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Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1500-1513页

作者： Jian-Rong Sun Dong-Mei chen Rong Huang Rui-Tao Wang Li-Qun Jia School of Clinical Medicine Beijing University of Chinese MedicineBeijing 100029China Integrated Chinese and Western Medicine Oncology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most common malignancies worldwide,and its development comprises a multistep process from intraepithelial neoplasia(IN)to carcinoma(CA).However,the critical regulators and underlying molecular mechanisms remain largely *** To explore the genes and infiltrating immune cells in the microenvironment that are associated with the multistage progression of ESCC to facilitate diagnosis and early *** A mouse model mimicking the multistage development of ESCC was established by providing warter containing 4-nitroquinoline 1-oxide(4NQO)to C57BL/6 ***,we established a control group without 4NQO treatment of ***,transcriptome sequencing was performed for esophageal tissues from patients with different pathological statuses,including low-grade IN(LGIN),high-grade IN(HGIN),and CA,and controlled normal tissue(NOR)*** expressed genes(DEGs)were identified in the LGIN,HGIN,and CA groups,and the biological functions of the DEGs were analyzed via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment *** CIBERSORT algorithm was used to detect the pattern of immune cell ***(IHC)was also conducted to validate our ***,the Luminex multiplex cytokine analysis was utilized to measure the serum cytokine levels in the *** Compared with those in the NOR group,a total of 681541,and 840 DEGs were obtained in the LGIN,HGIN,and CA groups,*** the intersection of the three sets of DEGs,we identified 86 genes as key genes involved in the development of *** analysis revealed that these genes were enriched mainly in the keratinization,epidermal cell differentiation,and interleukin(IL)-17 signaling *** analysis revealed that,compared with those in the NOR group,M0 and M1 macrophages in the 4NQO group showed stronger infiltration,which was validated by *** cytok

关键词： Esophageal squamous cell carcinoma Intraepithelial neoplasia Tumorigenesis Transcriptome sequencing Biomarkers Immune cell infiltration 4-nitroquinoline 1-oxid

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Y–Z deformable magnetic ring for the treatment of rectal stricture: A case report and review of literature

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World Journal of Gastroenterology 2024年第6期30卷 599-606页

作者： Miao-Miao Zhang Huan-chen Sha Yuan-Fa Qin Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Treatment of postoperative anastomotic stenosis for colorectal cancer is often challenging,especially for patients who do not respond well to *** cases where patients have undergone an enterostomy,the stenosis can be easily resolved through magnetic ***,common magnetic compre-ssion techniques cannot be performed on those without *** design-ed a novel Y–Z deformable magnetic ring(Y–Z DMR)and successfully applied it to a patient with a stenosis rectal anastomosis and without enterostomy after rectal cancer *** SUMMARY We here report the case of a 57-year-old woman who had undergone a laparo-scopic radical rectum resection(Dixon)for rectal ***,she started facing difficulty in defecation 6 months after *** colonoscopy indicated stenosis of the rectal *** balloon dilation was performed six times on ***,the stenosis still showed a trend of gradual *** the patient did not undergo an enterostomy,the conventional endoscopic magnetic compression technique could not be ***,we imple-mented a Y–Z DMR implemented through the anus under single *** magnetic ring fell off nine days after the operation and the rectal stenosis was *** patient was followed up for six months and reported good *** The Y–Z DMR deformable magnetic ring is an excellent treatment strategy for patients with rectal stenosis and without enterostomy.

关键词： Anastomotic stenosis Colorectal cancer Magnetosurgery Magnetic compression technique Magnetic surgery clinic Case report

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Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma

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BIOCELL 2024年第4期48卷 639-651页

作者： JIAN TANG chenQIANG ZHU YUN chen YUNLONG WU MING HE YI ZHOU MINGHUA XIE Department of Intensive Care Unit The First People’s Hospital of Linping DistrictHangzhouChina Department of Pharmacy The First People’s Hospital of Linping DistrictHangzhouChina

Background:The speciﬁc impact of sphingolipid metabolism on developing hepatocellular Carcinoma(HCC)remains *** study aims to explore the relationship between sphingolipid metabolism and HCC prognosis,immune response,and drug ***:Data were obtained from The Cancer Genome Atlas(TCGA)-Hepatocellular Carcinoma(LIHC)and Gene Expression Omnibus(GEO,GSE14520 datasets).47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)*** classifying HCC samples using the Non-negative Matrix Factorization(NMF)clustering method,differentially expressed genes were ***,8 risk genes were obtained by univariate analysis,survival random forest reduction and lasso *** expression of 8 risk genes was veriﬁed in ***:8 risk genes were used to construct the Sphingolipid score ***-Sphingolipid score predicted poor prognosis of HCC *** score was associated with immune checkpoints(IL-1B,TLR4,TGFB1,and IL-10),immune cells(Th2,Treg,MDSC,Neutrophil,Fibroblasts and macrophage),and MAPK *** the High-Sphingolipid score group,a signiﬁcantly higher proportion of patients with TP53(p53)mutations was signiﬁcantly higher(56%).Furthermore,patients with a high-Sphingolipid score were predicted to have a higher sensitivity to chemotherapy *** vitro validation showed that compared with normal liver cells LX-2,TRIM47,and S100A9 signiﬁcantly increased in liver cancer cells Hep G2,MHCC-97H,and Hep3B2.1-7,while SLC1A7,LPCAT1,and CFHR4 signiﬁcantly *** TRIM47 reduced the proliferation and promoted *** levels of ceramide synthesis-related indexes(CERS1,CERS6,CERS5,and SPTLC2)increased,and the ACER3 related to catalytic hydrolysis ***:We constructed a sphingolipid metabolism-related prognostic signature(Sphingolipid score)based on 8 risk ***47 may affect the development of liver cancer by regulating the relevant indicators of

关键词： Hepatocellular carcinoma Sphingolipid metabolism TRIM47 Prognosis

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Visible-light-activated aziridination reaction enables simultaneous resolving of C=C bond location and the sn-position isomers in lipids

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Chinese Chemical Letters 2024年第4期35卷 481-485页

作者： Qiongqiong Wan Yanan Xiao Guifang Feng Xin Dong Wenjing Nie Ming Gao Qingtao Meng Suming chen The Institute for Advanced Studies Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China

There is a close relationship between the biological functions of lipids and their structures, and various isomers greatly increases the complexity of lipid structures. The C=C bond location and sn-position are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Here, we develop a visible-light-activated aziridination reaction system, which enables the dual-resolving of the C=C bond location and sn-position isomerism of in lipids when combines with liquid chromatography-mass spectrometry(LC-MS). Based on the derivatization of C=C bonds with Ph I=NTs, their location in lipids could be easily identified by tandem MS. Especially, the sn-position isomers of unsaturated phosphatidylcholine(PC) can be separated and quantified by LC-MS after the derivatization. By using the proposed method, the significant changes of the sn-position isomers ratios of PC in mouse brain ischemia were revealed. This study offers a powerful tool for deep lipid structural biology.

关键词： Aziridination Lipid isomers C=C bond location sn-Position Mass spectrometry

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Abiotic transformation of chlorinated organics at the active surface of iron-bearing minerals in soils and sediments

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Science China Technological Sciences 2024年第10期67卷 2991-3008页

作者： LI XuXin YAN chen ZENG YuXi LI WenBin PENG TianWei SONG Biao ZHOU chengYun College of Environmental Science and Engineering Hunan University Key Laboratory of Environmental Biology and Pollution Control (Hunan University) Ministry of Education

Chlorinated organic compounds are emerging pollutants of widespread concern because of their toxicity, bioaccumulation,persistence, and lack of adequate regulatory measures. Their abiotic transformation, facilitated by iron-bearing minerals, is critical to their natural dissipation in soils and sediments. However, further exploration is needed to understand their underlying mechanisms and potential engineering applications under different redox conditions. This paper reviews the abiotic transformation behaviors and mechanisms of chlorinated organics at the active surface of iron-bearing minerals under anoxic and oxic conditions and summarizes the strategies for enhancing the abiotic transformation efficiency of chlorinated organics. The abiotic transformation rate under oxic conditions can be a few orders of magnitude higher than that under anoxic conditions. Under anoxic conditions, chlorinated organics undergo reductive dechlorination through reductive elimination, hydrogenolysis, dehydrohalogenation, and nucleophilic substitution. A close relationship between the abiotic transformation of chlorinated organics and the production of hydroxyl radicals by iron-bearing minerals under oxic conditions was discovered. Synthetic active iron-bearing minerals, carbonaceous materials, and biological synergy can facilitate abiotic dechlorination under anoxic conditions. Meanwhile, the regulation of redox conditions, the introduction of ligands, and the utilization of coexisting anions are proposed to enhance oxidative degradation. This study is expected to improve the comprehension of the abiotic degradation of chlorinated organics mediated by iron-bearing minerals and provide the theoretical foundation for developing new approaches aimed at addressing chlorinated organic pollution.

关键词： chlorinated organic compounds iron-bearing minerals dechlorination degradation remediation

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CFRP-PVC管约束珊瑚海水海砂混凝土柱轴压性能试验研究及有限元分析

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硅酸盐通报 2024年第3期43卷 891-904页

作者：朱和龙许瑞天梁宇涵梁莹杨倩陈宗平广西恒正建设工程质量检测有限公司防城港538001 广西大学土木建筑工程学院南宁530004 广西大学工程防灾与结构安全教育部重点试验室南宁530004 南宁学院土木与建筑工程学院南宁530200 广西职业师范学院土木建筑工程学院南宁530007

为研究碳纤维增强聚合物-聚氯乙烯复合管(CFRP-PVC)约束珊瑚海水海砂混凝土(CSSC)柱的轴心受压性能,对6个试件进行轴心受压加载试验和有限元参数分析,重点研究了PVC管内、外表面CFRP层数和脱空缺陷对该组合柱轴压性能的影响。结果表明,C... 详细信息

为研究碳纤维增强聚合物-聚氯乙烯复合管(CFRP-PVC)约束珊瑚海水海砂混凝土(CSSC)柱的轴心受压性能,对6个试件进行轴心受压加载试验和有限元参数分析,重点研究了PVC管内、外表面CFRP层数和脱空缺陷对该组合柱轴压性能的影响。结果表明,CFRP-PVC管可以有效约束CSSC,使其处于三轴受压状态,当内、外壁均粘贴CFRP时可以有效减缓突然破坏的特征。相同情况下,管内壁粘贴1层CFRP时具有更好的延性和承载力,管外壁粘贴2层CFRP时约束应力提高系数高达121.5%,脱空缺陷仅对延性有显著影响。基于ABAQUS软件建立了CFRP-PVC约束CSSC柱有限元模型,准确还原了组合柱在轴向荷载作用下的破坏过程和CFRP损伤形态。当组合柱套箍系数小于0.3或长径比大于14.54时,荷载-位移曲线会失去强化段,提高外层CFRP层数会小幅提高强化段刚度。提出了适用于CFRP-PVC约束CSSC的承载力计算方法,误差为1.2%。

关键词： CFRP-PVC复合管珊瑚海水海砂混凝土轴压性能有限元分析承载力计算

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Screening and identification of salt tolerance soybean varieties and germplasms

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Oil Crop Science 2024年第3期9卷 204-210页

作者： chen L. Peng L. Ouyang W. Yao H. Ye Y. Shan Z. Cao D. chen S. Yang Z. Huang Y. Han B. Sha A. Zhou X. chen H. Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural Affairs Oil Crops Research Institute of Chinese Academy of Agricultural Sciences Wuhan 430062 China College of Agriculture Yangtze University Jingzhou 434000 China

Soil salinization is a globally prevalent abiotic environmental stress. The imbalance of ions caused by high concentrations of sodium chloride results in a 40% reduction in soybean yield. Soybean, as an important crop for soil quality improvement, necessitates the identification of salt-tolerant varieties and germplasms to effectively utilize and enhance saline-alkali land. In this study, we assessed the salt tolerance of 435 soybean varieties and germplasms during the seedling stage. Among them, Qihuang34, You2104, Hongzhudou, Pamanheidou, and Osage exhibited grade 1 salt tolerance rates surpassing other tested materials. Furthermore, Hongzhudou and Qihuang34 demonstrated higher salt tolerance during germination and emergence stages based on their elevated rates of emergence, salt tolerance index, chlorophyll content, and shoot fresh weights. Overall findings provide valuable resources for molecular breeding efforts aimed at developing salt-tolerant soybean varieties suitable for cultivation in saline-alkali soils. © 2024 the Oil Crop Research Institute, Chinese Academy of Agriculture Sciences

关键词： Germination and emergence stage Germplasms Salt tolerance Seedling stage Soybean Varieties

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Experimental investigation on indoor daylight environment of building with Cadmium Telluride photovoltaic window

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Energy and Built Environment 2024年第3期5卷 404-413页

作者： Yilin Hu Qingwen Xue Haobo Wang Peng Zou Jinming Yang Shikeng chen Yuanda cheng State Key Laboratory of Green Building in Western China Xian University of Architecture&TechnologyXianChina College of Civil Engineering Taiyuan University of TechnologyTaiyuanChina

Photovoltaic(PV)windows have received more and more attention in recent years since their active energy-saving *** the surface covered with solar cell modules,the indoor daylight environment of PV windows is obviously different with clear glass ***,despite many scholars have studied the indoor daylight environment of PV windows,there few investigations study it from the perspective of human subjective visual *** this paper,the indoor daylight environment and human visual comfort of building with Cadmium Telluride Photovoltaic(CdTe-PV)window were ***,the parameters of indoor daylight environment and subjective questionnaires in rooms with CdTe-PV window and clear glass window were analyzed *** the basis of this,combined with indoor working surface illuminance and results of subjective questionnaires,the daylight illuminance threshold of human visual comfort was investigated by the method of Mean Bias Degree(MBD).Finally,an evaluation model for indoor daylight environment of buildings with CdTe-PV window was developed by Fuzzy Comprehensive Evaluation *** results showed that the working surface illuminance of CdTe-PV window was lower than that of clear glass room,the CCT of different windows room had a minor gap and the CdTe-PV window room was closer to the recommended range that was *** for CRI,both the CdTe-PV window room and the clear glass room could meet the visual comfort requirements of office ***,it was found that the requirement of human visual comfort was met when indoor working surface illuminance varies between 500-2200lx in the room with CdTe-PV *** last,according to the comprehensive evaluation model proposed in this paper,it was found that the indoor daylight environment of buildings with CdTe-PV window was excellent in the present experiment.

关键词： Cadmium Telluride photovoltaic(CdTe-PV)window Daylight environment Human visual comfort Fuzzy comprehensive evaluation method

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Engineering and understanding SnS_(0.5)Se_(0.5)@N/S/Se triple-doped carbon nanofibers for enhanced sodium-ion batteries

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Chinese Chemical Letters 2024年第4期35卷 226-230页

作者： Fanjun Kong Yixin Ge Shi Tao Zhengqiu Yuan chen Lu Zhida Han lianghao Yu Bin Qian School of Electronic and Information Engineering Changshu Institute of TechnologyChangshu 215500China Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes Suzhou UniversitySuzhou 234000China Far East Holding Group Co. Ltd.Yixing 214200China

Tin-based chalcogenides have attracted tremendous attention as an anode material for sodium storage owing to their unique structure and high theoretical capacity. Unfortunately, the large volume change and poor conductivity lead to sluggish reaction kinetics and poor cycling performance. Herein, SnS_(0.5)Se_(0.5)nanoparticles coupled with N/S/Se triple-doped carbon nanofibers(SnS_(0.5)Se_(0.5)@NSSe-C) are designed and synthesized through electrospinning and annealing process. Benefiting from the synergistic effects of SnS_(0.5)Se_(0.5)and NSSe-C, the SnS_(0.5)Se_(0.5)@NSSe-C nanofibers exhibit a high reversible capacity and ultralong cycle life at higher current density for sodium-ion batteries. Furthermore, the sodium storage mechanism and electrochemical reaction kinetics of the SnS_(0.5)Se_(0.5)@NSSe-C composite are characterized by the in-situ measurements. The theoretical calculations further reveal the structural advantages of SnS_(0.5)Se_(0.5)@NSSeC composite, which exhibits a high adsorption energy of Na+. This work can provide a novel idea for the synthesis of ternary tin-based chalcogenides and is beneficial for the investigation of their reaction kinetics.

关键词： SnS_(0.5)Se_(0.5) Carbon nanofibers Doping Density functional theory Sodium ion batteries

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Traceable ring signature schemes based on SM2 digital signature algorithm and its applications in the data sharing scheme

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Frontiers of Computer Science 2024年第2期18卷 251-253页

作者： Yongxin ZHANG Hong LEI Bin WANG Qinghao WANG Ning LU Wenbo SHI Bangdao chen Qiuling YUE R&D Department SSC Holding CompanyLtd.Chengmai 571924China School of Cyberspace Security(School of Cryptography) Hainan UniversityHaikou 570228China College of Computer Science and Engineering Northeastern UniversityShenyang 110819China School of Computer Science and Technology Xidian UniversityXi'an 710071China Blockchain Research Group Oxford-Hainan Blockchain Research InstituteChengmai 571924China

1 Introduction Identity privacy concerns hinder data sharing by casting doubt on the safeguarding of personal information,eroding trust,and impeding the willingness of individuals and organizations to exchange their data[1,2].The traceable ring signatures(TRSs)addresses the contradiction between identity privacy and regulation[3],no scheme has been developed thus far that is based on SM2,the Chinese cryptographic public key algorithm standard,without relying on centralized trust.

关键词： SM2 signature scheme

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