Influence of chronic intermittent hypoxia on growth associated protein 43 expression in the hippocampus of young rats

作     者：Yan Chen Chunling Zhao Chunlai Zhang Lirong Luo Guang Yu 

作者机构：Department of PhysiologyLuzhou Medical CollegeLuzhou 646000Sichuan ProvinceChina Functional Experiment Center of Luzhou Medical CollegeLuzhou 646000Sichuan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第16期

页      面：1241-1246页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071006[理学-神经生物学] 

基　　金：supported by a grant from Luzhou Medical College China 

主　　题：chronic intermittent hypoxia brain injury growth associated protein 43 obstructive sleep apneahypopnea syndrome hippocampus young rats neural regeneration 

摘      要：This study aimed to explore the pathological change to hippocampal neurons and the expression of growth associated protein 43 in 21-day-old young rats following chronic intermittent hypoxia. Hematoxylin-eosin staining results showed varying degrees of degeneration and necrosis in hippocampal neurons depending on the modeling time. Immunohistochemistry revealed that growth associated protein 43 expression in young rats following chronic intermittent hypoxia decreased, but that levels were still higher than those of normal rats at each time point, especially 4 weeks after modeling. During 1 5 weeks after modeling, a slow growth in rat weight was observed. Experimental findings indicate that chronic intermittent hypoxia may induce growth dysfunction and necrosis of hippocampal neurons, as well as increase the expression of growth associated protein 43 in young rats.