Environmental microcystin exposure triggers the poor prognosis of prostate cancer: Evidence from case-control, animal, and in vitro studies

作     者：Chun Pan Haixiang Qin Minghao Yan Xuefeng Qiu Wenyue Gong Wenxin Luo Hongqian Guo Xiaodong Han Chun Pan;Haixiang Qin;Minghao Yan;Xuefeng Qiu;Wenyue Gong;Wenxin Luo;Hongqian Guo;Xiaodong Han

作者机构：Immunology and Reproduction Biology Laboratory&State Key Laboratory of Analytical Chemistry for Life ScienceMedical SchoolNanjing UniversityNanjing 210093China Jiangsu Key Laboratory of Molecular MedicineNanjing UniversityNanjing 210093China Department of UrologyDrum Tower HospitalMedical School of Nanjing UniversityInstitute of UrologyNanjing UniversityNanjing 210008China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2023年第127卷第5期

页      面：69-81页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 100214[医学-肿瘤学] 0713[理学-生态学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.31870492,31901182) the Natural Science Foundation of Jiangsu Province of China(No.BK20190316) 

主　　题：Microcystin-leucine-arginine (MC-LR) Estrogen receptor-α(ERα) Epithelial-mesenchymal transition (EMT) Prostate cancer E-cadherin Vimentin 

摘      要：Microcystin-leucine-arginine(MC-LR)is positively linked with multiple cancers in ***,the association between MC-LR and the risk and prognosis of prostate cancer has not been conducted in epidemiological *** reported studies have linked MC-LR exposure to the poor prognosis of prostate cancer by conducting experimental *** content of MC-LR was detected in most of the aquatic food in wet markets and supermarkets in Nanjing and posed a health risk for ***-LR levels in both prostate cancer tissues and serum were significantly higher than *** adjusted odds ratio(OR)for prostate cancer risk by serum MC-LR was 1.75(95%CI:1.21-2.52)in the whole subjects,and a positive correlation between MC-LR and advanced tumor stage was *** curve analysis indicated patients with higher MC-LR levels in tissues exhibited poorer overall ***,animal,and cell studies confirmed that MC-LR exposure increases the expression of estrogen receptor-α(ERα)and promotes epithelial-mesenchymal transition(EMT)in prostate ***,MC-LR-induced decreased E-cadherin levels,increased vimentin levels,and increased migratory and invasive capacities of prostate cancer cells were markedly suppressed upon ERα***-LR-induced xenograft tumor growth and lungmetastasis in BALB/c nude mice can be effectively alleviated with ERα*** data demonstrated that MC-LR upregulated vimentin and downregulated E-cadherin through activating ERα,promoting migration and invasion of prostate cancer *** findings highlight the role of MC-LR in prostate cancer,providing new perspectives to understand MC-LR-induced prostatic toxicity.