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A neural mA pathway regulates behavioral aggregation in migratory locusts

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Science China life Sciences 2024年

作者： Xianliang Huang Qing li Yanan Xu Ang li Shanzheng Wang Yusheng Chen chunrui Zhang Xia Zhang Hailin Wang Cong Lü Baofa Sun Shaoqin li Le Kang Bing Chen Beijing Institute of Genomics Chinese Academy of Sciences College of Plant Science and Technology Huazhong Agricultural University State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences School of life Science Institutes of Life Science and Green Development Hebei University Institute of Health Sciences Anhui University State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

RNA N6-methyladenosine(m6A), as the most abundant modification of messenger RNA, can modulate insect behaviors, but its specific roles in aggregation behaviors remain unexplored. Here, we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta migratoria. Our results demonstrated that METTL3, METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or isolation. The individual knockdown of methyltransferases(i.e., METTL3 and METTL14) promoted locust movement and conspecific attraction, whereas ALKBH5 knockdown induced a behavioral shift toward the solitary phase. Furthermore, global transcriptome profiles revealed that m6A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of locusts. In summary, our in vivo characterization of the m6A functions in migratory locusts clearly demonstrated the crucial roles of the m6A pathway in effectively modulating aggregation behaviors.

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Clinical characteristics and outcomes of psoriasis patients with COVID-19: A retrospective, multicenter cohort study in China

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中华医学杂志(英文版) 2024年第14期137卷 1736-1743页

作者： liu Yanhua Xu Zhongrui Zhou Jian Chen Aijun Zhang Junling Kang Xiaojing Jiang Xian Lyu Chengzhi Shi chunrui Shi Yuling liu Xiaoming li Fuqiu Yang Bin Huang Yongmei Yu Chen Wang Gang Department of Dermatology Xijing Hospital Fourth Military Medical University Xi’an Shaanxi China Department of Dermatology The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin China Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous Region Urumqi Xinjiang China Department of Dermatology West China Hospital Sichuan University Chengdu Sichuan China Department of Psoriasis Dalian Dermatosis Hospital Dalian Liaoning China Department of Dermatology The First Hospital of Lanzhou University Lanzhou Gansu China Skin Disease Hospital of Tongji University Shanghai China Department of Dermatology The University of Hong Kong-Shenzhen Hospital Shenzhen Guangdong China Department of Dermatology The Second Hospital of Jilin University Changchun Jilin China Department of Dermatology Dermatology Hospital of Southern Medical University Guangzhou Guangdong China Department of Dermatology Xining First People’s Hospital Xining Qinghai China

Background: limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection on psoriasis patients. The objective of this study was to identify clinical factors associated with the prognosis of psoriasis following SARS-CoV-2 ***: A retrospective, multicenter study was conducted between March and May 2023. Univariable and multivariable logistic regression analyses were employed to identify factors associated with coronavirus disease 2019 (COVID-19)-related psoriasis outcomes. The study included 2371 psoriasis patients from 12 clinical centers, with 2049 of them having been infected with ***: Among the infected groups, lower exacerbation rates were observed in individuals treated with biologics compared to those receiving traditional systemic or nonsystemic treatments (22.3% [236/1058]vs. 39.8% [92/231]vs. 37.5% [140/373],P <0.001). Psoriasis progression with lesions (adjusted odds ratio [OR] = 8.197, 95% confidence interval [95% CI] = 5.685–11.820, compared to no lesions), hypertension (adjusted OR = 1.582, 95% CI = 1.068–2.343), traditional systemic (adjusted OR = 1.887, 95% CI= 1.263–2.818), and nonsystemic treatment (adjusted OR= 1.602, 95% CI= 1.117–2.297) were found to be associated with exacerbation of psoriasis after SARS-CoV-2 infection, but not biologics (adjusted OR = 0.931, 95% CI = 0.680–1.274, compared to no treatment), according to multivariable logistic regression ***: A reduced risk of psoriasis exacerbation after SARS-CoV-2 infection was observed with biologics compared to traditional systemic and nonsystemic treatments. Significant risk factors for exacerbation after infection were identified as existing psoriatic lesions and hypertension.

关键词： COVID-19 SARS-CoV-2 Psoriasis Treatment Biologics

Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD^(+)acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2185-2196页

作者： Dan li Tongjuan li Zhen Shang Lei Zhao Qian Xu Jiaqi Tan Yun Qin Yuanyuan Zhang Yang Cao Na Wang liang Huang Xiaojian Zhu Kuangguo Zhou liting Chen chunrui li Ting Xie Yi Yang Jue Wang Jianfeng Zhou Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Division of Pathology and Experimental Hematology and Cancer Biology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45248USA Immunotherapy Research Center for Hematologic Diseases of Hubei Province WuhanHubei 430030China Department of geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Medical Research Institute Wuhan UniversityWuhan 430071China

Internal tandem duplication(ITD)mutations of FMS-like tyrosine kinase-3(FLT3)are the most frequent genetic alterations in acute myeloid leukemia(AML)and predict a poor ***3 tyrosine kinase inhibitors(TKIs)provide short-term clinical responses,but the long-term prognosis of FLT3/ITD^(+)AML patients remains *** signaling is important in numerous types of ***,the role of Notch signaling in FLT3/ITD^(+)AML remains to be *** the current study,we found that Notch signaling was activated upon FLT3-TKI treatment in FLT3/ITD^(+)cell lines and primary *** Notch signaling can be blocked byγ-secretase inhibitors(GSIs),we examined the combinatorial antitumor efficacy of FLT3-TKIs and GSIs against FLT3/ITD^(+)AML and explored the underlying molecular *** a result,we observed synergistic cytotoxic effects,and the treatment preferentially reduced cell proliferation and induced apoptosis in FLT3/ITD^(+)AML cell lines and in primary AML ***,the combination of FLT3-TKI and GSI eradicated leukemic cells and prolonged survival in an FLT3/ITD^(+)patient-derived xenograft AML ***,differential expression analysis suggested that CXCR3 may be partially responsible for the observed synergy,possibly through ERK *** findings suggest that combined therapies of FLT3-TKIs with GSI may be exploited as a potential therapeutic strategy to treat FLT3/ITD^(+)AML.

关键词： FLT3 Notch treatment

IGIACP1 predicts the prognosis in multiple myeloma patients

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Oncology and Translational Medicine 2017年第5期3卷 217-220页

作者： Xiangyu Meng Xiaoping liu chunrui li Cheng Fang li He Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan University Wuhan 430071China Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Hematology Zhongnan Hospital of Wuhan University Wuhan 430071 China

Objective The aim of this study was to investigate the prognostic relevance of acid phosphatase 1(ACP1) expression in myeloma patients by using Gene Expression Omnibus(GEO) *** A comprehensive search was performed in the GEO database in order to find appropriate datasets. The expression level of ACP1 was extracted from the dataset involving both newly diagnosed and relapsed myeloma patients, and a comparison was made. Clinical follow-up data and ACP1 expression were extracted, and survival analysis of overall survival was performed to compare the high-(top quartile) and low-expression(bottom quartile) groups. Analyses using Kaplan-Meier estimation, log-rank test, and restricted mean survival time(RMST) comparison were *** The GSE 6477 dataset was used to make a comparison of the ACP1 expression levels among patients with newly diagnosed and relapsed myeloma. The ACP1 expression level was significantly higher in the relapsed group than in the newly diagnosed group [mean difference =-262.9, 95% confidence interval(CI) =(-420.2,-105.5), P = 0.002]. The GSE 2658 dataset was used for investigating the prognostic relevance of ACP1 expression in myeloma. The ACP1 high-expression group had a significantly worse prognosis [low vs high: hazard ratio = 0.54, 95% CI =(0.31, 0.95); χ2 = 5.02, log rank P = 0.0314]. The median survival was 55.9 months in the high-expression group and was not reached in the low-expression group. The restricted mean time loss(95% CI) was 11.03(12.97, 23.11) and 18.04(12.97, 23.11) for the low-and high-expression groups, respectively. The ratio of RMST(95% CI) between the two groups(high vs low) was 0.87(0.77, 0.99; P = 0.03).Conclusion Our study, for the first time, showed that ACP1 predicts the prognosis in multiple myeloma patients. Further studies are needed to determine the potential mechanism by which ACP1 is associated with clinical outcomes and should focus on the differential roles of low-molecular-weight protein t

关键词： multiple myeloma prognosis ACP1 low-molecular-weight protein tyrosine phosphatase (LMWPTP)

空气污染物对兰州市儿童特应性皮炎门诊人次的影响

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中国医学科学院学报 2024年第3期46卷 361-369页

作者：李璨王菲何苑石春蕊兰州大学第一临床医学院兰州730000 四川大学华西临床医学院成都610041 兰州大学第二医院皮肤科兰州730030 兰州大学第一医院皮肤科兰州730000

目的分析兰州市空气污染物与儿童特应性皮炎门诊人次的关系,为患儿的生活指导和相关部门的疾病预防提供科学依据。方法采用广义相加模型在控制长期趋势、假期效应、星期几效应和气象因素等混杂因素的基础上,分析兰州市空气污染物对儿童... 详细信息

目的分析兰州市空气污染物与儿童特应性皮炎门诊人次的关系,为患儿的生活指导和相关部门的疾病预防提供科学依据。方法采用广义相加模型在控制长期趋势、假期效应、星期几效应和气象因素等混杂因素的基础上,分析兰州市空气污染物对儿童特应性皮炎门诊人次的影响和滞后效应。结果NO_(2)、PM_(2.5)、PM_(10)、SO_(2)对儿童特应性皮炎门诊人次的影响在滞后当天(Lag0)最显著,但均无统计学意义(P均>0.05);CO也在Lag0影响最显著,其浓度每升高10μg/m^(3),儿童特应性皮炎门诊人次增加的超额危险度(ER)值为0.05%(95%CI=0~0.10%,P=0.049);O 3在累积滞后第7天(Lag07)影响最显著,其浓度每升高10μg/m^(3),儿童特应性皮炎门诊人次增加的ER值为7.40%(95%CI=5.31%~9.53%,P<0.001)。年龄分层显示,0~3岁特应性皮炎患儿对CO最敏感,其浓度每升高10μg/m^(3),门诊人次增加的ER值为0.09%(95%CI=0.04%~0.15%,P<0.001);7~14岁特应性皮炎患儿对O 3最敏感,其浓度每升高10μg/m^(3),门诊人次增加的ER值为8.26%(95%CI=4.99%~11.64%,P<0.001)。季节分层显示,CO在夏季和秋季对儿童特应性皮炎门诊人次的影响较强,ER值分别为0.45%和0.16%(P均<0.001);而O 3在冬季对门诊人次影响明显,ER值为20.48%(P<0.001)。结论兰州市空气污染物CO、O 3日平均浓度的升高与儿童特应性皮炎的门诊人次呈正相关,具有显著的季节效应和年龄分层敏感性。

关键词：特应性皮炎空气污染物广义相加模型

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长江中游通江湖泊对干流顶托作用变化规律

水科学进展 2024年第1期35卷 98-111页

作者：杨春瑞邓金运陈立郑柠辉赵晋武汉大学水资源工程与调度全国重点实验室湖北武汉430072

长江中游通江湖泊(洞庭湖和鄱阳湖)对干流的顶托作用直接关系到区域防洪安全。通过构造支流顶托强度指标并结合Copula函数,分析三峡水库蓄水前后两湖出流对长江干流顶托强度的变化和异同,讨论干支流流量分布和地形变化对两湖顶托强度变... 详细信息

长江中游通江湖泊(洞庭湖和鄱阳湖)对干流的顶托作用直接关系到区域防洪安全。通过构造支流顶托强度指标并结合Copula函数,分析三峡水库蓄水前后两湖出流对长江干流顶托强度的变化和异同,讨论干支流流量分布和地形变化对两湖顶托强度变化的贡献。研究结果表明:①三峡水库蓄水后,对干流顶托强度变化方面,汛期洞庭湖变化不大、鄱阳湖明显减弱;枯水期洞庭湖略有增强、鄱阳湖变化不大。②干支流流量分布导致的汇流比变化和江湖交汇区地形调整综合影响导致了两湖蓄水后顶托强度变化的差异;三峡水库蓄水后,干支流流量分布变化使洞庭湖、鄱阳湖对干流平均顶托强度分别减弱5.11%和13.45%;干流河床冲刷加剧导致的交汇区干支流河床高程差增大使洞庭湖、鄱阳湖对干流平均顶托强度分别增强6%和0.9%。

关键词：顶托作用汇流比 Copula函数长江中游洞庭湖鄱阳湖

Bilateral Masculine Mastoplasia Associated with Imatinib Mesylate:A Case Report and literature Review

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第1期31卷 145-146页

作者：赵丹王高翔李春蕊孟力 Department of Hemotology Tongji HospitalTongji Medical CollegeHuangzhong University of Science and Technology

1 CASE REPORT In June 2009, a 29-year-old Chinese male was diagnosed as having Philadelphia chromosome-positive chronic myeloid leukemia （chronic phase）; other than a high white blood cell count in peripheral blood （WBC, 254.00×10^9/L） and splenomegaly, the patient exhibited no abnormal physical signs in mammary glands. He was given hydroxyurea for several days before he received treatment with 400 mg of imatinib mesylate daily.

关键词： masculine mastoplasia imatinib mesylate side effect

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基于智能算法的煤改电用户负荷识别

电测与仪表 2023年第7期60卷 83-87页

作者：申洪涛张超李春睿吴一敌国网河北省电力有限公司电力科学研究院石家庄050000 国网河北省电力有限公司石家庄050011

建设泛在电力物联网使得为用户提供更加多样化和个性化的服务成为可能,近两年来煤改电工程发展迅速,如何通过用户负荷数据对煤改电用户进行识别成为一个研究热点。论文深入剖析了现阶段煤改电工程取得的成绩以及存在的问题,运用大数据... 详细信息

建设泛在电力物联网使得为用户提供更加多样化和个性化的服务成为可能,近两年来煤改电工程发展迅速,如何通过用户负荷数据对煤改电用户进行识别成为一个研究热点。论文深入剖析了现阶段煤改电工程取得的成绩以及存在的问题,运用大数据技术与泛在电力物联网技术可以很好地解决煤改电进程中存在的矛盾与问题。以某地区煤改电用户负荷特性为例描述了在采用蓄热式电锅炉取暖后的用电负荷特性的变化,通过构建粒子群优化后的支持向量机模型,对某地区电网冬季典型日用电负荷数据进行识别与分类,通过测试集的验证,论文建立的模型具有较高的识别精度,平均准确率达到98%,具有一定的实际价值。

关键词：煤改电泛在电力物联网负荷特性支持向量机负荷识别

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确定支架合理支护强度的数值模拟方法

中国煤炭 2011年第5期37卷 79-82页

作者：李春睿天地科技股份有限公司开采设计事业部北京市朝阳区100013 煤炭科学研究总院岩石力学与支护专业委员会北京市朝阳区100013

以支架和围岩的相互作用关系为理论依据,利用FLAC3D数值模拟软件对液压支架合理支护强度的确定方法进行了研究,提出了两种方法来确定液压支架的支护强度,一种是以工作面控顶区岩(煤)体的下沉量来判断支架的合理支护强度,另一种是以顶板(... 详细信息

以支架和围岩的相互作用关系为理论依据,利用FLAC3D数值模拟软件对液压支架合理支护强度的确定方法进行了研究,提出了两种方法来确定液压支架的支护强度,一种是以工作面控顶区岩(煤)体的下沉量来判断支架的合理支护强度,另一种是以顶板(煤)对支架的直接作用力来判断合理的支护强度,并结合现场应用实例说明了两种方法的合理性。

关键词：液压支架支护强度数值模拟控顶区域