检索结果-南通市图书馆

World Journal of Clinical Cases 2022年第19期10卷 6360-6369页

作者： Chou-Chin Lan Po-chun Hsieh chun-yao huang Mei-Chen Yang Wen-Lin Su Chih-Wei Wu yao-Kuang Wu Division of Pulmonary Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan

Non-small-cell lung cancer(NSCLC)causes significant mortality *** with chronic renal failure have an increased risk of developing *** Patients with chronic renal failure undergoing hemodialysis(HD)often exhibit poor performance,and chemotherapy is generally *** epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKIs)are effective treatment agents for NSCLC ***,the benefits andadverse effects of EGFR-TKIs in NSCLC undergoing HD are *** are noclinical studies on the effects of EGFR-TKIs on NSCLC patients undergoing *** reviewed all previous case reports about EGFR-TKIs in NSCLC patientsundergoing *** is difficult to design studies about the effects of EGFR-TKIs inpatients undergoing HD,and this review is quite ***-TKIs are welltolerated in patients undergoing *** main routes of elimination of EGFRTKIsare metabolism via the liver,and renal elimination is *** doses and pharmacokinetics of these EGFR-TKIs for patientsundergoing HD are similar to those for patients with normal renal *** protein binding of EGFR-TKIs is very high,and it is not necessary toadjust the dose after *** conclusion,EGFR-TKIs are effective and welltolerated in patients undergoing HD.

关键词： Hemodialysis Non-small-cell lung cancer Epidermal growth factor receptor Tyrosine-kinase inhibitors

Design and pricing of maintenance service contract based on Nash non-cooperative game approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第1期35卷 118-129页

作者： SU chun huang Kui School of Mechanical Engineering Southeast UniversityNanjing 211189China

Nowadays manufacturers are facing fierce *** from the products,providing customers with multiple maintenance options in the service contract becomes more popular,since it can help to improve customer satisfaction,and ultimately promote sales and maximize profit for the *** considering the combinations of corrective maintenance and preventive maintenance,totally three types of maintenance service contracts are ***,attractive incentive and penalty mechanisms are adopted in the *** this basis,Nash non-cooperative game is applied to analyze the revenue for both the manufacturer and customers,and so as to optimize the pricing mechanism of maintenance service contract and achieve a win-win *** experiments are *** results show that by taking into account the incentive and penalty mechanisms,the revenue can be improved for both the customers and ***,with the increase of repair rate and improvement factor in the preventive maintenance,the revenue will increase gradually for both the parties.

关键词： maintenance service contract Nash game incentive and penalty mechanism corrective maintenance preventive maintenance

Lesson Learned from COVID-19 Retrospective Study: An Entropy-Based Clinical-Interpretable Scorecard for Mortality Risk Control at ICU Admission

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第1期29卷 34-45页

作者： Chong yao Chonghui huangqi Anpeng huang Laboratory of Network Information Security Beihang UniversityBeijing 100191China Andrew and Erna Viterbi School of Engineering University of Southern CaliforniaLos AnglesCA 90089USA Beijing Goodwill Information and Technology Co. Ltd.and Mobile Health LaboratoryPeking UniversityBeijing 100871China

With severe acute respiratory syndrome coronavirus 2 spreading globally and causing 2019 coronavirus disease(COVID-19),a challenge that we unprepared for was about how to optimally plan and distribute limited top-medical resources for patients in need of urgent *** address this challenge,physicians desperately needed a scientific tool to methodically differentiate between cases with varying *** this study,the unique data of COVID-19 intensive care unit(ICU)patients provided by the national medical team in Wuhan were classified into discrete and continuous variable *** continuous data were discretized using an entropy-based method and transformed into serial information margins,in which each information margin is related to a specific symptom or clinical ***,all these native and processed discrete data were used to configure a readable scorecard through logistic regression,which is the desired scientific tool aforementioned.A total of 322 ICU patients(age:[median:64,interquartile range:54-75],males:178[55.28%],and death:72[22.36%])were included in the *** of mortality in COVID-19 patients can be evaluated using a scorecard model(calibration slope:1.343,Brier:0.048,Dxy=0.972,and population stability index=0.071),with desired model performances(accuracy=0.948,area under curve=0.99,sensitivity=1,and specificity=0.939).This new model can interpret clinical meanings from complex data,and compare it with existing machine learning methods through a black-box *** new data-information model answers a critical question of how a computing algorithm produces clinically meaningful results that will help physicians logically allocate medical resources for COVID-19 ***,this tool has limitations,giving that this research is a retrospective ***,this tool will be tested further and optimized for adaptation to similar clinical cases in the future.

关键词： COVID-19 scorecard clinical-interpretable machine learning ICU admission control

Synthesis and applications of carbon nanospheres:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第4期87卷 325-338页

作者： Yaqi yao Jinming Xu Yanqiang huang Tao Zhang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

The synthesis of carbon nanospheres(CNS)has developed rapidly in recent years,and they are widely used owing to the tunability of their porous structures and surface properties and the unique hydrodynamic advantages conferred by their spherical *** review summarizes the methods used to synthesize CNS and their applications in various *** review first describes the four main methods of CNS synthesis,*** template,spray-drying,hydrothermal carbonization,Stöber and chemical vapor depo-sition ***,applications in the fields of energy storage,adsorption,biological medicine,and catalysis are ***,some insights on the development and design of CNS are presented.

关键词： Carbon nanosphere Synthesis Application

In-situ powder mixing for laser-based directed energy deposition of functionally graded materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Manufacturing 2024年第1期12卷 150-166页

作者： Ji-Peng Chen Shou-chun Xie He huang School of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing210037People’s Republic of China Nanjing Huirui Photoelectric Technology Co. LtdNanjing211121People’s Republic of China

The mixing of powders is a highly relevant field under additive manufacturing,however,it has attracted limited interest to *** in-situ mixing of various powders remains a significant *** paper proposes a new method utilizing a static mixer for the in-situ mixing of multiple powders through the laser-based directed energy deposition(DED)of functionally graded ***,a powder-mixing experimental platform was established;WC and 316L powders were selected for the mixing ***,scanning electron microscopy,energy dispersive spectroscopy,and image processing were used to visually evaluate the homogeneity and proportion of the in-situ mixed ***,powder-mixing simulations were conducted to determine the powder-mixing *** the simulations,a powder carrier gas flow field and particle mixing were ***,a WC/316L metal matrix composite sample was produced using laser-based DED to verify the application potential of the static *** was found that the static mixer could adjust the powder ratio online,and a response time of 1–2 s should be considered when adjusting the ratio of the mixed powder.A feasible approach for in-situ powder mixing for laser-based DED was demonstrated and investigated,creating the basis for functionally graded materials.

关键词： Laser Deposition Static mixer Powder mixing Functionally graded materials

Coupling Analysis of Multiple Machine Learning Models for Human Activity Recognition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第6期79卷 3783-3803页

作者： Yi-chun Lai Shu-Yin Chiang yao-Chiang Kan Hsueh-chun Lin Department of Public Health China Medical UniversityTaichung406040Taiwan Department of Information and Telecommunications Engineering Ming Chuan UniversityGui-ShanTaoyuan333Taiwan Department of Electrical Engineering Yuan Ze UniversityChung-Li32003Taiwan Department and Institute of Health Service Administrations China Medical UniversityTaichung406040Taiwan

Artificial intelligence(AI)technology has become integral in the realm of medicine and healthcare,particularly in human activity recognition(HAR)applications such as fitness and rehabilitation *** study introduces a robust coupling analysis framework that integrates four AI-enabled models,combining both machine learning(ML)and deep learning(DL)approaches to evaluate their effectiveness in *** analytical dataset comprises 561 features sourced from the UCI-HAR database,forming the foundation for training the ***,the MHEALTH database is employed to replicate the modeling process for comparative purposes,while inclusion of the WISDM database,renowned for its challenging features,supports the framework’s resilience and *** ML-based models employ the methodologies including adaptive neuro-fuzzy inference system(ANFIS),support vector machine(SVM),and random forest(RF),for data *** contrast,a DL-based model utilizes one-dimensional convolution neural network(1dCNN)to automate feature ***,the recursive feature elimination(RFE)algorithm,which drives an ML-based estimator to eliminate low-participation features,helps identify the optimal features for enhancing model *** best accuracies of the ANFIS,SVM,RF,and 1dCNN models with meticulous featuring process achieve around 90%,96%,91%,and 93%,*** analysis using the MHEALTH dataset showcases the 1dCNN model’s remarkable perfect accuracy(100%),while the RF,SVM,and ANFIS models equipped with selected features achieve accuracies of 99.8%,99.7%,and 96.5%,***,when applied to the WISDM dataset,the DL-based and ML-based models attain accuracies of 91.4%and 87.3%,respectively,aligning with prior research *** conclusion,the proposed framework yields HAR models with commendable performance metrics,exhibiting its suitability for integration into the healthcare services system through AI-driven applications.

关键词： Human activity recognition artificial intelligence support vector machine random forest adaptive neuro-fuzzy inference system convolution neural network recursive feature elimination

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan yao Tang Tianwen huang Lining Ke En huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Fluid-solid coupling numerical simulation of micro-disturbance grouting treatment for excessive deformation of shield tunnel

在线全文

学校读者我要写书评

暂无评论

Underground Space 2024年第6期19卷 87-100页

作者： Yanjie Zhang Zheng Cao chun Liu Hongwei huang College of Civil Engineering and Architecture Henan University of TechnologyZhengzhou 450001China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

Micro-disturbance grouting is a recovery technique to reduce the excessive deformation of operational shield tunnels in urban *** grout mass behaves as a fluid in the ground before hardening to form a grout–soil mixture,which highlights the necessity of using fluid–solid coupling method in the simulation of grouting *** a discrete element modeling environment,this paper proposes a novel fluid-solid coupling method based on the pore density flow *** demonstrate the effectiveness of this method,it is applied to numerical simulation of micro-disturbance grouting process for treatment of large transverse deformation of a shield tunnel in Shanghai Metro,*** simulation results reveal the mechanism of recovering tunnel convergence by micro-disturbance grouting in terms of compaction and fracture of soil,energy analysis during grouting,and mechanical response of soil-tunnel interaction ***,the influence of the three main grouting parameters(i.e.,grouting pressure,grouting distance,and grouting height)on tunnel deformation recovery efficiency is evaluated through parametric *** order to efficiently recover large transverse deformation of shield tunnel in Shanghai Metro,it is suggested that the grouting pressure should be about 0.55 MPa,the grouting height should be in the range of 6.2–7.0 m,and the grouting distance should be in the range of 3.0–3.6 *** results provide a valuable reference for grouting treatment projects of over-deformed shield tunnel in soft soil areas.

关键词： Fluid-solid coupling Discrete element method Pore density flow Micro-disturbance grouting Soil-tunnel interaction

Enhancing sheepgrass through genomic exploration and targeted editing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第3期67卷 629-630页

作者： Miao Sun Sanwen huang yao Zhou Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Tropical Crop Breeding Shenzhen BranchGuangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Tropical Crop Breeding Chinese Academy of Tropical Agricultural SciencesHaikou 571101China

The growth of grass industry is essential for meeting human needs for proteins and sustaining grassland ecosystems(Bengtsson et al., 2019). Leymus chinensis, also known as sheepgrass, is a perennial Triticeae forage r... 详细信息

关键词： grassland sheep ecosystems

Simulation and reconstruction of particle trajectories in the CEPC drift chamber

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第8期35卷 9-22页

作者： Meng‑yao Liu Wei‑Dong Li Xing‑Tao huang yao Zhang Tao Lin Ye Yuan Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China Institute of High Energy Physics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The circular electron-positron collider(CEPC)is designed to precisely measure the properties of the Higgs boson,study electroweak interactions at the Z-boson peak,and search for new physics beyond the Standard *** a component of the 4th conceptual CEPC detector,the drift chamber facilitates the measurement of charged *** study implemented a Geant4-based simulation and track reconstruction for the drift *** the simulation,detector construction and response were implemented and added to the CEPC simulation *** development of track reconstruction involves track finding using the combinatorial Kalman filter method and track fitting using the tool of *** the simulated data,the tracking performance was *** results showed that both the reconstruction resolution and tracking efficiency satisfied the requirements of the CEPC experiment.

关键词： CEPC Drift chamber Detector simulation Track reconstruction