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加氢裂化装置氢源氢阱关联模型

计算机与应用化学 2017年第1期34卷 69-74页

作者：周凌子邓春冯霄中国石油大学(北京)重质油国家重点实验室北京102249 西安交通大学化学工程与技术学院陕西西安710049

目前氢网络的优化研究都视氢源的流率和浓度、氢阱的需求流率和浓度约束为固定的参数。实际上当加氢装置补充氢流股的组分发生变化,会引起其循环氢流股和高分气、低分气以及干气等氢源流股的流率、组成变化,从而影响氢网络的流率分配。... 详细信息

目前氢网络的优化研究都视氢源的流率和浓度、氢阱的需求流率和浓度约束为固定的参数。实际上当加氢装置补充氢流股的组分发生变化,会引起其循环氢流股和高分气、低分气以及干气等氢源流股的流率、组成变化,从而影响氢网络的流率分配。本文利用Aspen Hysys中的加氢裂化模块对某加氢裂化装置进行建模,以工业实际数据为基础,验证并调整模型。进而,改变装置入口氢阱流股(补充氢)的浓度,获得装置出口氢源流股(循环氢,低分气)流量和浓度的数据,通过数据拟合得到氢源氢阱的数学关联模型。结果表明,低分气流量随补充氢浓度增加线性减小,低分气浓度、循环气流量和浓度随补充氢浓度线性增加。

关键词：氢网络优化加氢裂化氢源氢阱关联模型

天津港30万吨级航道建成后港区泥沙回淤分析

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水道港口 2018年第2期39卷 133-138页

作者：刘维利温春鹏天津港(集团)有限公司天津300456 交通运输部天津水运工程科学研究所港口水工建筑技术国家工程实验室工程泥沙交通行业重点实验室天津300456

天津港是我国最大的人工港,近年来在港口深水化战略的实施下,航道等级已经提升到30万t级,通过实测资料和室内试验结果,对天津港海域的水文泥沙环境以及泥沙的水力特性进行了分析,同时利用实测水深图和数学模型计算,综合分析天津港30万t... 详细信息

天津港是我国最大的人工港,近年来在港口深水化战略的实施下,航道等级已经提升到30万t级,通过实测资料和室内试验结果,对天津港海域的水文泥沙环境以及泥沙的水力特性进行了分析,同时利用实测水深图和数学模型计算,综合分析天津港30万t级航道建成后港区淤积强度以及分布规律,以期为天津港年度维护疏浚计划的制定提供依据。

关键词：天津港 30万t级航道水力特性淤积规律

Design and pricing of maintenance service contract based on Nash non-cooperative game approach

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Journal of Systems Engineering and Electronics 2024年第1期35卷 118-129页

作者： SU chun HUANG Kui School of Mechanical Engineering Southeast UniversityNanjing 211189China

Nowadays manufacturers are facing fierce *** from the products,providing customers with multiple maintenance options in the service contract becomes more popular,since it can help to improve customer satisfaction,and ultimately promote sales and maximize profit for the *** considering the combinations of corrective maintenance and preventive maintenance,totally three types of maintenance service contracts are ***,attractive incentive and penalty mechanisms are adopted in the *** this basis,Nash non-cooperative game is applied to analyze the revenue for both the manufacturer and customers,and so as to optimize the pricing mechanism of maintenance service contract and achieve a win-win *** experiments are *** results show that by taking into account the incentive and penalty mechanisms,the revenue can be improved for both the customers and ***,with the increase of repair rate and improvement factor in the preventive maintenance,the revenue will increase gradually for both the parties.

关键词： maintenance service contract Nash game incentive and penalty mechanism corrective maintenance preventive maintenance

甘蓝型油菜种质氮素营养效率的鉴定及评价指标筛选

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中国油料作物学报 2018年第2期40卷 247-257页

作者：邹小云刘宝林李俊宋来强官春云江西省农业科学院作物研究所/江西省油料作物生物学重点实验室江西南昌330200 湖南农业大学油料作物研究所/国家油料作物改良中心湖南分中心湖南长沙410128 中国农业科学院油料作物研究所湖北武汉430062

为建立甘蓝型油菜种质氮素营养效率的鉴定及评价方法,筛选合理的次级评价指标和氮素营养高效基因型,在田间小区试验条件下设置低氮(45kg/hm^2.、中氮(180kg/hm^2.和高氮(2.0kg/hm^2.3个施氮水平,测定了416份不同生态类型甘蓝型油菜种质... 详细信息

为建立甘蓝型油菜种质氮素营养效率的鉴定及评价方法,筛选合理的次级评价指标和氮素营养高效基因型,在田间小区试验条件下设置低氮(45kg/hm^2.、中氮(180kg/hm^2.和高氮(2.0kg/hm^2.3个施氮水平,测定了416份不同生态类型甘蓝型油菜种质植株性状及氮素吸收效率(NAE)、氮素利用效率(NUE)和氮收获指数(NHI)。各性状在不同氮素水平下对氮的敏感性不同,低氮下第一次有效分枝数的变异程度最大,单株籽粒重次之;中氮和高氮处理水平下单株籽粒重的变异程度均表现为最大,低氮胁迫加大了种质间的差异。油菜种质氮素营养效率基因型间差异明显,表现中效类型的种质最多,高效和低效的较少。油菜种质间成熟期NAE的鉴定与评价应选择在低氮处理下,以单株籽粒重、单株地上干重和株高为间接指标进行选择效果明显;油菜种质间成熟期NUE的鉴定与评价应选择在高氮处理下,以单株地上干重、第一次有效分枝数、单株籽粒重和每角粒数为间接指标进行选择效果明显;油菜种质间成熟期NHI的鉴定与评价应选择在低氮处理下,以单株籽粒重、单株地上干重和茎基粗为间接指标进行选择效果明显。

关键词：甘蓝型油菜种质氮素营养效率单株籽粒重单株地上干重茎基粗

T细胞受体基因转导T细胞免疫治疗技术的研究进展

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生命科学 2017年第11期29卷 1197-1204页

作者：李伟施炜星杜盈王倩杨春霞泰州医药高新技术产业园区泰州225300 江苏西迪尔生物技术有限公司泰州225300 上海宇研生物技术有限公司上海200333

T细胞受体(T cell receptor,TCR)基因转导的T细胞疗法(TCR-T)是目前发展较快的一种新的过继性细胞免疫疗法,该方法主要是将肿瘤特异的TCR基因通过各种载体转入自体或异体的淋巴细胞中,再回输至患者体内以达到杀伤肿瘤细胞的目的。因此,... 详细信息

T细胞受体(T cell receptor,TCR)基因转导的T细胞疗法(TCR-T)是目前发展较快的一种新的过继性细胞免疫疗法,该方法主要是将肿瘤特异的TCR基因通过各种载体转入自体或异体的淋巴细胞中,再回输至患者体内以达到杀伤肿瘤细胞的目的。因此,肿瘤特异的高亲和性的TCR基因的获取是提高TCR-T细胞治疗的一个重要因素,TCR基因的高水平表达和TCR双链的正确配对也是确保TCR能够在T细胞表面发挥正常抗原识别功能的必要条件。现对TCR的表达及调控机制、TCR基因转导和亲和力的优化策略,以及TCR-T在肿瘤治疗临床试验中的进展与所面临的问题做了详细的阐述。

关键词： T细胞受体过继性细胞治疗 TCR-T脱靶效应临床试验

The role of innate immunity in diabetic nephropathy and their therapeutic consequences

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Journal of Pharmaceutical Analysis 2024年第1期14卷 39-51页

作者： Min Yang chun Zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Diabetic nephropathy (DN) is an enduring condition that leads to inflammation and affects a substantial number of individuals with diabetes worldwide. A gradual reduction in glomerular filtration and emergence of proteins in the urine are typical aspects of DN, ultimately resulting in renal failure. Mounting evidence suggests that immunological and inflammatory factors are crucial for the development of DN. Therefore, the activation of innate immunity by resident renal and immune cells is critical for initiating and perpetuating inflammation. Toll-like receptors (TLRs) are an important group of receptors that identify patterns and activate immune responses and inflammation. Meanwhile, inflammatory responses in the liver, pancreatic islets, and kidneys involve inflammasomes and chemokines that generate pro-inflammatory cytokines. Moreover, the activation of the complement cascade can be triggered by glycated proteins. This review highlights recent findings elucidating how the innate immune system contributes to tissue fibrosis and organ dysfunction, ultimately leading to renal failure. This review also discusses innovative approaches that can be utilized to modulate the innate immune responses in DN for therapeutic purposes.

关键词： Innate immunity Diabetic nephropathy Inflammation Toll-like receptor Inflammasomes

Pb induced dislocation defects of PtCo systems: Strain-triggered oxygen reduction reaction for PEMFC

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Nano Research 2024年第4期17卷 2462-2472页

作者： chun Jin Qiheng Wang Jingjun Liu Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing 100029China Beijing University of Chemical Technology Beijing 100029China

Design and development of advanced electrocatalysts with high performance and low Pt consumption are crucial for reducing the kinetic energy barrier of the cathode oxygen reduction reaction(ORR)and improving the efficiency of proton exchange membrane fuel cells(PEMFC).In this study,we demonstrate a Pb-modulated PtCo system for efficient ORR,in which the inclusion of Pb in ternary alloys induces dislocation defects due to the significant difference in atomic ***-PtCoPb was confirmed to exhibit significantly higher ORR activity and stability in acidic *** practical PEMFC applications,it outperforms the corresponding commercial Pt/C with a mass activity of 0.58 A·mgPt^(-1),making it a promising alternative to state-of-the-art Pt-based *** combination of experimental results and density functional theory(DFT)calculations offers valuable atomic-level insights into the dislocation *** with a larger atomic radius is located in the lattice stretching region below the dislocation slip plane,forming a structure similar to a Cottrell atmosphere,which reduces the dislocation energy and puts the system in a lower energy *** Cottrell atmosphere pins the dislocation structure and stabilizes the ternary *** adjusting the amount of added Pb,a moderate level of dislocation density induces a tuned strain effect,thereby enhancing the electrocatalytic mechanism by optimizing the electronic structure of the alloy surface and the adsorption and desorption of oxygen *** work provides valuable insights into the design and development of lattice dislocation defect structures to trigger strain effects for improving ORR performance.

关键词： dislocation defect strain effect Pb-modulated oxygen reduction reaction

Comprehensive modeling strategy for thermomechanical tribological behavior analysis of railway vehicle disc brake system

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Friction 2024年第1期12卷 74-94页

作者： Jiabao YIN chun LU Jiliang MO School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China Technology and Equipment of Rail Transit Operation and Maintenance Key Laboratory of Sichuan Province Chengdu 610031China

A comprehensive modeling strategy for studying the thermomechanical tribological behaviors is proposed in this *** wear degradation considering the influence of temperature(T)is predicted by Archard wear model with the help of the UMESHMOTION subroutine and arbitrary Lagrangian–Eulerian(ALE)remeshing *** the proposed method,the thermomechanical tribological behaviors of railway vehicle disc brake system composed of forged steel brake disc and Cu-based powder metallurgy(PM)friction block are studied *** effectiveness of the proposed methodology is validated by experimental test on a self-designed scaled brake test bench from the perspectives of interface temperature,wear degradation,friction noise and vibration,and contact status *** work can provide an effective way for the investigation of thermomechanical tribological behaviors in the engineering field.

关键词： tribological behaviors thermomechanical field wear prediction finite element simulation disc brake system railway vehicle

Supercoiled DNA Minicircles under Double-strand Breaks

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Chinese Journal of Polymer Science 2024年第9期42卷 1353-1359,I0007页

作者： Ye-Peng Qiao chun-Lai Ren National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China

Understanding how supercoiled DNA releases intramolecular stress is essential for its functional ***,the molecular mechanism underlying the relaxation process remains insufficiently *** we employed MD simulations based on the oxDNA2.model to investigate the relaxation process of a 336-base pair supercoiled minicircular DNA under double-strand breaks with two fixed *** simulations show that the conformational changes in the DNA occur continuously,with intramolecular stress release happening abruptly only when the DNA chain traverses the breakage *** relaxation process is influenced not only by the separation distance between the fixed ends but also their ***,we observe an inhibitory effect on the relaxation characterized by small angles,where short terminal loops impede DNA conformational adjustments,preserving the supercoiled *** findings elucidate the intricate interplay between DNA conformational change,DNA motion and intramolecular stress release,shedding light on the mechanisms governing the relaxation of supercoiled DNA at the molecular level.

关键词： Supercoiled DNA DNA minicircle DNA relaxation oxDNA model MD simulation