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Investigating the Head Impact Force-Induced Evolution of Hyperphosphorylated Tau Proteins in Brain Tissue Through Mechanical Mesoscale Finite Element Simulation

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Acta Mechanica Solida Sinica 2022年第4期35卷 705-715页

作者： Ge He lei fan Shanghai Key Laboratory of Mechanics in Energy Enginering Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Department of Mechanical Engineering Michigan State UniversityEast LansingMI 48824USA

For human heads that experienced repetitive subconcussive impacts,abnormal accumulation of hyperphosphorylated tau(p-tau)proteins was found in the postmortem brain *** numerically understand the cause–effect relationship between the external force and the microscopic volume change of the p-tau protein,we created a mesoscale finite element model of the multilayer brain tissue containing microscopic voids representing the p-tau *** model was applied under the loading boundary conditions obtained from a larger length scale simulation.A formerly developed internal state variable elastoplasticity model was implemented to describe the constitutive behaviors of gray and white matters,while the cerebrospinal fluid was assumed to be purely *** effects of the initial sizes and distances of p-tau proteins located at four different brain regions(frontal,parietal,temporal and occipital lobes)on their volumetric evolutions were *** is concluded that both the initial sizes and distances of the proteins have more or less(depending on the specific brain region)influential effects on the growth or contraction rate of the p-tau *** p-tau proteins located within the brain tissue at the frontal and occipital lobes are more heavily affected by the frontal impact load compared with those at the parietal and temporal *** summary,the modeling approach presented in this paper provides a strategy for mechanically studying the evolution of p-tau proteins in the brain tissue and gives insight into understanding the correlation between macroscopic force and microstructure change of the brain tissue.

关键词： Traumatic head injury Hyperphosphorylated tau(p-tau)protein Internal state variable Brain tissue

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JWST Observations Constrain the Time Evolution of Fine Structure Constants and Dark Energy-electromagnetic Coupling

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Research in Astronomy and Astrophysics 2024年第12期24卷 118-126页

作者： Ze-fan Wang lei lei lei Feng Yi-Zhong fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain Observatory Chinese Academy of Sciences School of Astronomy and Space Science University of Science and Technology of China

It was hypothesized in the literature that some physical parameters may be time-evolving and the astrophysical data can serve as a ***,the James Webb Space Telescope (JWST) released its early *** this work,we select the JWST spectroscopic observations of the high redshift (z>7.1) galaxies with strong[O III](λ=4959?and 5007?in the rest frame) emission lines to constraint the evolution of the fine structure constant(α).With the spectra from two galaxies at redshifts of 7.19 and 8.47,the deviation of α from its fiducial value is found to be as small as ■respectively (the first error is statistical and the latter is systematic).The combination of our results with the previous data reveals that ■Clearly,there is no evidence for a cosmic evolution of α.The prospect of further constraining the time evolution of α is also *** scalar field of dark energy is hypothesized to drive the acceleration of the universe’s expansion through an interaction with the electromagnetic *** integrating the observational data of the fine-structure constant variation,■,we have established a stringent upper limit on the coupling strength between dark energy and *** analysis yields ■at the 95%confidence level,representing the most stringent bound to date.

关键词： (cosmology:) dark energy cosmology: observations galaxies: high-redshift

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黄土边坡微生物矿化加固及植被恢复试验

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水土保持研究 2025年第1期32卷 227-234,242页

作者：雷磊王良樊成虎刘子瑞宋洋薛倩楠田堪良段金贵国网陕西省电力有限公司电力科学研究院西安710100 国网(西安)环保技术中心有限公司西安710100 国网陕西省电力有限公司西安710100 国网陕西省电力有限公司安康水力发电公司陕西安康725009 国网陕西省电力有限公司西安供电公司西安710048 西北农林科技大学水土保持研究所陕西杨凌712100 中国科学院水利部水土保持研究所陕西杨凌712100 黄河水利委员会西峰水土保持科学试验站甘肃庆阳745000

[目的]研究黄土边坡微生物矿化加固及植被恢复,为黄土边坡的加固及坡面土壤侵蚀防治提供新方法和新技术。[方法]采用微生物诱导碳酸钙沉淀(Microbially Induced Calcite Precipitation,MICP)技术对黄土边坡进行矿化加固处理,并在固化黄... 详细信息

[目的]研究黄土边坡微生物矿化加固及植被恢复,为黄土边坡的加固及坡面土壤侵蚀防治提供新方法和新技术。[方法]采用微生物诱导碳酸钙沉淀(Microbially Induced Calcite Precipitation,MICP)技术对黄土边坡进行矿化加固处理,并在固化黄土边坡上进行植被恢复,利用扫描电子显微镜(SEM)和光学显微镜,从微观角度探究MICP技术对黄土边坡矿化加固的作用机制,并统计分析了固化黄土边坡的植被恢复效果。[结果]采用MICP技术对黄土边坡进行固化处理后,在坡面上生成的固化层将松散且相邻的土壤颗粒胶结在一起,使黄土坡面形成一个整体,固化层最大厚度为0.23 cm,平均厚度为0.21 cm;固化黄土边坡恢复植被后第60天,A1,A2,B1,B2,A1B1,A2B2各区域内植被成活率比A0,B0,A0B0各区域分别显著提高26.66%,20%,37.5%,25%,33.33%,25%(p<0.05),第60天后,各区域内植被的成活率均差异显著,而且固化后加保水剂的A1,B1,A1B1各区域内植被的成活率最高;固化后加保水剂的B1和A1B1区域内紫穗槐高度和地径的生长变化量最大,且固化后加保水剂的A1,B1,A1B1各区域内麦冬草和紫穗槐的生长状况最好。[结论]采用MIC技术可以有效固化黄土坡面,与植被恢复技术相结合,既能防治土壤侵蚀,又能恢复生态环境。这种综合防治措施为黄土边坡水土流失防治与生态修复提供了良好的技术支持。

关键词：黄土边坡微生物矿化加固技术植被恢复边坡防护

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Defence Technology（防务技术） 2023年第9期27卷 138-153页

作者： Zeng Liu Cheng-lei fan chun-li Yang Zhu Ming San-bao Lin Lang-ping Wang State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China Inner Mongolia Metal Material Research Institute Yantai264000China

Ar-N_(2)-O_(2)ternary shielding gas is employed in dissimilar welding between high nitrogen steel and low alloy *** effect of O_(2)and N_(2)is investigated based on the systematical analysis of the metal transfer,nitrogen escape phenomenon,weld appearance,nondestructive detection,nitrogen content distribution,microstructure and mechanical *** are two nitrogen sources of the nitrogen in the weld:high nitrogen base material and shielding *** effect of shielding gas is mainly reflected in these two *** change of the droplet transfer mode affects the fusion ratio,N2in the shielding gas can increase nitrogen content and promote the nitrogen uniform *** addition of 2%O_(2)to Ar matrix can change the metal transfer from globular transfer to spray transfer,high nitrogen base material is thereby dissolved more to the molten pool,making nitrogen content increase,ferrite decrease and the mechanical properties *** applying N2-containing shielding gas,arc stability becomes poor and short-circuiting transfer frequency increases due to the nitrogen escape from droplets and the molten *** of the joints is improved with N_(2)increasing,but internal gas pores are easier to appear because of the poor capacity of low alloy steel to dissolve nitrogen,The generation of pores will greatly reduce the impact resistance.4-8%N2content in shielding gas is recommended in this study considering the integrated properties of the dissimilar welded joint.

关键词： High nitrogen steel Dissimilar steel joints Shielding gas Metal transfer Microstructure Mechanical properties

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Effect of Ultrasound on Heterogeneous Nucleation in TIG Welding of Al–Li Alloy

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Acta Metallurgica Sinica(English Letters) 2016年第12期29卷 1081-1088页

作者： Qi-Hao Chen San-Bao Lin chun-Li Yang Cheng-lei fan Hong-Liang Ge State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology

The effect of ultrasound on heterogeneous nucleation in a tungsten inert gas （TIG） weld pool of 2195 Al-Li alloy has been investigated by a series of experiments. An ultrasonic vibration was imposed on the surface of base material before turning off the welding arc during the TIG welding implemented at a fixed point. The results suggest that ultrasound could promote heterogeneous nucleation in the TIG weld pool of 2195 Al-Li alloy. The grain around the fusion zone is changed from a column grain to an equiaxed grain after applying the ultrasonic treatment. To study the influencing mechanism of ultrasound on heterogeneous nucleation, further investigations were implemented where the welding arc was turned off after turning off the ultrasonic power. The results show that the equiaxed grain around the fusion zone disappeared gradually with an increase in heat input after turning off the ultrasonic power. It suggests that ultrasound could promote the heterogeneous nucleation particle to nucleate in advance before turning off the welding arc and the crystal nucleus could again be melted with an increase in heat input after turning off the ultrasonic power. Moreover, the effects of the welding current and ultrasonic amplitude on heterogeneous nucleation in the weld pool of 2195 Al-Li alloy were also investigated. Possible influencing mechanism of the welding current and ultrasonic amplitude on heterogeneous nucleation was discussed.

关键词： Ultrasound TIG welding Grain Al-Li alloy

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Bounded Tiles in ■_p are Compact Open Sets

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Acta Mathematica Sinica,English Series 2020年第2期36卷 189-195页

作者： Ai Hua fan Shi lei fan LA MFA UMR 7352 CNRSUniversity of Picardie33 rue Saint Leu80039 AmiensFrance School of Mathematics and Statistics&Hubei Key Laboratory of Mathematical Sciences Central China Normal UniversityWuhan430079P.R.China

Any bounded tile of the field Qp of p-adic numbers is a compact open set up to a set of zero Haar *** this note,we present two simple and direct proofs of this fact.

关键词： p-adic field tile bounded compact open

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Solid electrolyte-electrode interface based on buffer therapy in solid-state lithium batteries

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International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1584-1602页

作者： lei-ying Wang Li-fan Wang Rui Wang Rui Xu chun Zhan Woochul Yang Gui-cheng Liu School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Department of Physics Dongguk UniversitySeoul 04620Republic of Korea

In the past few years,the all-solid lithium battery has attracted worldwide attentions,the ionic conductivity of some all-solid lithium-ion batteries has reached 10^(-3)-10^(-2) S/cm,indicating that the transport of lithium ions in solid electrolytes is no longer a major ***,some interface issues become research *** of these interfacial issues include the electrochemical decomposition reaction at the electrode-electrolyte interface;the low effective contact area between the solid electrolyte and the electrode *** order to solve the issues,researchers have pursued many different *** addition of a buffer layer between the electrode and the solid electrolyte has been at the center of this *** this review paper,we provide a systematic summarization of the problems on the electrode-solid electrolyte interface and detailed reflection on the latest works of buffer-based therapies,and the review will end with a personal perspective on the improvement of buffer-based therapies.

关键词： solid-state lithium-ion batteries solid electrolyte buffer layer interface

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A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang Juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Hydrogen evolution reaction

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Antibacterial hydrogel with pH-responsive microcarriers of slow-release VEGF for bacterial infected wounds repair

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Journal of Materials Science & Technology 2023年第13期144卷 198-212页

作者： Xiaofei Xie Huan lei Daidi fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an 710069China Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China

Bacterial infection causes wound inflammation and makes angiogenesis *** is urgent to develop effectively antibacterial and pro-vascularizing dressings for wound *** hydrogel is developed with pH-responsive drug-releasing microcarriers which were loaded with vascular endothelial growth factor(VEGF)that promotes angiogenesis and actively respond to wound pH for control and prolong VEGF *** surfaces of the microcarriers were coated with polydopamine which can reduce the silver nanoparticles(AgNPs)in situ,and dynamically crosslink with the polyacrylamide,which forms a stable slow-release system with different release behavior for the VEGF and *** hydrogel inhib-ited bacterial formation and accelerated wound *** the hydrogel dressing,83.3%±4.29%of the wound heals at day 7,which is 40.9%±8.5%higher than the non-treatment group in defect infected *** antibacterial properties of hydrogel down-regulate early inflammation-related cytokines,and the release of VEGF in the middle and late phases of wound healing in response to pH changes pro-motes angiogenesis and up-regulate the expression of angiogenesis-associated *** sequential release of antibacterial agents and pro-vascularizing agents in response to the change in wound microen-vironmental cues facilitate temporally controlled therapy that suites the need of different wound healing ***,the hydrogel loaded with multifunctional microcarriers that enable controlled release of AgNPs and VEGF is an effective system for treating infected wounds.

关键词： Antibacterial pH-responsive microcarriers Slow-release Infected wound repair

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A Rapid and Automatic Optimal Design Method for Six-Stage Axial-Flow Industry Compressor

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Journal of Thermal Science 2021年第5期30卷 1658-1673页

作者： lei fan JU Yaping ZHANG Chuhua School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an710049China

Existing aerodynamic design systems for multi-stage axial-flow compressor suffer from several limitations,such as experience dependent models and time costly *** attempts,however,have been devoted to the rapid and automatic optimization of aerodynamic performance at the preliminary design phase,which plays a crucial role in the final aerodynamic *** this work,a rapid and automatic aerodynamic optimal design method is developed for the multi-stage axial-flow compressor based on one-dimensional meanline design method,radial-equilibrium equation and genetic *** one-dimensional performance prediction model includes some popular empirical correlations to calculate the flow loss,incidence angle,deviation angle and flow *** radial-equilibrium equation is solved to obtain the spanwise distribution of aerodynamic and thermodynamic parameters at the inlet and outlet of each blade *** genetic algorithm is used for an automatic search of the global optimal compressor configuration aiming at maximizing the design *** developed method is illustrated with the aerodynamic optimal design of a 6-stage axial-flow industry compressor and verified by computational fluid dynamics *** results show that the developed method is capable of improving effectively the design efficiency and predicting accurately the aerodynamic performance of the 6-stage axial-flow industry compressor in a few *** work is of scientific significance to improve the axial-flow compressor design system and of engineering importance to release the designers from the heavy experience dependence especially at the preliminary design phase.

关键词： one-dimensional meanline design two-dimensional throughflow design three-dimensional CFD simulation optimal design genetic algorithm multi-stage axial-flow compressor

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