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Prolonged course of Paxlovid administration in a centenarian with COVID-19:A case report

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World Journal of Radiology 2024年第9期16卷 489-496页

作者： Yi-Xue Zhang Juan Tang Dan Zhu chun-yan wu Mei-Lan Liang Yuan-Tao Huang Department of Healthcare Haikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikou 570208Hainan ProvinceChina Department of Healthcare Hainan Chengmei HospitalHaikou 570000Hainan ProvinceChina

BACKGROUND According to the population statistics in 2023,there were 110000 people aged over 100 years in China,and the experience of using Paxlovid(nirmatrelvir/ritonavir)for centenarians is particularly *** article reports our experience of using Paxlovid in a centenarian with the novel coronavirus disease 2019(COVID-19)*** SUMMARY A 103-year-old female with mild COVID-19 and renal insufficiency was given sufficient Paxlovid for 2 days and a half dose for 3 *** treatment,the patient was complicated with lung infection and heart failure,and nucleic acid remained *** expert consultation,a full dose of Paxlovid was given again on the 9th day of admission for 2 days and a half dose for 3 ***,anti-heart failure and antibiotics were administered;the heart failure and pulmonary infection were ***,on the 33^(th) day of admission,nucleic acid turned negative,body temperature returned to normal,cough and sputum,fatigue,poor appetite and other symptoms basically *** patient was given Paxlovid via nasal feeding for 2 courses without deterioration of liver and kidney function,diarrhea,nausea and vomiting,myalgia,chest tightness and other side effects,and was discharged from hospital with good *** This case suggests that Paxlovid can be used cautiously in centenarians with renal insufficiency and two courses of treatment can be considered in patients with persistent positive nucleic acid.

关键词： COVID-19 Paxlovid Centenarians Renal insufficiency Heart failure Lung infection Case report

Pulmonary hypertension secondary to seronegative rheumatoid arthritis overlapping antisynthetase syndrome:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9851-9858页

作者： Cheng-yan Huang Ming-Jie Lu Jia-Hua Tian Dai-Shun Liu chun-yan wu Department of Respiratory Medicine The Third Affiliated Hospital of Zunyi Medical University(The First People’s Hospital of Zunyi)Zunyi 563000Guizhou ProvinceChina Clinical School Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patients with seronegative RA(SNRA).It is unclear whether there is an overlap between ASS and RA,or if ASS sometimes mimics *** hypertension(PAH)is common in connective tissue diseases(CTDs).However,published reports on CTD-PAH do not include overlapping CTDs,and its incidence and impact on patient prognosis are *** SUMMARY We report the case of a 63-year-old woman who presented with a 3-mo history of symptom aggravation of recurrent symmetrical joint swelling and pain that had persisted for over 10 *** patient was diagnosed with RA and interstitial lung *** patient repeatedly presented to the hospital’s respiratory and rhe-umatology departments with arthralgia,plus shortness of breath after *** tests indicated that anti-CCP and RF remained negative,while anti-J0-1 and anti-Ro-52 were strongly *** was not until recently that we recognized that this could be an unusual case of SNRA with concurrent *** pain was relieved after regular anti-rheumatic *** computed tomography scans showed that pulmonary interstitial changes did not progress significantly over several years;however,they showed gradual widening of the pulmonary artery,and cardiac ultrasound indicated elevated pulmonary artery systolic *** prescribed treatment of PAH was not effective in improving shortness of *** Overlap of RA and ASS may be *** research is necessary to facilitate early diagnosis,effective evaluation,and prognosis.

关键词： Rheumatoid arthritis Arthritis Antisynthetase syndrome Pulmonary hypertension Pulmonary arterial hypertension Case report

The Application of Kernel Smoothing to Time Series Data

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Acta Mathematicae Applicatae Sinica 2006年第2期22卷 219-226页

作者： Zhao-jun Wang Yi Zhao chun-jie wu yan-ting Li School of Mathematics Nankai University Tianjin 300071 China

There are already a lot of models to fit a set of stationary time series, such as AR, MA, and ARMA models. For the non-stationary data, an ARIMA or seasonal ARIMA models can be used to fit the given data. Moreover, there are also many statistical softwares that can be used to build a stationary or non-stationary time series model for a given set of time series data, such as SAS, SPLUS, etc. However, some statistical softwares wouldn＇t work well for small samples with or without missing data, especially for small time series data with seasonal trend. A nonparametric smoothing technique to build a forecasting model for a given small seasonal time series data is carried out in this paper. And then, both the method provided in this paper and that in SAS package are applied to the modeling of international airline passengers data respectively, the comparisons between the two methods are done afterwards. The results of the comparison show us the method provided in this paper has superiority over SAS＇s method.

关键词： Nonparametric regression kernel smoothing seasonal time series ARIMA model SAS package international airline passengers

Non-ultrawide bandgap CsPbBr_(3) nanosheet for sensitive deep ultraviolet photodetection

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Journal of Materials Science & Technology 2023年第28期159卷 251-257页

作者： chun-yan wu Yu-Xuan Le Li-yan Liang Jing-Yue Li Feng-Xia Liang Shi-Rong Chen Xiao-Ping yang Yu-Xue Zhou Lin-Bao Luo School of Microelectronics Hefei University of TechnologyHefei 230009China College of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

In this study,we report the fabrication of a sensitive deep ultraviolet(DUV)photodetector by using CsPbBr_(3) nanosheets synthesized through confined-space growth at room *** peak pho-toresponse of the device upon illumination blueshifts with decreasing thickness and a 68 nm CsPbBr_(3) nanosheet based device displays a peak response to 265 nm illumination,showing responsivity and spe-cific detectivity of 85 mA/W and 4.05×1011 Jones at 3 V bias,*** simulation re-veals that the blueshift is associated with the wavelength-dependent absorption coefficient of CsPbBr_(3) nanosheet:incident light with shorter wavelengths can be absorbed on the superficial surface,while long-wavelength light has a larger penetration depth,leading to dominant DUV absorption in thinner CsPbBr_(3) *** work will shed light on the facile and cost-effective fabrication of DUV photode-tectors from non-ultrawide bandgap(UWBG)all-inorganic perovskite materials.

关键词： Non-ultrawide bandgap semiconductors CsPbBr_(3)nanosheet Wavelength-dependent absorption coefficient Sensitive DUV photodetector

KAI1 inhibits lymphangiogenesis and lymphatic metastasis of pancreatic cancer in vivo

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 87-92页

作者： Xu Liu Xiao-Zhong Guo Hong-Yu Li Jiang Chen Li-Nan Ren chun-yan wu Department of Gastroenterology General Hospital of Shenyang Military Area

BACKGROUND: Several studies have shown that KAI1 inhibits tumor metastasis, but its mechanism is not clear. The present study aimed to determine the role of KAI1 in lymphatic metastasis, specifically in pancreatic cancer. METHODS: The KAI1 gene was transfected into the pancreatic cancer cell line MIA PaCa-2 and PANC-1 by using liposomes and selected by G418, and the protein was measured by Western blotting. After successful infection, the cell growth curve was studied by MTT, vascular endothelial growth factor C(VEGF-C) secretion by pancreatic cancer cell were measured by ELISA. The KAI1 and pCMV transfected MIA PaCa-2 cells were renamed as MIA PaCa-2-K and MIA PaCa-2-p. These two kinds of cells were injected into the subcuticular layer of nude mice; both tumor growth and metastasis through the lymphatic nodes were assessed. Lymphangiogenesis in tumors was measured by immunohistochemistry. RESULTS: The VEGF-C secretion was significantly reduced in MIA PaCa-2 cells compared with PANC-1 cells after being transfected with the KAI1 gene. The growth rate of subcutaneous tumors was similar after the injection of MIA PaCa-2-K, MIA PaCa-2, and MIA PaCa-2-p. MIA PaCa-2-K tumors showed slower lymphangiogenesis and lymph node metastasis compared with MIA PaCa-2 and MIA PaCa-2-p tumors. CONCLUSION: The overexpression of KAI1 inhibits the lymphangiogenesis and lymph node metastasis of MIA PaCa-2 pancreatic tumors.

关键词： KAI1 pancreatic cancer lymphatic metastasis lymphangiogenesis

Diterpenoids from the Roots of Salvia yunnanensis

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Natural Products and Bioprospecting 2015年第6期5卷 307-312页

作者： Fan Xia chun-yan wu Xing-Wei yang Xian Li Gang Xu School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products Kunming Medical UniversityKunming 650500People’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China

Two new diterpenoids,salyunnanins I and J(1 and 2),together with ten analogues,were isolated from the roots of Salvia *** structures of the new isolates,possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively,were elucidated on the basis of comprehensive spectroscopic *** of the compounds were tested for the inhibitory activities against six human tumor lines in vitro,and several ones showed moderate cytotoxic activities.

关键词： Salvia yunnanensis Diterpenoid Cytotoxicity

A projected gradient based game theoretic approach for multi-user power control in cognitive radio network

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Frontiers of Information Technology & Electronic Engineering 2018年第3期19卷 367-378页

作者： Yun-zheng TAO chun-yan wu Yu-zhen HUANG Ping ZHANG State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications College of Communications Engineering PLA University of Science and Technology

The fifth generation （5G） networks have been envisioned to support the explosive growth of data demand caused by the increasing traditional high-rate mobile users and the expected rise of interconnections between human and things. To accommodate the ever-growing data traffic with scarce spectrum resources, cognitive radio （CR） is considered a promising technology to improve spectrum utilization. We study the power control problem for secondary users in an underlay CR network. Unlike most existing studies which simplify the problem by considering only a single primary user or channel, we investigate a more realistic scenario where multiple primary users share multiple channels with secondary users. We formulate the power control problem as a non-cooperative game with coupled constraints, where the Pareto optimality and achievable total throughput can be obtained by a Nash equilibrium （NE） solution. To achieve NE of the game, we first propose a projected gradient based dynamic model whose equilibrium points are equivalent to the NE of the original game, and then derive a centralized algorithm to solve the problem. Simulation results show that the convergence and effectiveness of our proposed solution, emphasizing the proposed algorithm, are competitive. Moreover, we demonstrate the robustness of our proposed solution as the network size increases.

关键词： Cognitive radio networks Multi-user power control Non-cooperative game Nash equilibrium Projected gradient

Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin wu yan Sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： Zhi-xiong Bai Xiao-chun wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress