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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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High Performance MPI over the Slingshot Interconnect

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Journal of Computer Science & Technology 2023年第1期38卷 128-145页

作者： Kawthar Shafie Khorassani chen-chun chen Bharath Ramesh Aamir Shafi Hari Subramoni Dhabaleswar K.Panda Department of Computer Science and Engineering The Ohio State UniversityColumbusOH 43210U.S.A.

The Slingshot interconnect designed by HPE/Cray is becoming more relevant in high-performance computing with its deployment on the upcoming exascale *** particular,it is the interconnect empowering the first exascale and highest-ranked supercomputer in the world,*** offers various features such as adaptive routing,congestion control,and isolated *** deployment of newer interconnects sparks interest related to performance,scalability,and any potential bottlenecks as they are critical elements contributing to the scalability across nodes on these *** this paper,we delve into the challenges the Slingshot interconnect poses with current state-of-the-art MPI(message passing interface)*** particular,we look at the scalability performance when using Slingshot across *** present a comprehensive evaluation using various MPI and communication libraries including Cray MPICH,Open-MPI+UCX,RCCL,and MVAPICH2 on CPUs and GPUs on the Spock system,an early access cluster deployed with Slingshot-10,AMD MI100 GPUs and AMD Epyc Rome CPUs to emulate the Frontier *** also evaluate preliminary CPU-based support of MPI libraries on the Slingshot-11 interconnect.

关键词： AMD GPU interconnect technology MPI(message passing interface) Slingshot

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Eigenstate properties of the disordered Bose-Hubbard chain

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Frontiers of physics 2024年第4期19卷 57-72页

作者： Jie chen chun chen Xiaoqun Wang Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Physics Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Many-body localization(MBL)of a disordered interacting boson system in one dimension is studied numerically at the filling faction *** von Neumann entanglement entropy Svn is commonly used to detect the MBL phase transition but remains challenging to be directly *** on the U(1)symmetry from the particle number conservation,Svn can be decomposed into the particle number entropy S_(n) and the configuration entropy *** light of the tendency that the eigenstate's S_(c) nears zero in the localized phase,we introduce a quantity describing the deviation of S from the ideal thermalization distribution;finite-size scaling analysis illustrates that it shares the same phase transition point with Sv but displays the better critical *** observation hints that the phase transition to MBL might largely be determined by S and its fluctuations Notably,the recent experiments[***,et al.,Science 364,256(2019);***,et al.,***.19,481(2023)]demonstrated that this deviation can potentially be measured through the Sn ***,our investigations reveal that the thermalized states primarily occupy the low-energy section of the spectrum,as indicated by measures of localization length,gap ratio,and energy density *** low-energy spectrum of the Bose model closely resembles the entire spectrum of the Fermi(or spin XXZ)model,accommodating a transition from the thermalized to the localized ***,owing to the bosonic statistics,the high-energy spectrum of the model allows the formation of distinct clusters of bosons in the random potential *** analyze the resulting eigenstate properties and briefly summarize the associated *** distinguish between the phase regions at the low and high energies,a probing quantity based on the structure of S_(VN) is also *** work highlights the importance of symmetry combined with entanglement in the study of *** this regard,for the disordered Heisenberg XXZ

关键词： entanglement entropy decomposition U(1)symmetry thermalization-to-localization transition

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On the behavior of the product of independent random variables

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Science China Mathematics 2006年第3期49卷 342-359页

作者： SU chun chen Yu Department of Statistics and Finance University of Science and Technology of China Hefei 230026 China Department of Statistics and Finance University of Science and Technology of China Hefei 230026 China

For two independent non-negative random variables X and Y, we treat X as the initial variable of major importance and Y as a modifier (such as the interest rate of a portfolio).Stability in the tail behaviors of the product compared with that of the original variable X is of practical interests. In this paper, we study the tail behaviors of the product XY when the distribution of X belongs to the classes L and S, respectively. Under appropriate conditions, we show that the distribution of the product XY is in the same class as X when X belongs to class L or S, in other words, classes L and S are stable under some mild conditions on the distribution of Y. We also show that if the distribution of X is in class L(γ) (γ＞ 0) and continuous, then the product XY is in L if and only if Y is unbounded.

关键词： independent product, stability, tails of a distribution, heavy-tailed.

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Molecular transformation of dissolved organic matter in refinery wastewaters: Characterized by FT-ICR MS coupled with electrospray ionization and atmospheric pressure photoionization

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Petroleum Science 2023年第1期20卷 590-599页

作者： chen He Wei-Ming chen chun-Mao chen Quan Shi State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Oil and Gas Pollution ControlChina University of PetroleumBeijing 102249China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengduSichuan 611756China

Dissolved organic matter(DOM)in refinery wastewater is an extremely complex mixture of various organic *** mass spectrometry,it is impossible to characterize all of the DOM molecules with only one ionization *** this study,negative-ion,electrospray ionization(ESI),positive-ion ESI,and positive-ion atmospheric pressure photoionization(APPI)were coupled with Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS)to analyze the molecular composition of DOM in a refinery wastewater stream during the treatment *** were obvious differences in the heteroatom composition,number of DOM constituents,and chemical properties in refinery wastewater under the three ionization *** CHO and CHOS compounds detected by(+)ESI,basic CHN and CHON compounds detected by(þ)ESI,and hydrocarbons detected by(+)APPI were analyzed to determine the molecular transformations that occurred during *** an anaerobic biological treatment process,acidic CHO and CHOS compounds with a high oxygen content were preferentially removed,and acidic CHO and CHOS compounds with a low oxygen content were *** an aerobic biological process,acidic CHO and CHOS compounds with a low oxygen content were preferentially removed,and acidic CHO and CHOS compounds with a high oxygen content were *** whole biological treatment process has a poor removal efficiency for CHN and CHON compounds,and *** activated carbon(AC)adsorption process removed different heteroatom compounds mainly with a low oxygen content for acidic and basic *** transformation mechanism of CHO and CHOS compounds in the biological treatment process was analyzed by the Kendrick mass defect(KMD)theory and a mass difference network *** the anaerobic process,large amounts of oxygenated CHO and CHOS compounds were degraded by decarboxylation,deoxydation,demethoxylation,and dehydration reactions,and converted to lower oxygen content *** the aerobic

关键词： Refinery wastewater DOM Molecular transformation ESI APPI FT-ICR MS

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CONVERGENCE ANALYSIS OF MORLEY ELEMENT ON ANISOTROPIC MESHES

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Journal of Computational Mathematics 2006年第2期24卷 169-180页

作者： Shi-peng Mao Shao-chun chen ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China Department of Mathematics Zhengzhou University Zhengzhou 450052 China

The main aim of this paper is to study tile convergence of a nonconforming triangular plate element-Morley element under anisotropic meshes. By a novel approach, an explicit bound for the interpolation error is derived for arbitrary triangular meshes （which even need not satisfy the maximal angle condition and the coordinate system condition ）, the optimal consistency error is obtained for a family of anisotropically graded finite element meshes.

关键词： Anisotropic meshes Interpolation error Consistency error Morley element.

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Western blotting in the diagnosis of duodenal-biliary and pancreaticobiliary refluxes in biliary diseases

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 608-613页

作者： chun-Chih chen Department of General Surgery Shengjing HospitalChina Medical University

BACKGROUND: Currently adopted diagnostic methods for duodenal-biliary and pancreaticobiliary refluxes carry many flaws, so the incidence of the two refluxes demands further larger sample size studies. This study aimed to evaluate Western blotting for the diagnosis of refluxes in biliary diseases. METHODS: An oral radionuclide (99)mTc-DTPA test (radionuclide, RN) was conducted for the observation of duodenal-biliary reflux prior to measuring bile radioactivity and Western blotting for detecting bile enterokinase (EK). Pancreaticobiliary reflux was assessed by biochemical and Western blotting tests for biliary amylase activity and trypsin-1, respectively. In accordance with bile sample origin, our samples were classified into ductal bile and gall bile groups; based on each individual biliary disease, we further classified the ductal bile group into five subgroups, and the gall bile group into four sub-groups. Western blotting was conducted to assess the two refluxes in biliary diseases. RESULTS: Consistencies were noted between EK and RN tests when diagnosing duodenal-biliary reflux (P0.05); in the common bile duct cyst group, the EK positive rate was significantly lower than the trypsin-1 positive rate (P<0.05). CONCLUSIONS: Western blotting can accurately reflect duodenal-biliary and pancreaticobiliary refluxes. EK has greater sensitivity than RN for duodenal-biliary reflux. The majority of biliary amylase and lipase comes from the pancreas in all biliary diseases; pancreaticobiliary reflux is the predominant source in the common bile duct cyst group and duodenal-biliary reflux is responsible for the ductal pigment stone group.

关键词： pancreaticobiliary reflux duodenal-biliary reflux trypsin-1 enterokinase biliary diseases

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Electrical Properties of NASICON-type Structured Li1.3Al0.3Ti1.7（PO4）3 Solid Electrolyte Prepared by 1,2-Propylene glycol-assisted Sol-gel Method

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Chinese Journal of Chemical Physics 2012年第6期25卷 703-707,I0004页

作者： Lin-chaoZhang Peng chen Zhang Hu chun-hua chen CAS Key Laboratory of Materials for Energy Conversion Department of Materials Science. and EnEi-neering University of Science and Technology of China Hefei 230025 China

Lithium-ion conductor Liz.3Alo.3Ti1.7（P04）3 with an ultrapure NASICON-type phase is syn- thesized by a 1,2-propylene glycol （1,2-PG）-assisted sol-gel method and characterized by differential thermal analysis-thermo gravimetric analysis, X-ray diffraction, scanning elec- tron microscopy, electrochemical impedance spectroscopy, and chronoamperornetry test. Due to the use of 1,2-PG, a homogeneous and light yellow transparent precursor solu- tion is obtained without the precipitation of Ti4＋ and A13＋ with PO43- Well crystallized Lil.3Alo.3Til.7（PO4）3 can be prepared at much lower temperatures from 850 ~C to 950 ~C within a shorter synthesis time compared with that prepared at a temperature above 1000 ~C by a conventional solid-state reaction method. The lithium ionic conductivity of the sintered pellets is up to 0.3 mS/cm at 50 ℃ with an activation energy as low as 36.6 k J/tool for the specimen pre-sintered at 700 ℃ and sintered at 850 ℃. The high conductivity, good chemi- cal stability and easy fabrication of the Li1.3Al0.3Ti1.7（PO4）a provide a promising candidate as solid electrolyte for all-solid-state Li-ion rechargeable batteries.

关键词： Lithium aluminum titanium phosphate Lithium-ion conductor NASICONelectrolyte Impedance spectroscopy

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A Remark on the Beale-Kato-Majda Criterion for the 3D MHD Equations with Zero Kinematic Viscosity

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Acta Mathematicae Applicatae Sinica 2012年第2期28卷 209-214页

作者： Sadek GALA Xiao-chun chen Department of Mathematics University of Mostaganem Box 227 Mostaganem 27000 Algeria Department of Mathematics Chonqing Three Gorges University Wanzhou 404000 China

In this paper, we study the blow-up criterion of smooth solutions to the 3D magneto-hydrodynamic system in B^0∞,∞. We show that a smooth solution of the 3D MHD equations with zero kinematic viscosity in the whole sp... 详细信息

关键词： Magneto-hydrodynamic equations with zero viscosity B^0∞,∞ space blow-up criterion

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New Amines and Activation Modes in Asymmetric Aminocatalysis

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Chinese Journal of Chemistry 2021年第7期39卷 1775-1786页

作者： Zhi-Chao chen Wei Du Ying-chun chen Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China College of Pharmacy Third Military Medical UniversityShapingbaChongqing 400038China

Asymmetric aminocatalysis has become one of the most powerful strategies for the transformations of carbonyl substances over the past two ***,we describe the research from our laboratory that significantly expands the horizon of *** includes the development and application of cinchona-based primary amines,fruitful reactions based on HOMO-raising strategy,and the disclosure of amine/thiol double activation catalysis.

关键词： Organocatalysis Aminocatalysis Amine/thiol double catalysis Cycloaddition Domino reactions

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