of improving insulin availability in diabetic patients as well as ameliorating diabetes comorbidities,different strategies have been *** first approaches included enhancing endogenousβcell activity or transplanting new *** protocol for this kind of intervention has recently been optimized,leading to standardized *** is indicated for diabetic patients with severe hypoglycemia,complicated by impaired hypoglycemia awareness or exacerbated glycemic *** has been associated with improvement in all comorbidities associated with diabetes,quality of life,and ***,different trials are ongoing to further improve the beneficial effects of ***,to overcome some limitations associated with the availability of islets/pancreas,alternative therapeutic strategies are under evaluation,such as the use of mesenchymal stem cells(MSCs)or induced pluripotent stem cells for *** cotransplantation of MSCs with islets has been successful,thus providing protection against proinflammatory cytokines and hypoxia through different mechanisms,including exosome *** use of induced pluripotent stem cells is recent and requires further *** advantages of MSC implantation have also included the improvement of diabetes-related comorbidities,such as wound *** the number of advantages of the direct injection of MSCs,new strategies involving biomaterials and scaffolds have been developed to improve the efficacy of mesenchymal cell delivery with promising resul

关键词： Diabetes Pancreas/islet transplantation Mesenchymal stem cells Induced pluripotent stem cells Exosomes Scaffolds

Potential of photodynamic therapy in the management of infectious oral diseases

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World Journal of Experimental Medicine 2024年第1期14卷 1-5页

作者： cinzia Casu Germano Orrù Department of Surgical Science Oral Biotechnology LaboratoryUniversity of CagliariCagliari 09124Italy

Photodynamic therapy(PDT)can take place in the presence of three elements:Light with an appropriate wavelength;a photosensitizer;and the presence of *** type of treatment is very effective overall against bacterial,viral and mycotic *** the last 10 years many papers have been published on PDT with different types of photosensitizers(e.g.,methylene blue,toluidine blue,indocyanine green,curcumin-based photosensitizers),different wavelengths(e.g.,460 nm,630 nm,660 nm,810 nm)and various parameters(e.g.,power of the light,time of illumination,number of sessions).In the scientific literature all types of PDT seem very effective,even if it is difficult to find a standard protocol for each oral *** could be an interesting way to treat some dangerous oral infections refractory to common pharmacological therapies,such as candidiasis from multidrug-resistant Candida spp.

关键词： Photodynamic therapy oral infections Photodynamic therapy vs candidiasis Blue light 460 nm Streptococcus mutans

Adherence to Pharmacotherapy in Post-Menopausal Women with Hypertension or Metabolic Syndrome: Real World Experience

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International Journal of Clinical Medicine 2024年第3期15卷 145-154页

作者： Maria Maiello Francesca Amati Vincenzo Ezio Santobuono Andrea Igoren Guaricci cinzia Forleo Marco Matteo Ciccone Pasquale Palmiero Department of Cardiology ASL BR SSN3 Brindisi Italy Cardiovascular Diseases Section Interdisciplinary Department of Medicine (DIM) University of Bari “Aldo Moro” Bari Italy

Background: Adherence to medications is dependent upon a variety of factors, including individual characteristics of the patient, interactions with health care providers, and medication complexity. Even though several studies were conducted to test intervention strategies, results are uncertain. Aim: The aim of the study is to assess if a tailored combined intervention strategy improves medication adherence in a large population of post-menopausal women affected by hypertension or metabolic syndrome. Methods: We enrolled 6833 patients aged 50 to 69 years, 85.7% with hypertension, and 14.3% with metabolic syndrome. A network between patients, general practitioners, and cardiologists was established. Interventions included education, adequate information to patients, a simplified scheme of treatment, and periodic adherence assessment. These were either delivered as healthcare provider supports or using modern technology. Medication adherence was estimated by the proportion of days covered for all classes of drugs after the index date. Results: non-adherent hypertensive women were 297 (5%), and those with metabolic syndrome were 73 (7.4%) (p Conclusions: The rate of non-adherence in both settings of postmenopausal women was 7.7%, much lower than that described in the literature. This rate was increased in patients with metabolic syndrome;probably it is related to the complexity of the therapeutic scheme or to a poor consciousness of the disease. Therefore, implementing a tailored combined intervention can improve significantly patients’ adherence to medical therapy.

关键词： Adherence Cardiovascular Prevention Postmenopausal Women Hypertensive Metabolic Syndrome

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深海环境海洋生态系统监测与修复新技术

Engineering 2024年第3期34卷 195-211页

作者： Jacopo Aguzzi Laurenz Thomsen Sascha Flögel nathan J.Robinson Giacomo Picardi Damianos Chatzievangelou nixon Bahamon Sergio Stefanni Jordi Grinyó Emanuela Fanelli cinzia Corinaldesi Joaquin Del Rio Fernandez Marcello Calisti Furu Mienis Elias Chatzidouros Corrado Costa Simona Violino Michael Tangherlini Roberto Danovaro Instituto de Ciencias del Mar(ICM-CSIC) Barcelona 08003Spain Stazione Zoologica Anton Dohrn Naples 80121Italy University of Gothenburg Göteborg 40530Sweden GEOMAR Helmholtz Centre for Ocean Research Kiel 24148Germany Fundación Oceanogràfic de la Comunitat Valenciana Valencia 46013Spain Royal netherlands Institute for Sea Research(nIOZ) Den Burg Texel 1790 ABNetherlands Polytechnic University of Marche(UnIVPM) Ancona 60131Italy SARTI-MAR of the Universitat Politecnica de Catalunya(UPC) Vilanova i la Geltrú08800Spain Lincoln Institute for Agri-food Technology University of LincolnLincoln LN22LGUK Engitec Systems International Limited Limassol 3083Cyprus Consiglio per la Ricerca in Agricoltura e L’analisi Dell’economia Agraria(CREA) Centro di Ricerca Ingegneria e Trasformazioni AgroalimentariMonterotondo 00015Italy

The United nations(Un)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural *** ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work ***,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial *** expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

关键词： Ecosystem restoration Robotic manipulation Acoustic tracking Fishery resources Artificial reefs

Thrombin in peripheral nerves:friend or foe?

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neural Regeneration Research 2021年第6期16卷 1223-1224页

作者： Elena Pompili cinzia Fabrizi Department of Anatomy HistologyForensic Medicine and OrthopedicsSapienza UniversityRomeItaly

Differently from the central nervous system(CnS),the peripheral nervous system(PnS)exhibits a high regenerative *** ability is related to the remarkable plasticity of Schwann cells(SCs)which after nerve injury convert to a repair-promoting phenotype to a large *** injury is accompanied by a rapid rise of thrombin levels(Bushi et al.,2016;Gera et al.,2016).Thrombin is the key effector protease of the coagulation cascade which elicits hormonelike actions by the activation of G-protein coupled receptors known as proteaseactivated receptors(PARs).Inflammation and coagulation are two complex and interconnected pathways whose mutual interactions have been only partially elucidated.

关键词： mutual injury convert

SRAM-Based FPGA Systems for Safety-Critical Applications： A Survey on Design Standards and Proposed Methodologies

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Journal of Computer Science & Technology 2015年第2期30卷 373-390页

作者： cinzia Bernardeschi Luca Cassano Andrea Domenici Department of Information Engineering University of Pisa Pisa 56122 Italy Dipartimento di Elettronica Informazione e Bioingegneria Politecnico di Milano Milano 20133 Italy

As the ASIC design cost becomes affordable only for very large-scale productions, the FPGA technology is currently becoming the leading technology for those applications that require a small-scale production. FPGAs can be considered as a technology crossing between hardware and software. Only a small-number of standards for the design of safety-critical systems give guidelines and recommendations that take the peculiarities of the FPGA technology into consideration. The main contribution of this paper is an overview of the existing design standards that regulate the design and verification of FPCA-based systems in safety-critical application fields. Moreover, the paper proposes a survey of significant published research proposals and existing industrial guidelines about the topic, and collects and reports about some lessons learned from industrial and research projects involving the use of FPGA devices.

关键词： design verification electronic design safety-critical system SRAM-based FPGA

Pharmacogenomics in Parkinson's disease: which perspective for developing a personalized medicine?

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neural Regeneration Research 2019年第1期14卷 75-76页

作者： cinzia Ciccacci Paola Borgiani Department of Biomedicine and Prevention Section of Genetics School of Medicine University of Rome Tor Vergata

Every disease treatment is ideally finalized to prevent symptom occurrence,to stop or slow down the progression of disease,to alleviate complications already present and consequently to improve the quality of life for each ***,in Parkinson’s disease(PD)a treatment able to completely cure the disease is not so far ***,until now,the current therapies only allow to control the disease symptoms,

关键词：疾病治疗开发个性化疾病症状职业人员允许控制并发症

A Framework for the Assessment of Research and Its Impacts

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Journal of Data and Information Science 2017年第4期2卷 7-42页

作者： cinzia Daraio Department of Computer Control and Management Engineering A.Ruberti(DIAG)Sapienza University of RomeItaly

This paper proposes a holistic framework for the development of models for the assessment of research activities and their impacts. It distinguishes three dimensions, including in an original way, data as a main dimension, together with theory and methodology. Each dimension of the framework is further characterized by three main building blocks： education, research, and innovation （theory）; efficiency, effectiveness, and impact （methodology）; and availability, interoperability, and ＂unit-free＂ property （data）. The different dimensions and their nine constituent building blocks are attributes of an overarching concept, denoted as ＂quality.＂ Three additional quality attributes are identified as implementation factors （tailorability, transparency, and openness） and three ＂enabling＂ conditions （convergence, mixed methods, and knowledge infrastructures） complete the fi-amework. A framework is required to develop models of metrics. Models of metrics are necessary to assess the meaning, validity, and robustness of metrics. The proposed framework can be a useful reference for the development of the ethics of research evaluation. It can act as a common denominator for different analytical levels and relevant aspects and is able to embrace many different and heterogeneous streams of literature. Directions for future research are provided.

关键词： Evaluation of research Efficiency Effectiveness Impacts Modeling Responsible metrics Ethics of research evaluation

Amyotrophic lateral sclerosis disease burden:doing better at getting better

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neural Regeneration Research 2023年第8期18卷 1728-1729页

作者： cinzia Volonté Susanna Amadio national Research Council-Institute for Systems Analysis and Computer Science“Antonio Ruberti” Cellular Neurobiology UnitIRCCS Fondazione Santa LuciaRomeItaly Cellular neurobiology Unit IRCCS Fondazione Santa LuciaRomeItaly

Amyotrophic lateral sclerosis(ALS)is classified as a multigenic,multifactorial,and heterogeneous neurodegenerative/neuroinflammatory disease that slays especially upper and lower motor neurons controlling voluntary muscle *** the insurgence that is characterized by typical symptoms such as weakness in the limbs and muscle twitches,the disease rapidly evolves into progressive muscle atrophy,paralysis,and lastly death occurring by respiratory failure usually within 2-4 years of diagnosis.

关键词： sclerosis paralysis respiratory