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Comparison Study of Chitosan/β-Cyclodextrin and Carboxymethyl Chitosan/β-Cyclodextrin Microspheres

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Wuhan University Journal of Natural Sciences 2009年第4期14卷 362-368页

作者： LI Ruobao zhao chunling ZHANG Weifen SHI Lihong TANG Jinbao Department of Basic Medicine Weifang Medical UniversityWeifang 261053Shandong China Shandong Provincial Key Laboratory of Applied Pharmacology Weifang Medical University Weifang 261053 Shandong China

To compare two microspheres of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin loaded theophylline as pulmonary sustained drug delivery carriers, the characteristics and ciliotoxicity were studied. The drug loadings of chitosan/ β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin micro- spheres were 21.09% and 21.42%, and the encapsulation efficiencies were 91.40% and 92.80%. The distributions of 50% （d0.5） of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 4.89 and 5.83 μm, respectively. Both micro- spheres showed spherical shape with smooth or wrinkled surfaces. FT-IR of chitosan/β-cyclodextrin microspheres demonstrated that theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin, while for the carboxymethyl chitosan/β-cyclodextrin microspheres theophylline had interaction with carboxymethyl chitosan. The moisture absorption showed that an equilibrium was reached within 24 h. The two microspheres possessed better adaptability. In vitro release of theophylline from chitosan/ β-cyclodextrin microspheres was slower than that from carboxy- methyl chitosan/β-cyclodcxtrin microspheres at pH 6.8.

关键词： theophylline chitosan carboxymethyl chitosan microspheres in vitro release

Influence of chronic intermittent hypoxia on growth associated protein 43 expression in the hippocampus of young rats

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Neural Regeneration Research 2012年第16期7卷 1241-1246页

作者： Yan Chen chunling zhao Chunlai Zhang Lirong Luo Guang Yu Department of Physiology Luzhou Medical CollegeLuzhou 646000Sichuan ProvinceChina Functional Experiment Center of Luzhou Medical College Luzhou 646000Sichuan ProvinceChina

This study aimed to explore the pathological change to hippocampal neurons and the expression of growth associated protein 43 in 21-day-old young rats following chronic intermittent hypoxia. Hematoxylin-eosin staining results showed varying degrees of degeneration and necrosis in hippocampal neurons depending on the modeling time. Immunohistochemistry revealed that growth associated protein 43 expression in young rats following chronic intermittent hypoxia decreased, but that levels were still higher than those of normal rats at each time point, especially 4 weeks after modeling. During 1 5 weeks after modeling, a slow growth in rat weight was observed. Experimental findings indicate that chronic intermittent hypoxia may induce growth dysfunction and necrosis of hippocampal neurons, as well as increase the expression of growth associated protein 43 in young rats.

关键词： chronic intermittent hypoxia brain injury growth associated protein 43 obstructive sleep apneahypopnea syndrome hippocampus young rats neural regeneration

Clinicopathological characteristics of 8697 patients with COVID-19 in China:a meta-analysis

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Family Medicine and Community Health 2020年第2期8卷 46-56页

作者： Jieyun Zhu Zhimei Zhong Pan Ji Hongyuan Li Bocheng Li Jielong Pang Jianfeng Zhang chunling zhao Department of Emergency Medicine The Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China

Objective Our study aims to present a summary of the clinicopathological characteristics of patients affected by the coronavirus disease 2019(COVID-19)that can be used as a reference for further research and clinical *** Studies were included in the meta-analysis if they had cohort,case-control or case series designs and provided sufficient details on clinical symptoms,laboratory outcomes and asymptomatic *** PubMed,Embase,Chinese Biomedical Literature Database,Wanfang,China Science and Technology Journal Database and China National Knowledge Infrastructure databases were electronically searched to identify related studies published between 1 January 2020 and 16 March *** reviewers independently examined the literature,extracted relevant data and assessed the risk of publication bias before including the studies in the *** The confirmed cases of *** A total of 55 unique retrospective studies involving 8697 patients with COVID-19 were ***-analysis showed that a higher proportion of infected patients were male(53.3%),and the two major symptoms observed were fever(78.4%)and cough(58.3%).Other common symptoms included fatigue(34%),myalgia(21.9%),expectoration(23.7%),anorexia(22.9%),chest tightness(22.9%)and dyspnoea(20.6%).Minor symptoms included nausea and vomiting(6.6%),diarrhoea(8.2%),headache(11.3%),pharyngalgia(11.6%),shivering(15.2%)and rhinorrhea(7.3%).About 5.4%of the patients were *** patients showed normal leucocyte counts(64.7%)and elevated C reactive protein levels(65.9%).Lymphopaenia was observed in about 47.6%of the infected patients,along with abnormal levels of myocardial enzymes(49.4%)and liver function(26.4%).Other findings included leucopenia(23.5%),elevated D-dimer(20.4%),elevated erythrocyte sedimentation rate(20.4%),leucocytosis(9.9%),elevated procalcitonin(16.7%)and abnormal renal function(10.9%).Conclusions The most commonly experienced symptoms of pati

关键词： patients elevated characteristics

Impairment of cognitive function and reduced hippocampal cholinergic activity in a rat model of chronic intermittent hypoxia

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Neural Regeneration Research 2011年第17期6卷 1301-1305页

作者： chunling zhao Yan Chen Chunlai Zhang Linya Lā Qian Xu Department of Physiology Luzhou Medical College Luzhou 646000 Sichuan Province China Department of Pediatric Surgery Affifiated Hospital of Luzhou Medical College Luzhou 646000 Sichuan Province China

The present study established a rat model of chronic intermittent hypoxia （CIH） to simulate obstructive sleep apnea syndrome. CIH rats were evaluated for cognitive function using the Morris water maze, and neuronal pathology in the hippocampus was observed using hematoxylin-eosin staining. In addition, hippocampal choline acetyl transferase （CHAT） and nicotinic acetylcholine receptor （nAChR） expression was determined by immunohistochemistry. Our results revealed necrotic hippocampal neurons, decreased ChAT and nAChR expression, as well as cognitive impairment in CIH rats. These results suggest that hippocampal neuronal necrosis and decreased cholinerqic activity may be involved in CIH-induced cognitive impairment in rats.

关键词： hypoxia brain memory dysfunction choline acetyl transferase nicotinic acetylcholinereceptor chronic intermittent hypoxia rat neural regeneration

rAdinbitor, a novel disintegrin from Agkistrodon halys brevicaudus stejneger inhibits adhesion and proliferation of SMMC-7721 cells

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The Chinese-German Journal of Clinical Oncology 2008年第7期7卷 390-393页

作者： chunling zhao Xiuyun Cui Feng Ren Baochang zhao Department of Biochemical and Molecular Biology Dalian Medical University Dalian 116027 China

Objective： To investigate the effects of rAdinbitor on the adhesion and proliferation of human hepatoma cell strain 8MMC-7721. Methods： Cell adhesion assay was used to observe the effect of rAdinbitor on the adhesion of 8MMC-7721 cells to fibronectin （FN）. Crystal violet staining was performed to detect the influence of rAdinbitor on the adhesion of 8MMC- 7721 cells. MTT assay was employed to detect the inhibitory effects of different concentration of rAdinbitor on the proliferation of 8MMC-7721 cells. The morphologic changes of the control 8MMC-7721 cells and the apoptotic cells induced by 200μg/mL rAdinbitor for 36 h were observed under light microscope after HE staining. Flow cytometry analysis was applied to determine the apoptosis rate of 8MMC-7721 cells. Results：（1） FN promoted the adhesion of human hepatoma cell strain 8MMC-7721 in a dose-dependent manner. （2） rAdinbitor could dose-dependently inhibit the adhesion of SMMC-7721 cells to FN. The higher the concentration was, the stronger the inhibition was. There was significant difference among the groups （P 〈 0.05）. （3） rAdinbitor had a strong inhibition on the proliferation of 8MMC-7721 cells and showed a dose-dependent manner （P 〈 0.05）. After a 48 h exposure, the IC50 value of rAdinbitor was 177.83 μg/mL. （4） After exposure of 8MMC-7721 cells to 200μg/mL rAdinbitor for 36 h, the early morphologic changes appeared and the apoptosis rate was 20.68%, significantly higher than that of the control group （2.38%, P 〈 0.05）. Conclusion： rAdinbitor can dose-dependently inhibit the 8MMC-7721 cells adhesion to FN, and can inhibit the proliferation in dose-dependent manner and promote their apoptosis.

关键词： rAdinbitor disintegrin hepatoma adhesion proliferation apoptosis

Effect of Ginsenoside Rbl on Expressive Proteome of Rat Neurons

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Agricultural Biotechnology 2012年第2期1卷 17-19页

作者： Chunyan ZHANG Qian XU chunling zhao Chunlai ZHANG Department of Biochemistry Luzhou Medical College Department of Physiology Luzhou Medical College

[ Objective ] This study aimed to explore the effect of ginsenoside Rbl on expressive proteome of rat neurons by technologies of proteomics, bioinformat- ies and MS peptide fingerprinting. [ Method ] Rat neurons were cultured conventionally and randomly separated into two groups. The experimental group was trea- ted with 5 μg/rnl Rbl for 20 min, while control group was added with the same amount of medium. After cell lysis, the whole-cell protein was extracted. Two-di- mensional electrophoresis （2-DE） was used to separate the extracts. Differential expression of proteome between the two groups was analyzed by using ImageMaster 2D Platinum v5.0 software and the two protein spots expressed differently were selected for differential identification with MALDI-TOF-MS. [ Result] Based on the matching and comparative analysis of the protein spots, 418 protein spots were detected in experimental group, including 226 protein spots with differently expres- sive levels; according to the mass spectrometry, the two ginsenoside Rbl-related and differentially-expressed protein spots were identified as cytochrome P-450 and phosducin-like protein, and both of them were phosphorylated proteins. [ Conclusion ] This study showed that the functions of those identified proteins were in- volved in signal transduction, suggesting that the effect of ginsenoside Rbl on expressive proteome of rat neurons might be related to the corresponding signal trans- duction networks.

关键词： Ginsenoside Rbl Rat neurons Expressive proteome Bioinformatics

马克思政治经济学的社会关系分析基础及其当代意义——纪念《资本论》发表150周年

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政治经济学评论 2017年第6期8卷 161-167页

作者：赵春玲南开大学马克思主义学院

与以往见物不见人的经济学分析不同,以唯物史观为根本方法论的马克思政治经济学的基本出发点是人与人之间的社会关系。马克思把特定社会关系即资本主义生产关系作为其经济学的研究对象,在经济研究过程中始终强调社会关系分析,《资本论... 详细信息

与以往见物不见人的经济学分析不同,以唯物史观为根本方法论的马克思政治经济学的基本出发点是人与人之间的社会关系。马克思把特定社会关系即资本主义生产关系作为其经济学的研究对象,在经济研究过程中始终强调社会关系分析,《资本论》中表述的核心范畴和基本原理突出地表明了这一分析主题。社会关系分析使人们对经济问题的认识从现象层次深入到本质层次,为我们洞察社会经济结构和经济关系、认识经济本质、把握经济社会发展规律提供了科学的方法。当代,重申马克思关于社会关系的研究,明确地把社会关系作为经济分析的基础,对于经济学能够更好地解释现实问题、沿着正确方向发展极端重要。

关键词：马克思政治经济学社会关系生产关系唯物史观

新质生产力理论对马克思生产力理论的创新性发展

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政治经济学评论 2024年第6期 115-130页

作者：赵春玲南开大学马克思主义学院

新质生产力是马克思主义政治经济学中国化时代化的创新范畴，赋予了马克思生产力理论以新的时代内涵和实践要求。主要体现在：对新阶段中国社会生产力发展的新趋势、新特征、新规律做出了全新总结和阐释，对新阶段科技创新推动生产力发... 详细信息

新质生产力是马克思主义政治经济学中国化时代化的创新范畴，赋予了马克思生产力理论以新的时代内涵和实践要求。主要体现在：对新阶段中国社会生产力发展的新趋势、新特征、新规律做出了全新总结和阐释，对新阶段科技创新推动生产力发展的核心地位、重要作用及其规律做出新阐释，对新时代生产力要素质变及其组合的跃迁做出与时俱进的新概括，对生产力发展路径和方式转换的新趋势做出了新概括，对全面深化改革加快形成与新质生产力相适应的新型生产关系的独有内涵做出了新阐释。为推进马克思生产力理论的中国化、时代化发展做出了创新性贡献。在以中国式现代化全面推进强国建设、民族复兴伟业的关键时期，我们要坚持以新质生产力理论为指导，深入推进改革创新，为中国式现代化持续注入强劲动力。

关键词：马克思生产力理论新质生产力创新性发展

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货币政策最终目标评价与选择

生产力研究 2007年第21期 37-39页

作者：赵春玲南京财经大学经济学院江苏南京210003

文章对我国二十年来的货币政策理论与实践进行研究,并引用了理性预期学派的一些观点,认为在我国微观经济主体的理性预期因素日益加强的条件下,旨在促进经济增长的货币政策必然导致通货膨胀倾向。结论是我国货币政策目标应坚持"币值稳定... 详细信息

文章对我国二十年来的货币政策理论与实践进行研究,并引用了理性预期学派的一些观点,认为在我国微观经济主体的理性预期因素日益加强的条件下,旨在促进经济增长的货币政策必然导致通货膨胀倾向。结论是我国货币政策目标应坚持"币值稳定"的单一目标。

关键词：货币政策目标理性预期经济增长通货膨胀