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Low-power laser irradiation promotes the proliferation and osteogenic differentiation of human periodontal ligament cells via cyclic adenosine monophosphate

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International Journal of Oral Science 2013年第2期5卷 85-91页

作者： Jyun-Yi Wu Chia-Hsin Chen Li-Yin Yeh Ming-Long Yeh chun-chan ting Yan-Hsiung Wang Institute of Biomedical Engineering National Cheng Kung University Department of Physical Medicine and Rehabilitation Kaohsiung Medical University Hospital Department of Physical Medicine and Rehabilitation Faculty of MedicineCollege of MedicineKaohsiung Medical University Department of Physical Medicine and Rehabilitation Kaohsiung Municipal Ta-Tung Hospital Department of Oral Hygiene College of MedicineKaohsiung Medical University School of Dentistry College of Dental MedicineKaohsiung Medical University Orthopaedic Research Center College of MedicineKaohsiung Medical University

Retaining or improving periodontal ligament （PDL） function is crucial for restoring periodontal defects. The aim of this study was to evaluate the physiological effects of low-power laser irradiation （LPLI） on the proliferation and osteogenic differentiation of human PDL （hPDL） cells. Cultured hPDL cel Is were irradiated （660 nm） daily with doses of O, 1, 2 or 4 J .cm-2. Cell proliferation was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide （MTT） assay, and the effect of LPLI on osteogenic differentiation was assessed by Alizarin Red S staining and alkaline phosphatase （ALP） activity. Additionally, osteogenic marker gene expression was confirmed by real-time reverse transcription-polymerase chain reaction （RT-PCR）. Our data showed that LPLI at a dose of 2 ***-2 significantly promoted hPDL cell proliferation at days 3 and 5. In addition, LPLI at energy doses of 2 and 4 ***-2 showed potential osteogenic capacity, as it stimulated ALP activity, calcium deposition, and osteogenic gene expression. We also showed that cyclic adenosine monophosphate （cAMP） is a critical regulator of the LPLI-mediated effects on hPDL cells. This study shows that LPLI can promote the proliferation and osteogenic differentiation of hPDL cells. These results suggest the potential use of LPLI in clinical applications for periodontal tissue regeneration.

关键词： cell proliferation cyclic adenosine monophosphate human periodontal ligament cells low-power laser irradiation osteogenic differentiation

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The cGAS-Sting-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 Sting type I interferon

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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-Yu Liu Sha-Sha Cui ting-ting Li Xiao-Meng Yang Zhijuan Liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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Dietary analysis of the House Swift(Apus nipalensis)in Hong Kong using prey DNA in faecal samples

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Avian Research 2021年第1期12卷 86-101页

作者： chun ting chung Hok Sze Wong Man Long Kwok Qi Meng King Ming chan School of Life Sciences The Chinese University of Hong KongSha Tin 999077N.TChina Swift and Swallow Research Group The Hong Kong Bird Watching Society7CV Ga Building532 Castle Peak RoadLai Chi KokKowloonHong Kong 999077China

Background:To understand the dietary composition of the highly aerial swift(Apodidae),ecologists conventionally depend on the morphological identification of prey items from food boluses or stomach contents,but these techniques are often invasive,require expertise in identification,and often cannot produce accurate identifications at the species ***:DNA barcoding was used to analyse the dietary composition of House Swifts(Apus nipalensis)in Hong Kong,*** samples from five different colonial nest sites were collected between 2019 and *** used universal primers to amplify a region of the cytochrome C oxidase gene from prey DNA in the faecal samples for identification ***:Ten different orders and 44 families from three different classes of Arthropoda were identified in the collected faecal ***,Hemiptera and Diptera were the most prevalent groups of prey found in the *** in the dietary composition of House Swifts during the breeding(April to September)and nonbreeding(October to March)season were also ***,particularly ants(Formicidae),were predominant in the diet during the breeding season,whereas Diptera and Hemiptera were predominant during the non-breeding ***:The prey groups identified in this study were similar to those identified in a previous study of the diet of House Swift,which also suggests a possible role of House Swifts in reducing the numbers of local insect *** study demonstrates the usefulness of applying molecular tools for the dietary analysis of aerial *** local forested areas may be crucial for the maintenance of House Swift population.

关键词： Diet DNA barcoding House swift Urbanisation threat

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-ting Sun Li-ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Convergence Rate for Galerkin Approximation of the Stochastic Allen–Cahn Equations on 2D Torus

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Acta Mathematica Sinica,English Series 2021年第3期37卷 471-490页

作者： ting MA Rong chan ZHU College of Mathematics Sichuan UniversityChengdu 610065P.R.China Department of Mathematics Beijing Institute of TechnologyBeijing 100081P.R.China Department of Mathematics University of BielefeldD-33615 BielefeldGermany

In this paper we discuss the convergence rate for Galerkin approximation of the stochastic Allen–Cahn equations driven by space-time white noise on T^(2). First we prove that the convergence rate for stochastic 2D heat equation is of order α-δ in Besov space C^(-α) for α∈(0, 1) and δ > 0 arbitrarily small. Then we obtain the convergence rate for Galerkin approximation of the stochastic Allen–Cahn equations of order α-δ in C^(-α) for α∈(0, 2/9) and δ > 0 arbitrarily small.

关键词： Stochastic Allen–Cahn equations convergence rate Galerkin projection Besov space white noise

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan ting Liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

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Acrosome reaction in the cumulus oophorus revisited:involvement of a novel sperm-released factor NYD-SP8

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Protein & Cell 2011年第2期2卷 92-98页

作者： ting ting Sun Chin Man chung Hsiao chang chan Epithelial Cell Biology Research Center School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina

Fertilization is a process involving multiple steps that lead to the final fusion of one sperm and the oocyte to form the *** of the steps,acrosome reaction(AR),is an exocytosis process,during which the outer acrosome membrane fuses with the inner sperm membrane,leading to the release of acrosome enzymes that facilitate sperm penetration of the egg *** AR has been investigated for decades,the initial steps of AR in vivo,however,remain largely unknown.A well elucidated model holds the view that AR occurs on the surface of the zona pellucida(ZP),which is triggered by binding of sperm with one of the ZP glycosylated protein,***,this model fails to explain the large number of‘falsely’acrosome-reacted sperms found within the cumulus layer in many species *** the emerging evidence of cross-talk between sperm and cumulus cells,the potential significance of AR in the cumulus oophorus,the outer layer of the egg,has been gradually *** we review the acrosome status within the cumulus layer,the cross-talk between sperm and cumulus cells with the involvement of a novel spermreleased factor,NYD-SP8,and re-evaluate the importance and physiological significance of the AR in the cumulus in fertilization.

关键词： sperm acrosome reaction cumulus NYP-SP8 progesterone

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Resonance-Enhanced Photon Excitation Spectroscopy of the Even-Parity Autoionizing Rydberg States of Xe

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Chinese Journal of Chemical Physics 2008年第5期21卷 401-406页

作者： chun-yan Li ting-ting Wang Jun-feng Zhen Qun Zhang Yang Chen Hefei National Laboratory for Physical Sciences at Microscale Department of Chemical Physics University of Science and Technology of China Hefei 230026 China

Xenon atoms were produced in their metastable states 5p^56s[3/2]2 and 5p^56s＇[1/2]0 in a pulsed DC discharge in a beam, and subsequently excited to the even-parity autoionizing Rydberg states 5p^5np＇ [3/2] 1,[1/2] 1, and 5p^5nf＇ [5/2] 3 using single photon excitation. The excitation spectra of the even-parity autoionizing resonance series from the metastable 129Xe were obtained by recording the autoionized Xe＋ with time-of-flight ion detection in the photon energy range of 28000-42000 cm-1. A wealth of autoionizing resonances were newly observed, from which more precise and systematic spectroscopic data of the level energies and quantum defects were derived.

关键词： Xe Pulsed DC discharge Resonance-enhanced photon excitation spectroscopy Autoionizing resonance

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Relationships between Chronic Diseases and Depression among Middleaged and Elderly People in China: A Prospective Study from CHARLS

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Current Medical Science 2020年第5期40卷 858-870页

作者： chun-hong JIANG Feng ZHU ting-ting QIN School of Management Hubei University of EducationWuhan 430205China Department of Biliary-Pancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Given the rapid increase in the prevalence of chronic diseases in aging populations,this prospective study including 17707 adults aged≥45 years from China Health and Retirement Longitudinal Study was used to estimate the associations between chronic discase,multimorbidity,and depression among middle-aged and elderly adults in China,and explore the mediating *** symptoms were assessed using the 10-item Centre for Epidemiological Studies Depression Scale(CES-D-10)*** chronic physical conditions,including hypertension,diabetes,dyslipidemia,cancer,chronic lung disease,liver disease,heart failure,stroke,kidney disease,arthritis or rheumatism,asthma,digestive disease were *** prevalence rates for physical multimorbidity and depression(CES-D-10≥10)were 43.23%and 36.62%,*** multivariable logistic models and generalized estimating equation(GEE)models,we found all 12 chronic physical conditions,and multimorbidity were significantly associated with *** mobility problems and chronic pain explained more than 30%of the association for all chronic conditions,with particularly high percentages for stroke(51.56%)and cancer(51.06%)in mobility problems and cancer(53.35%)in chronic *** activities of daily living(ADL)explained 34.60%of the stroke-cancer relationship,while sleep problems explained between 10.15%(stroke)and 14.89%(chronic lung disease)of the *** with chronic diseases or multimorbidity are significantly more likely to be *** symptoms involving limitations of ADL and mobility difficulties mediated much of the association between chronic diseases and incident *** symptoms could be targeted for interventions to ameliorate the incidence of depression among individuals with chronic conditions.

关键词： chronic disease multimorbidity depression functional symptoms mediation effect

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