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Advances in Medical Applications of Additive Manufacturing

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Engineering 2020年第11期6卷 1222-1231页

作者： chunxu li Dario Pisignano Yu Zhao Jiajia Xue Department of Orthopaedics Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing J 00730China National Enterprise for Nanoscience and Nanotechnology Nanoscience InstituteNational Research CouncilPisa 1-56127Italy Department of Physics University of PisaPisa 1-56127Italy Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029China

In the past few decades,additive manufacturing(AM)has been developed and applied as a cost-effective and versatile technique for the fabrication of geometrically complex objects in the medical *** this review,we discuss current advances of AM in medical applications for the generation of pharmaceuticals,medical implants,and medical *** and transdermal drugs can be fabricated by a variety of AM *** types of hard and soft clinical implants have also been realized by AM,with the goal of producing tissue-engineered *** addition,medical devices used for diagnostics and treatment of various pathological conditions have been *** growing body of research on AM reveals its great potential in medical *** goal of this review is to highlight the usefulness and elucidate the current limitations of AM applications in the medical field.

关键词： Additive manufacturing Medical applications Pharmaceutics Medical implants Medical devices

Development and Evaluation of a Wearable Lower limb Rehabilitation Robot

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Journal of Bionic Engineering 2022年第3期19卷 688-699页

作者： Wanting li Keping liu chunxu li Zhongbo Sun Shui liu Jian Gu Department of Control Engineering Changchun University of TechnologyChangchun130012China Centre for Robotics and Neural Systems University of PlymouthPlymouthPL48AAUK School of Mechatronical Engineering Changchun University of TechnologyChangchun130012China

This paper introduces a rigid-flexible coupling wearable exoskeleton robot for lower limb,which is designed in light of gait biomechanics and beneficial for low limb movement disorders by implementing gait *** rationality of the proposed mechanism is shown with the implementation of the dynamic simulation through MSC *** the purposes of lightweight,the exoskeleton mechanism is optimized through finite element *** can be concluded from performance evaluation experiment,the mechanism has certain advantages over existing exoskeleton robots,namely,comfortable,lightweight,low cost,which can be utilized for rehabilitation training in medical institutions or as a daily-walking ancillary equipment for patients.

关键词： Wearable rehabilitation robot Biomechanics Robot mechanism design Virtual analysis

Joint action of phoxim and fenvalerate on reproduction in male rats

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Asian Journal of Andrology 2004年第4期6卷 337-341页

作者： li-chunxu, Ning-YuZhan, Ruliu lingSong Xin-RuWang InstituteofToxicology NanjingMedicalUniversityNanjing210029China

Aim: To evaluate the joint action of phoxim and fenvalerate on the reproductive function in male Sprague-Dawley rats. Methods: The 2×2 factorial analysis experiment was used in the study. The pesticides were orally given at daily doses of phoxim (Pho) 8.2 nig/kg, fenvalerate (Fen) 3.3 mg/kg and Pho 8.2+Fen 3,3 mg/kg (Pho:Fen = 5:2), 5 days a week for 60 days. Sperm motility was measured with computer-assisted sperm motility analysis (CASA) and daily sperm production estimated. Immunoenzymatic method and electron microscopy were used to evaluate the serum testosterone and the testicular morphology, respectively. Results: There were significant decreases in sperm motility parameters in the treated animals, including straight line velocity (VSL), beat cross frequency (BCF), linearity (liN) and straightness (STR). After treated with Fen, significant decreases in VSL, liN and STR were demonstrated. Significant decreases of daily sperm production were seen in animals treated with Pho and Pho+Fen in comparison with the controls. Serum testosterone levels were not significantly changed in the treated groups. Factorial ANOVA showed that no significant interactions were noted between Pho and Fen in sperm motility, sperm production and serum testosterone. Both the single and mixed pesticides caused various degrees of testicular lesions, involving vacuolation of endoplasmic reticulum and necrosis of Sertoli cells. Conclusion: The pesticides may cause sperm motility changes and testicular lesions in male rats. The action of Pho and Fen may be additive.

关键词： joint action phoxim fenvalerate sperm reproductive function

A hydrogel spinal dural patch with potential anti-inflammatory,pain relieving and antibacterial effects

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Bioactive Materials 2022年第8期7卷 389-401页

作者： Jiahao li Jingjing Tian chunxu li Longyun Chen Yu Zhao Department of Orthopaedic Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Science Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology State Key Laboratory of Complex Severe and Rare DiseaseMolecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

CSFL caused by spinal dural defect is a common complication of spinal surgery,which need repair such as suture or ***,low intracranial pressure symptoms,wound infection and prolonged hospital associated with pin-hole leakage or loose seal effect were often occurred after surgical suture or sealants ***,pressure resistance and high viscosity spinal dural repair patch in wet environment without suture or sealants was highly ***,a bioactive patch composed of alginate and polyacrylamide hydrogel matrix cross-linked by calcium ions,and chitosan adhesive was *** fabricated patch exhibits the capabilities of promoting defect closure and good tight seal ability with the bursting pressure is more than 790 mm H2O in wet *** addition,the chitosan adhesive layer of the patch could inhibit the growth of bacterial in vitro,which is meaningful for the postoperative ***,the patch also significantly reduced the expression of GFAP,IBA-1,MBP,TNF-α,and COX-2 in early postoperative period in vivo study,exerting the effects of anti-inflammatory,analgesic and adhesion ***,the bioactive patch expected to be applied in spinal dural repair with the good properties of withstanding high pressure,promoting defect closure and inhibiting postoperative infection.

关键词： Alginate hydrogel Chitosan adhesive Dural defect repair Anti-inflammatory Bacteriostasis

基于自适应分段双下垂的孤岛交直流混合微电网功率协调控制

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电力建设 2025年第1期46卷 86-96页

作者：米阳顾符亦可李春煦鲍薇燕跃豪刘晓辉杨亚男上海电力大学电气工程学院上海市200090 国网河南省电力公司郑州供电公司郑州市450006

为提高孤岛交直流混合微电网中双向AC/DC变换器的功率分配精度,提出一种自适应分段双下垂控制策略。首先利用归一法将交流频率和直流电压变换到同一区间,确定变换器传输功率。其次,为合理规划双向AC/DC变换器的工作模式,对交流子网和直... 详细信息

为提高孤岛交直流混合微电网中双向AC/DC变换器的功率分配精度,提出一种自适应分段双下垂控制策略。首先利用归一法将交流频率和直流电压变换到同一区间,确定变换器传输功率。其次,为合理规划双向AC/DC变换器的工作模式,对交流子网和直流子网进行负载状态划分;设置动作阈值避免频繁启停,当功率差额超过启动阈值时,Ⅰ段采用传统双下垂控制,Ⅱ段将自适应函数加入双下垂控制,使双向AC/DC变换器能在子网有功差额较大时更快达到功率平衡,从而提高双向AC/DC变换器的协调控制能力和使用寿命;再对系统进行解耦分析验证所提控制策略的稳定性。最后,在Matlab/simulink和Rtlab中搭建孤岛交直流混合微电网对提出的自适应分段双下垂控制策略进行分析验证。

关键词：交直流混合微电网双下垂控制双向AC/DC变换器功率协调控制

Continuously released Zn^(2+)in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties

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Bioactive Materials 2023年第6期24卷 361-375页

作者： chunxu li Fengbo Sun Jingjing Tian Jiahao li Haidan Sun Yong Zhang Shigong Guo Yuanhua lin Xiaodan Sun Yu Zhao Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China State Key Laboratory of Advanced Ceramics and Fine Processing School of MaterialsTsinghua UniversityBeijingChina Medical Science Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Core Facility of Instrument Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina The State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina Department of Rehabilitation Medicine Southmead HospitalBristolUK

Long-term nonunion of bone defects has always been a major problem in orthopedic *** bone graft materials such as Poly(lactic-co-glycolic acid)/β-tricalcium phosphate(PLGA/β-TCP)scaffolds are expected to solve this problem due to their suitable degradation rate and good ***,insufficient mechanical properties,lack of osteoinductivity and infections after implanted limit its large-scale clinical ***,we proposed a novel bone repair bioscaffold by adding zinc submicron particles to PLGA/β-TCP using low temperature rapid prototyping 3D printing *** first screened the scaffolds with 1 wt%Zn that had good biocompatibility and could stably release a safe dose of zinc ions within 16 weeks to ensure long-term *** designed,the scaffold had a multi-level porous structure of biomimetic cancellous bone,and the Young’s modulus(63.41±1.89 MPa)and compressive strength(2.887±0.025 MPa)of the scaffold were close to those of cancellous *** addition,after a series of in vitro and in vivo experiments,the scaffolds proved to have no adverse effects on the viability of BMSCs and promoted their adhesion and osteogenic differentiation,as well as exhibiting higher osteogenic and anti-inflammatory properties than PLGA/β-TCP scaffold without zinc *** also found that this osteogenic and anti-inflammatory effect might be related to Wnt/β-catenin,P38 MAPK and NFkB *** study lay a foundation for the follow-up study of bone regeneration mechanism of Zn-containing *** envision that this scaffold may become a new strategy for clinical treatment of bone defects.

关键词： 3D printing Zinc submicron particles Osteoinductivity Anti-inflammatory Bone defect repair

Fabrication and characterization of electrospun TiO2/CuS micro-nano-scaled composite fibers

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Progress in Natural Science:Materials International 2012年第1期22卷 59-63页

作者： Delong li,chunxu Pan School of Physics and Technology,Center for Electron Microscopy and MOE Key Laboratory of Artificial Micro-and Nano-structures,Wuhan University,Wuhan 430072,China School of Physics and Technology Center for Electron Microscopy and MOE Key Laboratory of Artificial Micro- and Nano-structures Wuhan University Wuhan 430072 China

A process to fabricate a kind of novel micro-nano scaled TiO2 /CuS composite fibers by electrospinning technique and chemical precipitation method was developed in the present *** microstructures and photoelectronic properties of the fibers were characterized using SEM,FT-IR,UV-vis and fluorescence *** results revealed that the TiO2 portion in the composite fibers was a mixture rutile and anatase phases while TiO2 and CuS had been fully *** fibers had smooth surface with a diameter of 50-300 *** with pure TiO2 fiber,the TiO2 /CuS micro-nano-scaled composite fibers exhibited a strong absorption in the visible light region and the efficiency of photo-induced charge separation were *** composite system is of widely potential applications in the areas such as solar cells,supercapacity,photocatalysis,etc.

关键词： Electrospinning TiO 2 CuS Composite fiber

Virtual Implementation of Radar Full Pulse Description Word for Battlefield Electromagnetic Environment

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Virtual Implementation of Radar Full Pulse Description Word ...

第30届中国控制与决策会议

作者： chunxu li Zhuojun Xu Chengzhi Yang Hongchao Wu Yantao Tian College of Communication Engineering Jilin University Aviation University of Air Force

In view of the problem that the current electromagnetic environment platform is not able to provide the real signal source for electronic reconnaissance, in this paper the complex electromagnetic environment faced by modern warfare is analyzed, and design the electromagnetic environment platform which can provide an approximate real environment for cognitive reconnaissance. Based on the signal feature modeling and the calculation of the feature parameters, the platform can obtain the approximate radar pulse data, and through the data fusion and coding, can get the approximate battlefield electromagnetic environment data, and show the data through the chart. The data can be more effectively applied to the process of modern radar reconnaissance signal processing, and provide a more realistic platform for the modern war in the cognitive reconnaissance. Experiments show that the generated data has the better similarity as the real battlefield data, and can provide the data source for the signal processing.

关键词： Electromagnetic Environment Modern War Cognition Reconnaissance Signal Processing

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论高校图书馆信息资源的开发与利用

四川图书馆学报 1998年第6期 55-57页

作者：李惇绪四川师范学院图书馆

文章阐述了高校图书馆开发信息资源的潜力和意义，论述了高校图书馆开发信息资源的基础建设，探讨了开发信息资源的主要途径。

关键词：高校图书馆开发信息资源利用