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Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3

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Cellular & Molecular Immunology 2023年第2期20卷 189-200页

作者： Jae-sung Kim Hyo Keun Kim Joongho Lee Sein Jang Euni Cho Seok-Jun Mun Seokhyun Yoon chul-su yang Department of Bionano Technology Hanyang UniversitySeoul04673Korea Institute of Natural Science&Technology Hanyang UniversityAnsan15588Korea Department of Molecular and Life Science Hanyang UniversityAnsan15588Korea Center for Bionano Intelligence Education and Research Ansan15588Korea Department of Computer Science College of SW ConvergenceDankook UniversityYongin16890Korea Department of Electronics&Electrical Engineering College of EngineeringDankook UniversityYongin16890Korea

CD82 is a transmembrane protein that is involved in cancer suppression and activates immune cells;however, information on the NLRP3 inflammasome is limited. Herein, we show that although CD82 suppressed the activation of the NLRP3 inflammasome in vivo and in vitro, CD82 deficiency decreased the severity of colitis in mice. Furthermore, two binding partners of CD82, NLRP3 and BRCC3, were identified. CD82 binding to these partners increased the degradation of NLRP3 by blocking BRCC3-dependent K63-specific deubiquitination. Previous studies have shown that CD82-specific bacteria in the colon microbiota called Bacteroides vulgatus (B. vulgatus) regulated the expression of CD82 and promoted the activation of the NLRP3 inflammasome. Accordingly, we observed that B. vulgatus administration increased mouse survival by mediating CD82 expression and activating NLRP3 in mice with colitis. Overall, this study showed that CD82 suppression reduced the pathogenesis of colitis by elevating the activation of the NLRP3 inflammasome through BRCC3-dependent K63 deubiquitination. Based on our findings, we propose that B. vulgatus is a novel therapeutic candidate for colitis.

关键词： CD82 NLRP3 BRCC3 Colitis Inflammation

Research on Cavitation Characteristics and Influencing Factors of Herringbone Gear Pump

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2917-2946页

作者： Jinlong yang Kwang-Hee Lee chul-Hee Lee Department of Mechanical Engineering of Inha University Incheon22212South Korea

Cavitation is a common issue in pumps,causing a decrease in pump head,a fall in volumetric efficiency,and an intensification of outlet flow *** is one of the main hazards that affect the regular operation of the *** on pump cavitation mainly focuses on mixed flow pumps,jet pumps,external spur gear pumps,***,there are few cavitation studies on external herringbone gear *** addition,pumps with different working principles significantly differ in the flow and complexity of the internal flow ***,it is urgent to study the cavitation characteristics of external herringbone gear *** with experimentalmethods,visual research and cavitation area identification are achieved through computation fluid dynamic(CFD),and changing the boundary conditions and shape of the gear rotor is *** simulation yields a head error of only 0.003%under different grid numbers,and the deviation between experimental and simulation results is less than 5%.The study revealed that cavitation causes flow pulsation at the outlet,and the cavitation serious area is mainly distributed in the meshing gap and meshing *** can be inhibited by reducing the speed,increasing the inlet pressure,and changing the helix angle can be *** example,when the inlet pressure is 5 bar,the maximumgas volume fraction in themeshing area is less than 50%.These results provide a reference for optimizing the design and finding the optimal design parameters to reduce or eliminate cavitation.

关键词： Herringbone gear pump cavitation rotating speed inlet pressure helix angle TwinMesh

A multi-agent collaboration scheme for energy-efficient task scheduling in a 3D UAV-MEC space

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Frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 824-838页

作者： yang LI Ziling WEI Jinshu su Baokang ZHAO College of Computer National University of Defense TechnologyChangsha 410073China Academy of Military Sciences Beijing 100091China

Multi-access edge computing(MEC)presents computing services at the edge of networks to address the enormous processing requirements of intelligent *** to the maneuverability of unmanned aerial vehicles(UAVs),they can be used as temporal aerial edge nodes for providing edge services to ground users in ***,MEC environment is usually dynamic and *** is a challenge for multiple UAVs to select appropriate service ***,most of existing works study UAV-MEC with the assumption that the flight heights of UAVs are fixed;i.e.,the flying is considered to occur with reference to a two-dimensional plane,which neglects the importance of the *** this paper,with consideration of the co-channel interference,an optimization problem of energy efficiency is investigated to maximize the number of fulfilled tasks,where multiple UAVs in a threedimensional space collaboratively fulfill the task computation of ground *** the formulated problem,we try to obtain the optimal flight and sub-channel selection strategies for UAVs and schedule strategies for *** on the multi-agent deep deterministic policy gradient(MADDPG)algorithm,we propose a curiosity-driven and twin-networks-structured MADDPG(CTMADDPG)algorithm to solve the formulated *** uses the inner reward to facilitate the state exploration of agents,avoiding convergence at the sub-optimal ***,we adopt the twin critic networks for update stabilization to reduce the probability of Q value *** simulation results show that CTMADDPG is outstanding in maximizing the energy efficiency of the whole system and outperforms the other benchmarks.

关键词： Multi-access edge computing Multi-agent reinforcement learning Unmanned aerial vehicles Task scheduling

Composite Converter Combined APFC with Switched-capacitor Converter

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 281-291页

作者： Qing Fu Yishan Chen Yixing su yang Hang School of Physics Sun Yat-Sen UniversityGuangzhou 510275China

To reduce switch numbers and voltage stress in semiconductor devices,this paper proposes a novel single-phase converter combined Active Power Factor Correction(APFC)with switched-capacitor *** addition,dynamic voltage regulation and voltage gain are improved by integrating the boost converter and switching capacitor *** interstage bulk capacitor is no longer *** average current control with redistribution of voltage in cells is proposed to obtain voltage lift ability of the switching capacitor cells and maintain a high-power *** study and verify the proposed converter preliminarily,theoretical analysis and simulation are presented in the ***,a 50o W prototype with two different configurations is built for experimental *** proposed converter can reach 95.62%of maximum efficiency,0.99 of power factor,and 3.55%of THD with 600 V output voltage,simultaneously.

关键词： AC-DC converter composite conveter power factor correction switched capacitor

Exploring the potential of constructing a hybrid supercapacitor with FeCoNi-LDH porous material containing oxygen vacancies for high-performance energy storage applications

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Nano Research 2024年第9期17卷 8134-8144页

作者： Jihao su Ling yang Dengbin Yu Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China College of Chemistry Jilin UniversityChangchun 130022China University of Science and Technology of China Hefei 230026China

A significant challenge in developing high-performance hybrid supercapacitors(HSCs)is the need to reasonably construct advanced architectures that consist of various components and exhibit superior electrochemical capacitance *** FeCoNi-layered double hydroxide(FeCoNi-LDH)porous material has a specific capacitance of 1960 F·g^(-1)when used as the anode material at 1 A·g^(-1).The FeCoNi-LDH material exhibits nanoplates with a distinct spindle morphology on their *** to the combined action of the three metals and abundant oxygen vacancies,they exhibit unique rate performance and cycle *** electronic structure of LDH and the regulation of oxygen vacancy were confirmed by density functional theory(DFT)*** suggests that the strength of hydroxide can reduce the energy required for oxygen vacancy formation in FeCoNi-LDH nanosheets and enhance ion and charge transfer,as well as electrolyte adsorption on the electrode *** FeCoNi-LDH//activated carbon(AC)HSC has an energy density of 53.2 Wh·kg^(-1)at a power density of 800 W·kg^(-1),surpassing other devices composed of comparable materials during the same *** study made significant advances in the design and synthesis of a ternary LDH porous structure with distinct oxygen vacancies,as well as its potential application in electrochemical energy storage.

关键词： oxygen vacancy FeCoNi-layered double hydroxide(FeCoNi-LDH) theory calculation electrode material hybrid supercapacitor

Adaptive multi-channel Bayesian graph attention network for IoT transaction security

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Digital Communications and Networks 2024年第3期10卷 631-644页

作者： Zhaowei Liu Dong yang Shenqiang Wang Hang su School of Computer and Control Engineering Yantai UniversityYantai264005China Department of Electronics Information and BioengineeringPolitecnico di MilanoMilan20133Italy

With the rapid advancement of 5G technology,the Internet of Things(IoT)has entered a new phase of appli-cations and is rapidly becoming a significant force in promoting economic *** to the vast amounts of data created by numerous 5G IoT devices,the Ethereum platform has become a tool for the storage and sharing of IoT device data,thanks to its open and tamper-resistant ***,Ethereum account security is necessary for the Internet of Things to grow quickly and improve people's *** modeling Ethereum trans-action records as a transaction network,the account types are well identified by the Ethereum account classifi-cation system established based on Graph Neural Networks(GNNs).This work first investigates the Ethereum transaction ***,experimental metrics reveal that the Ethereum transaction network is neither optimal nor even satisfactory in terms of accurately representing transactions per *** flaw may significantly impede the classification capability of GNNs,which is mostly governed by their *** work proposes an Adaptive Multi-channel Bayesian Graph Attention Network(AMBGAT)for Ethereum account clas-sification to address this *** uses attention to enhance node features,estimate graph topology that conforms to the ground truth,and efficiently extract node features pertinent to downstream *** extensive experiment with actual Ethereum transaction data demonstrates that AMBGAT obtains competitive performance in the classification of Ethereum accounts while accurately estimating the graph topology.

关键词： Internet of things Graph representation learning Node classification Security mechanism

A versatile model with three-dimensional triangular lattice for unconventional transport and various topological effects

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National Science Review 2024年第1期11卷 204-214页

作者： Jing-yang You Gang su Yuan Ping Feng Department of Physics National University of Singapore Kavli Institute for Theoretical Sciences and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences Centre for Advanced 2D Materials National University of Singapore

The finite Berry curvature in topological materials can induce many subtle phenomena, such as the anomalous Hall effect(AHE), spin Hall effect(SHE), anomalous Nernst effect(ANE), non-linear Hall effect(NLHE) and bulk photovoltaic effects. To explore these novel physics as well as their connection and coupling, a precise and effective model should be developed. Here, we propose such a versatile model—a 3D triangular lattice with alternating hopping parameters, which can yield various topological phases,including kagome bands, triply degenerate fermions, double Weyl semimetals and so on. We reveal that this special lattice can present unconventional transport due to its unique topological surface states and the aforementioned topological phenomena, such as AHE, ANE, NLHE and the topological photocurrent effect. In addition, we also provide a number of material candidates that have been synthesized experimentally with this lattice, and discuss two materials, including a non-magnetic triangular system for SHE, NLHE and the shift current, and a ferromagnetic triangular lattice for AHE and ANE. Our work provides an excellent platform, including both the model and materials, for the study of Berry-curvature-related physics.

关键词： three-dimensional triangular lattice different topological phases various topological effects Berry curvature

Fast strength-ductility synergistically adjusting of cold spray additive manufactured Cu deposits via electric pulse processing

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Chinese Journal of Aeronautics 2024年第5期37卷 558-569页

作者： Dong WU Yaxin XU Wenya LI Xiawei yang Yu su State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of Friction Welding Technologies School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Electric Pulse Processing(EPP)treatment was innovatively introduced to optimize the strength and ductility of the CSAMed Cu *** results show that EPP is an efficient and fast post-treatment to improve the strength and ductility(within tens of seconds).The larger the pulse current and number of pulses,the better the mechanical ***,this research found that when the heat input determined by pulse current and number of pulses exceeds a certain threshold(pulse current intensity is 2000 A,number of pulses is 10),increasing the number of repeat time could also effectively improve the mechanical properties.A tensile strength of 210 MPa and a ductility of 14.0%could be obtained with reasonable EPP parameters(pulse current intensity is 2000 A,number of pulses is 10,and repeat number is 2),which is similar to those of conventional annealing(e.g.,tensile strength is 272 MPa,elongation is 28.3%).The microstructure evolution analysis shows that EPP can effectively improve the bonding quality between the deposited particles by recrystallization,promote grain growth and the formation of twins,which is the main reason for the improvement of mechanical properties.

关键词： Cold spray additive manufacturing Copper deposit Mechanical property Electric pulse processing Post treatment

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Tungsten oxide/nitrogen-doped carbon nanotubes composite catalysts for enhanced redox kinetics in lithium-sulfur batteries

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Chinese Journal of Chemical Engineering 2024年第3期67卷 58-67页

作者： Deqing He Zihao Xie Qian yang Wei Wang Chao su School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

The sluggish redox kinetics of polysulfides in lithium-sulfur(Li-S)batteries are a significant obstacle to their widespread adoption as energy storage ***,recent studies have shown that tungsten oxide(WO_(3))can facilitate the conversion kinetics of polysulfides in Li-S ***,we fabricated host materials for sulfur using nitrogen-doped carbon nanotubes(N-CNTs)and WO_(3).We used low-cost components and simple procedures to overcome the poor electrical conductivity that is a disadvantage of metal *** composites of WO_(3) and N-CNTs(WO_(3)/N-CNTs)create a stable framework structure,fast ion diffusion channels,and a 3D electron transport network during electrochemical reaction *** a result,the WO_(3)/N-CNT-Li2S6 cathode demonstrates high initial capacity(1162 mA·h·g^(-1) at 0.5℃),excellent rate performance(618 mA·h·g^(-1) at 5.5℃),and a low capacity decay rate(0.093%up to 600 cycles at 2℃).This work presents a novel approach for preparing tungsten oxide/carbon composite catalysts that facilitate the redox kinetics of polysulfide conversion.

关键词： Li-S batteries Composites Ion diffusion channels 3D electron transport network Redox kinetics

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