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Gut microbiota and Chinese medicine syndrome: altered fecal microbiotas in spleen(Pi)-deficient patients

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Journal of Traditional Chinese Medicine 2020年第1期40卷 137-143页

作者： Peng Ying zhang Shuoying Liu Zhiwei Ji Jia Wu chunfu Yang Jingyu Li Xiaobo School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

OBJECTIVE:To investigate the fecal microbiota changes in patients with spleen(Pi)-deficiency(SPD),a common Chinese medicine syndrome with digestive and absorptive disturbances and to provide insight into the relationship between Chinese medicine syndrome and gut ***:Fecal microbiotas from the stool samples of 53 SPD patients and 35 healthy subjects were analyzed via 16 S r RNA gene polymerase chain reaction(PCR)-denaturation gradient gel electrophoresis(DGGE).SPD-related marker genes from20 SPD patients and 20 healthy subjects were identified through gene sequencing,while some genes were quantified using quantitative PCR(q PCR).Discriminant analysis was conducted using SPSS software,and the canonical discriminant function formula for Pi-deficiency was ***:Alterations in microbiota diversity and composition between the SPD and healthy groups were demonstrated via 16 S r RNA gene PCR-DGGE combined with multivariate statistical *** microbiota changes were also observed among different SPD-subtype *** SPD-related markers were found,and putative species corresponding to these markers were identified through gene sequencing,which may have potential associations with the common digestive dysfunctions in SPD patients.q PCR methods were established for two of these markers,which were significantly altered in the SPD *** canonical discriminant function formula was calculated for SPD,and the validity rates of these markers were over 85%.CONCLUSION:Fecal microbiotas are altered in patients with SPD,which may provide insight for further studies on clinically diagnosing and treating *** results may also provide data to gain a better understanding of Traditional Chinese Medicine syndrome and gut dysbiosis.

关键词： Syndrome differentiation treatment Gastrointestinal microbiome Spleen-deficiency

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碳化法制备拟薄水铝石技术的研究进展

工业催化 2011年第4期19卷 21-25页

作者：唐国旗张春富孙长山严斌杨国祥田保亮戴伟中国石化北京化工研究院北京100013 江苏三剂实业有限公司江苏泰州225509

从碳化法制备拟薄水铝石的机理、生产过程中的成胶温度、NaAlO_2溶液浓度、CO_2浓度、干燥温度、老化温度和时间及碳化法分解生产的传统间歇、超重力法碳化间歇和连续碳化工艺进行了评述,并对碳化法今后发展提出了建议。

关键词：催化剂工程碳化法偏铝酸钠拟薄水铝石

De novo assembly of a new Olea europaea genome accession using nano pore seque ncing

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Horticulture Research 2021年第1期8卷 1179-1190页

作者： Guodong Rao Jianguo zhang Xiaoxia Liu chunfu Lin Huaigen Xin Li Xue Chenhe Wang State Key Laboratory of Tree Genetics and Breed ing Research Institute of ForestryChinese Academy of ForestryBeijing 100091China Collaborative Innovation Center of Susta in able Forestry in Southern China Nanjing Forestry UniversityNanjing 210037China Key Laboratory of Tree Breeding and Cultivation National Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China MIANNING Yuansheng Agricultural Science and Technology Co. Ltd.Liangshan Yi Autonomous Prefecture Mianning CountySichuan 615600China Biomarker Technologies Corporation Beijing 101300China

Olive(Olea europaea L.)is internationally renowned for its high-end product,extra virgin olive *** incomplete genome of *** was previously obtained using shotgun sequencing in *** further explore the genetic and breeding utilization of olive,an updated draft genome of olive was obtained using Oxford Nanopore third-generation sequencing and Hi-C *** different assembly strategies were used to assemble the fi nal genome of 1.30 Gb,with contig and scaffold N50 sizes of4.67 Mb and 42.60 Mb,*** greatly increased the quality of the olive *** assembled 1.1 Gb of sequences of the total olive genome to 23 pseudochromosomes by Hi-C,and 53,518 protein-coding genes were predicted in the current *** genomics analyses,including gene family expansion and contraction,whole-genome replication,phylogenetic analysis,and positive selection,were *** on the obtained high-quality olive genome,a total of nine gene families with 202 genes were identi fi ed in the oleuropein biosynthesis pathway,which is twice the number ofgenes identi fi ed from the previous *** new accession of the olive genome is of suf fi cient quality for genome-wide studies on gene function in olive and has provided a foundation for the molecular breeding of olive species.

关键词： breeding Olea assembly

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基于红外阵列的温控器膜片突跳检测装置设计

盐城工学院学报（自然科学版） 2023年第2期36卷 50-54页

作者：杨昊宇张春富王鹏杨佳武谈格彭华伟许杰盐城工学院电气工程学院江苏盐城224051 盐城市计量测试所江苏盐城224008

为了实现双金属膜片突跳动作和突跳温度的同步检测,设计了一款双金属膜片突跳检测装置。装置利用单片机控制温控仪表对双金属膜片加热并实时检测温度,同时通过红外阵列检测双金属膜片的突跳,当其发生突跳时对接收到的信号进行逻辑处理,... 详细信息

为了实现双金属膜片突跳动作和突跳温度的同步检测,设计了一款双金属膜片突跳检测装置。装置利用单片机控制温控仪表对双金属膜片加热并实时检测温度,同时通过红外阵列检测双金属膜片的突跳,当其发生突跳时对接收到的信号进行逻辑处理,检测突跳双金属膜片的位置与突跳温度。通过实验验证了系统的可行性、电路设计的合理性以及双金属膜片突跳动作检测的准确性。

关键词：单片机红外阵列双金属膜片突跳检测

Inula britannica ameliorates alcohol-induced liver injury by modulating SIRT1-AMPK/Nrf2/NF-κB signaling pathway

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Chinese Herbal Medicines 2024年第4期16卷 667-678页

作者： Zhennan Meng Mengyuan Li Xiaoli Wang Kuo zhang chunfu Wu Xiaoshu zhang Faculity of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: Inula britannica is a traditional Chinese medicinal and functional food with various effects such as anti-liver injury, hypoglycemia, antioxidants, and anti-tumor. The aim of this study was to investigate the protective effects and mechanisms of the ethanolic extract of I. britannica(EEIB) on alcohol-induced liver injury in ***: Fifty-six female C57BL/6 mice were randomly divided into seven groups: control group(Con),ethanol feeding model group(EtOH), Silibinin positive treatment group(EtOH + Silibinin 100 mg/kg),EEIB treatment group(EtOH + EEIB 100, 200, and 400 mg/kg), and EEIB control group(EEIB 400 mg/kg). The National Institute on Alcohol Abuse and Alcoholism(NIAAA) ethanol-feeding model was used to study the effects of EEIB on alcohol-induced lipid metabolism, inflammation, oxidative stress, and fibril formation in mice by histopathological evaluation, immunofluorescence staining, Western blotting analysis and molecular ***: EEIB reduced liver indices to different degrees to normal levels and improved liver morphology in mice. EEIB inhibited alcohol-induced liver injury by activating the sirtuin 1(SIRT1)-adenosine monophosphate-activated protein kinase(AMPK) signaling pathway in the liver of alcohol-fed mice, in which sesquiterpenes may be the potential active ingredients, and also down-regulated the expression of alpha-smooth muscle actin(a-SMA), collagen alpha(Collagen I), tumor necrosis factor-alpha(TNFa) and attenuated alcohol-induced liver injury. In addition, EEIB also activated the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway, which alleviated alcohol-induced liver injury at the level of oxidative stress. Notably, the EEIB control group demonstrated that EEIB had no toxic effects in mice. EEIB reduced alcoholic liver injury in a dose-dependent manner. Its therapeutic efficacy was comparable to, if not better than, that of Silibinin when administered at a dose of 400 mg/***: EEIB showed sig

关键词： alcoholic liver injury inflammation Inula britannica L. sesquiterpenes SIRT1-AMPK/Nrf2

N-methyl-D-aspartate receptor subunit expression in memory-related brain areas of lead-exposed rats

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Neural Regeneration Research 2010年第23期5卷 1787-1794页

作者： Qiwen Zhu Weijian Hou Jianwen Zhao Yu Yang Qi zhang Li Guo Lihong Shang YinglinCao chunfu Wu Department of Physiology Shenyang Medical College Shenyang 110034 Liaoning Province China Department of Tissue Engineering China Medical University Shenyang 110001 Liaoning Province China Department of Pharmacology Shenyang Pharmaceutical University Shenyang 110016 Liaoning Province China

Lead exposure induces decreased hippocampal N-methyI-D-aspartic acid （NMDA） receptor gene and protein expressions, which influences the molecular mechanisms of learning and memory. However, lead poisoning-induced differences in NMDA subunit expression, and the correlation of lead poisoning with learning and memory, remain poorly understood. The present study measured differences in expression of NMDA receptor subunits NR1, NR2A, and NR2B in memory-related brain regions of rats who underwent different doses of lead exposure. Results demonstrated decreased NR1, NR2A, and NR2B subunit expressions in some memory-related brain areas. The inhibitory effect of 4.8 mmol/L lead exposure on hippocampal NR2B was most significant, although NR2A expression also significantly decreased following 14.4 mmol/L lead exposure. There was no difference in NR1 expression following exposure to 〈 4.8 mmol/L lead, although the inhibitory effect of 19.6 mmol/L lead exposure was strongest for NR1 expression in the hippocampus. Inhibitory avoidance test results revealed that greater concentrations of lead exposure resulted in decreased learning and memory. Therefore, lead toxicity was dependent on NMDA receptor subunit composition, and NR1, NR2A, and NR2B expressions were associated with time and concentration of lead exposure.

关键词： lead exposure N-methyI-D-aspartate receptor memory-related brain areas neural regeneration rats

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 263-272页

作者： Xudong zhang Jincheng Wang Baoqiang Wu Tao Li Lei Jin Yong Wu Peng Gao Zhen zhang Xihu Qin chunfu Zhu Department of Hepato-biliary-pancreatic Surgery The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhouJiangsuChina Nanjing Medical University NanjingJiangsuChina Dalian Medical University DalianLiaoningChina

Background and Aims:Gallbladder polyp(GBP)assessment aims to identify the early stages of gallbladder *** studies have analyzed the risk factors for malignant *** this retrospective study,we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with ***:We devel-oped a nomogram-based model in a training cohort of 233 GBP *** information,ultrasonographic find-ings,and blood test findings were ***-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram *** internal validation was conducted in 225 consecutive *** and clinical bene-fit of the model were evaluated using receiver operating characteristic curves and decision curve analysis(DCA),***:Age,cholelithiasis,carcinoembryonic antigen,polyp size,and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training *** with five other proposed predic-tion methods,the established nomogram model presented better discrimination of neoplastic GBPs in the training co-hort(area under the curve[AUC]:0.846)and the validation cohort(AUC:0.835).DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five ***:Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decision-making.

关键词： Gallbladder polyps Neoplastic polyp Preoperative diagnosis Nom-ogram model

Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs

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Journal of Animal Science and Biotechnology 2018年第2期9卷 361-369页

作者： Jiawei Wang chunfu Qin Ting He Kai Qiu Wenjuan Sun Xin zhang Ning Jiao Weiyun Zhu Jingdong Yin State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health College of Animal Science and Technology Nanjing Agricultural University College of Biotechnology and Food Science Hebei Normal University for Nationalities

Background: Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most of the world. In China, pigs were raised with alfalfa-containing diets to seek for good quality ***, the influence of dietary alfalfa involving high level of insoluble dietary fiber(IDF) on pig intestinal luminal microbiota composition remains unclear. The objective of this study was to investigate the effects of alfalfa on luminal microbiota and short chain fatty acids(SCFA) production, and gene expressions involved in SCFA sensing, transporting and absorbing in pig caecal ***: Twenty-four growing pigs were randomly allotted to four diets containing 0%, 5%, 10% and 15% alfalfa meal for a 28-d experiment. Ingestion of alfalfa meal-contained diets significantly increased the ratio of body weight gain to feed consumption. Illumina MiS eq sequencing of the V3 region of the 16 S r RNA genes showed that alfalfa-containing diet significantly decreased the relative abundance of genera Turicibacter, Acidiphilium, Paracoccus, Propionibacterium,Corynebacterium, Pseudomonas, Acinetobacter, and Staphylococcus, and increased the relative abundance of genera Lachnospira, Marvinbryantia, and Desulfovibrio in the caecal digesta. Butyrate concentration was significantly increased in the hindgut by the supplementation of alfalfa meal in diets. The m RNA gene expressions of FFAR3, SMCT1, MCT1,PYY, and GCG were significantly increased in the caecal mucosa of pigs fed alfalfa ***: Our results suggested that alfalfa-containing diet has exerted significant impacts on caecal microbiota composition, butyrate concentration and significantly upregulated m RNA expression of host caecal mucosal genes involved in SCFA sensing and absorption as well as regulation of satiety.

关键词： Alfalfa meal Growing pigs Insoluble fiber Microbiota SCFA

The linear and nonlinear optical effects of white light

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Science China(Physics,Mechanics & Astronomy) 2009年第5期52卷 649-664页

作者： QI XinYuan LIU SiMin GUO Ru LU Yi GAO YuanMei LIU ZhaoHong HUANG chunfu zhang XiaoHua ZHU Nan XU JingJun Photonics Center Institute of PhysicsNankai UniversityThe Key Laboratory of Weak Light Nonlinear PhotonicsMinistry of EducationTianjin 300071China Teda Applied Physics School Nankai UniversityThe Key Laboratory of Weak Light Nonlinear PhotonicsMinistry of EducationTianjin 300457China School of Automatic Engineering of Tianjin University of Technology Tianjin 300191China College of Physics and Electronics of Shandong Normal University Jinan 250014China College of Science Shandong Jianzhu UniversityJinan 250101China Tianjin Normal University Tianjin 300384China National Laboratory for Infrared Physics Shanghai 200083China

An overview of our research group’s experimental and theoretical developments is provided on the linear and nonlinear optical effects of white light since 2003. Their work includes the experimental researches on the white light one-dimensional photovoltaic dark spatial solitons and the waveguides and directional couplers induced by them, the circular and elliptic white-light dark spatial solitons and the white-light photorefractive phase masks, two-dimensional white-light photonic lattices and the applications of the white-light dark spatial solitons in the digital image transmission field, the interaction between the two-dimensional white-light dark spatial solitons to enhance or to improve the correlated degree of the white light through the interaction between the white-light beam and coherent dark spatial solitons, the interaction between the one- or two-dimensional white-light dark spatial solitons and the two-dimensional white-light photonic lattices, respectively. We also numerically simulate the interaction between two or more partially incoherent bright spatial solitons and the white bright spatial soliton pairs in the saturated logarithmic nonlinear medium. We have observed experimentally for the first time, the modulation instability of the coherent light and white light, respectively, in self-defocusing medium and so on.

关键词： white-light linear nonlinear spatial soliton