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曲安奈德球后注射联合黄斑格栅样光凝治疗黄斑水肿

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国际眼科杂志 2014年第10期14卷 1834-1836页

作者：荆献华宋春媛中国山东省淄博市临淄区人民医院眼科 255400 潍坊医学院中国山东省潍坊市261053

目的:探讨曲安奈德玻璃体腔注射联合黄斑格栅样光凝治疗黄斑水肿的临床疗效与安全性。方法:选择我院2009-07/2013-11间收治的150例150眼黄斑水肿患者,按照数字随机法分为研究组(75例75眼)与对照组(75例75眼),对照组患者采用黄斑格栅样... 详细信息

目的:探讨曲安奈德玻璃体腔注射联合黄斑格栅样光凝治疗黄斑水肿的临床疗效与安全性。方法:选择我院2009-07/2013-11间收治的150例150眼黄斑水肿患者,按照数字随机法分为研究组(75例75眼)与对照组(75例75眼),对照组患者采用黄斑格栅样光凝治疗,研究组采用曲安奈德玻璃体腔注射联合黄斑格栅样光凝治疗,分别于治疗前,治疗后7d;1,3,9mo检测患者最佳矫正视力,并行光学相干断层扫描(optical coherence tomography,OCT)和荧光素眼底血管造影(fundus fluorescein angiography,FFA)检测。结果:治疗后两组患者视力均明显改善(P0.05),研究组黄斑中心凹视网膜神经上皮层厚度显著低于对照组(P<0.05);研究组出现7例眼压轻度增高,经降眼压治疗后均恢复正常。结论:曲安奈德玻璃体腔注射联合黄斑格栅样光凝治疗黄斑水肿的临床疗效确切,可以有效提高患者视力,降低黄斑水肿症状,安全可靠,适于临床推广与应用。

关键词：曲安奈德玻璃体腔注射黄斑格栅样光凝黄斑水肿

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue Li Ziliang Xie Wenjiao Zhou Huan Tong Dawen Yang Anjia Zhang yuan Wu Xiping song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin Dai Lei Ye Tao song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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气质联用同时测定食品中四种防腐剂

中国食品添加剂 2017年第5期28卷 204-208页

作者：景赞肖燕袁春红宋宇航吕雪梅刘超乐山市食品药品检验检测中心乐山614000

目的:研究建立气质联用同时测定各类食品中丙酸、山梨酸、脱氢乙酸、苯甲酸的方法。方法:在酸性条件下用乙醚提取目标物,采用改性聚乙二醇极性毛细管柱分离,通过选择合适的监测离子,建立气质联用方法,分别从回收率、精密度和检出限3个... 详细信息

目的:研究建立气质联用同时测定各类食品中丙酸、山梨酸、脱氢乙酸、苯甲酸的方法。方法:在酸性条件下用乙醚提取目标物,采用改性聚乙二醇极性毛细管柱分离,通过选择合适的监测离子,建立气质联用方法,分别从回收率、精密度和检出限3个方面考察方法的适用性。结果:在0~2.0g/kg测定范围内,加标样品回收率为91.6%~101.2%,精密度为0.9%~2.1%,检出限为0.03~0.11 mg/kg。结论:该方法可以同时测定四种防腐剂,检出限优于常规方法,灵敏度高,并且缩短了检验周期,结果准确可靠,为今后大范围推广提供了理论依据。

关键词：防腐剂气质联用食品

Temperature of intermediate mass fragments in simulated ^(40)Ca + ^(40)Ca reactions around the Fermi energies by AMD model

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Nuclear Science and Techniques 2016年第5期27卷 146-151页

作者： chun-Wang Ma chun-yuan Qiao Tian-Tian Ding Yi-Dan song Institute of Particle and Nuclear Physics Henan Normal University

The primary fragments in ^(40)Ca +^(40)Ca reactions at 35,50,80,100,140,and 300 MeV/u were simulated using the antisymmetrized molecular dynamics model,in the phase space at t=300 fm/c with a coalescence radius R_c=5 *** standard Gogny interactions g0,g0 as,and gOass were adopted in simulating the collisions at an impact parameter of b=0 *** was found,using an isobaric yield ratio method,that temperature of the primary fragment depends on the incident energy and hardness of the interaction *** temperature obtained in this work agrees with the results by the self-consistent fitting method.

关键词：模型模拟中等质量碎片温度 MD模型 Ca 反应费米能分子动力学

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Evaluation of Coronal and Interplanetary Magnetic Field Extrapolation Using PSP Solar Wind Observation

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Research in Astronomy and Astrophysics 2023年第7期23卷 247-262页

作者： Yue-chun song Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China

Using solar wind observation near PSP perihelions as constraints,we have investigated the parameters in various PFSS model *** is found that the interplanetary magnetic field extrapolation with source surface height R_(SS)=2 Rs is better than that with R_(SS)=2.5 *** and GONG magnetograms show similar performances in the simulation of magnetic field variation,but the former appears to have a slight advantage in reconstruction of intensity while the latter is more adaptable to sparser *** finite-difference method of constructing eigenvalue problems for potential fields can achieve similar accuracy as the analytic method and greatly improve the computational *** modeling performs relatively less well in magnetic field prediction,but it is able to provide rich information about solar-terrestrial space.

关键词： magnetohydrodynamics(MHD) (Sun:)solar—terrestrial relations (Sun:)solar wind magnetic fields

Expert consensus on the diagnosis and treatment of heat stroke in China

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Military Medical Research 2020年第1期7卷 23-43页

作者： Shu-yuan Liu Jing-chun song Han-Ding Mao Jin-Bao Zhao Qing song 无 Emergency Department Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Critical Care Medicine No.908th Hospital of PLANanchang 360104China Department of Critical Care Medicine First Medical CenterChinese PLA General HospitalBeijing 100853China Expert Group of Heat Stroke Prevention and Treatment of the People's Liberation Army People's Liberation Army Professional Committee of Critical Care Medicine

Heat stroke(HS)is a fatal disease caused by thermal damage in the body,and it has a very high mortality *** 2015,the People’s Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China,Expert consensus on standardized diagnosis and treatment for heat *** an increased understanding of HS and new issues that emerged during the HS treatment in China in recent years,the 2015 consensus no longer meet the requirements for HS prevention and *** is necessary to update the consensus to include the latest research evidence and establish a new consensus that has broader coverage,is more practical and is more in line with China’s national *** new expert consensus includes new concept of HS,recommendations for laboratory tests and auxiliary examinations,new understanding of diagnosis and differential diagnosis,On-site emergency treatment and In-hospital treatment,translocation of HS patients and prevention of HS.

关键词： Heat stroke Classic Exertional Diagnosis Treatment Expert consensus