检索结果-南通市图书馆

Evaluation of the efficacy of neoadjuvant chemotherapy for intermediate and advanced breast cancer by 3.0T MR and ultrasound combined with tumour markers

引用

Clinical Research Communications 2024年第3期7卷 53-60页

作者： Bao-Jun Pan chun-Lei Sun Yu-Hua liu Guo-Zheng Tan chun-yun liu Hai-Jie Xu Qing-Yu Meng Ji-Xuan liu Xiang-Dong Wei Wen-Ming Cao Thyroid and mammary department Shandong Changle People’s HospitalWeifang 262400China. Gynecology Department Pingshan District Central HospitalShenzhen 518122China.

Objective:To evaluate the efficacy of neoadjuvant chemotherapy before and after neoadjuvant chemotherapy for intermediate and advanced breast cancer using 3.0T MR and ultrasound in combination with tumour markers(CEA,CA-153,CA125),and to provide therapeutic references for the clinicians,so as to better satisfy the needs of treatment for intermediate and advanced breast cancer ***:The team collected 30 patients who were diagnosed with intermediate and advanced breast cancer by biopsy and received neoadjuvant chemotherapy,and divided them into sensitive and insensitive groups according to the MP grading of postoperative pathological *** team retrospectively analysed the changes in the values of serum CEA,CA-153,and CA 125 before and after the neoadjuvant chemotherapy,the changes in the average ADC of the lesions before and after the observation by MRI,and the changes in the volume and size of lesions before and after the observation by ultrasonography to assess the effects of neoadjuvant chemotherapy individually,and the results of neoadjuvant chemotherapy were evaluated *** effect of neoadjuvant chemotherapy was assessed *** of the above was evaluated independently,and the accuracy of each item was calculated by comparing the evaluation results with the pathological examination results,and the accuracy of the single item was compared with the accuracy of the three combined tests to determine whether the combined evaluation was more ***:All three examination and testing methods can achieve high accuracy,and the combined evaluation of the three is more accurate than the evaluation of the single way,and the difference is statistically significant(P<0.05).Conclusion:In neoadjuvant chemotherapy for breast cancer patients,the combined assessment of MR,CDFI and tumour markers can more comprehensively and accurately assess the effect of ADC,and more accurately guide the clinical treatment and determine the progn

关键词： breast cancer neoadjuvant chemotherapy MR ultrasound tumour markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyploid organisms

引用

Science China(Life Sciences) 2012年第4期55卷 301-311页

作者： SONG Can liu ShaoJun XIAO Jun HE WeiGuo ZHOU Yi QIN QinBo ZHANG chun liu yun Key Laboratory of Protein Chemistry and Fish Developmental Biology of Ministry of Education of China College of Life Sciences Hunan Normal University Changsha 410081 China

Polyploids are organisms with three or more complete chromosome sets. Polyploidization is widespread in plants and animals, and is an important mechanism of speciation. Genome sequencing and related molecular systematics and bioinformatics studies on plants and animals in recent years support the view that species have been shaped by whole genome duplication during evolution. The stability of polyploids depends on rapid genome recombination and changes in gene expression after formation. The formation of polyploids and subsequent diploidization are important aspects in long-term evolution. Polyploids can be formed in various ways. Among them, hybrid organisms formed by distant hybridization could produce unreduced gametes and thus generate offspring with doubled chromosomes, which is a fast, efficient method of polyploidization. The formation of fertile polyploids not only promoted the interflow of genetic materials among species and enriched the species diversity, but also laid the foundation for polyploidy breeding. The study of polyploids has both important theoretical significance and valuable applications. The production and application of polyploidy breeding have brought remarkable economic and social benefits.

关键词： polyploid whole genome duplication diploidization distant hybridization polyploidy breeding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stannous oxalate as a novel catalyst for the synthesis of polytrimethylene terephthalate

引用

Chinese Chemical Letters 2007年第7期18卷 872-874页

作者： Yu Rong Ren Shu Yong Jia Shou Cai Zhang chun Ling liu yun Cheng Cui Department of Chemistry Jilin Normal University Siping 136000 China

Stannous oxalate was prepared efficiently and characterized by XRD and FT-IR. It exhibited higher catalytic activity and had profitable effect than tetrabutyl titanate and stannous octoate for the synthesis of polytrimethylene terephthalate （PTT） via esterification-route. Over this catalyst, the degree of esterification of pure terephthalic acid was up to 94.4% at 260 ℃ after 1.5 h,while the intrinsic viscosity and content of terminal carboxyl groups of the corresponding PTT polyester, polymerized at 260 ℃,60 Pa for 2 h, was 0.8950 dL/g and 15 mol/t, respectively. Stannous oxalate was a promising catalyst for the synthesis of PTT polyester.

关键词： Polytrimethylene terephthalate Polyester Stannous oxalate Esterification-route Intrinsic viscosity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of rare earth elements on inclusions, microstructure and impact toughness of spring steel

引用

Journal of Iron and Steel Research International 2024年第4期31卷 933-944页

作者： chun-lei Hao Chao-yun Yang Peng liu Yi-kun Luan Bao-guang Sang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Mechanical Engineering and Automation Dalian Polytechnic UniversityDalian 116034LiaoningChina

Spring steel is an indispensable basic part manufacturing material in mechanical equipment,which is widely used in transportation tools such as automobiles,railways,construction machinery and other *** effects of rare earth(RE)on inclusions,microstructure,carbides and impact toughness of 50CrV spring steel were studied by means of optical microscope,scanning electron microscope,transmission electron microscope and impact *** results show that the addition of rare earth can modify the main MnS and Al_(2)O_(3) inclusions in steel to form spherical or near-spherical rare earth inclusions,and the size of inclusions is significantly *** the quenched structure,the size of martensite slab becomes smaller and the structure is *** tempering,the carbide changes from sheet to ellipse,which makes it easier for spring steel to form stress concentration cracks under *** becomes finer and more dispersed,which leads to better pinning of grain boundaries and smaller grain *** impact toughness of 50CrV-RE spring steel increased from 21 to 41 J by 95%due to the improvement of inclusions,microstructure and carbides by rare *** is possible to improve the strength and toughness of spring steel for the improvement of railway running speed and the development of vehicle lightweight in China.

关键词： Rare earth-Spring steel Inclusion Microstructure Impact toughness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dependence of Performance of Organic Light-emitting Devices on Sheet Resistance of Indium-tin-oxide Anodes

引用

Chemical Research in Chinese Universities 2006年第4期22卷 427-431页

作者： ZHOU Liang ZHANG Hong-jie YU Jiang-bo MENG Qing-guo PENG chun-yun liu Feng-yi DENG Rui-ping PENG Ze-ping LI Zhe-feng Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

The dependence of the performance of organic light-emitting devices（OLEDs） on the sheet resistance of indiumtin-oxide（ITO） anodes was investigated by measuring the steady state current density brightness voltage characteristics and the electroluminescent spectra. The device with a higher sheet resistance anode shows a lower current density, a lower brightness level, and a higher operation voltage. The electroluminescence（EL） efficiencies of the devices with the same structure but different ITO anodes show more complicated differences. Furthermore, the shift of the light-emitting zone toward the anode was found when an anode with a higher sheet resistance was used. These performance differences are discussed and attributed to the reduction of hole injection and the increase in voltage drop over ITO anode with the increase in sheet resistance.

关键词： Organic light-emitting device(OLED) Indium-tin-oxide(ITO) Sheet resistance Balance of holes and electrons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rebuilding the theory of isotope fractionation for evaporation of silicate melts under vacuum condition

引用

Acta Geochimica 2024年第4期43卷 661-676页

作者： Jie Wang yun liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China CAS Center for Excellence in Comparative Planetology Hefei 230026China

Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion *** on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations of laboratory experiments due to its oversimplified ***,we point out that the Hertz-Knudsen-equation-based theory is incomplete for silicate melt evaporation cases and can only be used for situations where the vaporized species is identical to the one in the *** propose a new model designed for silicate melt evaporation under *** model considers multiple steps including mass transfer,chemical reaction,and *** derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,*** model can eff ectively reproduce most reported KIFFs of laboratory experiments for various elements,i.e.,Mg,Si,K,Rb,Fe,Ca,and ***,the KIFF-mixing model referring that an overall rate of evaporation can be determined by two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and *** addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts by using the fitting slope in ln(−ln f)versus ln(t).Notably,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.

关键词： Evaporation Kinetic isotopic fractionation Chemical kinetics Hertz-Knudsen equation CAIS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pb induced dislocation defects of PtCo systems: Strain-triggered oxygen reduction reaction for PEMFC

引用

Nano Research 2024年第4期17卷 2462-2472页

作者： chun Jin Qiheng Wang Jingjun liu Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing 100029China Beijing University of Chemical Technology Beijing 100029China

Design and development of advanced electrocatalysts with high performance and low Pt consumption are crucial for reducing the kinetic energy barrier of the cathode oxygen reduction reaction(ORR)and improving the efficiency of proton exchange membrane fuel cells(PEMFC).In this study,we demonstrate a Pb-modulated PtCo system for efficient ORR,in which the inclusion of Pb in ternary alloys induces dislocation defects due to the significant difference in atomic ***-PtCoPb was confirmed to exhibit significantly higher ORR activity and stability in acidic *** practical PEMFC applications,it outperforms the corresponding commercial Pt/C with a mass activity of 0.58 A·mgPt^(-1),making it a promising alternative to state-of-the-art Pt-based *** combination of experimental results and density functional theory(DFT)calculations offers valuable atomic-level insights into the dislocation *** with a larger atomic radius is located in the lattice stretching region below the dislocation slip plane,forming a structure similar to a Cottrell atmosphere,which reduces the dislocation energy and puts the system in a lower energy *** Cottrell atmosphere pins the dislocation structure and stabilizes the ternary *** adjusting the amount of added Pb,a moderate level of dislocation density induces a tuned strain effect,thereby enhancing the electrocatalytic mechanism by optimizing the electronic structure of the alloy surface and the adsorption and desorption of oxygen *** work provides valuable insights into the design and development of lattice dislocation defect structures to trigger strain effects for improving ORR performance.

关键词： dislocation defect strain effect Pb-modulated oxygen reduction reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear volume effects in kinetic isotope fractionation:A case study of mercury oxidation by chlorine species

引用

Acta Geochimica 2024年第3期43卷 411-423页

作者： Chenlu Yang Yining Zhang yun liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

It is well-known that the equilibrium isotope fractionation of mercury(Hg)includes classical massdependent fractionations(MDFs)and nuclear volume effect(NVE)induced mass-independent fractionations(MIFs).However,the effect of the NVE on these kinetic processes is not *** total fractionations(MDFs+NVEinduced MIFs)of several representative Hg-incorporated substances were selected and calculated with ab initio calculations in this work for both equilibrium and kinetic ***-induced MIFs were calculated with scaled contact electron densities at the nucleus through systematic evaluations of their accuracy and errors using the Gaussian09 and DIRAC19 packages(named the electron density scaling method).Additionally,the NVE-induced kinetic isotope effect(KIE)of Hg isotopes are also calculated with this method for several representative Hg oxidation reactions by chlorine *** KIEs for 202 Hg/^(198)Hg ranging from−2.27‰to 0.96‰are *** anomalous^(202)Hg-enriched KIEs(δ^(202)Hg/^(198)Hg=0.83‰,0.94‰,and 0.96‰,)caused by the NVE are observed,which are quite different from the classical view(i.e.,light isotopes react faster than the heavy ones).The electron density scaling method we developed in this study can provide an easier way to calculate the NVE-induced KIEs for heavy isotopes and serve to better understand the fractionation mechanisms of mercury isotope systems.

关键词： Nuclear volume effect Kinetic fractionation Hg isotopes Ab initio calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of the vortical structures on the hydrodynamic performance of a pitching hydrofoil

引用

Journal of Hydrodynamics 2024年第2期36卷 406-420页

作者： Rui Yuan Hui-yun Hao Qin Wu yun-qing liu Biao Huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

The objective is to study the vortical structural behaviors of a transient pitching hydrofoil and their effects on the hydrodynamic performance. The pitching motion of the hydrofoil is set to pitch up with an almost constant rate from 5° to 15° and then back to 5°, with the Reynolds number 4.4×10^(5) and the frequency 2 Hz. The results show that the main coherent structures around the pitching hydrofoil include small-scale laminar separation bubble (LSB), large-scale second vortex (SV) and trailing edge vortex (TEV) which are all vortical. The relationship between the vortical structure and the lift is investigated with the finite-domain impulse theory. It indicates that the major part of the lift is contributed by the LSB, whereas the shedding and the formation of the SV and TEV cause the fluctuation of the lift. The proper orthogonal decomposition (POD) method is applied to capture the most energetic modes, revealing that the LSB mode occupies a large amount of energy in the flow field. The dynamic mode decomposition (DMD) method accurately extracts the dominant frequency and modal characteristics, with the first mode corresponding to the mean flow, the second mode corresponding to the LSB structure and the third and fourth modes corresponding to the vortex shedding.

关键词： Hydrodynamics vortical structures finite-domain impulse theory proper orthogonal decomposition(POD) dynamic mode decomposition(DMD) Pitching hydrofoil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MRm-DLDet:a memory-resident malware detection framework based on memory forensics and deep neural network

引用

Cybersecurity 2024年第1期7卷 88-109页

作者： Jiaxi liu yun Feng Xinyu liu Jianjun Zhao Qixu liu Institute of Information Engineering Chinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China

Cyber attackers have constantly updated their attack techniques to evade antivirus software detection in recent *** popular evasion method is to execute malicious code and perform malicious actions only in ***-cious programs that use this attack method are called memory-resident malware,with excellent evasion capability,and have posed huge threats to cyber *** static and dynamic methods are not effective in detect-ing memory-resident *** addition,existing memory forensics detection solutions perform unsatisfactorily in detection rate and depend on massive expert knowledge in memory *** paper proposes MRm-DLDet,a state-of-the-art memory-resident malware detection framework,to overcome these ***-DLDet first builds a virtual machine environment and captures memory dumps,then creatively processes the memory dumps into RGB images using a pre-processing technique that combines deduplication and ultra-high resolution image cropping,followed by our neural network MRmNet in MRm-DLDet to fully extract high-dimensional features from memory dump files and detect *** receives the labeled sub-images of the cropped high-resolution RGB images as input of ResNet-18,which extracts the features of the *** trains a network of gated recurrent units with an attention ***,it determines whether a program is memory-resident malware based on the detection results of each sub-image through a specially designed voting *** created a high-quality dataset consisting of 2,060 benign and memory-resident *** other words,the dataset contains 1,287,500 labeled sub-images cut from the MRm-DLDet transformed ultra-high resolution RGB *** implement MRm-DLDet for Windows 10,and it performs better than the latest methods,with a detection accuracy of up to 98.34%.Moreover,we measured the effects of mimicry and adversarial attacks on MRm-DLDet,and the experimental results demonstrated the robustness

关键词： Memory-resident malware Memory forensics Malware detection Deep learning Ultra-high resolution image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：