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“双创”背景下高校视觉传达设计专业五位一体的教学路径研究

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湖南包装 2024年第3期39卷 196-198页

作者：周文敏周春灵湖南女子学院湖南长沙410004 湖南师范大学湖南长沙410012

高校教育作为创新创业的先导力量,对于高校视觉传达设计专业来说,培养“双创”人才是迫切需要解决的问题。因此,在教学过程中,需要打破过去僵化的单一模式,将“双创”理念融入教学目标,并合理设计教学内容。通过对“双创”教育现存问题... 详细信息

高校教育作为创新创业的先导力量,对于高校视觉传达设计专业来说,培养“双创”人才是迫切需要解决的问题。因此,在教学过程中,需要打破过去僵化的单一模式,将“双创”理念融入教学目标,并合理设计教学内容。通过对“双创”教育现存问题的分析,提出了创新性的“学、练、赛、创、产”五位一体教学改革模式,以期为促进专业教育与“双创”教育的融合提供一条实际可行的教学途径。

关键词：视觉传达设计创新创业五位一体

畜禽粪污及沼气设施等有限空间沼气中毒原因及防范措施研究

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中国沼气 2024年第3期42卷 66-72页

作者：胡华清李忠华朱师逸周春玲周世金严菘安丽华云南省农村能源管理总站云南昆明650051 云南省普洱市农业环保和农村能源站云南普洱665000 云南省广南县农业农村局云南广南663300

近年来,各级农业农村部门狠抓农村沼气设施、畜禽粪污贮存池等安全管理,取得积极成效。但是,云南各地农村仍发生多起畜禽粪污设施及沼气设施等有限空间沼气中毒意外事故,安全漏洞、盲点、隐患依然突出,新的安全风险又在形成,对人民群众... 详细信息

近年来,各级农业农村部门狠抓农村沼气设施、畜禽粪污贮存池等安全管理,取得积极成效。但是,云南各地农村仍发生多起畜禽粪污设施及沼气设施等有限空间沼气中毒意外事故,安全漏洞、盲点、隐患依然突出,新的安全风险又在形成,对人民群众造成严重人身伤害。就加强农村沼气安全管理使用对策进行专题研究,在对国内相关文献、相关理论及沼气中毒事故的研究基础上,通过文献研究法、案例分析法等方法,深入了解沼气的成分构成、危害机制及其中毒类型,结合中毒事故案例深入分析其原因和问题,提出预防措施和政策建议,以减少中毒风险,保护人民群众生命和健康。

关键词：有限空间沼气中毒原因分析防范措施

A continuous 200-ka palaeoclimatic record from stalagmite in Tangshan Cave, Nanjing

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Chinese Science Bulletin 1998年第3期43卷 233-237页

作者： Yongjin Wang Qi Chen Zechun Liu Ye Chen chunling zhou Conglun Lu Nanjing Normal Univ Dept Geog Nanjing 210097 Peoples R China

An oxygen isotope temperature record from 381 to 166 kaB.P. ( 230 Th/ 234 U dating and tuned ages) has been obtained by combining data on the isotopic composition of calcites with that of fluid inclusions trapped in a stalagmite from a limestone cave in which a fossil cranium deposited. Several laminae in microsequence of the stalagmite represent climatic events or shifts. The Nanjing man fossil was older than 381 kaB.P.

关键词： stable isotope climatic change stalagmite Nanjing.

Design method of extractant for liquid-liquid extraction based on elements and chemical bonds

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Chinese Journal of Chemical Engineering 2024年第4期68卷 193-202页

作者： Yuwen Wei chunling Zhang Yue Zhang Lili Wang Li Xia Xiaoyan Sun Shuguang Xiang Institute of Process System Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao 266042China Yantai Guobang Chemical Machinery Technology Co. Ltd.Yantai 264002China

In the petrochemical industry process, the relative volatility between the components to be separated is close to one or the azeotrope that systems are difficult to separate. Liquid-liquid extraction is a common and effective separation method, and selecting an extraction agent is the key to extraction technology research. In this paper, a design method of extractants based on elements and chemical bonds was proposed. A knowledge-based molecular design method was adopted to pre-select elements and chemical bond groups. The molecules were automatically synthesized according to specific combination rules to avoid the problem of “combination explosion” of molecules. The target properties of the extractant were set, and the extractant meeting the requirements was selected by predicting the correlation physical properties of the generated molecules. Based on the separation performance of the extractant in liquid-liquid extraction and the relative importance of each index, the fuzzy comprehensive evaluation membership function was established, the analytic hierarchy process determined the mass ratio of each index, and the consistency test results were passed. The results of case study based on quantum chemical analysis demonstrated that effective determination of extractants for the analysis of benzene-cyclohexane systems. The results unanimously prove that the method has important theoretical significance and application value.

关键词： Molecular design Element and chemical bonds Molecular simulation Thermodynamics Solvent extraction

Predicting Users’ Latent Suicidal Risk in Social Media: An Ensemble Model Based on Social Network Relationships

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Computers, Materials & Continua 2024年第6期79卷 4259-4281页

作者： Xiuyang Meng chunling Wang Jingran Yang Mairui Li Yue Zhang Luo Wang School of Information Science and Technology Beijing Forestry UniversityBeijing100083China Engineering Research Center for Forestry-Oriented Intelligent Information Processing of National Forestry and Grassland Administration Beijing100083China

Suicide has become a critical concern,necessitating the development of effective preventative *** media platforms offer a valuable resource for identifying signs of suicidal *** progress in detecting suicidal ideation on social media,accurately identifying individuals who express suicidal thoughts less openly or infrequently poses a significant *** tackle this,we have developed a dataset focused on Chinese suicide narratives from Weibo’s Tree Hole feature and introduced an ensemble model named Text Convolutional Neural Network based on Social Network relationships(TCNN-SN).This model enhances predictive performance by leveraging social network relationship features and applying correction factors within a weighted linear fusion *** is specifically designed to identify key individuals who can help uncover hidden suicidal users and *** model,assessed using the bespoke dataset and benchmarked against alternative classification approaches,demonstrates superior accuracy,F1-score and AUC metrics,achieving 88.57%,88.75%and 94.25%,respectively,outperforming traditional TextCNN models by 12.18%,10.84%and 10.85%.We assert that our methodology offers a significant advancement in the predictive identification of individuals at risk,thereby contributing to the prevention and reduction of suicide incidences.

关键词： Suicide risk prediction social media social network relationships Weibo Tree Hole deep learning

Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

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BIOCELL 2024年第7期48卷 1105-1113页

作者： chunling LIANG JING CHEN XIAOJIE CHEN WEI YAN JIE YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy ***ﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac ***:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁ***:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HCFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁ*** the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(ChIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was ***:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HCFs upon Ang II ***5B bound to the TREM1 promoter and upregulated its transcriptional ***,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 ***:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁ***ﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： Cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation

Highly selective photocatalytic oxidation of methane to methyl hydroperoxide

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Nano Research 2024年第4期17卷 2473-2480页

作者： chunling Bo Li Zhang Xiaolong Liu Huaiqiu Chang Yingxue Sun Xinyi Zhang Ting Tan Lingyu Piao National Center for Nanoscience and Technology Beijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

Partial oxidation of methane into primary oxidation products with high value remains a *** this work,photocatalytic oxidation of methane(CH_(4))with high methyl hydroperoxide(CH_(3)OOH)selectivity is achieved using pure titanium oxide(TiO_(2))without any cocatalyst at room temperature and atmospheric *** CH_(3)OOH production rate can reach up to 2050±88μmol·g^(-1)·h^(-1) at pH≈7.0 with 100%selectivity in the liquid *** stable reaction cycle can reach more than 30 *** low-cost system achieves superior CH_(4) conversion activity and selectivity compared with similar *** energy of hydrogen peroxide(H_(2)O_(2))to adsorbed hydroperoxyl radical(^(*)OOH)has a significantly lower reaction energy than conversion to adsorbed hydroxyl radical(*OH)on the(210)surface of the TiO_(2).The^(*)OOH preferentially combines with methyl radical(·CH_(3))to form the most energetically favorable CH_(3)*** mild oxidative environment of this system prevents the reduction of CH_(3)OOH to CH_(3)OH or over-oxidation of CH_(4),which ensures the final CH_(3)OOH with high selectivity and *** work provided a low-cost but highly efficient method to achieve partial oxidation with superior selectivity,i.e.,to convert CH_(4) into high-value chemicals.

关键词： photocatalytic methane oxidation methyl hydroperoxide titanium oxide

Membrane vesicles derived from Streptococcus suis serotype 2 induce cell pyroptosis in endothelial cells via the NLRP3/Caspase-1/GSDMD pathway

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Journal of Integrative Agriculture 2024年第4期23卷 1338-1353页

作者： Keda Shi Yan Li Minsheng Xu Kunli Zhang Hongchao Gou chunling Li Shaolun Zhai Institute of Animal Health Guangdong Academy of Agricultural Sciences/Key Laboratory of Livestock Disease Prevention ofGuangdong Province/Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of GuangdongProvinceMinistry of Agriculture and Rural AffairsGuangzhou 510640China Maoming Branch Guangdong Laboratory for Lingnan Modern Agricultural Science and TechnologyMaoming 525000China College of Animal Science&Technology Zhongkai University of Agriculture and EngineeringGuangzhou 510225China

Streptococcus suis serotype 2(*** 2)is a zoonotic pathogen that clinically causes severe swine and human infections(such as meningitis,endocarditis,and septicemia).In order to cause widespread diseases in different organs,*** 2 must colonize the host,break the blood barrier,and cause exaggerated *** the last few years,most studies have focused on a single virulence factor and its influences on the *** vesicles(MVs)can be actively secreted into the extracellular environment contributing to bacteria-host ***-negative bacteria-derived outer membrane vesicles(OMVs)were recently shown to activate host Caspase-11-mediated non-canonical inflammasome pathway via deliverance of OMV-bound lipopolysaccharide(LPS),causing host cell ***,little is known about the effect of the MVs from *** 2(Gram-positive bacteria without LPS)on cell ***,we investigated the molecular mechanism by which *** 2 MVs participate in endothelial cell *** this study,we used proteomics,electron scanning microscopy,fluorescence microscope,Western blotting,and bioassays,to investigate the MVs secreted by *** ***,we demonstrated that *** 2 secreted MVs with an average diameter of 72.04 nm,and 200 proteins in MVs were ***,we showed that MVs were transported to cells via mainly dynamin-dependent *** *** 2 MVs activated NLRP3/Caspase-1/GSDMD canonical inflammasome signaling pathway,resulting in cell pyroptosis,but it did not activate the Caspase-4/-5 *** importantly,endothelial cells produce large amounts of reactive oxygen species(ROS)and lost their mitochondrial membrane potential under induction by *** 2 *** results in this study suggest for the first time that MVs from *** 2 were internalized by endothelial cells via mainly dynamin-dependent endocytosis and might promote NLRP3/Caspase-1/GSDMD pathway by mitochondrial damage,which produced mtDNA and ROS under induction,

关键词： Streptococcus suis serotype 2 membrane vesicles endocytosis pyroptosis NLRP3 inflammasomes mitochondrial damage endothelial cell

Multifunctional Film Assembled from N‑Doped Carbon Nanofiber with Co–N_(4)–O Single Atoms for Highly Efficient Electromagnetic Energy Attenuation

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Nano-Micro Letters 2024年第11期16卷 359-376页

作者： Jia Xu Bei Li Zheng Ma Xiao Zhang chunling Zhu Feng Yan Piaoping Yang Yujin Chen College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001People’s Republic of China Key Laboratory of In‑Fiber Integrated Optics College of Physics and Optoelectronic EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China

Single-atom materials have demonstrated attractive physicochemical ***,understanding the relationships between the coordination environment of single atoms and their properties at the atomic level remains a considerable ***,a facile waterassisted carbonization approach is developed to fabricate well-defined asymmetrically coordinated Co–N_(4)–O sites on biomass-derived carbon nanofiber(Co–N_(4)–O/NCF)for electromagnetic wave(EMW)*** such nanofiber,one atomically dispersed Co site is coordinated with four N atoms in the graphene basal plane and one oxygen atom in the axial ***-depth experimental and theoretical studies reveal that the axial Co–O coordination breaks the charge distribution symmetry in the planar porphyrin-like Co–N_(4) structure,leading to significantly enhanced dielectric polarization loss relevant to the planar Co–N_(4) ***,the film based on Co–N_(4)–O/NCF exhibits light weight,flexibility,excellent mechanical properties,great thermal insulating feature,and excellent EMW absorption with a reflection loss of−45.82 dB along with an effective absorption bandwidth of 4.8 *** findings of this work offer insight into the relationships between the single-atom coordination environment and the dielectric performance,and the proposed strategy can be extended toward the engineering of asymmetrically coordinated single atoms for various applications.

关键词： Co single atoms Asymmetric coordination structure Axial oxygen coordination Electromagnetic wave absorption Multifunctional film