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Application of endoscopic endonasal approach in skull base surgeries: summary of 1886 cases in a single center for 10 consecutive years

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Chinese Neurosurgical Journal 2020年第3期6卷 133-140页

作者： Chuzhong Li Haibo Zhu Xuyi Zong Xinsheng Wang Songbai Gui Peng Zhao Chunhui liu Jiwei Bai Lei Cao Yazhuo Zhang Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina Department of Neurosurgery Beijing Tiantan Hospital affiliated to Capital Medical UniversityBeijingChina Beijing Institute for Brain Disorders Brain Tumor Center BeijingChina China National Clinical Research Center for Neurological Diseases No.119 South 4th Ring West RoadFengtai DistrictBeijing 100050China

Background:Endonasal endoscopic skull base surgery has undergone rapid technological developments and is now widely performed,but its strengths and weaknesses deserve further investigation and deliberation.This study was performed to investigate the surgical indications,complications,and technical advantages and disadvantages of endonasal endoscopic skull base surgery.Methods:The clinical data of 1886 endoscopic endonasal skull base surgeries performed in our ward at Beijing Tiantan Hospital from June 2006 to June 2016 were retrospectively analyzed.Results:One thousand ninety-three(73.4%,1490)pituitary adenomas,54(24.9%,217)chordomas,28(80.0%,35)craniopharyngiomas,and 15(83.3%,18)meningiomas underwent total resection.Two patients died postoperatively,both having pituitary adenomas.Other postoperative complications included olfactory disorders(n=226,11.9%),postoperative cerebrospinal fluid leakage(n=78,4.1%),hypopituitarism(n=74,3.9%),diabetes insipidus(n=64,3.4%),intracranial infection(n=36,1.9%),epistaxis(n=24,1.3%),vascular injury(n=8,0.4%),optic nerve injury(n=8,0.4%),and oculomotor movement impairment(n=4,0.2%).In total,1517(80.4%)patients were followed up for 6 to 126 months(average,42.5 months)postoperatively.A total of 196(13.2%)pituitary adenomas and 13(37.1%)craniopharyngiomas recurred but no meningiomas recurred.Chordomas recurred in 97(44.7%)patients,in whom 5-year survival rate was 65%.Conclusion:Endoscopic surgery is an innovative surgical technique and the first choice for most midline extradural lesions such as chordomas,and an excellent choice for pituitary adenomas.It probably will be a good technique for many kinds of craniopharyngiomas and a common technique for most of skull base meningiomas,so the surgical indications of these cases should be chosen carefully to make good use of its respective advantages.

关键词： Complication Indication Neuroendoscopy Skull base surgery Endonasal approach

White matter regeneration induced by aligned fibrin nanofiber hydrogel contributes to motor functional recovery in canine T12 spinal cord injury

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Regenerative Biomaterials 2022年第1期9卷 260-270页

作者： Zheng Cao Weitao Man Yuhui Xiong Yi Guo Shuhui Yang Dongkang liu He Zhao Yongdong Yang Shenglian Yao Chuzhong Li lingyun Zhao Xiaodan Sun Hua Guo Guihuai Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced MaterialsSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Center for Biomedical Imaging Research Tsinghua UniversityBeijing 100084China Department of Orthopedics Dongzhimen HospitalBeijing 100007China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Neurosurgical Institute Beijing Tiantan HospitalBeijing 100070China

A hierarchically aligned fibrin hydrogel(AFG)that possesses soft stiffness and aligned nanofiber structure has been successfully proven to facilitate neuroregeneration in vitro and in vivo.However,its potential in promoting nerve regeneration in large animal models that is critical for clinical translation has not been sufficiently specified.Here,the effects of AFG on directing neuroregeneration in canine hemisected T12 spinal cord injuries were explored.Histologically obvious white matter regeneration consisting of a large area of consecutive,compact and aligned nerve fibers is induced by AFG,leading to a significant motor functional restoration.The canines with AFG implantation start to stand well with their defective legs from 3 to 4 weeks postoperatively and even effortlessly climb the steps from 7 to 8 weeks.Moreover,high-resolution multi-shot diffusion tensor imaging illustrates the spatiotemporal dynamics of nerve regeneration rapidly crossing the lesion within 4 weeks in the AFG group.Our findings indicate that AFG could be a potential therapeutic vehicle for spinal cord injury by inducing rapid white matter regeneration and restoring locomotion,pointing out its promising prospect in clinic practice.

关键词： aligned fibrin hydrogel spinal cord injury white matter regeneration diffusion tensor imaging canine

光甘草定-白藜芦醇-虎杖苷组合物的协同美白抗氧抗炎活性

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香料香精化妆品 2024年第3期 99-107,233页

作者：黄洁谢翀潘志李楚忠陈庆生龚盛昭黄亚东暨南大学生命科学技术学院广东广州510632 环亚化妆品科技有限公司研究院广东广州510663 广东轻工职业技术学院广东广州510300

围绕体外美白相关功效,对10种美白成分进行了功效对比,并从中优选出强功效成分进行组合筛选,发现了由虎杖苷、白藜芦醇、光甘草定构成的组合物具备较强美白效果,即使在较低浓度0.0001μmol/L,该组合物可显著抑制细胞内黑色素生成(抑制率... 详细信息

围绕体外美白相关功效,对10种美白成分进行了功效对比,并从中优选出强功效成分进行组合筛选,发现了由虎杖苷、白藜芦醇、光甘草定构成的组合物具备较强美白效果,即使在较低浓度0.0001μmol/L,该组合物可显著抑制细胞内黑色素生成(抑制率19.47%)及酪氨酸酶活性(抑制率23.7%),同时表现出较强自由基清除能力,DPPH的IC50为0.3445 mmol/L,羟自由基的IC50为19.82 mmol/L。另外,该组合物具备一定抗炎活性,可抑制一氧化氮(NO)和肿瘤坏死因子(TNFα)的生成,并显著下调小眼畸形相关转录因子(MITF)通路相关基因表达。为其在化妆品类中的应用提供了理论依据。

关键词：美白黑色素酪氨酸酶虎杖苷白藜芦醇光甘草定小眼畸形相关转录因子(MITF)

Application of robotic-assisted endoscopic third ventriculostomy

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Journal of Translational Neuroscience 2018年第1期3卷 32-36页

作者： Peng Zhao Yinyan Wang Jiwei Bai Bin li Chuzhong Li Songbai Gui Xinsheng Wang Xuyi Zong Yazhuo Zhang Neurosurgical Department Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Key Laboratory of Central Nervous System Injury Research Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050 China Beijing Neurosurgical Institute Center of Brain Tumor Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100050 China

Objective:This case series study explored the application of ROSA(robot of stereotactic assistant)robotic-assisted endoscopic third ventriculostomy(ETV)in the treatment of hydrocephalus.Methods:Three patients(January2016-October2017)diagnosed with hydrocephalus based on preoperative computed tomograph(CT)and magnetic resonance imaging(MRI)scans were recruited.Navigation planning scan was performed before operation.ROSA robot localization program was used to simulate and analyze the path planning of hydrocephalus ETV and store it in the system.All the three patients underwent robotic-assisted ETV.The patients'clinical symptoms,imaging manifestations and related complications were evaluated,and a3-month follow-up survey was conducted.Prognostic factors were also analyzed.Results:ETV under the guidance of ROSA robot was successfully performed on the three patients.CT,MRI and cerebrospinal fluid(CSF)cine showed that the ventricles were narrowed,that the velocity and flow of the stoma were normal,and that the CSF flow was smooth.After discharge,the symptoms of hydrocephalus were significantly improved.Localization of the robot and design of the surgical path were key to success of the operation.Conclusions:ROSA robotic-assisted ETV is a feasible procedure.The patients recovered well,and the symptoms relieved.More efforts are needed to optimize artificial intelligence and the application of precision treatment in the nervous system.

关键词： robot hydrocephalus neuroendoscope third ventriculostomy artificial intelligence(AI)

Immunohistochemical study of NR2C2, BTG2, TBX19, and CDK2 expression in 31 paired primary/recurrent non-functioning pituitary adenomas

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Immunohistochemical study of NR2C2, BTG2, TBX19, and CDK2 ex...

促肾上腺皮质激素细胞肿瘤生化静默机制研究进展

第十四届中国医师协会神经外科医师年会

作者： Xiaohui Yao Yazhuo Zhang lijuan Wu Rui cheng Chuzhong Li Chongxiao QU Hongming Ji Shanxi provincial people's hospital Key laboratory of central nervous system injury research Beijing Neurosurgical InstituteCapital Medical University

This study investigated potential markers for predicting non-functioning pituitary adenoma(NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients, including 60 non-recurrent NFPA cases that included non-invasion and invasion subtypes, and 43 recurrent cases that included primary NFPA. A total of 31 paired patient samples were evaluated(12 patients with one surgery and 31 who had undergone two operations, with both tumors analyzed). Expressions of nuclear receptor subfamily 2 group C member 2(NR2C2), B cell translocation gene 2, T-box(TBX)19, and cyclin-dependent kinase(CDK)2 in surgically resected specimens were assessed by immunohistochemistry. The relationship between marker expression and clinical characteristics including age, sex, tumor volume, and follow-up time were analyzed. Tumor volume and invasion as well as follow-up time were significantly associated with invasion and recurrence(P < 0.01). Of the 60 non-recurrent samples, 15/41 and 13/19 showed high NR2C2 expression in the non-invasion and invasion groups, respectively(χ =5.287, P = 0.021). NR2C2 was also overexpressed in 43 primary recurrent cases(χ =5.433, P = 0.02), whereas CDK2(χ = 11.242, P = 0.001) and TBX19(χ = 4.875, P = 0.027) were downregulated. In the 31 paired samples, NR2C2 was more highly expressed in the recurrent as compared to the primary tumor. High NR2C2 expression was associated with NFPA invasion, recurrence, and progression,while TBX19 and CDK2 were associated with NFPA recurrence.

关键词： Non-functioning pituitary adenoma NR2C2 BTG2 CDK2 TBX19 Immunohistochemistry

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中华神经医学杂志 2023年第6期22卷 623-626页

作者：孙瑛璇李储忠张亚卓首都医科大学北京市神经外科研究所北京100070

促肾上腺皮质激素细胞肿瘤(CTs)根据患者有无库欣病表现可以分为功能型CTs和静默型CTs(SCTs)2种亚型。2种亚型肿瘤的病理表现一致,免疫组织化学染色检测均可见促肾上腺皮质激素(ACTH)和T-box转录因子19的表达,但SCTs患者外周血ACTH水平... 详细信息

促肾上腺皮质激素细胞肿瘤(CTs)根据患者有无库欣病表现可以分为功能型CTs和静默型CTs(SCTs)2种亚型。2种亚型肿瘤的病理表现一致,免疫组织化学染色检测均可见促肾上腺皮质激素(ACTH)和T-box转录因子19的表达,但SCTs患者外周血ACTH水平正常,无库欣病表现,且表现为侵袭性生长,术后复发率高。有研究表明SCTs生化静默的机制涉及阿片黑素皮质素原(POMC)(ACTH前体)基因的表达和ACTH分泌的各个过程。本文现围绕正常腺垂体细胞ACTH生理合成及调控,SCTs中POMC基因的转录、转录后调控、翻译后调控以及ACTH分泌异常等方面对SCTs的生化静默机制进行综述,以期为SCTs的研究和临床诊治提供参考。

关键词：促肾上腺皮质激素细胞肿瘤生化静默阿片黑素皮质素原促肾上腺皮质激素

“出离”与“菩提”:论王维山水诗中的佛学意境——以《辋川集》二十首为例

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三门峡职业技术学院学报 2024年第1期23卷 61-67页

作者：黎京焱北京第二外国语学院文化与传播学院北京100024

“出离心”与“菩提心”作为佛教的两大核心思想,既是证入佛法智慧的元点,又是实修的根本着力处。而《辋川集》作为王维晚年“禅境诗”中的精品,多角度、深层次地反映出他深邃的佛学思想及精深的美学造诣。因此,对王维《辋川集》二十首... 详细信息

“出离心”与“菩提心”作为佛教的两大核心思想,既是证入佛法智慧的元点,又是实修的根本着力处。而《辋川集》作为王维晚年“禅境诗”中的精品,多角度、深层次地反映出他深邃的佛学思想及精深的美学造诣。因此,对王维《辋川集》二十首中“出离心”与“菩提心”这两大基本特征进行剖析和解读,冀以对王维的佛学思想以及诗歌创作有更深刻的认识。

关键词：王维禅辋川集

Different therapeutic proportion of patients undergone coronary angiography in the era of development in MSCT

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Journal of Geriatric Cardiology 2008年第2期5卷 83-85页

作者： Juan Deng Wenbin Wang Shuoqing Hu Yue Xiao Feng liang Xuewei Guo Haiying Wang Pengchuan Zhang Dayi Hu Tianchang li chuzhong Tang Jiyun Wang Changlin Lu Department of Cardiology Daxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyDaxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyDaxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyDaxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyDaxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyDaxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyDaxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyDaxing HospitalCapital University of Medical ScienceBeijing 102600China Department of CardiologyBeijing People''s HospitalBeijing UniversityBeijing 100044China Department of CardiologyBeijing Tongren HospitalCapital University of Medical SciencesBeijing 107300China Department of CardiologyBeijing People''s HospitalBeijing UniversityBeijing 100044China Department of CardiologyBeijing Tongren HospitalCapital University of Medical SciencesBeijing 107300China Department of CardiologyBeijing Tongren HospitalCapital University of Medical SciencesBeijing 107300China

Objective To study the different therapeutic proportion of the patient populations undergone coronary angiography (CAG) in the era of development in multislice spiral computed tomography(MSCT). Methods Two hundred and fifty four consecutive patients(mean age 59.24±10.65) , who underwent CAG at Daxing Hospital from February 2007 through October 2007, were enrolled, 160 patients were male and 94 were female. By evaluating from the coronary angiogram, the patients were not diagnosed to have coronary heart disease(CHD) with less than 50% diameter stenosis of coronary artery; the patients to have CHD with more than or equal to 50% stenosis of coronary artery; the patients were performed the procedure of percutaneous coronary intervention(PCI) with more than or equal to 70% stenosis; the patients were proposed to have coronary aortic bypass graft(CABG) surgery with left main coronary artery lesions or diffuse triple coronary artery lesions. Results In the 254 consecutive patients, 59 patients(23.2%) had not been diagnosed to have CHD; 195(76.8%)to have CHD, of these patients with CHD, 49 patients(19.3%)were not indicated for PCI (including the patients receiving follow-up coronary angiography after stenting), 81(31.9%)had been performed the procedure of stent implantation, 57(22.4%)proposed to have CABG, 8(3.1%)the procedure of PCI had not been successful, or had not been performed because of patients opposing to this therapy. Conclusion Multislice spiral computed tomography can be applied as a non-invasive screening tool to exclude the presence of CHD, to increase the positive proportion of the populations with CHD in all patients receiving coronary angiograhpy, to avoid the use of CAG in a subset of

关键词： coronary heart disease multislice spiral computed tomography coronary angiography

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一种天然植物组方的舒缓修护功效

香料香精化妆品 2022年第5期 30-35页

作者：李楚忠陈庆生龚盛昭广州环亚化妆品科技股份有限公司广东广州510663 广东轻工职业技术学院广东广州510300

为了测试一种天然植物组方的舒缓、修护功效,采用UVB紫外光诱导HaCaT细胞产生炎症因子,将不同质量分数的天然植物组方与其进行共培养,测试组方的抗炎效果;通过人体测试,对受试者使用前后皮肤的红斑指数、黑素指数、经皮失水率进行测试... 详细信息

为了测试一种天然植物组方的舒缓、修护功效,采用UVB紫外光诱导HaCaT细胞产生炎症因子,将不同质量分数的天然植物组方与其进行共培养,测试组方的抗炎效果;通过人体测试,对受试者使用前后皮肤的红斑指数、黑素指数、经皮失水率进行测试。结果显示,制备的天然植物组方具有较好的抗炎作用,对于TNF-α、IL-1α、IL-6均具有明显的抑制作用;使用13天后,受试者皮肤红斑指数、黑素指数、经皮失水率较使用前皆有改善,差异有统计学意义(P <0.05)。13天的试验期间未出现任何皮肤不良反应,表明其具有良好的安全性,适用于敏感性皮肤人群。

关键词：牡丹皮金银花积雪草马齿苋敏感皮肤