检索结果-南通市图书馆

Cell Research 2005年第3期15卷 167-175页

作者： Shih Ling hwang,Nancy Pei-Yee chung,Jacqueline Kwai-Yi CHAN,Chen-Lung Steve LIN Department of surgery Kaohsiung Medical University Kaohsiung Taiwan China Department of surgery The University of Hong Kong Medical Centre Queen Mary Hospital Pokfulam Road Hong KongSAR China Department of surgery The University of Hong Kong Medical Centre Queen Mary Hospital Pokfulam Road Hong KongSAR China Department of surgery The University of Hong Kong Medical Centre Queen Mary Hospital Pokfulam Road Hong KongSAR China

Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for the tryptophan catabolism. In human and murine cells, IDO inhibits antigen-specific T cell proliferation in vitro and suppresses T cell responses to fetal alloantigens during murine pregnancy. In mice, IDO expression is an inducible feature of specific subsets of dendritic cells (DCs), and is important for T cell regulatory properties. However, the effect of IDO and tryptophan deprivation on DC func- tions remains unknown. We report here that when tryptophan utilization was prevented by a pharmacological inhibitor of IDO, 1-methyl tryptophan (1MT), DC activation induced by pathogenic stimulus lipopolysaccharide (LPS) or inflam- matory cytokine TNF-α was inhibited both phenotypically and functionally. such an effect was less remarkable when DC was stimulated by a physiological stimulus, CD40 ligand. Tryptophan deprivation during DC activation also regu- lated the expression of CCR5 and CXCR4, as well as DC responsiveness to chemokines. These results suggest that tryptophan usage in the microenvironment is essential for DC maturation, and may also play a role in the regulation of DC migratory behaviors.

关键词： Indoleamine 2 3-dioxygenase (IDO) dendritic cells activation T cell tryptophan chemokine.

Multiple bowel intussusceptions from metastatic localized malignant pleural mesothelioma:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第31期16卷 3984-3986页

作者： Hsien Liu Yu-Jen Cheng Hsin-Pao Chen Jau-chung hwang Po-Chih Chang Division of General surgery Department of Sur-geryE-DA Hospital/I-Shou University Division of Thoracic surgery Department of SurgeryE-DA Hospital/I-Shou University Division of Colon and Rectal surgery Depart-ment of SurgeryE-DA Hospital/I-Shou University Department of Pathology E-DA Hospital/I-Shou University

Localized malignant pleural mesothelioma (LMPM) is a rare occurrence, and gastrointestinal intra-luminal metastases have not previously been reported. Herein, we report a patient with LMPM who presented with a local recurrence 10 mo after initial en bloc surgical resection. Abdominal computed tomography was performed for intractable, vague abdominal pain with episodic vomiting, which showed a "target sign" over the left lower quadrant. Laparotomy revealed several intra-luminal metastatic tumors in the small intestine and colon and a segmental resection of metastatic lesions was performed. Unfortunately, the patient died of sepsis despite successful surgical intervention. Though local recurrence is more frequent in LMPM, the possibility of distant metastasis should not be ignored in patients with non-specifi c abdominal pain.

关键词： Localized malignant pleural mesothelioma Intussusception Distant metastasis

Comparison of the clinical efficacy of medical treatment of symptomatic benign prostatic hyperplasia between normal and obese patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2011年第5期13卷 728-731页

作者： Seung Hwan Lee Cheol Young Oh Kyung Kgi Park Mutt su chung Se Jeong Yoo Byung Ha chung Department of Urology Yonsei University Health System Seoul Korea Department of Urology Hallym University Anyang 431-070 Chuncheon

We aimed to investigate the difference in efficacy of medical treatment of symptomatic benign prostatic hyperplasia （BPH） between normal and obese patients with BPH; obesity was determined by either body mass index （BMI） or waist circumference （WC）. In this 12-week prospective observational study, a total of 175 patients aged ≥40 years with International Prostate Symptom Scores （IPSS） ≥12 points and prostate volume≥20 ml were prospectively enrolled. The patients were divided into two groups according to BMI or WC. Patients received the doxazosin gastrointestinal therapeutic system （GITS） at a dose of 4 mg once per day for 12 weeks. The changes from baseline in the IPSS, maximal urinary flow rate （Qmax）, post-void residual volume, quality of life （QoL） scores and adverse events （AEs） were analysed. Of the 175 enrolled patients, 132 completed the study. Sixty-seven patients had BMI 〉23 kg m-2, and 43 had WC 〉90 cm. Obese patients represented by WC 〉90 cm or BMI≥ 23 kg m-2 had a significantly greater prostate volume compared with non-obese patients at baseline. Total IPSS was significantly higher in the WC 〉90 cm group compared to the WC ≤ 90 cm group. Total I PSS was positively correlated with prostate volume （P=-0.031） and WC （P=0.045）. All groups showed significant improvements in total IPSS and QoL at 12 weeks. However, the improvement of total IPSS was greater in the high-BMI and high-WC groups. The most frequent AE was dizziness （n= 13）, and it was significantly lower in the obese BPH patients. Obesity was associated with increased prostate volume and lower urinary tract symptoms. Alpha-blockers appear to be efficacious for controlling symptoms, especially in obese men.

关键词： Alpha-blocker benign prostatic hyperplasia body mass index prostate waist circumference

Realization of orientation interpolation of 6-axis articulated robot using quaternion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2012年第12期19卷 3407-3414页

作者： AHN Jin-su chung Won-jee JUNG Chang-doo School of Mechatronics Changwon National UniversityChangwon 641-773Korea

In general, the orientation interpolation of industrial robots has been done based on Euler angle system which can result in singular point （so-called Gimbal Lock）. However, quaternion interpolation has the advantage of natural （specifically smooth） orientation interpolation without Gimbal Lock. This work presents the application of quatemion interpolation, specifically Spherical Linear IntERPolation （SLERP）, to the orientation control of the 6-axis articulated robot （RS2） using LabVIEW and RecurDyn. For the comparison of SLERP with linear Euler interpolation in the view of smooth movement （profile） of joint angles （torques）, the two methods are dynamically simulated on RS2 by using both LabVIEW and RecurDyn. Finally, our original work, specifically the implementation of SLERP and linear Euler interpolation on the actual robot, i.e. RS2, is done using LabVIEW motion control tool kit. The SLERP orientation control is shown to be effective in terms of smooth joint motion and torque when compared to a conventional （linear） Euler interpolation.

关键词： quaternion spherical linear interpolation (SLERP) Euler angle linear Euler interpolation 6-axis articulated robot

维普期刊数据库

Application of response surface method for optimal transfer conditions of multi-layer ceramic capacitor alignment system

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第3期18卷 726-730页

作者： PARK su-seong KIM Jae-min chung Won-jee SHIN O-chul School of Mechatronics Changwon National University

The multi-layer ceramic capacitor (MLCC) alignment system aims at the inter-process automation between the first and the second plastic *** a result of testing performance verification of MLCC alignment system,the average alignment rates are 95% for 3216 chip,88.5% for 2012 chip and 90.8% for 3818 *** MLCC alignment system can be accepted for practical use because the average manual alignment is just 80%.In other words,the developed MLCC alignment system has been upgraded to a great extent,compared with manual *** on the successfully developed MLCC alignment system,the optimal transfer conditions have been explored by using *** simulations using ADAMS has been performed according to the cube model of *** using MiniTAB,the model of response surface has been established based on the simulation *** optimal conditions resulted from the response optimization tool of MiniTAB has been verified by being assigned to the prototype of MLCC alignment system.

关键词： multi-layer ceramic capacitor (MLCC) alignment system response surface method (RSM) MiniTAB ADAMS

维普期刊数据库

Duodenal variceal bleeding after balloon-occluded retrograde transverse obliteration: Treatment with transjugular intrahepatic portosystemic shunt

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第22期18卷 2877-2880页

作者： Min Joung Kim Byoung Kuk Jang Woo Jin chung Jae Seok hwang Young Hwan Kim Department of Gastroenterology Keimyung University School of Medicine Dongsan Medical Center 194 Dongsan-dong Jung-gu Daegu 700-712 South Korea Department of Diagnostic Radiology Keimyung University School of Medicine Dongsan Medical Center 194 Dongsan-dong Jung-gu Daegu 700-712 South Korea

We report a case of duodenal varix bleeding as a long term complication of balloon occluded retrograde transvenous obliteration (BRTO), which was successfully treated with a transjugular intrahepatic portosystemic shunt (TIPS). A 57-year-old man was admitted to the emergency room suffering from melena. He had under-gone BRTO to treat gastric varix bleeding 5 mo before admission. Endoscopy and a computed tomography (CT) scan showed complete obliteration of the gastric varix, but the nodular varices in the second portion of the duodenum expanded after BRTO, and spurting blood was seen. TIPS was performed for treatment of duodenal variceal bleeding, because attempts at endoscopic varix ligation were unsuccessful. The post-operative course was uneventful and the patient was discharged without complications. A follow up CT scan obtained 21 mo after TIPS revealed a patent TIPS tract and complete obliteration of duodenal varices, but multinodular hepatocellular carcinoma had developed. He died of hepatic failure 28 mo after TIPS.

关键词： Duodenal variceal bleeding Balloon occlud-ed retrograde transvenous obliteration Transjugularintrahepatic portosystemic shunt

Characterization of focal hypermetabolic thyroid incidentaloma: An analysis with F-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第1期10卷 155-165页

作者： Haejun Lee Yoo Seung chung Joon-Hyop Lee Ki-Young Lee Kyung-Hoon hwang Department of Nuclear Medicine Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea Department of Endocrine surgery Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea Department of Endocrinology and Metabolism Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea

BACKGROUND Incidentally found thyroid tumor(thyroid incidentaloma,TI)on F-18 fluorodeoxyglucose(FDG)positron emission tomography-computed tomography(PETCT)is reported in 2.5%-5%of patients being investigated for non-thyroid *** to 50%of these cases have been diagnosed to be malignant by cytological/histological ***(US)and fine-needle aspiration cytology are recommended for thyroid nodules with high FDG uptake(hypermetabolism)that are 1 cm or greater in *** is important to accurately determine whether a suspicious hypermetabolic TI is malignant or *** To distinguish malignant hypermetabolic TIs from benign disease by analyzing F-18 FDG PET-CT parameters and to identify a cut-off *** Totally,12761 images of patients who underwent F-18 FDG PET-CT for nonthyroid purposes at our hospital between January 2016 and December 2020 were retrospectively reviewed,and 339 patients[185 men(mean age:68±11.2)and 154 women(mean age:63±15.0)]were found to have abnormal,either focal or diffuse,thyroid FDG *** a thorough review of their medical records,US,and cytological/histological reports,46 eligible patients with focal hypermetabolic TI were included in this *** TIs were categorized as malignant and benign according to the cytological/histological reports,and four PET parameters[standardized uptake value(suV)max,suV_(peak),suV_(mean),and metabolic tumor volume(MTV)]were measured on FDG *** lesion glycolysis(TLG)was calculated by multiplying the suV_(mean) by *** parametric and non-parametric methods were used to compare the five parameters between malignant and benign *** operating characteristic(ROC)curve analysis was performed to identify a cut-off *** Each of the 46 patients[12 men(26.1%;mean age:62±13.1 years)and 34 women(73.9%;mean age:60±12.0 years)]with focal hypermetabolic TIs had one focal hypermetabolic *** them,26(56.5%)were malignant and 20(43.5%)were ***_(max

关键词： Thyroid incidentaloma Malignancy Fluorodeoxyglucose positron emission tomography/computed tomography Standardized uptake value Cut-off

A facile route to tungsten oxide nanomaterials with controlled morphology and structure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2011年第5期9卷 517-521页

作者： Hsuan-Ching Lin Cherng-Yuh su Zhong-Kun Yang chung-Kwei Lin Keng-Liang Ou Institute of Atomic and Molecular Sciences Academia Sinica Taipei Taiwan China Institute of ManufacturingEngineering National Taipei University of Technology Taipei 106 Taiwan China Department of Materials Science and Engineering Feng-Chia University Taichung 407 Taiwan China Department of Oral Medicine Taipei Medical University Taipei 110 Taiwan China

Various tungsten oxide-based nanomaterials have been prepared by a modified plasma arc gas condensation technique without the use of catalysts or substrates. These products could be obtained by controlling the processing parameters during experiment. All the as-obtained samples were characterized by field emission gun scanning electron microscopy, high-resolution transmission electron microscopy, and X- ray diffraction techniques. The results revealed that as-prepared tungsten oxide nanomaterials （WO3, W190s5 and WsO14） with different phases and morphologies could be obtained by decreasing the oxygen content in the chamber. In addition, W18049 nanotubes and nanorod bundles were fabricated by con- trolling the Ar/O2 ratio under He plasma gas. W18Q9/TiO2 core-shell nanoparticles were also prepared by evaporating a dual target. The experimental results showed that the present technique is unique and feasible for the fabrication of nanomaterials for use in different applications.

关键词： Plasma arc gas condensation Titanium oxide Tungsten oxide Nanoparticle Nanorods

维普期刊数据库

In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria,Streptococcus mutans and Streptococcus sobrinus

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 308-314页

作者： Okhee Choi su Kyung Cho Junheon Kim chung Gyoo Park Jinwoo Kim Division of Applied Life Science (BK21 Plus) Gyeongsang National University Institute of Agriculture & Life Science Gyeongsang National University

Objective:To evaluate the antibacterial activity of Cinnamomum verum(***) from32 different essential oils against cariogenic bacteria,Streptococcus mutans(***)and Streptococcus sobrinus(***).Methods:The antibacterial activities of each essential oil were individually investigated against *** and *** essential oil of *** was selected for further evaluation against *** and *** chromatography mass spectrometry was used to determine the major constituents of *** essential *** addition,the minimum inhibitory concentration(MIC) and minimum bactericidal concentration of the most effective constituent was ***:The essential oil from *** exhibited the greatest antibacterial *** chromatography mass spectrometry analysis revealed that the major components of *** essential oil were cinnamaldehyde(56.3%),cinnamyl acetate(7.1%) and bphellandrene(6.3%).The MIC of cinnamaldehyde was measured using broth dilution *** MIC of cinnamaldehyde was 0.02%(v/v) against both bacterial strains *** minimum bactericidal concentration of cinnamaldehyde against *** and *** were 0.2% and 0.1%(v/v),***:The essential oil of *** and its major component cinnamaldehyde possessed considerable in vitro antibacterial activities against cariogenic bacteria,*** and *** *** results showed that the essential oil of *** and its bioactive component,cinnamaldehyde,have potential for application as natural agents for the prevention and treatment of dental caries.

关键词： Streptococcus mutans Streptococcus sobrinus Cariogenic bacteria Essential oil Antibacterial activity Cinnamaldehyde

Helicobacter pylori seropositivity in diabetic patients is associated with microalbuminuria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第1期19卷 97-102页

作者： Goh Eun chung Nam Ju Heo Min Jung Park su Jin chung Hae Yeon Kang Seung Joo Kang Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM:To investigate the relationship between Helicobacter pylori(***) seropositivity and the presence of ***:Between December 2003 and February 2010,asymptomatic individuals who visited the Seoul National University Healthcare System Gangnam Center for a routine check-up and underwent tests for *** immunoglobulin G antibodies and urinary albumin to creatinine ratio(UACR) were *** study subjects completed a structured questionnaire,anthropometric measurements and laboratory *** immunoglobulin G was identified using an enzyme-linked immunosorbent assay kit.A random single-void urine sample,collected using a clean-catch technique,was obtained to determine the *** presence of microalbuminuria was defined as a UACR from 30 to 300 μg/*** presence of diabetes mellitus(DM) was defined as either a fasting serum glucose level greater than or equal to 126 mg/dL or taking anti-diabetic *** logistic regression analysis was performed to identify the risk *** dependent variable was microalbuminuria,and the independent variables were the other study ***:A total of 2716 subjects(male,71.8%;mean age,54.9 years) were *** them,224 subjects(8.2%) had microalbuminuria and 324 subjects(11.9%) had been diagnosed with *** with microalbuminuria had a significantly higher *** seropositivity rate than subjects without microalbuminuria(60.7% vs 52.8%,P = 0.024).Multivariate analysis after adjustment for age,body mass index(BMI),waist circumference,and glucose and triglyceride levels showed that *** seropositivity was significantly associated with microalbuminuria [odds ratio(OR),1.40,95% CI,1.05-1.89,P = 0.024].After the data were stratified into cohorts by glucose levels(≤ 100 mg/dL,100 mg/dL subjects after adjust

关键词： Helicobacter pylori Seropositivity Microalbuminuria Atherosclerosis Diabetes