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Acta Mechanica Sinica 2011年第5期27卷 785-795页

作者： chun-chuan liu feng-ming li ting-wei liang wen-hu huang P. O. Box 137 School of AstronauticsHarbin Institute of Technology150001 Harbin China

In this paper,wave and vibratory power transmission in a finite L-shaped Mindlin plate with two simply supported opposite edges are investigated using the wave *** dynamic responses,active and reactive power flow in the finite plate are calculated by the Mindlin plate theory （MPT） and classic plate theory （CPT）.To satisfy the boundary conditions and continuous conditions at the coupled junction of the finite L-shaped plate,the near-field and far-field waves are entirely contained in the wave *** in-plane longitudinal and shear waves are also *** results indicate that the vibratory power flow based on the MPT is different from that based on the CPT not only at high frequencies but also at low and medium *** influence of the plate thickness on the vibrational power flow is *** the results it is seen that the shear and rotary inertia correction of the MPT can influence the active and reactive power at the junction of the L-shaped plate not only at high frequencies but also at low and medium ***,the effects of structural damping on the active and reactive power flow at the junction are also analyzed.

关键词： Finite L-shaped Mindlin plate Active power flow Reactive power flow Wave approach

Design study on medium beta superconducting half-wave resonator at IMP

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Nuclear Science and Techniques 2016年第4期27卷 21-27页

作者： An-Dong Wu Sheng-hu Zhang wei-ming Yue Tian-Cai Jiang Yong-ming li feng-feng Wang Sheng-Xue Zhang liang-Jian wen Ran huang Yuan He Hong-wei Zhao Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049 China

A 325-MHz superconducting half-wave resonator has been designed with β = 0.51. Three shapes of the inner conductors(race track, ring shape and elliptical shape) were optimized to decrease the peak electromagnetic fields and minimize the dissipated RF power on the cavity walls. In order to suppress the operation frequency shift caused by fluctuations of the helium pressure and maximize the tuning ranges, the frequency shifts and mechanical properties were studied on the electric and magnetic areas. The helium vessel was designed to keep the mechanical structure as robust as possible.

关键词：超导谐振器设计 IMP 射频功率压力波动调谐范围机械性能频率变化

Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： Jian-Chao liang Zhi-feng Ding chun-lin li Yi-ming hu Zhi-Xin Zhou Gan-wen lie Xiao-Nan Niu wen-Bin huang hui-Jian hu Xing-feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China huizhou Institute of Forestry(huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the hu line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the hu line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation hu line Species dispersal ability Breeding birds

A QTC-based signal readout for position-sensitive multi-output detectors

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Nuclear Science and Techniques 2016年第5期27卷 208-214页

作者： wei Zhou Zhi-ming Zhang Dao-Wu li Pei-lin Wang Bao-Tong feng Xian-Chao huang ting-ting hu Xiao-hui li Yan Chen Ying-Jie Wang Yan-Tao liu Yi-wen Zhang Shi-feng Sun Xiao-Yue Gu ming-Jie Yang Xiong Xiao Long wei Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Beijing Engineering Research Center of Radiographic Techniques and Equipment Beijing 100049 China University of Chinese Academy of Sciences Beijing 100049

A new signal readout method for position-sensitive multi-output detectors,such as those in high-energy spectroscopy measurement and nuclear imaging,was developed by combining the charge division circuit,summing circuit and charge-to-time conversion(QTC) *** 64 outputs of a Hamamatsu H8500 position-sensitive photomultiplier tube were processed,and three digital pulses were *** widths of digital pulses were determined using the time-to-digital converter in an field programmable gate *** energy and position information of incident y-rays is estimated based on the proportionality between the width of digital pulses and input charge created by y-photons.A prototype was built using discrete components and tested,and the energy and position resolutions were improved compared with that obtained with standard *** method greatly simplifies the front-end electronics and the digital *** enables a compact electronics system and an easy integration into an ASIC.

关键词：输出信号位置灵敏探测器多输出读出位置灵敏光电倍增管现场可编程门阵列时间-数字转换器位置敏感探测器

Design and tests of the prototype a beam monitor of the CSR external target experiment

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Nuclear Science and Techniques 2022年第3期33卷 137-151页

作者： hu-lin Wang Zhen Wang Chao-Song Gao Jian-wei liao Xiang-ming Sun Hai-Bo Yang Cheng-Xin Zhao Jun liu Peng Ma Zi-li li Bi-hui You Ping Yang Di Guo Le Xiao Dong-liang Zhang Yue-Zhao Zhang Sheng Dong Wan-Han feng Yu-Xin Qiao Zheng-Yu hu Qing-wen Ye Zeng-Tao Guo Guang-ming huang feng liu PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China hubei Provincial Engineering Research Center of Silicon Pixel Chip&Detection Technology Wuhan 430079China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

A prototype beam monitor was designed to provide tracking information for heavy-ion projectiles for the cool storage ring(CSR)external target experiment(CEE)at the Heavy Ion Research Facility in Lanzhou(HIRFL).High granularity and direct charge sensing are the main features of this *** measures the beam position in a two-dimensional(2D)plane transverse to the beam direction on an event-by-event *** current design consists of two field cages inside a single vessel that operates independently and has electrical drift fields in orthogonal *** tests of the prototype were performed using a^(241)Am a *** results show that a spatial resolution of less than 40μm and a time resolution of less than 600 ns can be achieved.

关键词： CEE Beam monitor Heavy ion Topmetal sensor Tracking Field cage

Determining the level of extra-pair paternity in yellow-bellied prinias,a socially monogamous passerine

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Zoological Research 2021年第1期42卷 108-115页

作者： Zhi-feng Ding chun-Lan Zhang wen-Sui Zhang Qian-Min Yuan Long-Wu Wang Gang Ren En li hui-Jian hu wei liang Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China State Forestry Administration of China Key Laboratory for Biodiversity Conservation in Mountainous Areas of Southwest Karst School of Life SciencesGuizhou Normal UniversityGuiyangGuizhou 550001China College of life Sciences Anhui Normal UniversityWuhuAnhui 241000China Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal UniversityHaikouHainan 571158China

DEAR EDITOR,Previous work based on molecular evidence has shown that most socially monogamous birds follow a genetic polyandrous mating ***,our knowledge about avian mating systems is heavily biased toward the north temperate zone,with data on tropical birds remaining relatively *** uneven distribution of both phylogenetic and spatial sampling has hampered our understanding and interpretation of *** this study,we investigated the frequency of extra-pair paternity(EPP)in a tropical population of yellow-bellied prinias(Prinia flaviventris)in Guangxi,southern China.A total of 129 individuals belonging to 24 nests were sampled,among which 12 out of 83 chicks(14.46%)in seven nests were found to be EPP *** nests in which all nestlings were sampled,only five out of 56 chicks were EPP offspring,accounting for an unbiased EPP rate of 8.93%.This rate is below the average rate of EPP in the family *** possible causes of EPP in prinias and the occurrence of EPP in birds with high resource investment and intensive parental care are *** study highlights the value of genome-wide markers in determining relatedness in a wild bird species without a reference genome.

关键词： EPP EDIT yellow

p38αMAP kinase promotes asthmatic inflammation through modulation of alternatively activated macrophages

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Journal of Molecular Cell Biology 2019年第12期11卷 1095-1097页

作者： li-Nian huang Lei Sun li-ming liu hui-hui Zhang Zhong-Bo liang Yan Rui Jun-feng hu Yong Zhang John WChristman feng Qian Department of Respiration and Critical Care Medicine First Affiliated Hospital of Bengbu Medical CollegeAnhui Province Key Laboratory of Translational Cancer ResearchBengbu Medical CollegeBengbu 233004China Engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Department of Internal Medicine Section of PulmonaryCritical Careand Sleep MedicineThe Ohio State UniversityColumbusOH 43210-1252USA

Asthma is characterized by reversible airflow obstruction, bronchial hyper-reactivity, and chronic airway remodeling (Al-Muhsen et al., 2011). Pulmonary macrophages have been implicated in asthmatic inflammation (Lee et al., 2015;Qian et al., 2015). The p38 mitogen-activated protein kinase (MAPK) plays an essential role in inflammation, but its role in asthma has not been determined (Kim et al., 2008). Here, our data show that macrophage-specific p38α MAPK-deficient mice displayed attenuated asthmatic inflammation in response to three allergens (dust mite, ragweed, and Aspergillus;DRA). Furthermore, we found that the protective effect was strongly associated with a reduction in the alternatively activated macrophage (AAM) polarization in vivo and in vitro. Taken together, our data indicate that p38α MAPK in macrophages contributes to AAM polarization and could be a therapeutic target for asthma.

关键词： inflammation al. asthma

Molecular detection of the powdery mildew resistance genes in winter wheats DH51302 and Shimai 26

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Journal of Integrative Agriculture 2020年第4期19卷 931-940页

作者： QU Yun-feng WU Pei-pei hu Jing-huang CHEN Yong-xing SHI Zhan-liang QIU Dan li Ya-hui ZHANG Hong-jun ZHOU Yang YANG li liu Hong-wei Zhu Tong-quan liu Zhi-yong ZHANGYan-ming li Hong-jie Key Laboratory of Molecular Cytogenetic and Genetic Breeding of Heilongjiang Province/College of life Science and Technology Harbin Normal UniversityHarbin 150025P.R.China National Engineering Laboratory for Crop Molecular Breeding/Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101P.R.China Shijiazhuang Academy of Agricultural and Forestry Sciences Shijiazhuang 050041P.R.China Wheat Research Institute Zhumadian Academy of Agricultural SciencesZhumadian 463000P.R.China

Resistance to powdery mildew is an important trait of interest in many wheat breeding programs. The information on genes conferring resistance to powdery mildew in wheat cultivars is useful in parental selection. Winter wheat breeding line DH51302 derived from liangxing 99 and cultivar Shimai 26 derived from Jimai 22 showed identical infection patterns against 13 isolates of Blumeria graminis f. sp. tritici(Bgt) that causes wheat powdery mildew. DH51302 and Shimai 26 were crossed to a powdery mildew susceptible cultivar Zhongzuo 9504 and the F2:3 families were used in molecular localization of the resistance genes. Fourteen polymorphic markers, which were linked to Pm52 from liangxing 99, were used to establish the genetic linkage maps for the resistance genes Pm DH51302 and Pm SM26 in DH51302 and Shimai 26, respectively. These genes were placed in the same genetic interval where Pm52 resides. Analysis of gene-linked molecular markers indicated that Pm DH51302 and Pm SM26 differed from other powdery mildew resistance genes on chromosome arm 2 BL, such as Pm6, Pm33, Pm51, Ml Zec1, Ml AB10, and Pm64. Based on the results of reaction patterns to different Bgt isolates and molecular marker localization, together with the pedigree information, DH51302 and Shimai 26 carried the same gene, Pm52, which confers their resistance to powdery mildew.

关键词： Triticum aestivum Blumeria graminis f.sp.tritici Pm52 molecular mapping

Pressure-driven metallization with significant changes of structural and photoelectric properties in two-dimensional EuSbTe_(3)

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Rare Metals 2024年第11期43卷 5943-5952页

作者： Zhi-Kai Zhu Zhong-Yang li Zhen Qin Yi-ming Wang Dong Wang Xiao-hui Zeng Fu-Yang liu Hong-liang Dong Qing-Yang hu ling-Ping Kong Hao-Zhe liu wen-Ge Yang Yan-feng Guo Shuai Yan Xuan Fang wei He Gang liu State Key Laboratory of Featured Metal Materials and life-Cycle Safety for Composite Structures MOE Key Laboratory of New Processing Technology for Nonferrous Metals and Materialsand School of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Center for High Pressure Science and Technology Advanced Research(HPSTAR) Shanghai 201203China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Poly Technologies INCBeijing 100010China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China Sch Sci State Key Lab High Power Semicond LasersChangchun University Science and TechnologyChangchun 130022China Shanghai Key Laboratory of Material Frontiers Research in Extreme Environments(MFree) Shanghai Advanced Research in Physical Sciences(SHARPS)Shanghai 201203China

Two-dimensional materials are widely considered to be highly promising for the development of *** improve the performance of these devices,researchers often employ techniques such as defect ***,pressure is employed as a clean and novel means to manipulate the structural and physical properties of EuSbTe_(3),an emerging two-dimensional *** experimental results demonstrate that the structural phase transformation of EuSbTe_(3)occurs under pressure,with an increase in infrared reflectivity,a band gap closure,and a metallization at *** with X-ray diffraction(XRD)and Raman characterizations,it is evident that the pressure-driven transition from semiconductor Pmmn phase to metallic Cmcm phase causes the disappearance of the charge density ***,at a mild pressure,approximately 2 GPa,the maximum photocurrent of EuSbTe_(3)is three times higher than that at ambient condition,suggesting an untapped potential for various practical applications.

关键词： Pressure Phase transition Metallization Photoresponse Two-dimensional(2D)

Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway

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World Journal of Gastroenterology 2022年第1期28卷 123-139页

作者： Tao huang Yuan-Qing-Xiao li ming-Yu Zhou Rui-Han hu Gao-liang Zou Jian-Chao li Shu feng Yong-Mei liu Chang-Qin Xin Xue-Ke Zhao Department of Infectious Diseases Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Clinical Laboratory Center Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Infectious Diseases People’s Hospital of Weining YiHui and Miao Autonomous CountyWeining 553100Guizhou ProvinceChina

BACKGROUND Hepatic stellate cell(HSC)hyperactivation is a central link in liver fibrosis *** perform aerobic glycolysis to provide energy for their *** adhesion kinase(FAK)promotes aerobic glycolysis in cancer cells or fibroblasts,while FAK-related non-kinase(FRNK)inhibits FAK phosphorylation and biological *** To elucidate the effect of FRNK on liver fibrosis at the level of aerobic glycolytic metabolism in *** Mouse liver fibrosis models were established by administering CCl4,and the effect of FRNK on the degree of liver fibrosis in the model was *** growth factor-β1 was used to activate LX-2 *** phosphorylation at position 397(pY397-FAK)was detected to identify activated FAK,and the expression of the glycolysis-related proteins monocarboxylate transporter 1(MCT-1)and enolase1(ENO1)was *** analysis was performed to predict putative binding sites for c-myc in the ENO1 promoter region,which were validated with chromatin immunoprecipitation(ChIP)and dual luciferase reporter *** The pY397-FAK level was increased in human fibrotic liver *** knockout promoted liver fibrosis in mouse *** also increased the activation,migration,proliferation and aerobic glycolysis of primary hepatic stellate cells(pHSCs)but inhibited pHSC ***,opposite trends for these phenomena were observed after exogenous FRNK treatment in LX-2 ***,the FAK/Ras/c-myc/ENO1 pathway promoted aerobic glycolysis,which was inhibited by exogenous *** FRNK inhibits aerobic glycolysis in HSCs by inhibiting the FAK/Ras/c-myc/ENO1 pathway,thereby improving liver *** might be a potential target for liver fibrosis treatment.

关键词： liver fibrosis Hepatic stellate cells Focal adhesion kinase Focal adhesion kinase-related non-kinase Aerobic glycolysis Enolase1