Continuously released Zn^(2+)in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties
作者机构：Department of OrthopedicsPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China State Key Laboratory of Advanced Ceramics and Fine ProcessingSchool of MaterialsTsinghua UniversityBeijingChina Medical Science Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Core Facility of InstrumentInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina The State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina Department of Rehabilitation MedicineSouthmead HospitalBristolUK
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2023年第24卷第6期
页 面：361-375页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：supported by Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program(20191080871) the National Natural Science Foundation of China(82272464,82002314)
主 题：3D printing Zinc submicron particles Osteoinductivity Anti-inflammatory Bone defect repair
摘 要：Long-term nonunion of bone defects has always been a major problem in orthopedic *** bone graft materials such as Poly(lactic-co-glycolic acid)/β-tricalcium phosphate(PLGA/β-TCP)scaffolds are expected to solve this problem due to their suitable degradation rate and good ***,insufficient mechanical properties,lack of osteoinductivity and infections after implanted limit its large-scale clinical ***,we proposed a novel bone repair bioscaffold by adding zinc submicron particles to PLGA/β-TCP using low temperature rapid prototyping 3D printing *** first screened the scaffolds with 1 wt%Zn that had good biocompatibility and could stably release a safe dose of zinc ions within 16 weeks to ensure long-term *** designed,the scaffold had a multi-level porous structure of biomimetic cancellous bone,and the Young’s modulus(63.41±1.89 MPa)and compressive strength(2.887±0.025 MPa)of the scaffold were close to those of cancellous *** addition,after a series of in vitro and in vivo experiments,the scaffolds proved to have no adverse effects on the viability of BMSCs and promoted their adhesion and osteogenic differentiation,as well as exhibiting higher osteogenic and anti-inflammatory properties than PLGA/β-TCP scaffold without zinc *** also found that this osteogenic and anti-inflammatory effect might be related to Wnt/β-catenin,P38 MAPK and NFkB *** study lay a foundation for the follow-up study of bone regeneration mechanism of Zn-containing *** envision that this scaffold may become a new strategy for clinical treatment of bone defects.
维普期刊数据库