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Some rigid results on doubly twisted product complex Finsler manifolds

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Science China Mathematics 2025年第2期68卷 421-432页

作者： Hongchuan Xia Wei xiao chunping zhong School of Mathematics and Statistics Xinyang Normal UniversityXinyang 464000China School of Mathematical Sciences Xiamen UniversityXiamen 361005China

Let(M1×(λ_(1),λ_(2))M_(2),F)be a doubly twisted product complex Finsler manifold of two strongly pseudoconvex complex Finsler manifolds(M_(1),F_(1))and(M_(2),F_(2)).Denote by M the product manifold of M1and M_(2).In this paper,we first give the characterization for(M,F)to be of constant holomorphic curvature,and prove that(M,F)is of constant holomorphic curvature if and only if(M,F),(M_(1),F_(1)),and(M_(2),F_(2))all have vanishing holomorphic curvature under the condition that lnλ_(1)and lnλ_(2)are both pluriharmonic ***,we obtain the classification for(M,F)to be a complex Landsberg ***,we prove that a strongly convex doubly twisted product complex Finsler manifold(M,F)is projectively flat(*** flat)if and only ifλ_(1)F1andλ_(2)F_(2)are both complex Minkowski metrics.

关键词： doubly twisted product complex Finsler manifold holomorphic curvature complex Landsberg manifold

The ethics of theft:Reevaluating the impacts of floral larceny on plant reproductive success

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Plant Diversity 2025年第1期47卷 148-158页

作者： Jin-Ru zhong xiao-Fang Jin Michael C.Orr xiao-Qing Li Yong-Deng He Sheng-Wei Wang Qing-Feng Wang chun-Feng Yang zhong-Ming Ye College of Life Science Wuhan UniversityWuhan 430072China Entomologie Staatliches Museum für Naturkunde StuttgartStuttgart 70191Germany Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Plant Diversity and Specialty Crops Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China

Plants and their interaction partners offer unparalleled views of evolutionary *** larceny,entailing nectar extraction without pollinating,is thought to be an example of a harmful,antagonistic behavior,but the precise consequences of floral larceny on plant reproductive success remain *** conducted a comprehensive meta-analysis of 153 studies across 120 plant species,using 14 moderators to assess the effects of floral larceny on plant reproductive success and examine the key *** found that floral larceny negatively impacts flower traits,pollinator visitation,pollen deposition,and fruit set,while having a neutral effect on critical female fitness indicators,such as seed set and seed quality,as well as on male *** altering pollinator behavior,floral larceny may reduce geitonogamy,potentially enhancing genetic ***,factors such as pollinator type,plant mating system,and pollen limitation were identified as key moderators of these *** analysis reveals an ultimately neutral effect of floral larceny on plant reproductive success,with potential benefits in certain *** findings suggest that floral larceny plays a complex and multifaceted role within plant-pollinator interactions,facilitating the evolutionary stability and coexistence of floral larcenists and host plants.

关键词： Floral larceny Nectar robbing Nectar thief Plant-pollinator interactions Plant reproductive success Indirect effects

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-chun Yuan xiao Liu Mao-Ju Tang Man Luo xiao-Wu zhong Qiang Ma xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

Metamorphic P-T-t Evolution of Granulite in the Yishui Area:New Insights into the Tectonic Evolution of the Eastern Block,North China Craton

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 69-82页

作者： CHEN Ziyuan YUAN Mingkao zhong Zhenyu LI Tianqi WANG Guodong xiao Lingling School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Shandong Provincial Key Laboratory of Water and Soil Conservation and Environmental Protection/School of Resources and Environment Linyi UniversityLinyiShandong 276000China Shandong Institute of Geophysical and Geochemical Exploration Jinan 250013China Institute of Digital Geology and Energy Linyi UniversityLinyiShandong 276000China

The Yishui complex,located in the western Shandong area of the North China Craton,is representative of the Archean crystalline basement of the North China Craton to explore the early tectonic-thermal evolution history of the *** petrography,mineral chemistry,metamorphic evolution and zircon U-Pb dating are presented for felsic granulite and two-pyroxene granulite from the Yishui complex to contribute to new insights into the Neoarchean tectonic evolution of the North China *** mineral assemblages are recognized for these granulite samples,including the prograde(M1),peak(M2)and retrograde(M3)mineral *** geothermobarometry and phase equilibrium modeling yield P-T conditions of 6.5-10.9 kbar/718-839℃ for the peak metamorphism,which define a medium-pressure granulite-facies metamorphism occurred at middle to lower *** P-T paths with near-isobaric cooling(IBC)retrograde segments were *** LA-ICP-MS U-Pb dating suggests that the protolith of the felsic granulite was emplaced at 2541±7 Ma and the subsequent medium-pressure granulite-facies metamorphism occurred at 2518-2494 Ma.A two-stage mantle plume related crustal-scale sagduction geodynamic regime is proposed in the western Shandong terrane in the Neoarchean.

关键词： metamorphic evolution geochronology granulite Yishui complex North China Craton

Influence of Al,Cu and Mn additions on diffusion behaviors in CoCrFeNi high-entropy alloys

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 184-193页

作者： Juan CHEN Zhen-zhong ZHANG Jin-kun xiao Li-jun ZHANG Testing Center Yangzhou UniversityYangzhou 225009China School of Mechanical Engineering Yangzhou UniversityYangzhou 225009China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

The interdiffusion coefficients in Al_(0.2)CoCrFeNi,CoCrCu_(0.2)FeNi,and CoCrFeMn_(0.2)Ni high-entropy alloys were efficiently determined by combining diffusion couple experiments and high-throughput determination of interdiffusion coefficients(HitDIC)software at 1273−1373 *** results show that the addition of Al,Cu,and Mn to CoCrFeNi high-entropy alloys promotes the diffusion of Co,Cr,and Fe *** comparison of tracer diffusion coefficients indicates that there is no sluggish diffusion in tracer diffusion on the thermodynamic temperature scale for the present Al_(0.2)CoCrFeNi,CoCrCu_(0.2)FeNi,and CoCrFeMn_(0.2)Ni high-entropy *** linear relationship between diffusion entropy and activation energy reveals that the diffusion process of atoms is unaffected by an increase in the number of components as long as the crystal structure remains unchanged.

关键词： Co−Cr−Fe−Ni high-entropy alloy diffusion interdiffusivity diffusion couple

IL-17A mediates inflammation-related retinal pigment epithelial cells injury via ERK signaling pathway

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 15-27页

作者： Hui-Min zhong Bing-Qiao Shen Yu-Hong Chen xiao-Huan Zhao xiao-Xu Huang Min-Wen Zhou xiao-Dong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China National Clinical Research Center for Ophthalmic Diseases Shanghai 200080China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Key Laboratory of Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China

AIM:To investigate whether interleukin-17A(IL-17A)gets involved in the mechanisms of inflammation-related retinal pigment epithelium(RPE)cells injury and its significance in age-related macular degeneration(AMD).MRTHODS:A sodium iodate(NaIO3)mouse model as well as IL-17A-/-mice were *** effects of inflammatory cytokines in RPE cells and retinal microglia before and after NaIO3 modeling in vivo and in vitro,were investigated using immunofluorescence,immunoprotein blotting,and quantitative real-time fluorescence polymerase chain reaction(qRT-PCR),*** using recombinant IL-17A protein(rIL-17A)or IL-17A neutralizing antibody(IL-17A NAb)were used to observe the subsequent differences in fundus,fundus photography and optical coherence tomography(OCT),cell viability,and expression of oxidative stress-related markers before and after modeling,and to screen for key signaling ***:In the scenario of NaIO3 stimulation,RPE cells obviously tended to *** proliferation and activation of retinal microglia was confirmed in NaIO3-stimulated mice,whereas such effects induced by NaIO3 were significantly ameliorated with IL-17A NAb intervention or in IL-17A-/-*** addition,IL-17A promoted the proliferation and activation of microglia as well as oxidative damage and the secretion of inflammatory cytokines alongside NaIO3-induced damage in RPE cells in vivo and ex ***,the extracellular signalregulated kinase(ERK)signaling pathway was shown to be participated in the regulation of NaIO3-induced RPE cells injury mediated by IL-17A in vivo and ex vivo,as IL-17A induced inflammatory cytokines release in the NaIO3 model was alleviated after blocking the ERK ***:IL-17A probably promotes the NaIO3-induced RPE cells injury through exacerbating inflammation in terms of retinal microglia activation and inflammatory cytokines release via ERK signaling *** of IL-17A may be a new potential ta

关键词： age-related macular degeneration retinal pigment epithelium NaIO3 microglia IL-17A

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： xiaoling zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Bidirectional regulation of the cyclic guanosine monophosphateadenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 246-261页

作者： Ai-Yu Nie zhong-Hui xiao Jia-Li Deng Na Li Li-Yuan Hao Sheng-Hao Li xiao-Yu Hu College of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Infection Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are *** cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune *** a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in ***,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor *** To investigate the dual-regulation mechanism of cGAS-STING in *** This review was conducted according to the PRISMA *** study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science *** rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC *** All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 *** removing duplicates,remaining 964 records were ***,55 articles met the inclusion criteria and were included in this *** Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its *** cGAS-STING pathway activation will result in a suppressive tumor microenvironment.

关键词： Hepatocellular carcinoma Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene Interferon genes The metastasis of a tumor Immunology

Influence of heat treatment on microstructure of a newβ-solidifyingγ-TiAl alloy

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Journal of Iron and Steel Research International 2025年第1期32卷 239-248页

作者： Li Quan xiao-bing Li Peng Xue Jun-jie Hao Kun Qian Bo Chen Jian-zhong Li Kui Liu School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Department of Materials Science and Technology Ji Hua LaboratoryFoshan528200GuangdongChina

The high strength and stability of the full-lamellar structure guarantee the industrial application of theβ-solidifyingγ-TiAl ***,it is a huge challenge to design an alloy with good hot-deformability as well as the full-lamellar *** low-cost Ti-42.5Al-2Mn-0.4Mo-0.1B-0.1C(at.%)alloy was designed,which undergoes bothβandαsingle-phase region during the *** is found that the full-lamellar structure can be obtained by the solution heat treatment at 1230℃ for 20 min and then aging treatment at 800℃ for 3 ***,a new microstructure,namely,the pearlitic-like microstructure(PM)induced by theα_(2)/γ→βo+γcellular reaction was observed when the aging temperature is increased to above 800℃.The volume fraction of the PM is gradually increased from 0%to 25.5%,65%,and 94%according to elevated aging temperature from 800 to 900,1000,and 1050℃,*** mechanism of the reducedα_(2)/γlamellae and PM formation was discussed regarding the heterogeneous distribution ofβstabilizing elements and the interface energy stored inα_(2)/γlamellae.

关键词： β-γ-TiAl Alloy design Two-step heat treatment Full-lamellar structure Cellular reaction