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Unveiling DnA methylation in Alzheimer’s disease:a review of array-based human brain studies

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neural Regeneration Research 2024年第11期19卷 2365-2376页

作者： Victoria Cunha Alves eva Carro Joana Figueiro-silva neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain network Center for Biomedical Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in neuroscience Autonoma de Madrid UniversityMadridSpain neurotraumatology and subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain neurobiology of Alzheimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical Genetics University of ZurichZurichSwitzerland Department of Molecular Life science University of ZurichZurichSwitzerland

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DnA *** review comprehensively surveys recent human-centered studies that investigate whole genome DnA methylation in Alzheimer’s disease *** examination of various brain regions reveals distinctive DnA methylation patterns that associate with the Braak stage and Alzheimer’s disease *** entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the ***,AnK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal ***,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory *** complex role of BIn1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation *** the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease *** research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关键词： Alzheimer’s disease AnK1 BIn1 DnA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2

The effect of slime accumulated in a long-term operating UAsB using crude glycerol to treat s-rich wastewater

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Journal of Environmental sciences 2024年第1期135卷 353-366页

作者： Xudong Zhou eva Fernández-Palacios Antoni DDorado Javier Lafuente Xavier Gamisans David Gabriel Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China GEnOCOV Research Group Department of ChemicalBiological and Environmental EngineeringEscola d’EnginyeriaUniversitat Autònoma de Barcelona08193 BellaterraSpain Department of Mining Industrial and ICT EngineeringUniversitat Politècnica de CatalunyaAvinguda de les Bases de Manresa 61-7308242 ManresaSpain

An up-flow anaerobic sludge blanket(UAsB)reactor targeting sulfate reduction was operated under a constant TOC/s-sO2-4ratio of 1.5±0.3 g C/g s for 639 days using crude glycerol as carbon source.A filamentous and fluffy flocculant material,namely slime-like substances(sLs),was gradually accumulated in the bioreactor after the cease of methanogenic *** accumulation of sLs was followed by a decrease in the removal efficiencies and a deterioration in the *** characteristics of sLs were investigated to explore the causes of its formation and the effect of sLs on the UAsB *** showed that glycerol fermentation and sulfate reduction processes taking place in the reactor were mainly accomplished in the bottom part of the UAsB reactor,as the sludge concentration in the bottom was *** accumulation of sLs in the UAsB reactor caused sludge flotation that further led to biomass washout,which decreased the sulfate and glycerol removal *** activity tests performed with granular sludge(Gs),slime-covered granular sludge(sCGs)and sLs showed that there was no difference between Gs and sLs in the mechanism of glycerol fermentation and sulfate ***,the specific sulfate reduction rate of Gs was higher than that of sLs,while sLs showed a higher glycerol fermentation rate than that of *** different rates in Gs and sLs were attributed to the higher relative abundances of fermentative microorganisms found in sLs and higher relative abundances of sulfate reducing bacteria(sRB)found in Gs.

关键词： sludge flotation Granular sludge slime-like substances Glycerol fermentation sulfate reduction Removal efficiency

Astrophysical s-factor and reaction rate for 15n(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili n.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan new York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh national University 050040 AlmatyKazakhstan

We study radiative p^(15)n capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)n(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)n channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)n(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CnO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)n(p,γ)^(13)O,^(13)n(p,γ)^(14)O,^(14)n(p,γ)^(15)O,and ^(15)n(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)n system thermonuclear reaction rate potential cluster model CnO-cycle

Endoscopic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: Lessons learned from single-balloon enteroscopy-assisted ERCP

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo Garcés-Durán Laurent Monino Pierre H Deprez Hubert Piessevaux Tom G Moreels Department of Gastroenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endoscopic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography(sBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. Methods: We retrospectively analyzed 106 sBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary sBE-ERCP was performed in 34 patients and pancreatic sBE-ERCP in 17, including 5 with both indications. From a total of 106 sBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. Mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 sBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary sBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary sBE-ERCP). Mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary sBE-ERCP), without serious adverse events. After sBE-ERCP failure, endoscopic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclusions: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using sBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. sBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteroscopy Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy surgically altered anatomy Whipple’s procedure

Dynamic and electrical responses of a curved sandwich beam with glass reinforced laminate layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 155-178页

作者： n.sHAHVEIsI s.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic responses and generated voltage in a curved sandwich beam with glass reinforced laminate(GRL)layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact(LVI)are *** current study aims to carry out a dynamic analysis on the sandwich beam when the impactor hits the top face sheet with an initial *** the layer analysis,the high-order shear deformation theory(HsDT)and Frostig's second model for the displacement fields of the core layer are *** classical non-adhesive elastic contact theory and Hunter's principle are used to calculate the dynamic responses in terms of *** order to validate the analytical method,the outcomes of the current investigation are compared with those gained by the experimental tests carried out by other researchers for a rectangular composite plate subject to the *** element(FE)simulations are conducted by means of the ABAQUs *** effects of the parameters such as foam modulus,layer material,fiber angle,impactor mass,and its velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved sandwich beam glass reinforced laminate(GRL) pliable core low-velocity impact(LVI) classical non-adhesive elastic contact theory

Odor cues rather than personality affect tadpole deposition in a neotropical poison frog

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Current Zoology 2024年第3期70卷 332-342页

作者： Melissa Peignier Max Ringler eva Ringler Division of Behavioural Ecology Institute of Ecology and EvolutionUniversity of BernCH-3032 HinterkappelenSwitzerland Messerli Research Institute University of Veterinary Medicine Vienna1210 ViennaAustria Department of Behavioral and Cognitive Biology University of Vienna1030 ViennaAustria Departmento f Evolutionary Biology UniversityofVienna1030ViennaAustria lnstitute of Electronic Music and Acoustics University of Music and Performing Arts Graz8010 GrazAustria

Animals constantly need to evaluate available external and internal information to make appropriate ***,assessing,and acting on relevant cues in contexts such as mate choice,intra-sexual competition,and parental care is particularly important for optimizing individual reproductive *** factors can infuence decision-making,such as external environmental cues and the animal’s own internal state,yet,we have limited knowledge on how animals integrate available ***,we used an entire island population(57 males,53 females,and 1,109 tadpoles)of the neotropical brilliant-thighed poison frog Allobates femoralis to investigate how 2 factors(olfactory cues and personality traits)infuence the ability of males to fnd and use new resources for tadpole *** experimentally manipulated the location of tadpole deposition sites and their associated olfactory cues,and repeatedly measured exploration and boldness in adult *** further reconstructed tadpole deposition choices via inferred parent–offspring relationships of adult frogs and tadpoles deposited in our experimental pools using molecular parentage *** found that the discovery and use of new rearing sites were heavily infuenced by olfactory cues;however,we did not fnd an effect of the measured behavioral traits on resource discovery and *** conclude that in highly dynamic environments such as tropical rainforests,reliable external cues likely take priority over personality traits,helping individuals to discover and make use of reproductive resources.

关键词： animal personality Anura decision-making parental care tadpole transport.

Towards defining soil quality of Mediterranean calcareous agricultural soils:Reference values and potential core indicator set

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International soil and Water Conservation Research 2024年第1期12卷 145-155页

作者： Germán A.Durán Daniel sacristán Edelweis Farrús Jaume Vadell Institut de Recerca i FormacióAgrària i Pesquera de les Illes Balears C/Eusebi Estada14507009PalmaSpain Plant Biology Department University of Valencia46100BurjassotValenciaSpain soil and Environmental Quality Department Centro de Investigaciones sobre Desertificación-CIDE(CSIC-Universitat de València-Generalitat Valenciana)Carretera Moncada-Náquera km 4.546113MoncadaValenciaSpain Universitat de les Illes Balears Cra.De Valldemossakm 7507122PalmaSpain

To avoid soil degradation,adapt to climate change and comply with the sustainable Development goals 2030(Un General Assembly),establishing the quality/fertility of the agricultural soils of the Mediterranean region and evaluate how these evolve with time is *** enables adequate management practices to be *** Mediterranean calcareous region has received little attention in this sense,in spite its soil ***,24 different representative calcareous agricultural soils of the Mediterranean region,including the main management strategies of agricultural soils(rainfed and irrigated),were sampled from the island of Mallorca;and their physical,chemical and biological properties *** values obtained for most of the soil characteristics allowed to establish an initial approach to the reference values for the type of calcareous agricultural soils considered,and to clearly distinguish the effect of rainfed or irrigation management practices on soils properties and *** enzyme activities were not stimulated by the irrigation conditions assayed or they were only in dry conditions,suggesting optimum enzyme activities could be obtained when alternating dry and humid soil *** organic carbon,calcium carbonate and active lime revealed of significant importance in the collection of ***,the results obtained clearly indicate the heterogeneity of the region and its implications on the different soil ***,this study could serve as a starting point to adequately establish the quality(fertility)for Mediterranean calcareous agricultural soils and their reference values by conducting further research in this region and including more type of soils.

关键词： soil fertility Mediterranean agricultural soils Calcareous soils soil enzymes soil management

Early Phases of star Formation: Testing Chemical Tools

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Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： n.C.Martinez s.Paron COnICET-Universidad de Buenos Aires.Instituto de Astronomía y Física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

star-forming processes strongly influence the IsM ***,many high-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve large samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing these tools such as the use of the HCn/HnC ratio as a thermometer,and the use of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing massive young stellar objects at different evolutionary stages:infrared dark clouds(IRDCs),highmass protostellar objects(HMPOs),hot molecular cores(HMCs) and ultracompact H II *** found that the use of the HCn/HnC ratio as a universal thermometer in the IsM should be taken with care because the HCn optical depth is a big issue that can affect the ***,this tool should be utilized only after a careful analysis of the HCn spectrum,checking that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H could be useful to trace and distinguish regions among IRDCs,HMPOs and *** molecular line widths of these four species increase from the IRDC to the HMC stage,which can be a consequence of the gas dynamics related to the starforming processes taking place in the molecular *** results not only contribute with more statistics,acting as a probe of such chemical tools,useful to obtain information in large samples of sources,but also complement previous works through the analysis of other types of sources.

关键词： stars:formation IsM:molecules IsM:clouds

Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brain

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neural Regeneration Research 2024年第5期19卷 969-970页

作者： Anne-eva van der Wijk Ed VanBavel Amsterdam UMC location University of Amsterdam Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands Amsterdam neuroscience Neurovascular Disorders ProgramAmsterdamThe Netherlands Amsterdam Cardiovascular sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of therapeutics for brain diseases has remained challenging,in particular due to the difficulty of passing the blood-brain *** a result,the current arsenal of therapeutics targeting the brain is limited to small,lipid-soluble drugs and there is a lack of options for treating neuroblastomas,Alzheimer’s disease,and many other devastating *** the advances in strategies for crossing the blood-brain barrier such as the use of nanoparticles(Hersh et al.,2022;Duan et al.,2023),such delivery systems have not yet reached clinical ***,novel platforms for the transport of therapeutics across the blood-brain barrier remain highly *** specifically holds for large molecules such as monoclonal antibodies and recombinant proteins,as well as nucleotide-based therapeutics and cell *** efforts in this field are increasing exponentially,with thousands of publications in the last few years.

关键词： therapeutics holds spite