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Three dimensional modeling method of MIMICS adjacent mask spherical open cell aluminum foam-polyurethane composites based on DICOM data

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China Foundry 2020年第4期17卷 314-319页

作者： Ming-si Qi Wei Zhang Guang-ming Ren Yi-ping Yin Fan Zhang chun-xue lu North University of China Taiyuan 030051China Taiyuan Heating Power Groups Co. Ltd.Taiyuan 030001China Baotou North Hua'an Real Estate Co. Ltd.Baotou 014030China

The complexity and irregularity of the internal structure of aluminum foam and the particularity of the fabricating method make it difficult to establish a three-dimensional model that can accurately reflect the internal structure of aluminum foam-polyurethane composites. This study presents a method of three-dimensional reconstruction of the Materialise's Interactive Medical Image Control System (MIMICS) adjacent mask based on Digital Imaging and Communications in Medicine (DICOM) data. Firstly, spherical open cell aluminum foam-polyurethane composites with different pore sizes (5 mm, 7 mm, 9 mm) were prepared. Then the corresponding DICOM data of the spherical open cell aluminum foam-polyurethane composites were obtained by CT-scan. Based on adjacent mask, the three-dimensional simulation model of spherical open cell aluminum foam-polyurethane composites was successfully reconstructed in MIMICS. In order to verify the feasibility of this modeling method, a quasi-static compression simulation of the three-dimensional simulation model was carried out by ABAQUS, and the simulated stress-strain curves were acquired. The quasi-static compression experiments were performed on the prepared aluminum foam-polyurethane composites, and the experimental nominal stress-strain curves were obtained. The simulated nominal stress-strain curves were compared with the experimental nominal stress-strain curves. Results show that the two curves are basically the same. The feasibility and accuracy of the three-dimensional modeling method for the aluminum foam-polyurethane composites are verified.

关键词： aluminum foam-polyurethane CT-scan quasi-static compression 3D modeling simulation

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A three dimensional modeling method for spherical open cell aluminum foams based on spherical core stratification algorithm

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China Foundry 2019年第4期16卷 248-255页

作者： Ming-si Qi Wei Zhang Jun-yuan Wang Guang-ming Ren Yi-ping Yin chun-xue lu North University of China Taiyuan 030051 China Taiyuan Heating Power Groups Co. Ltd Taiyuan 030001 China Baotou North Hua'an Real Estate Co. Ltd. Baotou 014030 China

Because of the complexity and irregularity of the internal structure of aluminum foam, it is difficult to establish a three-dimensional model that can accurately reflect this structure. In this study, an algorithm, named spherical core stratification algorithm, for three-dimensional modeling of spherical aluminum foam was proposed, and by using this algorithm, a three-dimensional model for sphere aluminum foam with random pores has been successfully constructed. The constructed model not only has a high similarity with the real structure of spherical open cell aluminum foam, but also can match its pore size and thickness by adjusting the size and number of holes in the random pore. In order to verify the feasibility of the modeling method, firstly, the three-dimensional model of the cylindrical spherical aluminum foam with a size of Φ35 mm × 20 mm and pore diameter of 5 mm has been generated by using the new algorithm. Secondly, taking the influence of relative density and shape function on the compressive properties of spherical open cell aluminum foams into consideration, a quasi-static constitutive model suitable for the material has been established based on the Sherwood-Frost classical compression constitutive model, which provides material parameters for quasi-static compression simulation. The comparison results show that the established constitutive equation has a good fit with the experiment, with a fitting correlation coefficient of above 0.99. Finally, the quasi-static compression simulation was carried out by ABAQUS, and the simulated nominal stress-strain curve was obtained. The simulation results indicate that the simulated stressstrain curve had the same trend with the one obtained by the quasi-static compression experiment with a small deviation.

关键词： aluminum foam static compression constitutive equation 3D modeling numerical simulation

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Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review

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Journal of Geriatric Cardiology 2012年第4期9卷 411-414页

作者： Hai-Hong Ran Ran Zhang xue-chun lu Bo Yang Hui Fan Hong-Li Zhu Department of Geriatric Hematology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Because it is safe and well tolerated, imatinib is a standard first-line therapy for chronic myeloid leukemia (CML). Although there have been sporadic reports of imatinib-induced cardiotoxicity, including left ventricle (LV) dysfunction and heart failure, the evidence for it is contradictory. Here, we reported a case of an 88-year-old male patient with CML developed decompensated heart failure following imatinib therapy. Four days after the initiation of imatinib, the patient developed orthopnea, edema and a pleural effusion accompanied by abdominal distension, nausea and vomiting. The chest X-ray film showed an enlarged cardiac profile. The echocardiogram demonstrated a decreased LV ejection fraction and enlarged left-side cardiac chambers. B-type natriuretic peptide concentrations were markedly increased. The patient recovered soon after the withdrawal of imatinib and introduction of comprehensive therapy for heart failure. Imatinib-induced cardiotoxicity in elderly patients is a potentially serious complication thatmerits further evaluation.

关键词： Heart failure Chronic myeloid leukemia Imatinib

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Cardiovascular and cerebrovascular outcomes in elderly hypertensive patients treated with either ARB or ACEI

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Journal of Geriatric Cardiology 2012年第3期9卷 252-257页

作者： Cong Ma Jian Cao xue-chun lu Xin-Hong Guo Yan Gao Xian-Feng Liu Li Fan The First Department of Geriatric Cardiology South Building Chinese PLA General Hospital 28 Fuxing Road Beij'ing 100853 China Geriatric Department of Hematology South Building Chinese PLA General Hospital 28 Fuxing Road Beij'ing 100853 China The Institute of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beo'ing 100853 China

Background Although angiotensin converting enzyme inhibitors （ACEI） and angiotensin receptor blockers （ARB） are equally important in the treatment of hypertension, there is less evidence whether they have equal cardiovascular and cerebrovascular protective effects, especially in elder hypertensive patients. This study aims to clarify this unresolved issue. Methods This cross-sectional study included clinical data on 933 aged male patients with hypertension who received either an ARB or ACEI for more than two months between January 2007 and May 2011. The primary outcome was the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. The secondary endpoints were unstable angina, new atrial fibrillation, and transient ischemic attack. Results The median follow-up time was 24 months. Age, drug types, cerebral infarction history, renal dysfunction history were the independent predictors of the primary endpoint. The risk of an occurrence of a primary endpoint event was higher in the ARB group than the ACEI group [P = 0.037, hazard ratios （HR）： 2.124, 95% confidence interval （95% CI）： 1.048-4.306]. The Kaplan-Meier method also suggests that the rate of primary endpoint occurrence was higher in the ARB group than the ACEI group （P = 0.04）. In regard to the secondary endpoints, there were no significant differences between the two treatment arms （P = 0.137, HR： 1.454, 95% CI： 0.888-2.380）. Patient age and coronary heart disease history were independent predictors of the secondary endpoint. Conclusion ACEI were more effective than ARB in reducing cardiovascular and cerebrovascular morbidity and mortality in aged patients with hypertension.

关键词： Angiotensin receptor blocker Angiotensin converting enzyme inhibitor Renin-angiotensin-aldosterone system Angiotensintype 2 receptor

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Gene signatures to therapeutics:Assessing the potential of ivermectin against t(4;14)multiple myeloma

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World Journal of Clinical Oncology 2024年第1期15卷 115-129页

作者： Yang Song Hao-Jun Zhang Xia Song Jie Geng Hong-Yi Li Li-Zhong Zhang Bo Yang xue-chun lu School of Basic Medicine Medical School of Chinese PLABeijing 100853China School of Basic Medicine Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Medical CentreChinese PLA General HospitalBeijing 100853China

BACKGROUND Multiple myeloma(MM)is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone *** translocation,(t)(4;14),results in high-risk MM with limited treatment ***,there is an urgent need for identification and validation of potential treatments for this MM *** data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic *** To elucidate the molecular basis and search for potential effective drugs of t(4;14)MM subtype by employing a comprehensive *** The transcriptional signature of t(4;14)MM was sourced from the Gene Expression *** datasets,GSE16558 and GSE116294,which included 17 and 15 t(4;14)MM bone marrow samples,and five and four normal bone marrow samples,*** the differentially expressed genes were identified,the Cytohubba tool was used to screen for hub ***,the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes *** the STRING database and Cytoscape,protein–protein interaction networks and core targets were *** small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis,*** In this study,a total of 258 differentially expressed genes with enriched functions in cancer pathways,namely cytokine receptor interactions,nuclear factor(NF)-κB signaling pathway,lipid metabolism,atherosclerosis,and Hippo signaling pathway,were *** hub genes(cd45,vcam1,ccl3,cd56,app,cd48,btk,ccr2,cybb,and cxcl12)were *** drugs,including ivermectin,deforolimus,and isoliquiritigenin,were predicted by the Connectivity Map database to have potential therapeutic effects on t(4;14)*** molecular docking,ivermectin showed strong binding affinity to all 10 ide

关键词： Multiple myeloma Functional enrichment analysis Molecular docking simulation Gene expression profiling Therapeutic target Ivermectin

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中国城市用地增长极限规模测算

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中国人口·资源与环境 2013年第8期23卷 55-61页

作者：郑新奇薛春璐王伟杜娟中国地质大学(北京)土地科学技术学院北京100083 中央财经大学政府管理学院北京100081 黄河水利委员会山东黄河河务局山东济南250011

快速城市化出现的城市建设用地扩张问题,受到人们广泛关注,借鉴发达国家经验,我国需要测算一个极限区间值进行自上而下的总量控制,以促进最严格耕地保护制度和节约用地制度的落实。但是如何测算这个极限规模一直没有得到很好解决。本文... 详细信息

快速城市化出现的城市建设用地扩张问题,受到人们广泛关注,借鉴发达国家经验,我国需要测算一个极限区间值进行自上而下的总量控制,以促进最严格耕地保护制度和节约用地制度的落实。但是如何测算这个极限规模一直没有得到很好解决。本文提出了一个常规方法组合和关键指标相结合的技术思路来尝试解决这个问题。研究首先对城市用地扩展规模的影响因子进行了分析,讨论了城市人口数量和GDP分别与建成区面积相关性,确定了城市人口数量对建成区面积影响更大;在此基础上,采用逻辑斯蒂模型,依据我国1950-2010年经济数据,对城市化水平进行预测;用自回归分布滞后模型,依据1951-2010年全国人口数据对未来人口规模进行预测,并分为三个方案对结果进行了讨论;最后按照城市用地分类与规划建设用地标准,以节约集约用地为原则,将人均城市用地规模取值控制在65.0-115.0 m2,计算城市用地扩展极限规模。结果表明,到2045年,中国的城市化预测水平为79.99%,在中国人口增长控制较好的情况下,人口规模将达到14.97亿人,城市用地扩展规模为77 857.38-137 747.70 km2;若中国人口达到有关研究的预测峰值16亿人,中国城市化水平稳定在80%,城市用地扩展极限规模将会是83 200.00-147 200.00 km2。综合以上分析,未来我国的城市建设用地总量应在7.8万km2到14.7万km2之间。

关键词：城市用地规模扩展极限城市化人口预测

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Machine Learning-Based Scoring System for Early Prognosis Evaluation of Patients with Coronavirus Disease 2019

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Infectious Diseases & Immunity 2023年第2期3卷 83-89页

作者： Hao-Min Zhang Lei Shi Hao-Ran Chen Jun-Dong Zhang Ge-Liang Liu Zi-Ning Wang Peng Zhi Run-Sheng Wang Zhuo-Yang Li Xi-Meng Chen Fu-Sheng Wang xue-chun lu Department of Hematology the Second Medical CenterChinese PLA General Hospital BeijingNational Clinical Research Center for Geriatric DiseaseBeijing 100853China Department of Infectious Diseases the Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Wuhan Huo-Shen-Shan Hospital WuhanHubei ProvinceChina Management School Shanxi Medical UniversityTaiyuan 030002China Medical School of Chinese PLA Beijing 100853China Department of Respiratory Medicine the Second Medical Center and National Clinical Research Center for Geriatric DiseasesMedical College of PLAChinese PLA General HospitalBeijing 100853China

Background The global spread of coronavirus disease 2019(COVID-19)continues to threaten human health security,exerting considerable pressure on healthcare systems *** prognostic models for COVID-19 hospitalized or intensive care patients are currently available,prognostic models developed for large cohorts of thousands of individuals are still *** Between February 4 and April 16,2020,we enrolled 3,974 patients admitted with COVID-19 disease in the Wuhan Huo-Shen-Shan Hospital and the Maternal and Child Hospital,Hubei Province,China.(1)Screening of key prognostic factors:A univariate Cox regression analysis was performed on 2,649 patients in the training set,and factors affecting prognosis were initially ***,a random survival forest model was established through machine analysis to further screen for factors that are important for ***,multivariate Cox regression analysis was used to determine the synergy among various factors related to prognosis.(2)Establishment of a scoring system:The nomogram algorithm established a COVID-19 patient death risk assessment scoring system for the nine selected key prognostic factors,calculated the C index,drew calibration curves and drew training set patient survival curves.(3)Verification of the scoring system:The scoring system assessed 1,325 patients in the test set,splitting them into high-and low-risk groups,calculated the C-index,and drew calibration and survival *** The cross-sectional study found that age,clinical classification,sex,pulmonary insufficiency,hypoproteinemia,and four other factors(underlying diseases:blood diseases,malignant tumor;complications:digestive tract bleeding,heart dysfunction)have important significance for the prognosis of the enrolled patients with ***,we report the discovery of the effects of hypoproteinemia and hematological diseases on the prognosis of ***,the scoring system established here can effectiv

关键词： COVID-19 Machine learning Prognosis model

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Influence of gut bacteria on type 2 diabetes:Mechanisms and therapeutic strategy

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World Journal of Diabetes 2025年第1期16卷 27-33页

作者： xue Wen lu-Ming Qi Kui Zhao College of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina College of Materials and Chemical Engineering Southwest Forestry UniversityKunming 650224Yunnan ProvinceChina

The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic *** commentary examines the recent publication in World Journal of *** article explores the association between T2DM and gut microbiota,with a focus on the pathophysiological changes related to *** proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such *** editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic *** provides new insights for future research on gut-microbiota-based interventions for T2DM.

关键词： Type 2 diabetes Intestinal microbiome Intestinal axis Biological pathways Treatment Short-chain fatty acids

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痰热清注射液抑制白血病细胞体外增殖及其作用机制(英文)

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中西医结合学报 2011年第4期9卷 414-422页

作者：杨波卢学春张峰刘洋朱宏丽解放军总医院老年血液科北京100853 中国科学院北京基因组研究所北京100029

目的:探讨痰热清注射液对人白血病细胞体外增殖的影响及其作用机制。方法:将痰热清注射液以体积比稀释成1:2、1:4、1:8、1:16、1:32、1:64、1:128、1:256和1?512,共9个浓度组,分别处理增殖期慢性髓系白血病K562细胞和急性T淋巴细胞白血... 详细信息

目的:探讨痰热清注射液对人白血病细胞体外增殖的影响及其作用机制。方法:将痰热清注射液以体积比稀释成1:2、1:4、1:8、1:16、1:32、1:64、1:128、1:256和1?512,共9个浓度组,分别处理增殖期慢性髓系白血病K562细胞和急性T淋巴细胞白血病Molt4细胞,镜下观察不同时间点各浓度组细胞生长情况,应用活细胞计数试剂盒检测细胞增殖能力,绘制生长曲线,计算抑制率和半数抑制浓度(half inhibitory concentration,IC50);分别采用碘化丙啶染色法和碘化丙啶/膜联蛋白V双染法,通过流式细胞术检测Molt4细胞周期及凋亡的变化;采用实时定量聚合酶链反应方法分析痰热清注射液处理Molt4细胞后凋亡相关基因caspase-3和bcl-2的表达量变化。结果:痰热清注射液对K562和Molt4细胞增殖具有抑制作用,1?2至1?16稀释浓度组的细胞毒性大,细胞基本死亡;抑制作用呈剂量和时间依赖性,IC50分别为1?333和1?142稀释浓度。痰热清注射液1?32浓度组处理72h后,Molt4细胞处于S期的数量明显减少(P<0.05),凋亡细胞比例明显增加(P<0.05);同时,caspase-3表达增加,bcl-2表达明显减少(P<0.05)。结论:痰热清注射液可抑制白血病细胞体外增殖并促进其凋亡,该作用可能是通过减少S期细胞数量,下调bcl-2基因表达和上调caspase-3基因表达而实现的。

关键词：痰热清注射液白血病 K562细胞 Molt4细胞细胞增殖细胞凋亡

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Al_xGa_(1-x)As(100)表面性质的研究

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物理学报 1989年第12期38卷 1968-1973页

作者：黄春晖卢学坤丁训民复旦大学表面物理实验室

用紫外光电子能谱研究了Al_(0.7)Ga_(0.3)As的表面态结构,观察到Al_(0.7)Ga_(0.3)As在价带中的两个表面态结构。在1500L原子氢吸附后消失。研究了这两个表面态结构在热退火消除表面损伤过程中的变化。结合LEED和XPS的实验结果,确定在45... 详细信息

用紫外光电子能谱研究了Al_(0.7)Ga_(0.3)As的表面态结构,观察到Al_(0.7)Ga_(0.3)As在价带中的两个表面态结构。在1500L原子氢吸附后消失。研究了这两个表面态结构在热退火消除表面损伤过程中的变化。结合LEED和XPS的实验结果,确定在450℃左右的热退火可以有效地消除损伤,获得一个完整的Al_(0.7)Ga_(0.3)As(100)表面。

关键词： AlxGa1-xAs 表面性质半导体材料

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