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Metabolomic Analysis of the Anthocyanins Associated with Different Colors of Cymbidium goeringii in Guizhou, China

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1455-1466页

作者： Dongbo Wu Shuang Qu Lianwen Shen Shengqun Chen xia Jiang Ai Rao Yuxue zhao Yueyun Wang College of Pharmacy Guizhou University of Traditional Chines MedicineGuiyang550025China Research Institute of Juglans Regia Guizhou Academy of ForestryGuiyang550005China Guizhou Liping Rocky Desertification Ecosystem National Observation and Research Station Qiandongnan Prefecture556200China

Cymbidium goeringii is an economically important ornamental plant,and flower color is one of the main features of *** that contributes to its high economic *** clarify the molecular mechanisms underlying the role of anthocyanins in mediating differences in color among varieties,liquid chromatography–tandem mass spectrometry was used to perform anthocyanin-targeted metabolomics of seven *** varieties,including‘Jin Qian Yuan’(JQY),‘Jin Xiu Qian Yuan’(JXQY),‘Miao Jiang Su Die’(MJSD),‘Qian Ming Su’(QMS),‘Shi Chan’(SC),and‘Yang Ming Su’(YMS),as well as the *** detected 64 anthocyanins,including cyanidins,delphinidins,malvidins,pelargonidins,peonidins,petunidins,procyanidins,and *** identified six shared differentially accumulated metabolites(DAMs),including cyanidin-3-O-rutinoside,delphinidin-3-Osophoroside,pelargonidin-3-O-rutinoside,peonidin-3-O-(6-O-malonyl-beta-D-glucoside),peonidin-3-Osophoroside,and *** DAMs were enriched in the anthocyanin biosynthesis *** Encyclopedia of Genes and Genomes pathway analysis revealed that the differentially expressed metabolites were significantly enriched in the anthocyanin biosynthesis *** of the content of differentially expressed metabolites indicated that peonidin-3-O-(6-O-malonyl-beta-D-glucoside)was the key metabolite underlying color differences among *** *** B2,pelargonidin-3-O-galactoside,and naringenin might also affect the color formation of JQY and QMS,SC,and MJSD,*** results of this study shed light on the metabolic mechanism underlying flower color differences in *** at the molecular *** findings will aid future studies of the mechanism of flower color regulation in *** and have implications for the breeding of new varieties.

关键词： Cymbidium goeringii ﬂower color anthocyanins metabolomics

Isolation of exogenous fungi from Notoginseng Radix et Rhizoma and preliminary analysis of toxigenic fungi

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Journal of Future Foods 2024年第2期4卷 179-182页

作者： Lei Zhou xiangsheng zhao xiaomin Liu Hefang Wan chun Sui Xuyu Chen Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationNational Engineering Laboratory for Breeding of Endangered Medicinal MaterialsInstitute of Medicinal Plant Development(IMPLAD)Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeHaikou 570311China

Notoginseng Radix et Rhizoma(Sanqi in Chinese)is a precious traditional Chinese herbal *** has the effect of dispersing blood stasis and stopping bleeding,reducing swelling and fixing ***,it tends to contaminate with harmful fungi during storage,which may make it much less *** order to understand the fungal contamination of Notoginseng Radix et Rhizoma and master its composition of the exogenous *** surface fungi of Notoginseng Radix et Rhizoma samples collected from six Chinese provinces and districts were investigated by using dilution plate *** of aflatoxins by UPLC-MS/*** results showed that Penicillium citrinum was dominantly isolated from Notoginseng Radix et Rhizoma samples from No.1 to *** flavus,which produces aflatoxin,was dominantly isolated from Notoginseng Radix et Rhizoma samples from No.5 and *** addition,kinds of mycotoxin were assayed which were produced by three of those identified *** three fungi strains produced aflatoxin B1(AFB1)and one strain HBSQ1-5 additionally produced other three kinds of mycotoxin,AFB2,AFG1 and *** is the results implied that it will be very important to take serious cautions when using Notoginseng Radix et *** well as,understanding the composition of the exogenous fungi of Notoginseng Radix et Rhizoma and the strains of toxin-producing fungi,which can play an important role in guiding the storage of Notoginseng Radix et Rhizoma.

关键词： Notoginseng Radix et Rhizoma Exogenous fungal Amplicon sequencing Mycotoxin

Atomic-Scale Insights into Damage Mechanisms of GGr15 Bearing Steel Under Cyclic Shear Fatigue

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1265-1278页

作者： Qiao-Sheng xia Dong-Peng Hua Qing Zhou Ye-Ran Shi xiang-Tao Deng Kai-Ju Lu Hai-Feng Wang Xiu-Bing Liang zhao-Dong Wang State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China Defense Innovation Institute Academy of Military ScienceBeijing100071China

Alternating shear stress is a critical factor in the accumulation of damage during rolling contact fatigue,severely limiting the service life of ***,the specific mechanisms responsible for the cyclic shear fatigue damage in bearing steel have not been fully *** the mechanical response and microstructural evolution of a model GGr15 bearing steel under cyclic shear loading are investigated through the implementation of molecular dynamics *** samples undergo 30 cycles under three different loading conditions with strains of 6.2%,9.2%,and 12.2%,*** findings indicate that severe cyclic shear deformation results in early cyclic softening and significant accumulation of plastic damage in the bearing ***,samples subjected to higher strain-controlled loading exhibit higher plastic strain energy and shorter fatigue ***,strain localization is identified as the predominant damage mechanism in cyclic shear fatigue of the bearing steel,which accumulates and ultimately results in fatigue ***,simulation results also revealed the microstructural reasons for the strain localization(e.g.,BCC phase transformation into FCC and HCP phase),which well explained the formation of white etching *** study provides fresh atomic-scale insights into the mechanisms of cyclic shear fatigue damage in bearing steels.

关键词： Cyclic shear fatigue Molecular dynamic simulation Bearing steels Plastic damage accumulation

Ten-year observation of corneal densitometry and associated factors following small incision lenticule extraction

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 485-490页

作者： xiao-Song Han Fei xia Zhuo-Yi Chen Pei-Jun Yao Dong-Mei Yang Jing zhao Xing-Tao Zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000) Shanghai 200031China

●AIM:To investigate the long-term changes of corneal densitometry(CD)and its contributing elements after small incision lenticule extraction(SMILE).●METHODS:Totally 31 eyes of 31 patients with mean spherical equivalent of-6.46±1.50 D and mean age 28.23±7.38y were ***-scale examinations were conducted on all patients preoperatively and during *** acuity,manifest refraction,axial length,corneal thickness,corneal higher-order aberrations,and CD were evaluated.●RESULTS:All surgeries were completed successfully without complications or adverse ***-year safety index was 1.17±0.20 and efficacy 1.04±*** value of 0–6 mm zones in central layer was statistically significantly lower 10y postoperatively,compared with preoperative values(0–2 mmΔ=-1.62,2–6 mmΔ=-1.24,P<0.01).There were no correlations between CD values and factors evaluated.●CONCLUSION:SMILE is a safe and efficient procedure for myopia on a long-term *** values get lower 10y postoperatively,whose mechanism is to be further discussed.

关键词： myopia small incision lenticule extraction corneal densitometry

Perioperative chemotherapy improves survival of patients with locally advanced diffuse gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2878-2892页

作者： Ze-Feng Li Zheng Li xiao-Jie Zhang Chong-Yuan Sun He Fei chun-xia Du chun-Guang Guo Dong-Bing zhao Department of Pancreatic and Gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Whether patients with diffuse gastric cancer,which is insensitive to chemo-therapy,can benefit from neoadjuvant or adjuvant chemotherapy has long been *** To investigate whether perioperative chemotherapy can improve survival of patients with locally advanced diffuse gastric *** A total of 2684 patients with locally advanced diffuse gastric cancer from 18 population-based cancer registries in the United States were *** Compared with surgery alone,perioperative chemotherapy improved the prognosis of patients with locally advanced gastric *** stabilized inverse probability of treatment weighting(IPTW),the median overall survival(OS)times were 40.0 months and 13.0 months(P<0.001),*** IPTW,the median OS times were 33.0 months and 17.0 months(P<0.001),*** chemotherapy did not improve the prognosis of patients with locally advanced gastric cancer compared with adjuvant chemotherapy after *** IPTW,the median OS times were 38.0 months in the neoadjuvant chemotherapy group and 42.0 months in the adjuvant chemotherapy group(P=0.472).CONCLUSION Patients with diffuse gastric cancer can benefit from perioperative *** was no significant difference in survival between patients who received neoadjuvant chemotherapy and those who received adjuvant chemotherapy.

关键词： Gastric cancer Neoadjuvant chemotherapy Adjust chemotherapy Prognosis Survival

A Pt/CeO_(2)Hybrid Nanozyme with Stable Peroxidase Activity for the Detection of Acetylcholine

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Chemical Research in Chinese Universities 2024年第2期40卷 268-271页

作者： CUI Xulian MA Baofu PAN Hui xia Yu LIU Li zhao Baofeng LIANG Zhen ZHANG Lihua ZHANG Yukui State Key Laboratory of Medical Proteomics Dalian Institute of Chemical PhysicsChinese Academy of ScienceDalian116023P.R.China The Research Center for Medical Genomics Key Laboratory of Medical Cell BiologyMinistry of EducationSchool of Life ScienceChina Medical UniversityShenyang110001P.R.China River Fisheries Research Institute Chinese Academy of Fishery SciencesGuangzhou510000P.R.China

Acetylcholine(ACh)is a common neurotransmitterl)that is secreted by cholinergic neurons[2]and is found mainly in the peripheral and central nervous systems.[3]ACh transmits nerve signals from presynaptic to postsynapt... 详细信息

关键词： Acetylcholine/choline Nanozyme Hydrogen peroxide Alzheimer’s disease

Stepwise colloidal lithography toward scalable and various planar chiral metamaterials

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Rare Metals 2024年第2期43卷 723-735页

作者： Xiu Yang Yong Liu Fei-Liang Chen Qian-Qi Lin Rohit Chikkaraddy Shan-Shan Huang Shi-Lin xian Yi-Dong Hou Jing-Lei Du Liang-Ping xia chun-Lei Du School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China Zhuhai Multiscale Optoelectronics Technology Co. Ltd.Zhuhai915060China Hybrid Materials for Opto-Electronics Group Department of Molecules and MaterialsMESA+Institute for NanotechnologyMolecules Center and Center for Brain-Inspired Nano SystemsFaculty of Science and TechnologyUniversity of Twente7500 AEEnschedeThe Netherlands School of Physics and Astronomy University of BirminghamBirminghamB152TTUK College of Physics Sichuan UniversityChengdu610065China Key Laboratory of Micro Nano Optoelectronic Devices and Intelligent Perception Systems Yangtze Normal UniversityChongqing408100China

Chiral metamaterials(CMs)composed by artificial chiral resonators have attracted great attentions in the recent decades due to their strong chiroptical resonance and identifiable interaction with chiral materials,facilitating practical applications in chiral biosensing,chiral emission,and display ***,the complex geometry of CMs improves the fabrication difficulty and hinders their scalable fabrication for practical applications,especially in the visible and ultraviolet *** potential strategy is the colloidal lithography that enables parallel fabrication for scalable and various planar ***,we demonstrate a stepwise colloidal lithography technique that uses sequential deposition from multiple CMs and expand their variety and *** geometry and optical chirality of building blocks from single deposition are systematically investigated,and their combination enables a significant extension of the range of chiral patterns by multiple-step *** approach resulted in a myriad of complex designs with different characteristic sizes,compositions,and shapes,which are particularly beneficial for the development of nanophotonic *** addition,we designed a flexible chiral device based on PDMS,which exhibits a good CD value and excellent stability even after multiple inward and outward *** excellent compatibility to various substrates makes the planar CMs more flexible in practical applications in microfluidic biosensing.

关键词： Chiral metamaterials Colloidal lithography Nanophotonics Metasurfaces Plasmonics Nanofabrications Flexible devices

CNT array-induced nanobubble assembly,nanodisk fabrication and enhanced spectral detection of CNT bundle density

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Nano Research 2024年第8期17卷 7737-7745页

作者： Zhiyuan xia Ziming Ye Bo zhao Tingsong Zhang Qi Wang Kun Chen Meng Li xiaobing Kong Yu-Qing Zheng Enzheng Shi Yuanyuan Shang Anyuan Cao School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking UniversityBeijing 100871China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Engineering Westlake UniversityHangzhou 310024China

Alignment,functionalization and detection of carbon nanotube(CNT)bundles are vital processes for utilizing this onedimensional nanomaterial in ***,we report a polymer-assisted wet shearing method to acquire super-aligned craterpatterned CNT arrays by nanobubble(NB)self-assembly with a"migrate and aggregation"mechanism and use craters to controllably mold even-sized nanodisks periodically along CNT bundles with tunable *** green,low-cost method can be extended to diverse substrates and fabricate different *** an example,the Ag-nanodisk-patterned CNT arrays are utilized as substrates of surface-enhanced Raman scattering(SERS)for rhodamine 6G(R6G)and methylene blue(MB)in which a linear correlation is found between the SERS intensity and the CNT bundle density due to the periodic distribution of hot spots,enabling a spectral detection of CNT bundles and their densities by conventional dye *** from routine morphological characterization,this spectral method possesses an enhanced accuracy and a detection range of 0.1–2μm^(–1),showing its uniqueness in the detection of CNT bundle density since the intensity of traditional spectral merely relates to the quantity of CNTs,exhibiting its potential in future CNT-bundle-based electronics.

关键词： CNT arrays nanobubbles self-assembly nanodisks surface-enhanced Raman scattering(SERS)

Clinical Effect Analysis of Posterior Chamber Intraocular Lens Implantation for Correcting High Myopia and Astigmatism

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Journal of Clinical and Nursing Research 2024年第8期8卷 99-104页

作者： Bo xia Dan Dan zhao Hefei Southeast Eye Hospital Hefei 230000Anhui ProvinceChina Nanjing Southeast Eye Hospital Nanjing 210000Jiangsu ProvinceChina

Objective:To explore the corrective effect of posterior chamber intraocular lens implantation with phakic eyes in the treatment of high myopia and ***:From May 2023,the hospital began to collect the case data of diagnosis and treatment of high myopia and *** May 2024,310 cases were included,all of which were treated with posterior chamber intraocular lens *** visual acuity,astigmatism and axial position of the intraocular lens were observed before and after ***:At different time points after the operation,the patient’s vision was significantly improved compared with that before the operation(P<0.05),and the vision level was equal to or greater than the best-corrected vision before the *** different time points after the operation,the average rotation of the intraocular lens was less than 5 *** was significantly lower than that before the operation(P<0.05).After the operation,the intraocular pressure increased in 11 cases,accounting for 3.55%,with no adverse complications such as lens turbidity,glare and obvious halo ***:The posterior chamber intraocular lens implantation with phakic eyes has an ideal correction effect in the treatment of high myopia and astigmatism,which can effectively improve the vision level of patients and reduce the degree of astigmatism,and has high effectiveness and safety.

关键词： Posterior chamber intraocular lens implantation in phakic eyes High myopia Astigmatism Corrective effect