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Micro RNA transcriptome of skeletal muscle during yak development reveals that miR-652 regulates myoblasts differentiation and survival by targeting ISL1

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Journal of Integrative Agriculture 2023年第5期22卷 1502-1513页

作者： ZHOU Xue-lan GUO Xian LIANG chun-nian CHU Min wu Xiao-yun yan Ping Key Laboratory of Yak Breeding Engineering of Gansu Province Lanzhou Institute of Husbandry and Pharmaceutical SciencesChinese Academy of Agricultural SciencesLanzhou 730050P.R.China Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau Ministry of Agriculture and Rural AffairsLanzhou 730050P.R.China

The growth and development of skeletal muscle also determine the meat production of yak, ultimately affecting the economic benefits. Hence, improving growth performance is a top priority in the yak industry. Skeletal muscle development is a complex process involving the regulation of several genes, including microRNAs(miRNAs). However,the transcription of miRNAs in yak skeletal muscle during prenatal to postnatal stages is unknown. We used small RNA sequencing(small RNA-Seq) to determine the global miRNAs of longissimus dorsi muscle from yak(the samples were collected from three fetuses and three adults). Totally 264 differently expressed miRNAs(|log2(fold change)|>1and P-value≤0.05) were detected between the two groups. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis showed that differently expressed miRNAs-targeted genes participated in pathways associated with muscle development, such as MAPK, PI3K-Akt, and Hippo signaling pathways, etc. MiR-652, which was up-regulated in the fetal group, was transfected into C2C12 myoblasts to examine its role. miR-652 promoted(P≤0.05)proliferation and differentiation, but inhibited(P≤0.001) apoptosis at early period. Furthermore, miR-652 reduced(P≤0.001) the proportion of C2C12 myoblasts in the G1 phase while increasing(P≤0.01) the proportion of cells in the S and G2 phases. Dual-luciferase reporter assays indicated that ISL1 served as a target of miR-652. In general, these findings expand our understanding of yak skeletal muscle miRNAs, and suggested that miR-652 probably regulated myogenesis by regulating ISL1.

关键词： skeletal muscle small RNA sequencing miR-652 C2C12 myoblast /SL1

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Estimation of Turnover and Equilibrium of Soil Organic Matter Using a Mathematical Approach

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Pedosphere 2006年第5期16卷 634-645页

作者： wu chun-yan CHEN Yi WANG Jia-Yu WANG Sheng-Jia Institute of Environmental Resources ＆ Soil Fertilizer Zhejiang Academy of Agricultural Sciences Hangzhou 310021（China）

The methods based on N uptake of aerial-plants, soil organic matter (SOM) dynamics, Jenny's equation, and actual measurement of long-term field experiments in Jiaxing, Quzhou, Huangyan and Hangzhou of Zhejiang Province, China were used to determine the organic mineralization rate being helpful in estimating the organic requirement for SOM equilibrium. The results showed that the estimated mineralization ratios of SOM for Jiaxing and Quzhou were, respectively, 0.0404 and 0.0508 based on N uptake of aerial-plants in non-fertilized plots; 0.0405 and 0.012 using SOM dynamics in non-fertilized plots; and 0.0413 and 0.0513 using the actual investigated data and Jenny's equation. With Jenny's equation, soil organic C balance in manure + N-P-K plots was estimated at nearly 28.8 g kg-1 for Jiaxing and 32.4 g kg-1 for Quzhou with predicted SOM linearly related to the actual investigated values (r2 = 0.9640 for Jiaxing and 0.8541 for Quzhou). To maintain the SOM balance in the non-fertilized plots the recommended rate of organic materials was 3 000-6 600 kg ha-1, and the relevant rates of farm yard manure (FYM) in the manure and N-P-K plots were estimated at 3 375 (dry) and 17670 kg ha-1 (wet) for Jiaxing, 1845 (dry) and 6090 kg ha-1 (wet) for Quzhou.

关键词： equilibrium mathematic modeling rice fields soil organic matter (SOM) turnover

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Supported Pt-Ni bimetallic nanoparticles catalyzed hydrodeoxygenation of dibenzofuran with high selectivity to bicyclohexane

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Chinese Chemical Letters 2022年第1期33卷 234-238页

作者： Pengyu wu chun Cai Chemical Engineering College Nanjing University of Science and TechnologyNanjing 210094China

Catalytic hydrodeoxygenation(HDO)is one of the most effective methods to upgrade the oxygen-containing compounds derived from coal tar to valuable ***,an efficient bimetallic catalyst Pt_(1)Ni_(4)/MgO was prepared and applied in the HDO of dibenzofuran(DBF).High yield(95%)of the desired product bicyclohexane(BCH)was achieved at 240℃and 1.2 MPa of H_(2).Superior catalytic performance could be ascribed to the"relay catalysis"of Pt sites and Ni sites,and the reaction pathway is proposed as ***-up experiment and recyclability test were also performed,which demonstrated the recyclability and promising potential application of Pt_(1)Ni_(4)/MgO.

关键词： Hydrodeoxygenation Dibenzofuran Bicyclohexane Bimetallic catalyst Relay catalysis

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Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes

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World Journal of Clinical Cases 2025年第5期13卷 22-29页

作者： Hong Shi chun Liu Hong-yan Luo Department of Infrastructure Operation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Public Health Minzu Street Community Health Service CenterWuhan 430000Hubei ProvinceChina Caotang Community Health Service Center Chengdu 610031Sichuan ProvinceChina

BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease *** To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with *** One hundred patients with T2DM were selected as the research *** patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table *** conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing *** rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two *** The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both *** cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than

关键词： Community public health care Type 2 diabetes Blood sugar control Self-management ability Cognition level

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On the Covering Number c_λ(3,W_4^((3)),v)

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Acta Mathematicae Applicatae Sinica 2012年第4期28卷 631-638页

作者： yan wu yan-xun CHANG Institute of Mathematics Beijing Jiaotong University

Abstract A t-hyperwhesl （t 〉 3） of length l （or Wz（t） for brevity） is a t-uniform hypergraph （V, E）, where t E= {e1,e2,...,el} and vl,v2,...,vt are distinct vertices of V = Ui=1 ei such that for i= 1,...,1, vi,vi＋1 ∈ei and ei ∩ ej = P, j ∈ {i - 1, i,i ＋ 1}, where the operation on the subscripts is modulo 1 and P is a vertex of V which is different from vi, 1 〈 i 〈 l. In this paper, the minimum covering problem of MCλ（3, W（3）,v） is investigated. Direct and recursive constructions on MCλ（3, W（3）,v） are presented. The covering number cλ（3, W4（3）, v） is finally determined for any positive integers v 〉 5 and A.

关键词： t-(v Г λ) covering excess covering number candelabra (F t)-system

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Continuity of Hardy-Littlewood Maximal Function

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Acta Mathematicae Applicatae Sinica 2020年第4期36卷 982-990页

作者： Di wu Dun-yan yan School of Science Zhejiang University of Science and TechnologyHangzhou 310023China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

In the paper,we characterize a necessary and sufficient condition which ensures the continuities of the non-centered Hardy-Lit tiewood maximal function Mf and the centered Hardy-Lit tiewood maximal function Mcf on R^*** two applications,we can easily deduce that Mcf and Mf are continuous if f is continuous,and Mf is continuous if f is of local bounded variation on R.

关键词： Hardy-Littlewood maximal function bounded variation continuity

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Special Focus on Millimeter Wave Communications Techniques and Devices for 5G—Editorial

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Science China(Information Sciences) 2017年第8期60卷 5-6页

作者： Fu-chun ZHENG Gang wu Harbin Institute of Technology The University of York University of Electronic Science and Technology of China

Due to the rapid development of cost-effective CMOS solutions and recent experimental validation on communications over millimeter wave(mm Wave)bands,which span from 30 to 300 GHz,mm Wave communications technologies are being considered for 5G mobile systems to provide ultra-high data rates for front haul,back haul,and short or middle range broadband *** to the array gain of massive multiple-input multiple-output(m-MIMO)antenna arrays,the heavy path loss of mmWave

关键词： Wave for Editorial Special Focus on Millimeter Wave Communications Techniques and Devices for 5G MIMO on

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Guanosine-5'-triphosphate cyclohydrolase 1 regulated long noncoding RNAs are potential targets for microglial activation in neuropathic pain

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Neural Regeneration Research 2021年第3期16卷 596-600页

作者： yan-Hu Liang Guo-wu Chen Xue-Song Li Shu Jia chun-yang Meng Department of Clinical Medical College Jining Medical UniversityJiningShandong ProvinceChina Neuropathic Pain Institute for Spinal Nerve of Jining Medical University JiningShandong ProvinceChina Department of Spine Surgery Affiliated Hospital of Jining Medical UniversityJiningShandong ProvinceChina Department of Joint Surgery Yanzhou CampusAffiliated Hospital of Jining Medical UniversityJiningShandong ProvinceChina

Several studies have confirmed that microglia are involved in neuropathic *** of guanosine-5′-triphosphate cyclohydrolase 1(GTPCH1)can reduce the inflammation of ***,the precise mechanism by which GTPCH1 regulates neuropathic pain remains *** this study,BV2 microglia were transfected with adenovirus to knockdown GTPCH1 *** throughput sequencing analysis revealed that the mitogen-activated protein kinase(MAPK)related pathways and proteins were the most significantly downregulated molecular ***-expression network analysis of Mapk14 mRNA and five long noncoding RNAs(lnc RNAs)revealed their *** reverse transcription-polymerase chain reaction revealed that among five lnc RNAs,ENSMUST00000205634,ENSMUST00000218450 and ENSMUST00000156079 were related to the downregulation of Mapk14 mRNA *** provide some new potential targets for the involvement of GTPCH1 in neuropathic *** study is the first to note the differential expression of lnc RNAs and mRNA in GTPCH1 knockdown BV2 *** from this study reveal the mechanism by which GTPCH1 activates microglia and provide new potential targets for microglial activation in neuropathic pain.

关键词： cells factors inflammation microglia pain pathway protein RNA

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c.753＿754delAG, a novel CFTR mutation found in a Chinese patient with cystic fibrosis: A case report and review of the literature

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World Journal of Clinical Cases 2019年第15期7卷 2110-2119页

作者： Yu-Qing Wang Chuang-Li Hao wu-Jun Jiang yan-Hong Lu Hui-Quan Sun chun-yan Gao Min wu Department of Respiratory Medicine Children’s Hospital of Soochow University

BACKGROUND Cystic fibrosis(CF)is rare in Asian populations relative to the Caucasian *** this paper,we report the cystic fibrosis transmembrane conductance regulator(CFTR)variation in a family of Chinese CF patients,and systematically review the previous *** SUMMARY Here we report a 30-month-old Chinese girl who was diagnosed with CF based on her history and symptoms such as recurrent productive cough,wheezing with repeated infection of Pseudomonas aeruginosa,and *** computed tomography(CT)scanning revealed obvious exudative lesions and bilateral *** CT scanning revealed a low-density lesion in the left lobe of the liver.A diagnosis of CF was made based upon CFTR gene *** CFTR gene was sequenced using the blood samples of her and her parents and showed a heterozygous novel missense mutation of c.753_754delAG in exon *** addition,a heterozygous c.1240 C>T mutation was found in exon 10 of the *** mutation c.753_754delAG was verified to have been inherited from her mother,and the c.1240 C>T mutation was from her father who was diagnosed with congenital absence of vas *** A novel mutation of CFTR,c.753_754delAG,was found in a Chinese CF child.c.2909G>A is the most common mutation among Chinese CF patients.

关键词： Cystic fibrosis Cystic fibrosis transmembrane conductance regulator Mutation Chinese children Case report

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加强重点实验室大型仪器共享平台的建设

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中国当代医药 2017年第6期24卷 145-148页

作者：袁晓环张春雷武艳张羽飞车忠强牡丹江医学院医药研究中心黑龙江牡丹江157011 牡丹江医学院固定资产管理处黑龙江牡丹江157011

加强重点实验室大型精密仪器的共享运行机制,整合学校现有资源,全力扩大开放使用范围和促进共享水平的提高,进而创建优质的共享资源。本文围绕重点实验室的发展和学校及社会需求,对牡丹江医学院重点实验室大型仪器进行合理布局设计,整... 详细信息

加强重点实验室大型精密仪器的共享运行机制,整合学校现有资源,全力扩大开放使用范围和促进共享水平的提高,进而创建优质的共享资源。本文围绕重点实验室的发展和学校及社会需求,对牡丹江医学院重点实验室大型仪器进行合理布局设计,整合学校资源,构建开放共享体系模式,进一步建立智能管理平台,使仪器平台更科学、规范地为教学科研服务,为学校发展和地方经济建设服务。

关键词：重点实验室仪器共享智能管理

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