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Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 601-614页

作者： Bei Li Yong Zhang Xinyuan Liu Ziyang Zhang Shuqing Zhuang Xiaoli Zhong Wenbo Chen Yilin Hong Pingli Mo Shuhai Lin Shicong Wang chundong yu State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen361102China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian363000China Xiang'an Hospital of Xiamen University School of MedicineXiamen UniversityXiamen361005China Department of Cardiology Xiamen Key Laboratory of Cardiac ElectrophysiologyXiamen Institute of Cardiovascular DiseasesThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361003China

Pien Tze Huang(PZH),a class-1 nationally protected traditional Chinese medicine(TCM),has been used to treat liver diseases such as hepatitis;however,the effect of PZH on the progression of sepsis is ***,we reported that PZH attenuated lipopolysaccharide(LPS)-induced sepsis in mice and reduced LPS-induced production of proinflammatory cytokines in macrophages by inhibiting the activation of mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)***,PZH stimulated signal transducer and activator of transcription 3(STAT3)phosphorylation to induce the expression of A20,which could inhibit the activation of NF-κB and MAPK *** of the bile acid(BA)receptor G protein-coupled bile acid receptor 1(TGR5)in macrophages abolished the effects of PZH on STAT3 phosphorylation and A20 induction,as well as the LPS-induced inflammatory response,suggesting that BAs in PZH may mediate its anti-inflammatory effects by activating ***,deprivation of BAs in PZH by cholestyramine resin reduced the effects of PZH on the expression of phosphorylated-STAT3 and A20,the activation of NF-κB and MAPK signalling,and the production of proinflammatory cytokines,whereas the addition of BAs to cholestyramine resin-treated PZH partially restored the inhibitory effects on the production of proinflammatory ***,our study identifies BAs as the effective components in PZH that activate TGR5-STAT3-A20 signalling to ameliorate LPS-induced sepsis.

关键词： Pien Tze Huang Bile acids Sepsis Inflammation TGR5 STAT3-A20 signalling

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Establishment of an orthotopic perirenal space xenograft mousemodel of retroperitoneal sarcoma

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Cancer Communications 2021年第7期41卷 631-634页

作者： Fu’an Xie Dongmei Qin Lanlan Lian Ming Li Xu Kong Xiaogang Xia chundong yu Chenghua Luo Wengang Li Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujian 361102P.R.China Department of Hepatobiliary and Pancreatic&Organ Transplantation Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujian 361102P.R.China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell BiologySchool of Life SciencesXiamen UniversityXiamenFujian 361102P.R.China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing 102206P.R.China

Dear Editor,Soft tissue sarcomas are a heterogeneous group of rare malignancies with mesenchymal origin that can arise at any anatomic *** account for almost 1.5% of all malignancies in humans,with an increased incide... 详细信息

关键词： sarcoma arise renal

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Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses by suppressing NF-κB and Erk activation

Mycoepoxydiene inhibits lipopolysaccharide-induced inflammat...

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第六届全国化学生物学学术会议

作者： Tenghui Chen,Qiang Chen,yuemao Shen,and chundong yu~* School of Life Sciences,Xiamen University 422 Siming South Road,Xiamen,Fujian 361005

＜正＞Mycoepoxydiene（MycoE） is a compound extracted from Diaporthe phaseolorum as a secondary metabolism product（1）.Recent study demonstrated that MycoE is effective in repressing proliferation of cancer cells（2）;however,the effect of MycoE in inflammation is *** aim of this study is to investigate the function of mycoepoxydiene（MycoE） in regulating lipopolysaccharide

关键词： Mycoepoxydiene inflammation NF-κB Erk

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下呼吸道感染病儿病原菌分布及肺炎链球菌耐药分析

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齐鲁医学杂志 2016年第6期31卷 686-688页

作者：于美芹于春冬罗兵青岛大学附属青岛市妇女儿童医院检验科山东青岛266034 青岛大学医学院病原生物学教研室

目的探讨我院2015年下呼吸道感染病儿病原菌分布状况及肺炎链球菌的耐药性,以期对本地区下呼吸道感染病儿临床合理用药及社区医院的经验用药提供参考。方法收集我院2015年1—12月因下呼吸道感染收治入院的2 412例病儿的合格痰标本,采用V... 详细信息

目的探讨我院2015年下呼吸道感染病儿病原菌分布状况及肺炎链球菌的耐药性,以期对本地区下呼吸道感染病儿临床合理用药及社区医院的经验用药提供参考。方法收集我院2015年1—12月因下呼吸道感染收治入院的2 412例病儿的合格痰标本,采用VITEK-2全自动微生物分析仪进行菌种鉴定,采用VITEK-2、ATB Expression及Etest试条进行药敏试验。结果共分离出病原菌37种,合计827株,阳性率为34.29%,其中革兰阴性杆菌452株(54.66%),革兰阳性球菌350株(42.32%)。首位致病菌为肺炎链球菌197株(23.82%),第2至6位依次为金黄色葡萄球菌138株(16.69%)、肺炎克雷伯菌106株(12.82%)、大肠埃希菌90株(10.88%)、铜绿假单胞菌57株(6.89%)及阴沟肠杆菌46株(5.56%)。197株肺炎链球菌未发现对利奈唑胺、万古霉素、左氧氟沙星耐药者;对氯霉素、头孢噻肟、头孢曲松、青霉素、复方磺胺甲基异唑、四环素及红霉素耐药率分别为5.58%、6.09%、9.64%、36.04%、64.47%、81.22%与97.46%。结论肺炎链球菌是我院小儿下呼吸道感染的优势菌,临床应及时动态监测肺炎链球菌的药敏分析结果,合理、规范用药,以减缓耐药性的产生。

关键词：呼吸道感染儿童病原菌肺炎链球菌微生物敏感性试验

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下调TSPO表达不影响脂多糖诱导的小胶质细胞TNF-α和IL-1β以及IL-6的分泌

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细胞与分子免疫学杂志 2014年第9期30卷 897-900页

作者：豆晓锋张亚飞陈强李文娇李洋俞春东苏新辉厦门大学附属第一医院核医学科福建厦门361003 厦门大学生命科学学院福建厦门361102

目的研究相对分子质量(Mr)18 000转运蛋白(TSPO)基因表达下调对脂多糖(LPS)诱导BV-2小胶质细胞分泌TNF-α,IL-1β和IL-6的影响。方法以RNA干扰技术建立TSPO基因表达下调的细胞模型,实时荧光定量PCR(qRT-PCR)和Western blot法检测转染TSP... 详细信息

目的研究相对分子质量(Mr)18 000转运蛋白(TSPO)基因表达下调对脂多糖(LPS)诱导BV-2小胶质细胞分泌TNF-α,IL-1β和IL-6的影响。方法以RNA干扰技术建立TSPO基因表达下调的细胞模型,实时荧光定量PCR(qRT-PCR)和Western blot法检测转染TSPO siRNA BV-2细胞TSPO mRNA及蛋白水平表达的效果;用qRT-PCR法检测TSPO基因下调后小胶质细胞BV-2在LPS作用下分泌TNF-α、IL-1β和IL-6的mRNA水平表达的情况;ELISA检测TSPO基因下调小胶质细胞BV-2在LPS作用下分泌TNF-α、IL-1β和IL-6的蛋白水平表达的变化。结果成功建立了TSPO基因下调的细胞模型,稳定表达TSPO siRNA细胞的TSPO mRNA和蛋白水平表达均明显下降,TSPO基因下调后BV-2细胞在LPS作用下分泌TNF-α、IL-1β和IL-6的量无变化。结论下调TSPO的表达对LPS刺激引起的小胶质细胞TNF-α、IL-1β和IL-6的分泌无明显影响。

关键词： TSPO基因 RNA干扰炎症反应小胶质细胞

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机械刻槽埋栅高效硅太阳电池

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太阳能学报 1998年第1期19卷 1-3页

作者：赵玉文李仲明莫春东何少琪于元北京市太阳能研究所

报道了机械刻槽埋栅高效硅太阳电池的实验研究结果。最好电池的效率达１８．４７％，整个制作工艺过程比较简单，是一种有可能实现规模化生产的高效低成本电池技术。

关键词：机械刻槽埋栅电阳能电池硅太阳能电池

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短链酰基辅酶A脱氢酶缺乏症患儿临床特点及基因变异分析

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临床儿科杂志 2020年第9期38卷 687-690页

作者：王伟青李文杰宋东坡于春冬吕金峰陈艳萍青岛市妇女儿童医院新生儿筛查实验室山东青岛266000

目的探讨新生儿短链酰基辅酶A脱氢酶缺乏症(SCADD)基因型与表型的关系。方法回顾分析2015年至2018年,在青岛地区296627例新生儿中筛查发现的7例SCADD患儿的临床资料。结果研究期间初次筛查可疑阳性人数为4864例,初筛阳性率为0.16%;经基... 详细信息

目的探讨新生儿短链酰基辅酶A脱氢酶缺乏症(SCADD)基因型与表型的关系。方法回顾分析2015年至2018年,在青岛地区296627例新生儿中筛查发现的7例SCADD患儿的临床资料。结果研究期间初次筛查可疑阳性人数为4864例,初筛阳性率为0.16%;经基因检测确诊7例SCADD患儿,确诊阳性率为1/42375。7例患儿中,男性4例、女性3例,基因检测发现5种已知变异、4种未知变异,分别为c.1029+89_90 insC、c.1031A>G、c.1157G>A、c.164C>T和c.989G>A,c.1130C>T、c.1186G>A、c.445A>T和c.949A>G。结论SCADD基因型与血尿串联质谱筛查结果一致,但与临床表型关系不明确,早期诊断和治疗有助改善预后。

关键词：遗传代谢病短链酰基辅酶A脱氢酶缺乏症新生儿筛查

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SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis

SRC-3 is required for clearing bacteria and repressing infla...

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中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议

作者： Qiang Chen,~(12) Tenghui Chen,~1 Yixiang Xu,~1 Jingwei Zhu~1,yuan Jiang,~1 Yang Zhao,~1 Jianming Xu,~3 and chundong yu~(1*) The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering,School of Life Sciences,Xiamen University,Xiamen

Steroid receptor coactivator 3(SRC-3) is a multifunctional protein that plays an important role in regulation of bacterial lipopolysaccharide-induced ***,its involvement in host defense against bacterial infection remains *** we used SRC-3 knockout mice to assess the role of SRC-3 in antibacterial defense in ***-induced septic *** *** bacteria were injected intraperitoneally,SRC-3 deficient mice exhibited excessive local and systemic inflammatory responses and more severe bacterial burdens,leading to a significantly higher mortality compared with wild-type mice. Peritoneal macrophages of SRC-3 deficient mice showed a decrease in bacterial phagocytosis in culture and an increase in apoptosis,which was consistent with the defective bacterial clearance observed in SRC-3-deficient ***,SRC-3 null macrophages expressed much lower levels of the scavenger receptor A,the antioxidant enzyme catalase,and anti-apoptotic gene ***,our data demonstrate that SRC-3 is important in not only modulating the local and systemic inflammation but also intensifying bacterial clearance,which highlights a pivotal role of SRC-3 in the host defense system against bacterial infection.

关键词： SRC-3 inflammatory response

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Chickpea C2H2-Type Zinc Finger Protein ZF2 is a Positive Regulator in Drought Response in Arabidopsis

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 577-590页

作者： Sushuang Liu Yanmin Liu chundong Liu Xingwang yu Hao Ma Department of Life Sciences and Health Huzhou CollegeHuzhou313000China State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing210095China Department of Crop and Soil Sciences North Carolina State UniversityRaleigh27695-7620USA Institute of Desert in the Arid Areas College of Grassland and Environment SciencesXinjiang Agricultural UniversityUrumqi830052China

Drought is a major abiotic stress limiting agricultural crops production *** our study,we isolated a novel C2H2-type zinc finger protein gene ZF2 from ***2 consisted of 232 amino acids with two QALGGH motifs in Cys2/His2 zinc finger *** expression analysis of ZF2:GFP fusion protein showed that ZF2 was a nuclear localized *** the yeast assay system,the full-length of ZF2 did not show transcriptional *** of ZF2 gene was enhanced by treatments of several abiotic stresses and *** promoter region of ZF2 contained multiple stress-and hormone-related *** of ZF2 in Arabidopsis significantly improved the root length and fresh weight at seedling stage and enhanced the survival rates and proline content under drought *** results indicated that ZF2 functioned as a positive regulator in drought response.

关键词： ZF2 chickpea drought tolerance transgenic

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In Situ Raman Monitoring of Trace Antibiotics in Different Harsh Water Environments

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Energy & Environmental Materials 2024年第1期7卷 284-293页

作者： chundong Liu Fengcai Lei Maogang Gong Xiaoming Zhou Xiaofei Zhao Zhen Li Chao Zhang Baoyuan Man Jing yu School of Physics and Electronics Institute of Materials and Clean EnergyShandong Normal UniversityJinan 250014China College of Chemistry Chemical Engineering and Materials ScienceInstitute of Biomedical SciencesShandong Normal UniversityJinan 250014China Department of Physics and Astronomy University of KansasLawrenceKansas 66045USA Shandong Provincial Hospital Shandong First Medical UniversityJinan 250021China

In situ surface-enhanced Raman scattering(SERS)is a widely used operando analytical technique,while facing numerous complex factors in applications under aqueous environment,such as low detection sensitivity,poor anti-interference capability,etc.,resulting in unreliable *** address these issues,herein a new hydrophobic SERS strategy has been *** comprehensively designing and researching a SERS-active structure of superhydrophobic ZnO/Ag nanowires,we demonstrate that hydrophobicity can not only draw analytes from water onto substrate,but also adjust"hottest spot"from the bottom of the nanowires to the *** a result,the structure can simultaneously concentrate the dispersed molecules in water and the enhanced electric field in structure into a same zone,while perfecting its own anti-interference *** underwater in situ analytical enhancement factor of this platform is as high as 1.67×10^(11),and the operando limited of detection for metronidazole(MNZ)reaches to 10^(-9)*** importantly,we also successfully generalized this structure to various real in situ detection scenarios,including on-site detection of MNZ in corrosive urine,real-time warning of wrong dose of MNZ during intravenous therapy,in situ monitoring of MNZ in flowing wastewater with particulate interference,etc.,demonstrating the great application potential of this hydrophobic *** work realizes a synergistic promotion for in situ SERS performance under aqueous environment,and also provides a novel view for improving other in situ analytical techniques.

关键词： antibiotic detection hydrophobic structure In situ Raman metronidazole wettability

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