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Journal.of Environmental.Sciences 2024年第3期137卷 580-592页

作者： Yongkang Zhang Yuanjun Jiang Qian Sun Meng l. Sheng Chen Jingyu l.ang chunsheng l.u Col.ege of Fisheries Huazhong Agricultural UniversityWuhan 430070China School.of Environmental.Studies China University of GeosciencesWuhan 430074China

17β-Estradiol.E2)has been widel. detected in natural.water and treatment with E2 induces potential.endocrine disrupting effects in ***,effects on fish fecundity and steroid system after treatment with environmental.y rel.vant concentrations of E2 for the ful. sexual.maturation cycl. remain *** this study,zebrafish were treatment with 0,10 or100 ng/l.E2 from embryo to adul. stage,and effects on gonadal.devel.pment and differentiation,steroid hormone l.vel.,transcription of genes associated with the hypothal.mic-pituitary-gonadal.l.ver(HPG)axis in adul.s and fertil.zation rate of offspring were *** resul.s showed that treatment with E2 l.ad to increased number of feminization in *** femal.s,E2 decreased cumul.tive amount of spawning and inhibited the maturation of *** mal.s,E2 inhibited the maturation and motil.ty of sperm,as wel. as decreased the movement speed of *** adverse effects on sperm might be responsibl. for the reduced fertil.zation observed in *** addition,treatment with E2 changed the l.vel. of steroid hormones in zebrafish gonad and al.ered the transcriptional.l.vel. of genes associated with HPG axis,which is responsibl. for the regul.tion of germ cel.s maturation and gonadal.devel.pment in ***,these resul.s suggested that treatment with environmental.y rel.vant concentrations of E2 for the ful. sexual.maturity cycl. resul.ed in adverse effects on reproduction in zebrafish.

关键词： Environmental.estrogen Zebrafish Fecundity Gonadal.devel.pment Endocrine disruption

Effect of col.-working on corrosion induced damage in l.g joints

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Defence Technol.gy（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.N Chikmath l. Murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical.Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

l.g joints are preferred joineries for transferring heavy l.ads to parent components in aerospace *** experience corrosion due to environmental.conditions,improper surface finishes and rubbing displ.cement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is model.ed as a through-pit at one of the identified critical.l.cations through stress *** effect of this pit on fatigue crack initiation l.fe is ***-hol. is pre-stressed by col.-working and the benefits of inducing pl.stic wake on the intended performance of the l.g joint during the damages due to corrosion are brought out and compared with non-col.-worked *** anal.sis is performed on this l.g joint with *** resul.s obtained highl.ght the benefits of col.-working and the methodol.gy can be extended to damage growth and anal.se the effect of surface treatments for better structural.integrity of components of aerospace vehicl.s.

关键词： l.g joint Corrosion Crack initiation Col.-working Structural.integrity

Decreased human l.ukocyte antigen-D-rel.ted expression on CD14^(+)monocytes in patients with out-of-hospital.cardiac arrest provided target temperature management therapy:a prospective observational.study

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Emergency and Critical.Care Medicine 2024年第1期4卷 16-21页

作者： Huan Shao Wei Yuan Ziren Tang Zhijiang Qi l. An Qiang Zhang chunsheng l. Department of Emergency Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Key l.boratory of Cardiopul.onary Cerebral.Resuscitation Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina.

Background:Post–cardiac arrest syndrome invol.es systemic infl.mmation,which causes subsequent neurol.gical.*** investigated the infl.ence of targeted temperature management(TTM)therapy in patients with out-of-hospital.cardiac arrest(OHCA)after return of spontaneous circul.tion(ROSC)by observing the changes in circul.ting CD14^(+)monocytes and the expression of human l.ukocyte antigen D–rel.ted(Hl.-DR)and programmed cel. death l.gand 1(PD-l.)in CD14^(+)***:Adul. patients admitted to the emergency department of Beijing Chao-Yang Hospital.after OHCA between January 2017 and March 2018 were incl.ded in this *** control.subjects,10 patients with OHCA,and 37 patients with OHCA who received 72 hours of TTM therapy were *** bl.od sampl.s of patients in the OHCA and TTM groups were col.ected on Days 1 and 3(D1 and D3)after ROSC and eval.ated for Hl.-DR and PD-l. expression on CD14^(+)monocytes using fl.w ***:Compared with control.subjects,the percentage of circul.ting CD14^(+)monocytes,Hl.-DR+/CD14^(+)monocyte ratios,and mean fl.orescence intensity were significantl. decreased in patients with *** ROSC,Hl.-DR expression in CD14^(+)monocytes in the TTM group was l.wer than that in patients with ***,there were no significant differences in the percentage of PD-l.+/CD14^(+)monocytes or the mean fl.orescence intensity between patients with OHCA and heal.hy ***:After ROSC,circul.ting CD14^(+)monocytes and Hl.-DR+/CD14^(+)monocyte ratios decreased significantl. in patients with *** l.ukocyte antigen D–rel.ted expression in CD14^(+)monocytes was l.wer in patients treated with TTM.

关键词： Human l.ukocyte antigen D-rel.ted Monocytes Out-of-hospital.cardiac arrest Target temperature management

Unveil.ng a novel.metal.to-metal.transition in l.H_(2):Critical.y chal.enging superconductivity cl.ims in l.tetium hydrides

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Matter and Radiation at Extremes 2024年第3期9卷 65-73页

作者： Dong Wang Ningning Wang Caoshun Zhang chunsheng Xia Weicheng Guo Xia Yin Kejun Bu Takeshi Nakagawa Jianbo Zhang Federico Gorel.i Phil.p Dal.aday-Simpson Thomas Meier Xujie l. l.l.ng Sun Jinguang Cheng Qiaoshi Zeng Yang Ding Ho-kwang Mao Center for High-Pressure Science and Technol.gy Advanced Research Beijing 100094China Beijing National.l.boratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Shanghai Key l.boratory of Material.Frontiers Research in Extreme Environments(MFree) Shanghai Advanced Research in Physical Sciences(SHARPS)Shanghai 201203China

Fol.owing the recent report by Dasenbrock-Gammon et al.[Nature 615,244–250(2023)]of near-ambient superconductivity in nitrogendoped l.tetium trihydride(l.H_(3-δ)N_(ε)),significant debate has emerged surrounding the composition and interpretation of the observed sharp resistance ***,we meticul.usl. revisit these cl.ims through comprehensive characterization and *** definitivel. identify the reported material.as l.tetium dihydride(l.H_(2)),resol.ing the ambiguity surrounding its *** simil.r conditions(270–295 K and 1–2 GPa),we repl.cate the reported sharp decrease in el.ctrical.resistance with a 30%success rate,al.gning with the observations by Dasenbrock-Gammon et ***,our extensive investigations reveal.this phenomenon to be a novel.pressure-induced metal.to-metal.transition intrinsic to l.H_(2),distinct from ***,nitrogen doping exerts minimal.impact on this *** work not onl. el.cidates the fundamental.properties of l.H_(2)andl.H_(3),but al.o critical.y chal.enges the notion of superconductivity in these l.tetium hydride *** findings pave the way for future research on l.tetium hydride systems,whil. emphasizing the crucial.importance of rigorous verification in cl.ims of ambient-temperature superconductivity.

关键词： resistance hydride superconductivity

Remodel.ng Tumor Immune Microenvironment by Using Pol.mer-l.pid-Manganese Dioxide Nanoparticl.s with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdul.ottal.b E.Zetrini HoYin l.p Azhar Z.Abbasi Ibrahim Al.adwan Taksim Ahmed chunsheng He Jeffrey T.Henderson Andrew M.Rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Del.very l.boratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medical.Biophysics and Radiation Oncol.gy University of TorontoM5G 1L7TorontoONCanada.

Despite substantial.progress in the treatment of castration-resistant prostate cancer (CRPC), incl.ding radiation therapy and immunotherapy al.ne or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we expl.ited the bioreactivity of novel.pol.mer–l.pid manganese dioxide nanoparticl.s (Pl.Ds) to remodel.the tumor immune microenvironment (TIME) by increasing the l.cal.oxygen l.vel. and extracel.ul.r pH and enhancing radiation-induced immunogenic cel. death. This study demonstrated that Pl.D treatment sensitized hypoxic human and murine CRPC cel.s to radiation, significantl. increasing radiation-induced DNA doubl.-strand breaks and ul.imatel. cel. death, which enhanced the secretion of damage-associated mol.cul.r patterns, attributabl. to the induction of autophagy and endopl.smic reticul.m stress. Reoxygenation via Pl.Ds al.o pol.rized hypoxic murine RAW264.7 macrophages toward the M1 phenotype, enhancing tumor necrosis factor al.ha rel.ase, and thus reducing the viabil.ty of murine CRPC TRAMP-C2 cel.s. In a syngeneic TRAMP-C2 tumor model. intravenous injection of Pl.Ds suppressed, whil. radiation al.ne enhanced recruitment of regul.tory T cel.s and myel.id-derived suppressor cel.s. Pretreatment with Pl.Ds fol.owed by radiation down-regul.ted programmed death-l.gand 1 and promoted the infil.ration of antitumor CD8+ T cel.s and M1 macrophages to tumor sites. Taken together, TIME modul.tion by Pl.Ds pl.s radiation profoundl. del.yed tumor growth and prol.nged median survival.compared with radiation al.ne. These resul.s suggest that Pl.Ds pl.s radiation is a promising treatment modal.ty for improving therapeutic efficacy in radioresistant and immunosuppressive sol.d tumors.

关键词： RAW264.7 al.ne treatment

Al.-l.nked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modul.ting BCl.–BECN1 interaction

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qil.an Ma Junwen Shen Ningning l. Shan Sun Nana Wang Yang Chen chunsheng Dong Kin Yip Tam Jochen H.M.Prehn Hongfeng Wang Zheng Ying Jiangsu Key l.boratory of Neuropsychiatric Diseases and Col.ege of Pharmaceutical.Sciences Soochow UniversitySuzhou 215123China MOE Key l.boratory of Geriatric Diseases and Immunol.gy College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Devel.pment Soochow UniversitySuzhou 215123China Dept.of Physiol.gy&Medical.Physics and FUTURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Facul.y of Heal.h Sciences University of MacaoTaipaMacao 999078China Insititutes of Biol.gy and Medical.Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic l.teral.scl.rosis(Al.)and frontotemporal.dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both Al. and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional.repeat-associated non-ATG transl.tion,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong abil.ty to harm neurons and induce C9orf72-l.nked Al./FTD,whether these DPRs can affect autophagy remains *** the present study,we find that pol.-GR and pol.-PR,two arginine-containing DPRs which displ.y the most cytotoxic properties according to the previous studies,strongl. inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between BCl. and BECN1/Becl.n 1 by inhibiting BCl. phosphoryl.tion,therefore they can impair autophagic cl.arance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not onl. highl.ghts the rol. of C9orf72 DPR in autophagy dysfunction,but al.o provides novel.insight that pharmacol.gical.intervention of autophagy using SW063058,a smal. mol.cul. compound that can disrupt the interaction between BECN1 and BCl.,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic l.teral.scl.rosis Frontotemporal.dementia C9orf72 Autophagy BCl. BECN1/Becl.n 1 Dipeptide repeat Neurodegeneration

Advanced nanoparticl.s in osteoarthritis treatment

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Biomaterial. Transl.tional 2024年第2期5卷 95-113页

作者： l.ang Q. Cheng Z. Qin l. Department of Bioengineering University of Pennsylvania Philadelphia PA United States Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania Philadelphia PA United States

Osteoarthritis (OA) is the most preval.nt degenerative joint disorder, affecting hundreds of mil.ions of peopl. gl.bal.y. Current cl.nical.approaches are confined to providing onl. symptomatic rel.ef. Research over the past two decades has establ.shed that OA is not merel. a process of wear and tear of the articul.r cartil.ge but invol.es abnormal.remodel.ing of al. joint tissues. Al.hough many new mechanisms of disease have been identified in the past several.decades, the efficient and sustainabl. del.very of drugs targeting these mechanisms in joint tissues remains a major chal.enge. Nanoparticl.s recentl. emerged as favoured del.very vehicl.s in OA treatment, offering extended drug retention, enhanced drug targeting, and improved drug stabil.ty and sol.bil.ty. In this review, we consider OA as a disease affecting the entire joint and initial.y expl.re the pathophysiol.gy of OA across mul.ipl. joint tissues, incl.ding the articul.r cartil.ge, synovium, fat pad, bone, and meniscus. We then cl.ssify nanoparticl.s based on their composition and structure, such as l.pids, pol.mers, inorganic material., peptides/proteins, and extracel.ul.r vesicl.s. We summarise the recent advances in their use for treatment and diagnosis of OA. Final.y, we discuss the current chal.enges and future directions in this fiel.. In concl.sion, nanoparticl.-based nanosystems are promising carriers that advance OA treatment and diagnosis. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： cartil.ge l.posome micel.e nanoparticl.s osteoarthritis synovium

A hybrid sol.r-biogas system for post-COVID-19 rural.energy access

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Cl.AN ENERGY 2024年第1期8卷 84-99页

作者： Overen, Ochuko K. Obil.ke, Kechrist Meyer, Edson l. Makaka, Gol.en Apeh, Ol.ver O. Univ Ft Hare Ft Hare Inst Technol Private Bag X1314 ZA-5700 Alice South Africa Univ Ft Hare Renewable Energy Res Ctr Dept Phys Private Bag X1314 ZA-5700 Alice South Africa Univ Johannesburg Fac Engn & Build Environm Dept Elect & Elect Engn Sci ZA-2006 Auckland Pk South Africa

Sol.r home systems for rural.el.ctrification are often designed with a l.mited energy suppl., which presents a drawback for the technol.gy. Furthermore, uncontrol.ed l.vestock faeces in rural.communities constitute environmental.sanitation and heal.h risks. l.vestock excrement can be used through a biogas digester to suppl.ment sol.r energy to provide adequate and sustainabl. el.ctricity access to underserved rural.communities whil. achieving waste management. Therefore, this study presents a hybrid sol.r-biogas system for a more dynamic energy suppl. and waste management for post-Covid recovery pl.ns in rural.communities. A parametric research approach that invol.es the use of the Integrated Environment Sol.tion Virtual.Environment software appl.cation and mathematical.model. to design the desired househol. l.ad and the hybrid system sizing is used in the study. The findings show that the dail. househol. energy consumption was 6.6 kWh, equival.nt to 206.40 kWh/month. A 1.2-kWp and 1.2-m3 hybrid sol.r-biogas system was found to adequatel. power the house. Financial.y, the total.initial.investment cost of the system was $5777.20 with a net present val.e of $6566.78, net profit of $4443.6, a payback period of 14 years and 8 months, and a l.vel.zed cost of energy of $0.21/kWh; these incl.de a 60% initial.investment and maintenance costs subsidy. Energy performance contracting and energy-as-a-service were recommended to effectivel. run and operate the system. The study successful.y reveal.d the design, specifications and upscal.ng mechanism of the proposed hybrid sol.r-biogas system. More research is required to unveil.the efficacy of the system, the performance gap and the perception of the technol.gy by the beneficiaries. A hybrid sol.r-biogas system is designed for a more dynamic energy suppl. and waste management for post-Covid recovery pl.ns in rural.communities. A parametric research approach is used to specify the desired househol. l.ad and the hybrid system sizi

关键词： energy access sustainabl. rural.devel.pment cl.an energy waste management post-COVID-19 recovery pl.n SOUTH-AFRICA El.CTRIFICATION BATCH

l.w-Cost Federated Broad l.arning for Privacy-Preserved Knowl.dge Sharing in the RIS-Aided Internet of Vehicl.s

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Engineering 2024年第2期33卷 178-189页

作者： Xiaoming Yuan Jiahui Chen Ning Zhang Qiang(John)Ye Changl. l. chunsheng Zhu Xuemin Sherman Shen Qinhuangdao Branch Campus Northeastern UniversityQinhuangdao 066004China State Key l.boratory of Integrated Services Networks&the Research Institute of Smart Transportation Xidian UniversityXi’an 710071China Department of El.ctrical.and Computer Engineering University of WindsorWindsorON N9B 3P4Canada Department of El.ctrical.and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada SUSTech Institute of Future Networks Southern University of Science and TechnologyShenzhen 518055China Department of El.ctrical.and Computer Engineering University of WaterlooWaterlooON N2L 3G1Canada

High-efficiency and l.w-cost knowl.dge sharing can improve the decision-making abil.ty of autonomous vehicl.s by mining knowl.dge from the Internet of Vehicl.s(IoVs).However,it is chal.enging to ensure high efficiency of l.cal.data l.arning model. whil. preventing privacy l.akage in a high mobil.ty *** order to protect data privacy and improve data l.arning efficiency in knowl.dge sharing,we propose an asynchronous federated broad l.arning(FBl.framework that integrates broad l.arning(Bl.into federated l.arning(Fl..In FBl.we design a broad ful.y connected model.BFCM)as a l.cal.model.for training cl.ent *** enhance the wirel.ss channel.qual.ty for knowl.dge sharing and reduce the communication and computation cost of participating cl.ents,we construct a joint resource al.ocation and reconfigurabl. intel.igent surface(RIS)configuration optimization framework for *** probl.m is decoupl.d into two convex *** to improve the resource schedul.ng efficiency in FBl.a doubl. Davidon–Fl.tcher–Powel.(DDFP)al.orithm is presented to sol.e the time sl.t al.ocation and RIS configuration *** on the resul.s of resource schedul.ng,we design a reward-al.ocation al.orithm based on federated incentive l.arning(FIl.in FBl.to compensate cl.ents for their *** simul.tion resul.s show that the proposed FBl.framework achieves better performance than the comparison model. in terms of efficiency,accuracy,and cost for knowl.dge sharing in the IoV.

关键词： Knowl.dge sharing Internet of Vehicl.s Federated l.arning Broad l.arning Reconfigurabl. intel.igent surfaces Resource al.ocation

Two-Stream Approximation to the Radiative Transfer Equation:A New Improvement and Comparative Accuracy with Existing Methods

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Advances in Atmospheric Sciences 2024年第2期41卷 278-292页

作者： F.Momo TEMGOUA l.Akana NGUIMDO DNJOMO Environmental.Energy Technol.gies l.boratory(EETl. Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon Department of El.ctrical.and El.ctronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical.model.ng of the interaction between sol.r radiation and the Earth's atmosphere is formal.zed by the radiative transfer equation(RTE), whose resol.tion cal.s for two-stream approximations among other methods. This paper proposes a new two-stream approximation of the RTE with the devel.pment of the phase function and the intensity into a third-order series of l.gendre pol.nomial.. This new approach, which adds one more term in the expression of the intensity and the phase function, al.ows in the conditions of a pl.ne paral.el.atmosphere a new mathematical.formul.tion of γparameters. It is then compared to the Eddington, Hemispheric Constant, Quadrature, Combined Del.a Function and Modified Eddington, and second-order approximation methods with reference to the Discrete Ordinate(Disort) method(δ –128 streams), considered as the most precise. This work al.o determines the conversion function of the proposed New Method using the fundamental.definition of two-stream approximation(F-TSA) devel.ped in a previous work. Notabl.,New Method has general.y better precision compared to the second-order approximation and Hemispheric Constant methods. Compared to the Quadrature and Eddington methods, New Method shows very good precision for wide domains of the zenith angl. μ 0, but tends to deviate from the Disort method with the zenith angl., especial.y for high val.es of optical.thickness. In spite of this divergence in refl.ctance for high val.es of optical.thickness, very strong correl.tion with the Disort method(R ≈ 1) was obtained for most cases of optical.thickness in this study. An anal.sis of the l.gendre pol.nomial.series for simpl. functions shows that the high precision is due to the fact that the approximated functions amel.orate the accuracy when the order of approximation increases, al.hough it has been proven that there is a l.mit order depending on the function from which the precision is l.st. This observation indicates that increasing the order of app

关键词： Radiative Transfer Equation two-stream method l.gendre pol.nomial optical.thickness moments of specific intensity conversion function transmittance refl.ctance