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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko cindy yeuk-lam hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter Ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men

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Asian Journal of Andrology 2023年第6期25卷 674-679页

作者： Peter KF Chiu Thomas YT lam Chi-Fai Ng Jeremy YC Teoh Carmen CM Cho Hiu-Yee Hung cindy hong Monique J Roobol Winnie CW Chu Samuel YS Wong Joseph JY Sung SH Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong Kong SARChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong SARChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong Kong SARChina Erasmus MC Cancer Institute Erasmus Medical UniversityRotterdam 3015The Netherlands Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent *** aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening *** aged 50–75 years were prospectively recruited from a community-based PSA screening *** with PSA 4.0–10.0 ng ml^(−1) had PHI result *** prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥*** significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic *** total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI *** them,28.3%(53/187)had PI-RADS≥3 ***,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received *** the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,*** with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),*** benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<*** them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary *** benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 *** was an important risk stratification step for PCa

关键词： magnetic resonance imaging prostate prostate cancer prostate health index prostate-specific antigen screening

Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2009年第26期15卷 3288-3297页

作者： Elegance Ting Pui lam cindy Lo Kuen lam Ching Lung Lai Man Fung Yuen Daniel Yee Tak Fong Department of Medicine The University of Hong Kong Department of Nursing Studies The University of Hong Kong

AIM:To test the psychometric properties of a Chinese [(hong Kong) HK] translation of the chronic liver disease questionnaire (CLDQ).METHODS:A Chinese (HK) translation of the CLDQ was developed by iterative translation and cognitive *** was then administered to 72 uncomplicated and 78 complicated chronic hepatitis B (CHB) patients in hong Kong together with a structured questionnaire on service utilization,and the Chinese (HK) SF-36 Health Survey Version 2 (SF-36v2).RESULTS:Scaling success was ≥ 80% for all but three items.A new factor assessing sleep was found and items of two (Fatigue and Systemic Symptoms) subscales tended to load on the same *** consistency and test-retest reliabilities ranged from 0.58-0.90 for different *** validity was confirmed by the expected correlations between the SF-36v2 Health Survey and CLDQ *** scores of CLDQ were significantly lower in complicated compared with uncomplicated CHB,supporting sensitivity in detecting differences between ***:The Chinese (HK) CLDQ is valid,reliable and sensitive for patients with *** modif ications to the scaling structure might further improve its psychometric properties.

关键词：乙型肝炎心理测验慢性中国患者病毒感染肝病病情

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2751-2777页

作者： Yurong Lai Xiaoyan Chu Li Di Wei Gao Yingying Guo Xingrong Liu Chuang Lu Jialin Mao hong Shen Huaping Tang cindy Q.Xia Lei Zhang Xinxin Ding Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA Department of Pharmacokinetics Pharmacodynamics and Drug MetabolismMerck&Co.Inc.KenilworthNJ 07033USA Pharmacokinetics Dynamics and MetabolismPﬁzer Worldwide Research and DevelopmentGrotonCT 06340USA Eli Lilly and Company IndianapolisIN 46221USA Drug Metabolism and Pharmacokinetics BiogenCambridgeMA 02142USA Drug Metabolism and Pharmacokinetics Accent TherapeuticsInc.LexingtonMA 02421USA Department of Drug Metabolism and Pharmacokinetics GenentechA Member of the Roche GroupSouth San FranciscoCA 94080USA Drug Metabolism and Pharmacokinetics Department Bristol-Myers Squibb CompanyPrincetonNJ 08540USA Bioanalysis and Biomarkers Glaxo Smith KlineKing of the PrussiaPA 19406USA Department of Drug Metabolism and Pharmacokinetics Takeda Pharmaceuticals International Co.CambridgeMA 02139USA Ofﬁce of Research and Standards Ofﬁce of Generic DrugsCDERFDASilver SpringMD 20993USA Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Current afﬁliation:Translational Medicine EMD Serono Research&Development InstituteInc.BillericaMA 01821USA Current afﬁliation:Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA

Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical *** nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological *** progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the *** importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly *** increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME *** this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.

关键词： Drug discovery and development New drug application Biologics license application Pharmacokinetics ADME New modalities Model-informed drug development Micro-physiological systems

Comparison between empirical prokinetics, Helicobacter test-and-treat and empirical endoscopy in primary-care patients presenting with dyspepsia: A one-year study

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World Journal of Gastroenterology 2006年第31期12卷 5010-5016页

作者： Wayne HC Hu SK lam cindy LK lam WM Wong KF lam KC Lai YH Wong Benjamin CY Wong Annie OO Chan CK Chan Gabriel M Leung WM Hui Department of Medicine University of Hong Kong Hong Kong China Department of Statistics and Actuarial Science University of Hong Kong Hong Kong China Department of Community Medicine University of Hong Kong Hong Kong China

瞄准：调查最佳的策略在主要照顾对待消化不良的病人。方法：介绍给主要照顾门诊病人诊所的消化不良的病人随机被分到：(1 ) 实验内视镜检查法，(2 ) H pylori test-and-treat，并且(3 ) 实验专业版有 cisapride 的运动治疗。如果病人们... 详细信息

瞄准：调查最佳的策略在主要照顾对待消化不良的病人。方法：介绍给主要照顾门诊病人诊所的消化不良的病人随机被分到：(1 ) 实验内视镜检查法，(2 ) H pylori test-and-treat，并且(3 ) 实验专业版有 cisapride 的运动治疗。如果病人们在 2 wk 以后仍然保持征兆，早内视镜检查法被安排。症状严厉， quality-of-life (SF-36 ) 以及耐心的偏爱和满足被估计。所有病人由 wk 经历了内视镜检查法 6。病人们被跟随在上面为一年。结果：二百和三十四个病人被招募(163 女、吝啬的年龄 49 ) 。46% 是 H pylori 积极。测试的 26% H pylori 和运动病人显示出的 25% 实验专业版在 wk 的没有改进 2 后续和需要的早内视镜检查法。收到实验 cisapride 的 15% 病人对治疗作出回应很好，但是消化性溃疡是最后的诊断。症状分辨率和 quality-of-life 在这些组之中是类似的。为三策略的费用是每病人的 HK 美元 4343，美元 1771 和美元 1750。66% 病人喜欢有早内视镜检查法。结论：三策略是同等地有效的。实验专业版运动治疗是最不昂贵的，但是消化性溃疡可以与这治疗被错过。H pylori test-and-treat 是最划算的选择。

关键词：幽门螺杆菌内窥镜消化不良实验治疗

Acquisition repeatability of MRI radiomics features in the head and neck:a dual-3D-sequence multi-scan study

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 115-127页

作者： cindy Xue Jing Yuan Yihang Zhou Oi Lei Wong Kin Yin Cheung Siu Ki Yu Research Department Hong Kong Sanatorium&HospitalHong KongChina Medical Physics Department Hong Kong Sanatorium&HospitalHong KongChina

Radiomics has increasingly been investigated as a potential biomarker in quantitative imaging to facilitate personalized diagnosis and treatment of head and neck cancer(HNC),a group of malignancies associated with high ***,the feature reliability of radiomics is a major obstacle to its broad validity and generality in application to the highly heterogeneous head and neck(HN)*** particular,feature repeatability of radiomics in magnetic resonance imaging(MRI)acquisition,which is considered a crucial confounding factor of radiomics feature reliability,is still sparsely *** study prospectively investigated the acquisition repeatability of 93 MRI radiomics features in ten HN tissues of 15 healthy volunteers,aiming for potential magnetic resonance-guided radiotherapy(MRgRT)treatment of *** subject underwent four MRI acquisitions with MRgRT treatment position and immobilization using two pulse sequences of 3D T1-weighed turbo spin-echo and 3D T2-weighed turbo spin-echo on a 1.5T MRI *** repeatability of radiomics feature acquisition was evaluated in terms of the intraclass correlation coefficient(ICC),whereas within-subject acquisition variability was evaluated in terms of the coefficient of variation(CV).The results showed that MRI radiomics features exhibited heterogeneous acquisition variability and uncertainty dependent on feature types,tissues,and pulse *** a small fraction of features showed excellent acquisition repeatability(ICC>0.9)and low within-subject *** MRI scans improved the accuracy and confidence of the identification of reliable features concerning MRI acquisition compared to simple test-retest repeated *** study contributes to the literature on the reliability of radiomics features with respect to MRI acquisition and the selection of reliable radiomics features for use in modeling in future HNC MRgRT applications.

关键词： Radiomics Magnetic resonance guided radiotherapy Head and neck Repeatability Intraclass correlation coefficient

Bio-modulation of scaring Glaucoma Filtration Surgery using a novel application of coated magnesium

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Journal of Magnesium and Alloys 2021年第3期9卷 883-894页

作者： Xiangji Li Richard Filek Xiaomin Zhu Huanhuan Gao Liying Qiao hong Liu Lin Xie Yong Wang Fusheng Pan cindy ML Hutnik Department of Ophthalmology Institute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing 400042China Department of Ophthalmology Western UniversityIvey Eye InstituteSt.Joseph's Health Care LondonLondonONCanada Department of Ophthalmology The Third Affiliated HospitalChongqing Medical UniversityChongqing 400016China Collage of Material Science&Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400045China

Filtration surgery still plays a mainstream role of treatment for *** scarring is the main cause of surgical *** study evaluated the biocompatibility and anti-proliferative properties of pure magnesium with three different coatings,which are hydroxyapatite(HA),dicalcium phosphate dihydrate(DCPD)and DCPD+stearic acid(SA),in a primary culture of human tenon's capsule fibroblasts(HTCFs)and in rabbit Glaucoma Filtration *** and glass were used as controls in vitro,and trabeculectomy was used as control in *** results show the number and shape of HTCFs seeded on different coatings showed less quantity and poor cell *** type of coated magnesium demonstrated significantly decreased metabolic activity of ***+SA showed higher cytotoxicity than the other *** inhibition of proliferation was observed with the DCPD+SA *** expression ofα-SMA was decreased in the cells when seeded on all of the coated magnesium *** vivo,no obvious adverse effects were observed after *** significant difference existed for any of the different samples regarding different ion concentrations in the aqueous *** inflammatory response in the titanium,DCPD and DCPD+SA treated eyes was more intense than in the trabeculectomy alone and HA *** Blot analysis showed that collagen-1 andα-SMA expression was significantly lower in the titanium,HA,DCPD and DCPD+SA groups compared with the *** coatings on magnesium were able to affect the corrosive properties,which in turn,influenced the morphology and function of *** coated magnesium may be considered a very promising biodegradable material for the next generation of glaucoma drainage devices.

关键词： Glaucoma Glaucoma drainage device Fibrosis Tenon's capsule fibroblasts Magnesium Coating

Nowcasting China's GDP Using a Bayesian Approach

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Journal of Management Science and Engineering 2018年第4期3卷 232-258页

作者： Yixiao Zhang cindy L.Yu Haitao Li Yongmiao hong Department of Statistics Iowa State UniversityAmesIA 50011USA Department of Finance Cheung Kong Graduate School of BusinessBeijingChina Department of Economics Cornell UniversityIthacaNY 14853USA

Real time nowcasting is an assessment of current-quarter GDP from timely released economic and financial series before the GDP figure is *** a reliable current quarter nowcast in real time based on the most recently released economic and financial monthly data is crucial for central banks to make policy decisions and longer-term forecasting *** this study,we use dynamic factor models to bridge monthly information with quarterly GDP and achieve reduction in the dimensionality of the monthly *** develop a Bayesian approach to provide a way to deal with the unbalanced features of the dataset and to estimate latent common *** demonstrate the validity of our approach through simulation studies,and explore the applicability of our approach through an empirical study in nowcasting the China's GDP using 117 monthly data series of several categories in the Chinese *** simulation studies and empirical study indicate that our Bayesian approach may be a viable option for nowcasting the China's GDP.

关键词： Bayesian Analysis Dynamic Factor Models Kalman Filter Nowcasting Principal Component Analysis

A feasibility study of using biodegradable magnesium alloy in glaucoma drainage device

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 135-142页

作者： Xiang-Ji Li Lin Xie Fu-Sheng Pan Yong Wang hong Liu Yu-Rong Tang cindy-ML Hutnik Department of Ophthalmology University of Western Ontario Ivey Eye Institute St.Joseph's Hospital Department of Ophthalmology Institute of Surgery ResearchDaping Hospital Third Military Medical University Collage of Material Science & Engineering ChongqingUniversity National Engineering Research Center for Magnesium Alloys Chongqing University Department of Ophthalmology People's Hospital Zhongshan Branch

Technological advances in glaucoma have challenged the traditional treatment paradigm. Historically incisional surgery has been used in cases of advanced disease and/or uncontrolled intraocular pressures resistant to medical or laser interventions. More recently, perhaps due to advancements in imaging, surgery has been suggested to be beneficial earlier in the treatment paradigm. Despite these trends, surgical manipulation of the tissues and unpredictability of wound healing continue to result in surgical failure. Magnesium is an essential element for human body and plays a critically important role in maintaining the functional and structural integrity of several tissues, including the eye. Due to several of its advantageous properties such as non-toxicity, biodegradability, and high biological compatibility, magnesium alloy has attracted great attention as a novel biomaterial. Biodegradable cardiovascular stents made of magnesium alloy have already been introduced into clinical practice. The purpose of this review is to determine if bioabsorbable magnesium alloys can be utilized as a promising candidate for the development of a new generation of glaucoma surgical assistive devices.

关键词： glaucoma glaucoma drainage implant magnesium alloy anti-scarring

Topical application of adipose tissuederived mesenchymal stem cells(ADMSCs)reduced cerebral edema in experimental traumatic brain injury(TBI)-a preliminary study

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Chinese Neurosurgical Journal 2021年第2期7卷 131-136页

作者： Hui Ma Lian Xu Cui Ping Kuen lam cindy S.W.Tong Kin K.Y.Lo George K.C.Wong Wai Sang Poon Division of Neurosurgery Chow Tai Fook-Cheng Yu Tung Surgical Stem Cell Research CenterDepartment of SurgeryThe Chinese University of Hong KongShatinHong KongSARChina Division of Neurosurgery Department of SurgeryFo Shan First People’s HospitalFoshanGuangdongChina

Background:Our previous studies showed that topical application of mesenchymal stem cells(MSCs)improved functional recovery in rat traumatic brain injury(TBI)model,and hypoxic precondition further enhanced the therapeutic effects of *** was no previous study on the attenuation of cerebral edema by *** investigated whether topical application of normoxic and hypoxic MSCs could reduce cerebral edema in an experimental TBI ***:Two million normoxic(N=24)and hypoxic(N=24)MSCs were applied topically to exposed the cerebral cortex in a controlled cortical impact(CCI)*** MSCs were fixed in position with fibrin *** treatment was given to control animals(TBI only:n=24).After surgery,four animals in each group were sacrificed daily(day 1 to day 6)for edema *** animals without TBI were used as reference(n=4).The expressions of GFAP,AQP4,and MMP9 were also investigated by immunofluorescence staining and RT-PCR at day ***:The edema peaked within 3 days after *** with the control,hypoxic MSCs reduced brain water content significantly(p<0.05).Both hypoxic and normoxic MSCs downregulated the expression of MMP9 and normalized AQP4 distribution to astrocyte end ***:Our preliminary study showed that topical application of hypoxic MSCs suppressed both vasogenic and cytotoxic edema formation.

关键词： Topical MSCs Cerebral edema TBI