SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis
会议名称：《中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议》
会议日期：2010年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：SRC-3 inflammatory response
摘 要：Steroid receptor coactivator 3(SRC-3) is a multifunctional protein that plays an important role in regulation of bacterial lipopolysaccharide-induced ***,its involvement in host defense against bacterial infection remains *** we used SRC-3 knockout mice to assess the role of SRC-3 in antibacterial defense in ***-induced septic *** *** bacteria were injected intraperitoneally,SRC-3 deficient mice exhibited excessive local and systemic inflammatory responses and more severe bacterial burdens,leading to a significantly higher mortality compared with wild-type mice. Peritoneal macrophages of SRC-3 deficient mice showed a decrease in bacterial phagocytosis in culture and an increase in apoptosis,which was consistent with the defective bacterial clearance observed in SRC-3-deficient ***,SRC-3 null macrophages expressed much lower levels of the scavenger receptor A,the antioxidant enzyme catalase,and anti-apoptotic gene ***,our data demonstrate that SRC-3 is important in not only modulating the local and systemic inflammation but also intensifying bacterial clearance,which highlights a pivotal role of SRC-3 in the host defense system against bacterial infection.