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Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui chung chung Yip Chan Peng chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： NADH oxidase H2O2 production oxidative phosphorylation

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Dynamics of cytokines predicts risk of hepatocellular carcinoma among chronic hepatitis C patients after viral eradication

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World Journal of Gastroenterology 2022年第1期28卷 140-153页

作者： Ming-Ying Lu Ming-Lun Yeh Ching-I Huang Shu-Chi Wang Yi-Shan Tsai Pei-Chien Tsai Yu-Min Ko Ching-Chih Lin Kuan-Yu Chen Yu-Ju Wei Po-Yao hsu Cheng-Ting hsu Tyng-Yuan Jang Ta-Wei Liu Po-Cheng Liang Ming-Yen Hsieh Zu-Yau Lin Shinn-Cherng Chen chung-Feng Huang Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ming-Lung Yu Hepatitis Center and Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung 80708Taiwan School of Medicine and Hepatitis Research Center College of MedicineCenter for Cancer Research and Center for Liquid BiopsyKaohsiung Medical UniversityKaohsiung 80708Taiwan Department of Medical Laboratory Science and Biotechnology Kaohsiung Medical UniversityKaohsiung 80708Taiwan Health Management Center Department of Community MedicineKaohsiung Medical University HospitalKaohsiung 80708Taiwan Institute of Biomedical Sciences National Sun Yat-Sen UniversityKaohsiung 80708Taiwan

BACKGROUND Chronic hepatitis C virus(HCV)infection induces profound alterations in the cytokine and chemokine signatures in peripheral *** of HCV by antivirals results in host immune modification,which may interfere with immune-mediated cancer *** HCV patients who remain at risk of hepatocellular carcinoma(HCC)following HCV eradication remains an unmet *** hypothesized that antiviral therapy-induced immune reconstruction may be relevant to HCC *** To investigate the impact of differential dynamics of cytokine expression on the development of HCC following successful antiviral *** One hundred treatment-naïve HCV patients with advanced fibrosis(F3/4)treated with direct-acting antivirals(DAAs)or peginterferon/ribavirin who achieved sustained virologic response[SVR,defined as undetectable HCV RNA throughout 12 wk(SVR12)for the DAA group or 24 wk(SVR24)for the interferon group after completion of antiviral therapy]were enrolled since *** primary endpoint was the development of new-onset *** HCC surveillance(abdominal ultrasound andα-fetoprotein)was performed every six months during the ***,64 serum cytokines were detected by the multiplex immunoassay at baseline and 24 wk after *** HCC developed in 12 of the 97 patients over 459 person-years after HCV *** univariate analysis,the Fibrosis-4 index(FIB-4),hemoglobin A1c(HbA1c),the dynamics of tumor necrosis factor-α(TNF-α),and TNF-like weak inducer of apoptosis(TWEAK)after antiviral therapy were significant HCC *** multivariate Cox regression model showed thatΔTNF-α(≤-5.7 pg/mL)was the most important risk factor for HCC(HR=11.54,95%CI:2.27-58.72,P=0.003 in overall cases;HR=9.98,95%CI:1.88-52.87,P=0.007 in the interferon group).An HCC predictive model comprising FIB-4,HbA1c,ΔTNF-α,andΔTWEAK had excellent performance,with 3-,5-,10-,and 13-year areas under the curve of 0.882,0.864,0.903,and 1.000,r

关键词： Hepatitis C virus Hepatocellular carcinoma Sustained virologic response Tumor necrosis factor-α Tumor necrosis factor-like weak inducer of apoptosis Cytokine

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Ng, Wing chung. The Rise of Cantonese Opera. Hong Kong： Hong Kong University Press, 2015. ISBN： 9789888208401. 266 pp＋14 illustrations. $50.00 （cloth）.

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Frontiers of History in China 2016年第2期11卷 329-331页

作者： Madeline Y. hsu The University of Texas at Austin

Wing chung Ng＇s long-awaited second monograph does not disappoint. Ng turns his scrupulous analytical and research skills to the unwieldy, transient world of stage perform, ers and the business of Cantonese opera as it evolved from the late nineteenth to the first half of the twentieth century. Drawing on his nostalgia and experiences with popular regional entertainment while growing up in Hong Kong, the author has pieced together a vivid portrait of a constantly adapting, transnational business whose networks reached far into the Cantonese diamora.

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Real-world Effectiveness and Tolerability of Interferonfree Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C:A Multinational Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 646-658页

作者： Fanpu Ji Sally Tran Eiichi Ogawa chung-Feng Huang Takanori Suzuki Yu Jun Wong Hidenori Toyoda Dae Won Jun Liu Li Haruki Uojima Akito Nozaki Makoto Chuma Cheng-Hao Tseng Yao-Chun hsu Masatoshi Ishigami Takashi Honda Masanori Atsukawa Hiroaki Haga Masaru Enomoto Huy Trinh Carmen Monica Preda Phillip Vutien Charles Landis Dong Hyun Lee Tsunamasa Watanabe Hirokazu Takahashi Hiroshi Abe Akira Asai Yuichiro Eguchi Jie Li Xiaozhong Wang Jia Li Junping Liu Jing Liang Carla Pui-Mei Lam Rui Huang Qing Ye Hongying Pan Jiajie Zhang Dachuan Cai Qi Wang Daniel Q.Huang Grace Wong Vincent Wai-Sun Wong Junyi Li Son Do Norihiro Furusyo Makoto Nakamuta Hideyuki Nomura Eiji Kajiwara Eileen L.Yoon Sang Bong Ahn Koichi Azuma Kazufumi Dohmen Jihyun An Do Seon Song Hyun Chin Cho Akira Kawano Toshimasa Koyanagi Aritsune Ooho Takeaki Satoh Kazuhiro Takahashi Ming-Lun Yeh Pei-Chien Tsai Satoshi Yasuda Yunyu Zhao Yishan Liu Tomomi Okubo Norio Itokawa Mi Jung Jun Toru Ishikawa Koichi Takaguchi Tomonori Senoh Mingyuan Zhang Changqing Zhao Raluca Ioana Alecu Wei Xuan Tay Pooja Devan Joanne Kimiko Liu Ritsuzo Kozuka Elena Vargas-Accarino Ai-Thien Do Mayumi Maeda Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Ramsey Cheung Maria Buti Junqi Niu Wen Xie Hong Ren Seng Gee Lim Chao Wu Man-Fung Yuen Jia Shang Qiang Zhu Yoshiyuki Ueno Yasuhito Tanaka Jun Hayashi Ming-Lung Yu Mindie H.Nguyen Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of General Internal Medicine Kyushu University HospitalFukuokaJapan Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Hepatitis Research Center College of Medicine and Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoyaJapan Gastroenterology&Hepatology Changi General HospitalSinghealthSingapore Singhealth Duke-NUS Medicine Academic Clinical Program Singapore Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Department of Internal Medicine Hanyang UniversityCollege of MedicineSeoulKorea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoulKorea Department of Hepatology The Third People's Hospital of Kunming CityKunmingYunnanChina Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaJapan Gastroenterological Center Yokohama City University Medical CenterYokohamaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineE-Da Cancer HospitalKaohsiung Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Nippon Medical SchoolTokyoJapan Department of Gastroenterology Yamagata University Faculty of MedicineYamagataJapan Department of Transfusion Medicine and Department of Hepatology Osaka Metropolitan University Graduate School of MedicineOsakaJapan San Jose Gastroenterology San JoseCAUSA Gastroenterology&Hepatology Department Clinic Fundeni InstituteBucharestRomania Division of Gastroenterology and Hepatology University of WashingtonSeattleWAUSA Department of

Background and Aims:As practice patterns and hepatitis C virus(HCV)genotypes(GT)vary geographically,a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination *** study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs,focusing on GT3 and ***:We analyzed the sustained virological response(SVR12)of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific,North America,and Europe between 07/01/2014–07/01/***:The mean age was 62±13 years,with 49.6%*** demographic breakdown was 91.1%Asian(52.9%Japanese,25.7%Chinese/Taiwan residents,5.4%Korean,3.3%Malaysian,and 2.9%Vietnamese),6.4%White,1.3%Hispanic/Latino,and 1%Black/***,34.8%had cirrhosis,8.6%had hepatocellular carcinoma(HCC),and 24.9%were treatment-experienced(20.7%with interferon,4.3%with direct-acting antivirals).The largest group was GT1(10,246[64.6%]),followed by GT2(3,686[23.2%]),GT3(1,151[7.2%]),GT6(457[2.8%]),GT4(47[0.3%]),GT5(1[0.006%]),and untyped GTs(261[1.6%]).The overall SVR12 was 96.9%,with rates over 95%for GT1/2/3/6 but 91.5%for ***12 for GT3 was 95.1%overall,98.2%for GT3a,and 94.0%for ***12 was 98.3%overall for GT6,lower for patients with cirrhosis and treatment-experienced(TE)(93.8%)but≥97.5%for tretment-naive patients regardless of cirrhosis *** multivariable analysis,advanced age,prior treatment failure,cirrhosis,active HCC,and GT3/4 were independent predictors of lower SVR12,while being Asian was a significant predictor of achieving ***:In this diverse multinational realworld cohort of patients with various GTs,the overall cure rate was 96.9%,despite large numbers of patients with cirrhosis,HCC,TE,and GT3/***12 for GT3/6 with cirrhosis and TE was lower but st

关键词： Hepatitis C virus Liver cirrhosis Hepatocellular carcinoma Genotype DAA REAL-C

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Prospective randomized comparison of oral sodium phosphate and polyethylene glycol lavage for colonoscopy preparation

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World Journal of Gastroenterology 2005年第47期11卷 7486-7493页

作者： Kai-Lin Hwang William Tzu-Liang Chen Koung-Hong Hsiao Hong-Chang Chen Ting-Ming Huang Chien-Ming Chiu Ger-Haur hsu Department of Public Health Chung-Shan Medical University Taichung 402 Taiwan Center for Clinical Trials ChangHua Christian Hospital Changhua 500 TaiwanChina Division of Colorectal Surgery at ChangHua Christian Hospital Changhua 500 Taiwan China

AIM: To compare the effectiveness, patient acceptability, and physical tolerability of two oral lavage solutions prior to colonoscopy in a Taiwan Residents population. METHODS: Eighty consecutive patients were randomized to receive either standard 4 L of polyethylene glycol (PEG) or 90 mL of sodium phosphate (NaP) in a split regimen of two 45 mL doses separated by 12 h, prior to colonoscopic evaluation. The primary endpoint was the percent of subjects who had completed the preparation. Secondary endpoints included colonic cleansing evaluated with an overall assessment and segmental evaluation, the tolerance and acceptability assessed by a selfadministered structured questionnaire, and a safety profile such as any unexpected adverse events, electrolyte tests, physical exams, vital signs, and body weights. RESULTS: A significantly higher completion rate was found in the NaP group compared to the PEG group(84.2% vs 27.5%, P＜0.001). The amount of fluid suctioned was significantly less in patients taking NaP vs PEG (50.13±54.8 cc vs 121.13±115.4 cc, P＜0.001),even after controlling for completion of the oral solution(P = 0.031). The two groups showed a comparable overall assessment of bowel preparation with a rate of 'good' or 'excellent' in 78.9% of patients in the NaPgroup and 82.5% in PEG group (P = 0.778). Patients taking NaP tended to have significantly better colonic segmental cleansing relative to stool amount observedin the descending (94.7% vs 70%, P = 0.007) andtransverse (94.6% vs 74.4%, P = 0.025) colon. Slightly more patients graded the taste of NaP as 'good' or 'very good' compared to the PEG patients (32.5% vs 12.5%;P = 0.059). Patients' willingness to take the same preparation in the future was 68.4% in the NaP compared to 75% in the PEG group (P = 0.617). There was a significant increase in serum sodium and a significant decrease in phosphate and chloride levels in NaP group on the day following the colonoscopy without any clinical sequelae. Prolonged (＞2

关键词： Colonoscopy Bowel preparation Sodium phosphate Polyethylene glycol

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Diamond breakage on CMP pad conditioner

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金刚石与磨料磨具工程 2008年第S1期28卷 115-118页

作者： Liu Ping-Hsiao Sung James C. hsu Kai-Hung Sung Michael National Taipei University of Technology KINIK Company 64Chung-San Rd.Ying-Kuo National Taiwan University Advanced Diamond Solutions Inc.351 King Street Suite 813San FranciscoCA 94158U.S.A.

Diamond grits may be thermally weakened during the high temperature cycle of *** weakening may exhibit as diamond *** the dressing action,taller diamond grits are more likely to break due to the higher stress present.

关键词： diamond brazing diamond breakage CMP pad conditioner

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Integrated therapeutic plasma exchange and traditional Chinese medicine treatment in a patient with severe COVID-19:A case report

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Journal of Integrative Medicine 2022年第6期20卷 575-580页

作者： Chia-Wei Lin Wei-Chen hsu Chien-Lu Lu Su-Hsing Cheng Cheng-Pin Chen Yu-Chang Hou Department of Chinese Medicine Taoyuan General HospitalTaoyuan City 330TaiwanChina Department of Nephrology Taoyuan General HospitalTaoyuan City 330TaiwanChina Department of Infectious Disease Taoyuan General HospitalTaoyuan City 330TaiwanChina School of Public Health Taipei Medical UniversityTaipei City 110TaiwanChina Department of Bioscience Technology Chung Yuan Christian UniversityTaoyuan City 320TaiwanChina School of Chinese Medicine College of Chinese MedicineChina Medical UniversityTaichung City 404TaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan City 333TaiwanChina

This report presents the case of a 59-year-old man with severe COVID-19 that gradually progressed to cytokine release syndrome and then acute respiratory distress syndrome;he was successfully treated via integration of therapeutic plasma exchange and traditional Chinese *** patient initially presented with a sore throat,severe muscle aches,productive cough and *** the worsening of symptoms,remdesivir was ***,as the symptoms continued to worsen and a cytokine release syndrome was suspected,oxygen was provided through a high-flow nasal cannula(50 L/min)and therapeutic plasma exchange was performed to prevent worsening of the acute respiratory distress *** the same day,a course of traditional Chinese medicine was introduced in consultation with the infectious house *** patient’s symptoms gradually improved;the levels of C-reactive protein and D-dimers reduced,and the patient was weaned to a simple oxygen mask and eventually to room *** is the first reported case of the integration of these ***,they prevented the patient from requiring intubation,played a role in cytokine management,and also improved the clinical symptoms,including productive purulent sputum,cough,frequent stool passage and intermittent fever,with no adverse *** a result,the patient was discharged within two weeks of the integration of these ***,the integration of therapeutic plasma exchange and traditional Chinese medicine is an effective therapy for patients with severe COVID-19.

关键词： COVID-19 Therapeutic plasma exchange Traditional Chinese medicine

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Development of an efficient expression system with large cargo capacity for interrogation of gene function in bamboo based on bamboo mosaic virus

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Journal of Integrative Plant Biology 2023年第6期65卷 1369-1382页

作者： Yandong Jin Baijie Wang Mingchuan Bao Yujie Li Shengwu Xiao Yuhua Wang Jun Zhang Liangzhen Zhao Hangxiao Zhang Yau-Heiu hsu Mingjie Li Lianfeng Gu College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China Basic Forestry and Proteomics Research Center School of Future TechnologyCollege of ForestryFujian Agriculture and Forestry UniversityFuzhou 350002China Graduate Institute of Biotechnology Chung Hsing UniversityTaichung 40227China College of crop science Fujian Agriculture and Forestry UniversityFuzhou 350002China

Bamboo is one of the fastest growing plants among monocotyledonous species and is grown extensively in subtropical *** bamboo has high economic value and produces much biomass quickly,gene functional research is hindered by the low efficiency of genetic transformation in this *** therefore explored the potential of a bamboo mosaic virus(BaMV)-mediated expression system to investigate genotype-phenotype *** determined that the sites between the triple gene block proteins(TGBps)and the coat protein(CP)of BaMV are the most efficient insertion sites for the expression of exogenous genes in both monopodial and sympodial bamboo ***,we validated this system by individually overexpressing the two endogenous genes ACE1 and DEC1,which resulted in the promotion and suppression of intemode elongation,*** particular,this system was able to drive the expression of three 2A-linked betalain biosynthesis genes(more than 4 kb in length)to produce betalain,indicating that it has high cargo capacity and may provide the prerequisite basis for the development of a DNA-free bamboo genome editing platform in the *** BaMV can infect multiple bamboo species,we anticipate that the system described in this study will greatly contribute to gene function research and further promote the molecular breeding of bamboo.

关键词： ACE1 bamboo BaMV-mediated overexpression DEC1 expression virus-mediated genome editing

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Unripe Fruit Extracts of <i>Mangifera indica L.</i>Protect against AGEs Formation, Melanogenesis and UVA-Induced Cell Damage

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Food and Nutrition Sciences 2019年第2期10卷 188-197页

作者： Chin-Hsiu Yu Yu-Ting Lin Hsiang-Ling Su Kai-Wen Kan Fu-Chen Liu Shan-Yu Lin Yu-Ming chung Hsin-Fen hsu Yung-Hsiang Lin TCI Research and Design Center TCI Co. Ltd. Taiwan

In this study, we explored the effects of unripe fruit extracts of Mangifera indica L. on the anti-aging activity in skin cells. Mangifera indica L. is a popular economical and medicinal plant with numerous health-beneficial properties. The aqueous extracts of unripe fruit of Mangifera indica L. were obtained and subjected to HPLC and NMR analyses for the identification of bioactive compounds. The anti-glycation effect of Mango unripe fruit extracts was monitored by in vitro model system of AGEs (Advanced glycation end products) formation. Mango unripe fruit extracts significantly inhibited the AGEs formation in a dose-dependent manner. Meanwhile, Mango unripe fruit extracts possessed a comparable efficiency to commercialized Kojic acids in the inhibition of melanogenesis in B16-F10 melanoma cells. The UVA-induced cell damages can be prevented and repaired by Mango unripe fruit extracts in skin fibroblast CCD-966SK. Compared to the untreated control, Mango unripe fruit extracts significantly increased the cell viability while being applied before (36%) or after (43%) UVA irradiation. These results verified the potential application of Mango unripe fruit extracts in the skin protection and recovery from UVA irradiation, as well as the suppression of AGEs formation and melanogenesis.

关键词： Mangifera indica L. Anti-Glycation Melanogenesis UVA-Induced Cell Damage

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Computational Screening of Novel Mitogen-activated Protein Kinase Kinase-1 （MEK1） Inhibitors by Docking and Scoring

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Journal of Life Sciences 2011年第6期5卷 434-442页

作者： Po-Yuan Chen Hong-Jye Hong Mien-De Jhuo Tzu-Hurng Cheng Wei-Tse hsu Chieh-Hsi Wu Che-YenOu Yeng-Ting Yui Jing-Pin Lin Jing-Gung chung Department of Biological Science and Technology China Medical University Taichung 40402 Taiwan College of Chinese Medicine China Medical University Taichung 40402 Taiwan Schools of Pharmacy and Chinese Medicine China Medical University Taichung 40402 Taiwan Departments of Biotechnology Asia University Taichung 40402 Taiwan

The mitogen-activated protein kinase （MAPK） cell signal transduction pathways play a key role in determining the survival of cells. If these pathways can be controlled, they will prohibit the proliferation of cancer cells. To attain this goal, the authors utilize many drugs to interact with mitogen-activated protein kinase kinase-1 （MEK1） in MAPK, and use computer aided drug design （CADD） to analyze the ligand activities of proteins in MEKL The results show that in these drugs, the aromatic group in the terminal of the protein and the PHE209 will induce the stacking force, which is highly related to the actual activities of these drugs.

关键词： Docking and scoring computational screening mitogen-activated protein kinase kinase-1 (MEK1).

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