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"互联网+PACD"教学在外科诊断病理学线上/下课程建设中的应用

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中华医学教育探索杂志 2021年第4期20卷 396-398页

作者：董海影兴桂华李春旭杨帆张英博孙玉荣齐齐哈尔医学院临床病理诊断中心 161006

本研究提出在外科诊断病理学线上/下课程建设中应用"互联网+ PACD[即讲授(presentation)、内化吸收(assimilation)、临床病例诊断和分析(clinicopathological diagnosis)、讨论(discussion)]新模式,通过成绩测评和问卷调查评价了该教学... 详细信息

本研究提出在外科诊断病理学线上/下课程建设中应用"互联网+ PACD[即讲授(presentation)、内化吸收(assimilation)、临床病例诊断和分析(clinicopathological diagnosis)、讨论(discussion)]新模式,通过成绩测评和问卷调查评价了该教学的教学效果。结果发现,"互联网+ PACD"教学不仅能显著提高病理专业学生的专业课成绩,还能增强学生的学习兴趣、自信心、竞争与合作意识,得到了学生的肯定和认可。

关键词：外科诊断病理学 PACD 互联网+

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气相色谱法分析津酒白酒香味组分

酿酒 2020年第5期47卷 76-78页

作者：李春旭刘宏媛王津颖耿蔚华韩晓东张锦涛天津津酒集团有限公司技术中心天津300131

采用毛细管气相色谱法同时测定白酒中多种微量成分。色谱柱为PEG20M(38 m×0.25 mm×0.25μm),采用程序升温,分流进样方式,检测器为氢火焰离子化检测器(FID)。在选定的色谱条件下,各种微量成分得到较好的分离,方法回收率在90.5%~100.8%... 详细信息

采用毛细管气相色谱法同时测定白酒中多种微量成分。色谱柱为PEG20M(38 m×0.25 mm×0.25μm),采用程序升温,分流进样方式,检测器为氢火焰离子化检测器(FID)。在选定的色谱条件下,各种微量成分得到较好的分离,方法回收率在90.5%~100.8%之间,重现性好,准确度高。

关键词：分析检测白酒毛细管柱气相色谱微量成分

A Series of Pure Orange-yellow Iridium Complexes with Low Efficiency Roll-off： a Computational Study

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Chemical Research in Chinese Universities 2016年第3期32卷 451-454页

作者： SONG Mingxing HUANG Jian BAI Fuquan WANG chunxu liU Hongbo WANG Jin li Dongfei QIN Zhengkun College of Information Technology College of Physics Jilin Normal University Siping 136000 P. R. China Institute of Theoretical Chemistry Jilin University Changchun 130021 P. R. China

The electronic structures and spectroscopic properties of heteroleptic cyclometalated iridium（Ⅲ） complexes were investigated. The geometries, electronic structures, and the lowest-lying excited states of （DBQ）2Ir（acac） and （MDQ）2Ir（acac） were investigated via density functional theory-based approaches. A series of designed models of （DBQ）2Ir（dpis）, （DBQ）2Ir（tpip）, （MDQ）2Ir（dpis） and （MDQ）2Ir（tpip） was also calculated for comparison. The structures in the ground and excited states were optimized via B3LYP method. The lowest absorptions and emissions spectra were evaluated via TD-B3LYP and TD-PBE1PBE methods, The computational results reveal that the emission peaks of the designed complexes are at around 585-640 nm, which belong to the orange-yellow wavelength. The frontier molecular orbital properties indicate that the Ir（Ⅲ） complexes have low efficiency roll-off.

关键词： Organic light-emitting diode(OLED) Ir(Ⅲ) complex Time-dependent density functional theory(TD-DFT) Excited state Efficiency roll-off

Investigation on microstructure and properties of a combined precipitation hardening ultrahigh strength steel

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Baosteel Technical Research 2010年第S1期4卷 67-页

作者： WANG chunxu~(1)),li Yong~(1)),liU Xianmin~(1)) and TIAN Zhiling~(2)) 1) Institute for Structural materials,Central Iron and Steel Research Institute, Beijing 100081,China 2) China Iron and Steel Research Institute Group,Beijing 100081,China

The microstructure and properties of a combined precipitation hardening ultrahigh strength steel with nano-sized carbides and intermetallics were studied *** results show that after tempering at 300℃lots ofε-carbides are precipitated in the martensite,the strength rises and the toughness falls *** tempering at 430℃,much coarser cementite lamina are precipitated in martensitic laths,which causes the impact toughness falls to the minimum *** temperature further increasing the cementites are dissolved and M_2C carbides,β-NiAl intermetallics and reverse austenite begin to *** tensile strength and yield strength achieve the peak value at 470℃,490℃*** tested steel achieve a tensile strength of 2 120 MPa,a yield strength of 1 950 MPa and impact energy of 54 J/cm^2 after optimum tempering at 510℃.When tempering temperature is above 530℃the M_2C carbides and reverse austenite is *** tempering at 560℃the reverse austenite reaches the maximum volume fraction in present work.

关键词： ultra-high strength steel combined precipitation hardening intermetallics carbides

Prebiotic effect of sialylated immunoglobulin G on gut microbiota of patients with inflammatory bowel disease by in vitro fermentation

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Food Bioscience 2023年第2期52卷 356-368页

作者： chunxu Chen Tianhui li Guijie Chen Dan Chen Yujia Peng Bing Hu Yi Sun Xiaoxiong Zeng College of Food Science and Technology Nanjing Agricultural UniversityNanjing210095JiangsuChina College of Food Engineering Anhui Science and Technology UniversityFengyang233100AnhuiChina

Sialylated immunoglobulin G(IgG)is a kind of glycoproteins in breast milk with the property of *** previous work showed that sialylated IgG could significantly promote the growth of Bifidobacterium in the gut microbiota of healthy ***,whether sialylated IgG can benefit patients with inflammatory bowel disease(IBD)as prebiotics remains ***,its prebiotic effect on the gut microbiota of IBD patients was investigated by in vitro fermentation in this *** results showed that sialylated IgG could significantly enhance the diversity,richness and composition of gut microbiota in IBD samples compared with non-sialylated *** detail,sialylated IgG not only improved the growth of three common genera(Romboutsia,Prevotella and Akkermansia)with low relative abundance in IBD samples but also increased the genera(Bifidobacterium,Actinomyces,Atopobium and Citrobacter)with low relative abundance both in healthy and IBD fecal ***,the contents of short-chain fatty acids for fermentation group of fecal sample from IBD patients with sialylated IgG as the carbon source were higher than those for fermentation group of fecal sample from IBD patients with non-sialylated IgG as the carbon *** addition,the metabolic pathway results confirmed that sialylated IgG upregulated the functional genes related to hydrolysis,absorption and utilization of *** transcriptome sequencing results further showed that sialylated IgG could induce particular gene expression of Bifidobacterium bifidum to modulate the gut microbiota of IBD ***,as a kind of natural dietary component,sialylated IgG has potential applications in treating IBD.

关键词： Sialylated IgG Inflammatory bowel disease Anti-inflammation Gut microbiota Prebiotic effect

A comprehensive review of recent progress on enhancement-modeβ-Ga_(2)O_(3)FETs:Growth,devices and properties

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Journal of Semiconductors 2023年第6期44卷 7-23页

作者： Botong li Xiaodong Zhang li Zhang Yongjian Ma Wenbo Tang Tiwei Chen Yu Hu Xin Zhou chunxu Bian Chunhong Zeng Tao Ju Zhongming Zeng Baoshun Zhang School of Nano Technology and Nano Bionics University of Science and Technology of ChinaHefei 230026China Nano Fabrication Facility Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

Power electronic devices are of great importance in modern *** decades of development,Si power devices have approached their material limits with only incremental improvements and large conversion *** the demand for electronic components with high efficiency dramatically increasing,new materials are needed for power device *** gallium oxide,an ultra-wide bandgap semiconductor,has been considered as a promising candidate,and variousβ-Ga_(2)O_(3)power devices with high breakdown voltages have been ***,the realization of enhancement-mode(E-mode)β-Ga_(2)O_(3)field-effect transistors(FETs)is still challenging,which is a critical problem for a myriad of power electronic ***,researchers have made some progress on E-modeβ-Ga_(2)O_(3)FETs via various methods,and several novel structures have been *** article gives a review of the material growth,devices and properties of these E-modeβ-Ga_(2)O_(3)*** key challenges and future directions in E-modeβ-Ga_(2)O_(3)FETs are also discussed.

关键词： enhancement mode FETs β-Ga_(2)O_(3)

MRI T_(1)与T_(2)加权比在0~8岁儿童脑白质髓鞘化发育进程评估中的应用价值

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中华解剖与临床杂志 2025年第1期30卷 9-16页

作者：朱琳琳陈天骄李贤军刘晨越王帅达春旭黄心怡刘军杨健王苗苗西安交通大学第一附属医院医学影像科西安710061

目的探讨基于MRI的脑白质纤维束T_(1)与T_(2)加权比(T_(1)W/T_(2)W)在0~8岁儿童脑白质髓鞘化发育进程评估中的应用价值。方法横断面研究。纳入2011年8月—2023年7月西安交通大学第一附属医院219例儿童的头颅MRI资料,其中男125例、女94例... 详细信息

目的探讨基于MRI的脑白质纤维束T_(1)与T_(2)加权比(T_(1)W/T_(2)W)在0~8岁儿童脑白质髓鞘化发育进程评估中的应用价值。方法横断面研究。纳入2011年8月—2023年7月西安交通大学第一附属医院219例儿童的头颅MRI资料,其中男125例、女94例,年龄0~8(3.5±2.4)岁。根据儿童发育阶段分类按年龄将219例儿童受检者分为6组:≤6个月组21例,>6个月~1岁组24例,>1~2岁组40例,>2~3岁组23例,>3~4岁组22例,>4~6岁组42例,>6~8岁组47例。应用3.0 T MR扫描仪采集儿童T_(1)加权像及T_(2)加权像,通过外部校准流程计算获得T_(1)W/T_(2)W图,并基于Johns Hopkins University Diffusion Tensor Imaging-81图谱提取联络束、边缘束、投射束、连合束、脑干束5束纤维束及其代表性白质纤维(左侧上纵束、左侧扣带回海马部、左侧内囊前肢、胼胝体膝部及左侧小脑上脚)的T_(1)W/T_(2)W值。观察指标:(1)观察不同年龄组儿童脑白质T_(1)W/T_(2)W图像信号强度的特点,比较各年龄组患儿不同白质纤维束T_(1)W/T_(2)W值的差异;(2)观察不同白质纤维束及其代表性白质纤维的T_(1)W/T_(2)W值随年龄变化的特点,采用局部加权回归散点平滑法(LOESS)绘制回归拟合曲线,确认不同白质纤维束T_(1)W/T_(2)W值随年龄变化的折点,并依此折点划分不同发育阶段,观察不同发育阶段中不同白质纤维束T_(1)W/T_(2)W值与年龄的相关性。结果(1)不同年龄组儿童T_(1)W/T_(2)W图像显示:≤6个月组仅脑桥背侧、内囊后肢及部分皮质脊髓束区域具有较高的信号强度,随着年龄增加,胼胝体压部、胼胝体膝部、皮质脊髓束等区域高信号的范围及强度逐渐增加,从>2~3岁组开始整个大脑皮层下白质区域均具有较高的信号强度。(2)各年龄组间白质纤维束T_(1)W/T_(2)W值比较:脑干束T_(1)W/T_(2)W值,≤6个月组及>6个月~1岁组均低于>2~3岁组及其后的各年龄组,>1~2岁组低于>2~3岁组和>3~4岁组,差异均有统计学意义(P值均6个月~1岁组均低于>1~2岁组及其后的各年龄组,>1~2岁组低于>2~3岁组,差异均有统计学意义(P值均6个月~1岁组均低于>1~2岁组及其后的各年龄组,差异均有统计学意义(P值均2~8岁为缓慢发育阶段(134例)。不同白质纤维束T_(1)W/T_(2)W值在快速和缓慢发育阶段与年龄的相关性分析显示:在快速发育阶段,连合束、投射束、边缘束、联络束的T_(1)W/T_(2)W值均与年龄呈正相关(rs=0.71、0.60、0.53、0.61,P值均0.05);在缓慢发育阶段各白质纤维束T_(1)W/T_(2)W值与年龄均无相关性(P值均>0.05)。结论基于MRI的T_(1)W/T_(2)W值可用于量化评估儿童脑白质髓鞘化发育进程,可为2岁前儿童髓鞘损伤及发育异常的识别提供影像学参考。

关键词：脑白质髓鞘化磁共振成像 T_(1)与T_(2)加权比儿童

A low-cost slow control system for the PandaX-4T experiment

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Radiation Detection Technology and Methods 2019年第3期3卷 283-288页

作者： Peng Ji Xun Chen Andi Tan Chongjie Wang chunxu Yu li Zhao Ning Zhou liaoning Normal University Dalian 116029LiaoningChina INPAC School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMD 20742USA School of Physics Nankai UniversityTianjin 300071China

Background The PandaX-4T experiment is a next-generation dark matter search program located in the China Jinping Underground *** ensure the stability of the complex instrument during the planned operation,the status of the facility should be monitored *** The paper reports the design of the slow control system for the *** system is used to monitor the facility status and generate an alarm signal while the detector is in abnormal *** Low-cost hardware is employed for the distributed data ***-based data collection program was *** also used the open source software for data storage,visualization and anomaly detection,so that the development of the system is *** We finally achieved a low-cost and robust slow control system for the prototype detector in short *** is running well *** system will be integrated with the PandaX-4T facility in late 2019.

关键词： Dark matter experiment Slow control system Open source software

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早期头针巨刺治疗重型颅脑损伤临床观察

光明中医 2022年第9期37卷 1613-1615页

作者：侯可强何广云房铭窦美芳李春序樊官伟王德兴韩恒阳青岛市黄岛区中医医院康复科山东青岛266500 青岛市黄岛区中医医院药剂科山东青岛266500 青岛市黄岛区中医医院急诊科山东青岛266500 天津中医药大学中医药研究院天津300193

目的研究早期头针巨刺治疗重型颅脑损伤的可行性及有效性。方法将符合入选标准的200例患者随机分为4组,即对照组、治疗1组、治疗2组、治疗3组,每组50例。对照组予以神经外科常规治疗,治疗1组、治疗2组、治疗3组在对照组的基础上,分别从... 详细信息

目的研究早期头针巨刺治疗重型颅脑损伤的可行性及有效性。方法将符合入选标准的200例患者随机分为4组,即对照组、治疗1组、治疗2组、治疗3组,每组50例。对照组予以神经外科常规治疗,治疗1组、治疗2组、治疗3组在对照组的基础上,分别从伤后7 d、72 h、24 h开始加用头针巨刺治疗。采用脑卒中临床神经功能缺损程度评分法,简式Fugl-Meyer(FMA)运动功能评分法,改良Barthel指数(MBI)评分标准于治疗前、治疗30 d后评定患者的临床神经功能缺损程度、肢体运动功能和日常生活活动能力(ADL)。结果与本组治疗前比较:治疗1组、治疗2组、治疗3组神经功能缺损评分、FMA、MBI评分差异有统计学意义(P<0.01);对照组FMA评分差异具有统计学意义(P<0.05)。治疗后,与对照组比较:3组神经功能缺损评分、FMA、MBI评分差异均具有统计学意义(P<0.01)。治疗后,与治疗1组比较:治疗2组、治疗3组神经功能缺损评分有下降趋势但差异无统计学意义,FMA评分差异具有统计学意义(P<0.01);治疗2组MBI评分有上升趋势但差异无统计学意义,治疗3组MBI评分差异具有统计学意义(P<0.01)。治疗后,与治疗2组比较:治疗3组神经功能缺损评分有降低趋势但差异无统计学意义,FMA、MBI评分差异具有统计学意义(P<0.01)。结论早期头针巨刺法对重型颅脑损伤确有疗效,其临床应用越早效果越显著。

关键词：针刺疗法重型颅脑损伤头针疗法巨刺针法