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Simple application of adipose-derived stem cell-derived extracellular vesicles coating enhances cytocompatibility and osteoinductivity of titanium implant

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Regenerative Biomaterials 2021年第1期8卷 64-72页

作者： Lifeng Chen Shan Mou Jinfei Hou Huimin Fang Yuyang Zeng Jiaming Sun Zhenxing Wang Department of Plastic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Wuhan Clinical Research Center for Superficial Organ Reconstruction Wuhan Union Hos pitalHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China

Surface modification using bioactive molecules is frequently performed to improve the biological properties of medical metal biomaterial titanium(Ti)*** evidence suggests that mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)served as potent bioactive *** a subset of MSC EV,adipose-derived stem cel-derived extracellular vesicles(ADSC-EVs)could be obtained from abundant adipose ***,it possesses multiple re-generative properties and might be used to endow biological activities to medical Ti ***,we present a simple ADSC-EV coating strategy based on physisorption of *** ADSC-EV functionalized Ti implants(EV-Ti)revealed enhanced osteoblast compatibility and osteoinduc-tive *** spreading area of EV-Ti group was 1.62-and 1.48-fold larger than that of Ti group after 6 and 12 h of cell seeding,***,EV-Ti promoted alkaline phosphatase,col-lagen 1 and osteocalcin gene expression in osteoblast by 1.51-,1.68-and 1.82-fold compared with pristine Ti,***,the MSC-EVs modification method reported here provide a clinically translatable strategy to promote the bioactivity of Ti implants.

关键词： adipose-derived stem cll-derived extraellular vesicles titanium surface modification fibronectin osteoinductivity

One-step co-doping of ZnO and Zn^(2+)in osteoinductive calcium phosphate ceramics with synergistic antibacterial activity for regenerative repair of infected bone defect

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Journal of Materials Science & Technology 2023年第32期163卷 168-181页

作者： Tinghan He Hongxu Chen Puxin Liu Hao Shi Xiujuan Xu Cong Feng Yuyi Wang Xiangfeng Li Ning Lei Yumei Xiao Xiangdong Zhu Jianguo Xu Xingdong Zhang National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China

How to endow bone grafts with long-term antibacterial activity and good bone regenerative ability to achieve the regenerative repair of infected bone defects has been the focus of the clinical treatment of *** present study introduced a novel one-step route to realizing the co-doping of zinc oxide(ZnO)and zinc ion(Zn^(2+))in biphasic calcium phosphate(BCP)ceramics to utilize their synergistic *** with the conventional BCP ceramics(BCP-Ca),the ZnO/Zn^(2+)co-doping ones(BCP-Zn)possessed strong antibacterial ability on *** and *** as well as stimulated the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)*** synergistic antibacterial mechanism of ZnO and Zn^(2+)was also ***-Zn showed excellent osteoinductivity and angiogenesis at three months postoperatively in the canine intramuscular implantation ***,BCP-Zn exhibited excellent anti-infective ability and bone regenerative repair compared to BCP-Ca and control groups in the infected bone defect model of rat ***,these findings suggest that the simultaneous introduction of ZnO/Zn^(2+)could have immense potential to expand the application of osteoinductive BCP ceramics in the regenerative repair of infected bone defects.

关键词： Biphasic calcium phosphate ceramics Zinc oxide Zinc ion Antibacterial ability osteoinductivity

Application of osteoinductive calcium phosphate ceramics in giant cell tumor of the sacrum:report of six cases

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Regenerative Biomaterials 2022年第1期9卷 156-162页

作者： Yitian Wang Xiangfeng Li Yi Luo Li Zhang Hezhong Chen Li Min Qing Chang Yong Zhou Chongqi Tu Xiangdong Zhu Xingdong Zhang Department of Orthopedics Orthopedics Research InstituteWest China HospitalSichuan UniversityChengdu 610041China Bone and Joint 3D-Printing&Biomechanical Laboratory Department of OrthopedicsWest China HospitalSichuan UniversityNo.37 GuoxuexiangChengdu 610041SichuanChina National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Sichuan Baiameng Bioactive Materials Limited Liability Company No.37 GuoxuexiangChengdu 610041SichuanChina

This study aimed at evaluating the possibility and effectiveness of osteoinductive bioceramics to fill the tumor cavity following the curettage of sacral giant cell tumor(GCT).Six patients(four females and two males,25–45 years old)underwent nervesparing surgery,in which the tumor was treated by denosumab,preoperative arterial embolization and extensive *** remaining cavity was filled with commercial osteoinductive calcium phosphate(CaP)bioceramics,whose excellent osteoinductivity was confirmed by intramuscular implantation in beagle *** patients were followed by computed tomography(CT)scans *** to the modified Neer criterion,five cases obtained Type I healing status,and one case had Type *** the latest follow-up,no graft-related complications and local recurrence were *** CT scan indicated a median time of healing initiation of 3months postoperatively,and the median time for relatively complete healing was *** excellent bone regenerative ability of the ceramics was also confirmed by increased CT attenuation value,blurred boundary and cortical rim *** conclusion,osteoinductive CaP bioceramics could be an ideal biomaterial to treat the large remaining cavity following extensive curettage of sacral ***,further investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： calcium phosphate bioceramics giant cell tumor sacrum osteoinductivity

Continuously released Zn^(2+)in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties

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Bioactive Materials 2023年第6期24卷 361-375页

作者： Chunxu Li Fengbo Sun Jingjing Tian Jiahao Li Haidan Sun Yong Zhang Shigong Guo Yuanhua Lin Xiaodan Sun Yu Zhao Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China State Key Laboratory of Advanced Ceramics and Fine Processing School of MaterialsTsinghua UniversityBeijingChina Medical Science Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Core Facility of Instrument Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina The State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina Department of Rehabilitation Medicine Southmead HospitalBristolUK

Long-term nonunion of bone defects has always been a major problem in orthopedic *** bone graft materials such as Poly(lactic-co-glycolic acid)/β-tricalcium phosphate(PLGA/β-TCP)scaffolds are expected to solve this problem due to their suitable degradation rate and good ***,insufficient mechanical properties,lack of osteoinductivity and infections after implanted limit its large-scale clinical ***,we proposed a novel bone repair bioscaffold by adding zinc submicron particles to PLGA/β-TCP using low temperature rapid prototyping 3D printing *** first screened the scaffolds with 1 wt%Zn that had good biocompatibility and could stably release a safe dose of zinc ions within 16 weeks to ensure long-term *** designed,the scaffold had a multi-level porous structure of biomimetic cancellous bone,and the Young’s modulus(63.41±1.89 MPa)and compressive strength(2.887±0.025 MPa)of the scaffold were close to those of cancellous *** addition,after a series of in vitro and in vivo experiments,the scaffolds proved to have no adverse effects on the viability of BMSCs and promoted their adhesion and osteogenic differentiation,as well as exhibiting higher osteogenic and anti-inflammatory properties than PLGA/β-TCP scaffold without zinc *** also found that this osteogenic and anti-inflammatory effect might be related to Wnt/β-catenin,P38 MAPK and NFkB *** study lay a foundation for the follow-up study of bone regeneration mechanism of Zn-containing *** envision that this scaffold may become a new strategy for clinical treatment of bone defects.

关键词： 3D printing Zinc submicron particles osteoinductivity Anti-inflammatory Bone defect repair

Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size

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Bioactive Materials 2022年第5期7卷 90-106页

作者： Xiangfeng Li Quan Zhou Yonghao Wu Cong Feng Xi Yang Linnan Wang Yumei Xiao Kai Zhang Xiangdong Zhu Limin Liu Yueming Song Xingdong Zhang National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu610064China Department of Orthopaedic Surgery West China Hospital of Sichuan UniversityChengdu610041China

osteoinductivity is a crucial factor to determine the success and efficiency of posterolateral spinal fusion(PLF)by employing calcium phosphate(Ca-P)*** this study,three kinds of Ca-P ceramics with microscale to nanoscale gain size(BCP-control,BCP-micro and BCP-nano)were prepared and their physicochemical properties were ***-nano had the spherical shape and nanoscale gain size,BCP-micro had the spherical shape and microscale gain size,and BCP-control(BAM®)had the irregular shape and microscale gain *** obtained BCP-nano with specific nanotopography could well regulate in vitro protein adsorption and osteogenic differentiation of MC3T3 *** vivo rabbit PLF procedures further confirmed that nanotopography of BCP-nano might be responsible for the stronger bone regenerative ability comparing with BCP-micro and ***,due to nanocrystal similarity with natural bone apatite,BCP-nano has excellent efficacy in guiding bone regeneration of PLF,and holds great potentials to become an alternative to standard bone grafts for future clinical applications.

关键词： Calcium phosphate ceramics Nanotopography Osteogenic differentiation osteoinductivity Posterolateral spinal fusion

Osteogenesis Capacity of a Novel BMP／a-TCP Bioactive Composite Bone Cement

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Journal of Wuhan University of Technology(Materials Science) 2004年第2期19卷 30-34页

作者： YANGWei-zhong ZHOUDa-li YINShao-ya YINGuang-fu GAOLi-da ZHANGYun SichuanUniversity TianjinHuanhuHospital

To improve the osteogenesis ability of a-tricalcium phosphate (α-TCP) bone cement, a novel BMP/ α-TCP composite bone cement was prepared. By measuring the setting time and compressive strength, the hydration characteristic of bone cement was evaluated. Animal experiments including histological observation, radiographic investigation as well as digital image analyses reveal the difference of osteogenesis ability among BMP,a-TCP bone cement and BMP/α-TCP composite bone cement. Results show that α-TCP bone cement possesses excellent hydration and setting properties as well as high mechanical property. Comparison experiments show that BMP/ α-TCP composite bone cement has a stronger osteogenesis ability. The gross observation of the implant site does not exhibit any inflammation or necrosis. Histological analyses reveal that the material has good osteointegration with host bone, and new bone formation is detected within the materials, which are degrading. Strong osteogenesis ability of the composite is due to not only the excellent osteoconductive potential but also the osteoinductive potential contributed by active BMP releasing and the material degradation. Large skull defect could be well-healed by filling BMP/α-TCP composite bone cement. This novel material proves itself to be an absorbable and bioactive bone cement with an osteogenesis ability.

关键词： α-tricalcium phosphate (α-TCP) bone morphogenetic proteins (BMP) bone cement osteogenesis osteoinductivity bone tissue engineering

Surface Modification and Coating of the Carbon/Carbon Composite in the Medical Fields

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Surface Modification and Coating of the Carbon/Carbon Compos...

两种新型骨诱导鱼骨源衍生双向磷酸钙骨移植替代物的制备和表征（英文）

2012 China Functional Materials Technology and Industry Forum

作者： Wen-feng Xu Fei Liu Kui Li Fu-hang Xiong Qiu-hong Huang Xiao-ling Liao Institute of Biomaterials and living cell imaging technique School of Metallurgy and Materials EngineeringChongQing University of science & technology

Carbon/Carbon composite is considered to be one of the best biomaterials substitute to human hard tissues due to its excellent biocompatibility and the much closed elastic modulus to human *** has been widely used and studied to the fields of artificial bones materials,but the osteoinductivity need to be *** recent years,the commonly used surface modification to improve their bone induction,such as hydroxyapatite,chitosan and so on,which prompted the adsorption of osseous protein,adhesion and growth of *** is believed the surface modification and coating of the carbon/carbon composite should promote its application in artificial *** article reviews the modified coat of medical carbon / carbon composites in recent years,and proposed some recommendations for the development of medical carbon / carbon composite in the future.

关键词： Carbon/Carbon composite Surface modification Coating osteoinductivity

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两种新型骨诱导鱼骨源衍生双向磷酸钙骨移植替代物的制备和表征（...