Thrombin in peripheral nerves:friend or foe?

作     者：Elena Pompili Cinzia Fabrizi Elena Pompili;Cinzia Fabrizi

作者机构：Department of AnatomyHistologyForensic Medicine and OrthopedicsSapienza UniversityRomeItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第6期

页      面：1223-1224页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by grants from Sapienza University to CF(RM118164328DF7F2 and RM11916B88BF39BB) 

主　　题：mutual injury convert 

摘      要：Differently from the central nervous system(CNS),the peripheral nervous system(PNS)exhibits a high regenerative *** ability is related to the remarkable plasticity of Schwann cells(SCs)which after nerve injury convert to a repair-promoting phenotype to a large *** injury is accompanied by a rapid rise of thrombin levels(Bushi et al.,2016;Gera et al.,2016).Thrombin is the key effector protease of the coagulation cascade which elicits hormonelike actions by the activation of G-protein coupled receptors known as proteaseactivated receptors(PARs).Inflammation and coagulation are two complex and interconnected pathways whose mutual interactions have been only partially elucidated.