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中国有色金属学会会刊：英文版 2004年第Z1期14卷 413-419页

作者： ZOU Yang pan chun-xu FU Qiang Department of Physics & Center for Electron Microscopy Wuhan University Wuhan 430063 China Department of Physics & Center for Electron Microscopy Wuhan University Wuhan 430063 China Department of Physics & Center for Nano-Science and Technology Wuhan University Wuhan 430063 China

The present work studied the corrosion properties around the fusion boundaries of 2.25Cr-1Mo steel with stainless steel strip overlay joints under as welded condition and after post-weld heat treatment (PWHT) in H2 S containing solution (NACE TM-01-77 standard) with different time. An in-situ observation method was introduced for evaluating corrosive progress in the fusion boundary in H2 S containing solution, that is, the samples were marked firstly at the boundary and then treated in the solution for variant time. Each time after the corrosion treatment, the observations were kept to focus at the same marked area by using scanning electron microscopy (SEM) to observe the corrosion progress. The results reveal that the fusion boundary is the worst region for corrosion resistance when comparing with other boundaries, and a broad fusion boundary has a stronger resistance for "hydrogen induced disbonding" than a narrow one.

关键词： dissimilar steel welding fusion boundary H2S corrosion post-weld heat treatment

CPT-11 Chemotherapy Rescued A Patient with Atypical Sclerosing Epithelioid Fibrosarcoma from Emergent Condition

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Chinese Journal of Cancer Research 2012年第3期24卷 253-256页

作者： chun-hua pan Xi-qun Han Jian-sheng Li Department of Medical Oncology Affiliated Tumor Hospital of Guangzhou Medical CollegeGuangzhou 510095China Department of Pathology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 520515China Department of Image Affiliated Tumor Hospital of Guangzhou Medical CollegeGuangzhou 510095China

Sclerosing epithelioid fibrosarcoma （SEF） is a rare and poorly defined variant of fibrosarcoma, but generally insensitive to chemotherapy and progresses with poor prognosis. We report the marvelous effect of irinotecan hydrochloride （CPT-11） chemotherapy in rescuing a patient with atypical SEF from emergent condition, who underwent recurrences after several treatment methods. Small dose of CPT-11 was administered to the patient, with which, the size of superficial mass （cervical lymph node） gradually decreased observed by the naked eyes in 5 days. X-ray and CT image proved a marked reduction in the size of the tumor. CPT-11 is valuable for the treatment of this aggressive sarcoma. In condition of emergency caused by sarcoma oppression, administering a tolerable small dose of topoisomerase I-inhibiting drug could be a beneficial choice.

关键词： Sclerosing epithelioid fibrosarcoma CPT- Chemotherapy

Development of the Embedded Protective Device Based on ARM

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Journal of China University of Mining and Technology 2005年第4期15卷 344-347页

作者： LIU Xiao-wen LI Na pan chun-de School of Information ＆ Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

An embedded protective device for 35kV power line is worked out based on Philips’ LPC2292 ARM MCU. Several aspects such as embedded design technique adopted in the system framework, application of adaptive theory in data acquisition, Board Support Packet (BSP) developing and task dispatching related to operating system are discussed. Both hardware and software framework of the system are given. Advanced hardware platform and software development environment is applied in design of the system, with the advanced co-design technology.

关键词： microcomputer protective device ARM embedded operating system adaptive theory BSP

BmCyclin B and BmCyclin B3 are required for cell cycle progression in the silkworm, Bombyx mori

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Science China(Life Sciences) 2013年第4期56卷 360-365页

作者： pan MinHui HONG KaiLi CHEN XiangYun pan chun CHEN XueMei KUANG XiuXiu LU Cheng State Key Laboratory of Silkworm Genome Biology Southwest University

Cyclin B is an important regulator of the cell cycle G2 to M phase transition. The silkworm genomic database shows that there are two Cyclin B genes in the silkworm (Bombyx mori), BmCyclin B and BmCyclin B3. Using silkworm EST data, the cyclin B3 (EU074796) gene was cloned. Its complete cDNA was 1665 bp with an ORF of 1536 bp derived from seven exons and six introns. The BmCyclin B3 gene encodes 511 amino acids, and the predicted molecular weight is 57.8 kD with an isoelectric point of 9.18. The protein contains one protein damage box and two cyclin boxes. RNA interference-mediated reduction of BmCyclin B and BmCyclin B3 expression induced cell cycle arrest in G2 or M phase in BmN-SWU1 cells, thus inhibiting cell proliferation. These results suggest that BmCyclin B and BmCyclin B3 are necessary for completing the cell cycle in silkworm cells.

关键词： Bombyx mori cell cycle BmCyclin B BmCyclin B3 cell proliferation

Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi chun-Hsu pan Hui-Yu Huang Chieh-Hsi Wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

Hemichorea in patients with temporal lobe infarcts: Two case reports

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World Journal of Clinical Cases 2024年第4期12卷 806-813页

作者： Xu-Dong Wang Xing Li chun-Lian pan Department of Neurology Puren Hospital Affiliated to Wuhan University of Science and TechnologyWuhan 430081Hubei ProvinceChina School of Medicine Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina

BACKGROUND Hemichorea and other hyperkinetic movement disorders are uncommon present-ations of stroke and are usually secondary to deep infarctions affecting the basal ganglia and ***,temporal ischemic lesions causing hemichorea are *** report the cases of two patients with acute ischemic temporal lobe infarct strokes that presented as *** SUMMARY Patient 1:An 82-year-old woman presented with a 1-mo history of involuntary movement of the left extremity,which was consistent with *** diffusion-weighted imaging(DWI)revealed an acute ischemic stroke that predominantly affected the right temporal cortex,and magnetic resonance angiography of the head showed significant stenosis of the right middle cerebral artery(MCA).Treatment with 2.5 mg of olanzapine per day was *** she was discharged from the hospital,her symptoms appeared to have improved compared with those previously ***-seven days after the first admission,she was readmitted due to acute ischemic *** tomogra-phy perfusion showed marked hypoperfusion in the right MCA *** emergency transfemoral cerebral angiogram was performed and showed severe stenosis in the M1 segment of the right *** percutaneous transluminal angioplasty was successfully performed,abnormal movements or other neuro-logic problems did not *** 2:A 76-year-old man was admitted to our hospital for a 7-d history of right-upper-sided involuntary *** showed an acute patchy ischemic stroke in the left temporal lobe without basal ganglia *** diffusion tensor imaging confirmed fewer white matter fiber tracts on the left side than on the opposite *** with 2.5 mg of olanzapine per day improved his condition,and he was *** When acute hemichorea suddenly appears,temporal cortical ischemic stroke should be considered a possible *** addition,hemichorea may be a sign of impending cerebral infarcti

关键词： Acute ischemic stroke Temporal ischemic stroke Movement disorders Cortical hemichorea Case report

Synthesis and Characterization of Electroless Ni-P/Ni-Mo-P Duplex Coating with Different Thickness Combinations

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Acta Metallurgica Sinica(English Letters) 2017年第10期30卷 1008-1016页

作者： Gong-Sheng Song Shuo Sun Zhong-Chi Wang Cheng-Zhi Luo chun-Xu pan School of Physics and Technology and MOE Key Laboratory of Artificial Micro- and Nano-StructuresWuhan University School of Science Shenyang University of Technology Center for Electron Microscopy Wuhan University

In this work, a novel duplex Ni-P/Ni-Mo-P coating upon the aluminum（Al） substrate was synthesized via an electroless plating, i.e., the binary Ni-P coating as a transition layer and the ternary Ni-Mo-P coating on the top. It was found that the duplex coating was of a high hardness,large elastic modulus,low porosity and excellent corrosion resistance. In addition, experimental results revealed that for a total 20 μm coating thickness, the duplex coating with a 7 μm of the Ni-Mo-P coating exhibited the best corrosion resistance in 0.5 mol/L sulfuric acid solution, which was attributed to its compact structure and low porosity. This duplex Ni-P/Ni-Mo-P coating with a thin ternary Ni-Mo-P layer is expected to solve the problem of low deposition rate of ternary alloy coating and thereby may expand applications of Al and its alloys in the fields of machine manufacture and corrosion environment.

关键词： Electroless plating Aluminum (Al) Porosity Ni-P/Ni-Mo-P duplex coating Corrosion resistance

Strain-tuned magnetic properties in(Ga,Fe)Sb:First-principles study

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Chinese Physics B 2021年第9期30卷 388-392页

作者： Feng-chun pan Xue-Ling Lin Xu-Ming Wang School of Physics and Electronic-Electrical Engineering Ningxia UniversityYinchuan 750021China

In view of the importance of enhancing ferromagnetic(FM)coupling in dilute magnetic semiconductors(DMSs),the effects of strain on the electronic structures and magnetic properties of(Ga,Fe)Sb were examined by a first-principles *** results of the investigation indicate that Fe_(Ga) substitution takes place in the low-spin state(LSS)with a total magnetic moment of 1μB in the strain range of-3%to 0.5%,which transitions to the high-spin state(HSS)with a total magnetic moment of 5μB as the strain changes from 0.6%to 3%.We attribute the changes in the amount and distribution of the total moment to the influence of the crystal field under different *** FM coupling is strongest under a strain of about 0.5%,but gradually becomes weaker with increasing compressive and tensile *** magnetic coupling mechanism is discussed in *** results highlight the important contribution of strain to magnetic moment and FM interaction intensity,and present an interesting avenue for the future design of high Curie temperature(TC)materials in the(Ga,Fe)Sb system.

关键词： GaSb Fe ferromagnetism strain

Plasma Transferred Arc Surface Alloying of Cr-Ni-Mo Powders on Compacted Graphite Iron

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Journal of Iron and Steel Research International 2016年第6期23卷 618-624页

作者： Ji-jun FENG chun-xu pan Liu-lin LU Qi-wen HUANG Hua-tang CAO School of Physics and Technology Wuhan University Wuhan 430072 Hubei China Dongfeng Commercial Vehicle Technology Center Wuhan 430056 Hubei China School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 Hubei China Department of Advanced Production Engineering Engineering and Technology Institute Groningen University of Groningen Groningen 9747 The Netherlands

A Cr-Ni-Mo overlayer was deposited on the surface of compacted graphite iron（CGI）by the plasma transferred arc（PTA）alloying *** microstructure of Cr-Ni-Mo overlayer was characterized by optical microscopy（OM）,scanning electron microscopy（SEM）equipped with energy dispersive spectroscopy（EDS）,and X-ray diffractometer（XRD）.Results show that the cross-section consists of four regions：alloying zone（AZ）,molten zone（MZ）,heat affected zone（HAZ）,and the substrate（SUB）.The microstructure of AZ mainly consists of cellularγ-（Fe,Ni）solid solution,residual austenite and a network of eutectic Cr7C3 carbide while the MZ area has a typical feature of white cast iron（M3C-type cementite）.The martensite/ledeburite double shells are observed in the *** decreasing the concentration of Cr-Ni-Mo alloys,the fracture mode changes from ductile in the AZ to brittle in the *** maximum hardness of the AZ（450 HV0.2）is lower than that of the MZ（800 HV0.2）.The eutectic M3 C and M7C3 carbides increase the microhardness,while the austenite decreases that of the AZ.

关键词： microhardness diffractometer graphite eutectic dispersive alloying martensite carbide austenite decreasing

Environmental microcystin exposure triggers the poor prognosis of prostate cancer: Evidence from case-control, animal, and in vitro studies

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Journal of Environmental Sciences 2023年第5期127卷 69-81页

作者： chun pan Haixiang Qin Minghao Yan Xuefeng Qiu Wenyue Gong Wenxin Luo Hongqian Guo Xiaodong Han Immunology and Reproduction Biology Laboratory&State Key Laboratory of Analytical Chemistry for Life Science Medical SchoolNanjing UniversityNanjing 210093China Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjing 210093China Department of Urology Drum Tower HospitalMedical School of Nanjing UniversityInstitute of UrologyNanjing UniversityNanjing 210008China

Microcystin-leucine-arginine(MC-LR)is positively linked with multiple cancers in ***,the association between MC-LR and the risk and prognosis of prostate cancer has not been conducted in epidemiological *** reported studies have linked MC-LR exposure to the poor prognosis of prostate cancer by conducting experimental *** content of MC-LR was detected in most of the aquatic food in wet markets and supermarkets in Nanjing and posed a health risk for ***-LR levels in both prostate cancer tissues and serum were significantly higher than *** adjusted odds ratio(OR)for prostate cancer risk by serum MC-LR was 1.75(95%CI:1.21-2.52)in the whole subjects,and a positive correlation between MC-LR and advanced tumor stage was *** curve analysis indicated patients with higher MC-LR levels in tissues exhibited poorer overall ***,animal,and cell studies confirmed that MC-LR exposure increases the expression of estrogen receptor-α(ERα)and promotes epithelial-mesenchymal transition(EMT)in prostate ***,MC-LR-induced decreased E-cadherin levels,increased vimentin levels,and increased migratory and invasive capacities of prostate cancer cells were markedly suppressed upon ERα***-LR-induced xenograft tumor growth and lungmetastasis in BALB/c nude mice can be effectively alleviated with ERα*** data demonstrated that MC-LR upregulated vimentin and downregulated E-cadherin through activating ERα,promoting migration and invasion of prostate cancer *** findings highlight the role of MC-LR in prostate cancer,providing new perspectives to understand MC-LR-induced prostatic toxicity.

关键词： Microcystin-leucine-arginine (MC-LR) Estrogen receptor-α(ERα) Epithelial-mesenchymal transition (EMT) Prostate cancer E-cadherin Vimentin