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Pulmonary hypertension secondary to seronegative rheumatoid arthritis overlapping antisynthetase syndrome:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9851-9858页

作者： Cheng-yan Huang Ming-Jie Lu Jia-Hua Tian Dai-Shun Liu chun-yan wu Department of Respiratory Medicine The Third Affiliated Hospital of Zunyi Medical University(The First People’s Hospital of Zunyi)Zunyi 563000Guizhou ProvinceChina Clinical School Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patients with seronegative RA(SNRA).It is unclear whether there is an overlap between ASS and RA,or if ASS sometimes mimics *** hypertension(PAH)is common in connective tissue diseases(CTDs).However,published reports on CTD-PAH do not include overlapping CTDs,and its incidence and impact on patient prognosis are *** SUMMARY We report the case of a 63-year-old woman who presented with a 3-mo history of symptom aggravation of recurrent symmetrical joint swelling and pain that had persisted for over 10 *** patient was diagnosed with RA and interstitial lung *** patient repeatedly presented to the hospital’s respiratory and rhe-umatology departments with arthralgia,plus shortness of breath after *** tests indicated that anti-CCP and RF remained negative,while anti-J0-1 and anti-Ro-52 were strongly *** was not until recently that we recognized that this could be an unusual case of SNRA with concurrent *** pain was relieved after regular anti-rheumatic *** computed tomography scans showed that pulmonary interstitial changes did not progress significantly over several years;however,they showed gradual widening of the pulmonary artery,and cardiac ultrasound indicated elevated pulmonary artery systolic *** prescribed treatment of PAH was not effective in improving shortness of *** Overlap of RA and ASS may be *** research is necessary to facilitate early diagnosis,effective evaluation,and prognosis.

关键词： Rheumatoid arthritis Arthritis Antisynthetase syndrome Pulmonary hypertension Pulmonary arterial hypertension Case report

The Application of Kernel Smoothing to Time Series Data

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Acta Mathematicae Applicatae Sinica 2006年第2期22卷 219-226页

作者： Zhao-jun Wang Yi Zhao chun-jie wu yan-ting Li School of Mathematics Nankai University Tianjin 300071 China

There are already a lot of models to fit a set of stationary time series, such as AR, MA, and ARMA models. For the non-stationary data, an ARIMA or seasonal ARIMA models can be used to fit the given data. Moreover, there are also many statistical softwares that can be used to build a stationary or non-stationary time series model for a given set of time series data, such as SAS, SPLUS, etc. However, some statistical softwares wouldn＇t work well for small samples with or without missing data, especially for small time series data with seasonal trend. A nonparametric smoothing technique to build a forecasting model for a given small seasonal time series data is carried out in this paper. And then, both the method provided in this paper and that in SAS package are applied to the modeling of international airline passengers data respectively, the comparisons between the two methods are done afterwards. The results of the comparison show us the method provided in this paper has superiority over SAS＇s method.

关键词： Nonparametric regression kernel smoothing seasonal time series ARIMA model SAS package international airline passengers

Non-ultrawide bandgap CsPbBr_(3) nanosheet for sensitive deep ultraviolet photodetection

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Journal of Materials Science & Technology 2023年第28期159卷 251-257页

作者： chun-yan wu Yu-Xuan Le Li-yan Liang Jing-Yue Li Feng-Xia Liang Shi-Rong Chen Xiao-Ping yang Yu-Xue Zhou Lin-Bao Luo School of Microelectronics Hefei University of TechnologyHefei 230009China College of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

In this study,we report the fabrication of a sensitive deep ultraviolet(DUV)photodetector by using CsPbBr_(3) nanosheets synthesized through confined-space growth at room *** peak pho-toresponse of the device upon illumination blueshifts with decreasing thickness and a 68 nm CsPbBr_(3) nanosheet based device displays a peak response to 265 nm illumination,showing responsivity and spe-cific detectivity of 85 mA/W and 4.05×1011 Jones at 3 V bias,*** simulation re-veals that the blueshift is associated with the wavelength-dependent absorption coefficient of CsPbBr_(3) nanosheet:incident light with shorter wavelengths can be absorbed on the superficial surface,while long-wavelength light has a larger penetration depth,leading to dominant DUV absorption in thinner CsPbBr_(3) *** work will shed light on the facile and cost-effective fabrication of DUV photode-tectors from non-ultrawide bandgap(UWBG)all-inorganic perovskite materials.

关键词： Non-ultrawide bandgap semiconductors CsPbBr_(3)nanosheet Wavelength-dependent absorption coefficient Sensitive DUV photodetector

KAI1 inhibits lymphangiogenesis and lymphatic metastasis of pancreatic cancer in vivo

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 87-92页

作者： Xu Liu Xiao-Zhong Guo Hong-Yu Li Jiang Chen Li-Nan Ren chun-yan wu Department of Gastroenterology General Hospital of Shenyang Military Area

BACKGROUND: Several studies have shown that KAI1 inhibits tumor metastasis, but its mechanism is not clear. The present study aimed to determine the role of KAI1 in lymphatic metastasis, specifically in pancreatic cancer. METHODS: The KAI1 gene was transfected into the pancreatic cancer cell line MIA PaCa-2 and PANC-1 by using liposomes and selected by G418, and the protein was measured by Western blotting. After successful infection, the cell growth curve was studied by MTT, vascular endothelial growth factor C(VEGF-C) secretion by pancreatic cancer cell were measured by ELISA. The KAI1 and pCMV transfected MIA PaCa-2 cells were renamed as MIA PaCa-2-K and MIA PaCa-2-p. These two kinds of cells were injected into the subcuticular layer of nude mice; both tumor growth and metastasis through the lymphatic nodes were assessed. Lymphangiogenesis in tumors was measured by immunohistochemistry. RESULTS: The VEGF-C secretion was significantly reduced in MIA PaCa-2 cells compared with PANC-1 cells after being transfected with the KAI1 gene. The growth rate of subcutaneous tumors was similar after the injection of MIA PaCa-2-K, MIA PaCa-2, and MIA PaCa-2-p. MIA PaCa-2-K tumors showed slower lymphangiogenesis and lymph node metastasis compared with MIA PaCa-2 and MIA PaCa-2-p tumors. CONCLUSION: The overexpression of KAI1 inhibits the lymphangiogenesis and lymph node metastasis of MIA PaCa-2 pancreatic tumors.

关键词： KAI1 pancreatic cancer lymphatic metastasis lymphangiogenesis

Diterpenoids from the Roots of Salvia yunnanensis

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Natural Products and Bioprospecting 2015年第6期5卷 307-312页

作者： Fan Xia chun-yan wu Xing-Wei yang Xian Li Gang Xu School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products Kunming Medical UniversityKunming 650500People’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China

Two new diterpenoids,salyunnanins I and J(1 and 2),together with ten analogues,were isolated from the roots of Salvia *** structures of the new isolates,possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively,were elucidated on the basis of comprehensive spectroscopic *** of the compounds were tested for the inhibitory activities against six human tumor lines in vitro,and several ones showed moderate cytotoxic activities.

关键词： Salvia yunnanensis Diterpenoid Cytotoxicity

A projected gradient based game theoretic approach for multi-user power control in cognitive radio network

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Frontiers of Information Technology & Electronic Engineering 2018年第3期19卷 367-378页

作者： Yun-zheng TAO chun-yan wu Yu-zhen HUANG Ping ZHANG State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications College of Communications Engineering PLA University of Science and Technology

The fifth generation （5G） networks have been envisioned to support the explosive growth of data demand caused by the increasing traditional high-rate mobile users and the expected rise of interconnections between human and things. To accommodate the ever-growing data traffic with scarce spectrum resources, cognitive radio （CR） is considered a promising technology to improve spectrum utilization. We study the power control problem for secondary users in an underlay CR network. Unlike most existing studies which simplify the problem by considering only a single primary user or channel, we investigate a more realistic scenario where multiple primary users share multiple channels with secondary users. We formulate the power control problem as a non-cooperative game with coupled constraints, where the Pareto optimality and achievable total throughput can be obtained by a Nash equilibrium （NE） solution. To achieve NE of the game, we first propose a projected gradient based dynamic model whose equilibrium points are equivalent to the NE of the original game, and then derive a centralized algorithm to solve the problem. Simulation results show that the convergence and effectiveness of our proposed solution, emphasizing the proposed algorithm, are competitive. Moreover, we demonstrate the robustness of our proposed solution as the network size increases.

关键词： Cognitive radio networks Multi-user power control Non-cooperative game Nash equilibrium Projected gradient

Complete Convergence Properties of the Sums for -mixing Sequences of Random Variables

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Chinese Quarterly Journal of Mathematics 2011年第2期26卷 159-163页

作者： wu yan-chun wu Qun-ying School of Science Guilin University of Technology Guilin 541004 China

This paper discusses complete convergence properties of the sums of -mixing random *** a result,we improve the corresponding results of wu Qunying(2001). And extended the Baum and Katz complete convergence to the case of -mixing random sequences by moment inequality and truncating without necessarily adding any extra conditions.

关键词： -mixing random sequences complete convergence moment condition

Interfacial state induced ultrasensitive ultraviolet light photodetector with resolved flux down to 85 photons per second

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Nano Research 2015年第4期8卷 1098-1107页

作者： Yong-Qiang Yu Lin-Bao Luo Ming-Zheng Wang Bo Wang Long-Hui Zeng chun-yan wu Jian-Sheng Jie Jian-Wei Liu Li Wang Shu-Hong Yu School of Electronic Science and Applied Physics Anhui Provincial Key Laboratory of Advanced Functional Materials and Devices Hefei University of Technology Hefei Anhui 230009 China Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Suzhou Jiangsu 215123 China Division of Nanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry University of Science and Technology of China Hefei 230026 China

We present an ultrasensitive ultraviolet （UV） detector based on a p-type ZnS nanoribbon （NR）/indium tin oxide （ITO） Schottky barrier diode （SBD）. The device exhibits a pseudo-photovoltaic behavior which can allow the SBD to detect UV light irradiation with incident power of 6 × 10^-17 W （-85 photons/s on the NR） at room temperature, with excellent reproducibility and stability. The corresponding detectivity and photoconductive gain are calculated to be 3.1 × 10^20 ***1/2.W^-1 and 6.6 × 10^5, respectively. It is found that the presence of the trapping states at the p-ZnS NWITO interface plays a crucial role in determining the ultrahigh sensitivity of this nanoSBDs. Based on our theoretical calculation, even ultra-low photon fluxes on the order of several tens of photons could induce a significant change in interface potential and consequently cause a large photocurrent variation. The present study provides new opportunities for developiphigh-performance optoelectronic devices in the future.

关键词： II-VI group detectivity Schottky barrier diode optoelectronic device interfacial states

Nanochannel-confined growth of crystallographically orientated perovskite nanowire arrays for polarization-sensitive photodetector application

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Science China Materials 2021年第10期64卷 2497-2506页

作者： Rui Huang Di-Hua Lin Jia-Yin Liu chun-yan wu Di wu Lin-Bao Luo School of Electronic Science and Applied Physics Hefei University of TechnologyHefei 230009China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China

Highly ordered perovskite nanowire(PNW)arrays are important building blocks for potential application in integrated optoelectronic devices due to their unique ***,a recordable digital versatile disk-assisted nanochannel-confined growth(NCG)strategy was developed for large-scale growth of different kinds of PNW arrays with preferentially crystallographic orientation on various *** constructed from MAPb I3 NW arrays exhibits prominent photoresponse properties with a responsivity of 20.56 A W^(-1) and specific detectivity of 4.73×10^(12) Jones,*** is more,the photodetector can function as a polarization-sensitive photodetector due to the crystallographic orientation of the one-dimensional PNW arrays,with a polarization ratio of *** proposed NCG strategy provides a cost-efficient and effective method for the fabrication of high-quality PNW arrays with potential applications in future integrated devices and systems.

关键词： nanochannel-confined growth one-dimensional nanostructures optoelectronic devices polarization photodetection template