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Dual alarmin-receptor-specific targeting peptide systems for treatment of sepsis

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Acta Pharmaceutica Sinica B 2024年第12期14卷 5451-5463页

作者： Seok-Jun Mun Euni Cho woo Jin Gil Seong Jae Kimc Hyo Keun Kim Yu Seong Ham chul-Su Yang Department of Bionano Engineering Hanyang UniversitySeoul 04673Republic of Korea Center for Bionano Intelligence Education and Research Ansan 15588Republic of Korea Department of Molecular and Life Science Hanyang UniversityAnsan 15588Republic of Korea Department of Medicinal and Life Science Hanyang UniversityAnsan 15588Republic of Korea

The pathophysiology of sepsis is characterized by a systemic inflammatory response to infec-tion;however,the cytokine blockade that targets a specific early inflammatory mediator,such as tumor necrosis factor,has shown disappointing results in clinical *** sepsis,excessive endotoxins are internalized into the cytoplasm of immune cells,resulting in dysregulated pyroptotic cell death,which induces the leakage of late mediator alarmins such as HMGB1 and *** late mediators of lethal sepsis,overwhelming amounts of alarmins bind to high-affinity TLR4/MD2 and low-affinity RAGE re-ceptors,thereby amplifying inflammation during early-stage *** this study,we developed a novel alarmin/receptor-targeting system using a TLR4/MD2/RAGE-blocking peptide(TMR peptide)derived from the HMGB1/PTX3-receptors interacting *** TMR peptide successfully attenuated HMGB1/PTX3-and LPS-mediated inflammatory cytokine production by impairing its interactions with TLR4 and ***,we developed TMR peptide-conjugated liposomes(TMR-Lipo)to improve the peptide *** combination therapy,moderately antibiotic-loaded TMR-Lipo demon-strated a significant therapeutic effect in a mouse model of cecal ligation-and puncture-induced *** identification of these peptides will pave the way for the development of novel pharmacological tools for sepsis therapy.

关键词： Sepsis High mobility group box 1 Pentraxin 3 Liposome Antibiotics

Low-dose amitriptyline combined with proton pump inhibitor for functional chest pain

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World Journal of Gastroenterology 2013年第30期19卷 4958-4965页

作者： Se woo Park Hyuk Lee Hyun Jik Lee Jun chul Park Sung Kwan Shin Sang Kil Lee Yong Chan Lee Ji Eun Kim Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine Biostatistics Collaboration Unit Yonsei University College of Medicine

AIM:To investigate the efficacy of amitriptyline with proton pump inhibitor(PPI)for the treatment of functional chest pain(FCP).METHODS:This was a randomized,open-label trial investigating the addition of low dose amitriptyline(10 mg at bedtime)to a conventional dose of rabeprazole(20 mg/d)(group A,n = 20)vs a double-dose of rabeprazole(20 mg twice daily)(group B,n = 20)for patients with FCP whose symptoms were refractory to *** primary efficacy endpoints were assessed by global symptom score assessment and the total number of individuals with > 50% improvement in their symptom ***:The between-group difference in global symptom scores was statistically significant during the last week of treatment(overall mean difference;3.75 ± 0.31 vs 4.35 ± 0.29,the between-group difference;P 50%,whereas only 26.3% of patients in group B had a similar treatment response(70.6% vs 26.3%,P = 0.008).Specifically,patients in group A had a significantly greater improvement in the domains of body pain and general health perception than did patients in group B(52.37 ± 17.00 vs 41.32 ± 12.34,P = 0.031 and 47.95 ± 18.58 vs 31.84 ± 16.84,P = 0.01,respectively).CONCLUSION:Adding amitriptyline to a PPI was more effective than a double-dose of PPI in patients with FCP refractory to a conventional dose of PPI.

关键词： Functional chest pain Proton pump inhibitor Amitriptyline

Relationship between physicochemical characteristics of Korean wheat flour and quality attributes of steamed bread

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Journal of Integrative Agriculture 2019年第11期18卷 2652-2663页

作者： Ji-Eun Kim Byung-Kee Baik chul Soo Park Jae-Han Son Chang-Hyun Choi Youngjun Mo Tae-Il Park Chon-Sik Kang Seong-woo Cho Department of Crop Science&Biotechnology Chonbuk National UniversityJeonju 54896Korea USDA-ARS CSWQRU Soft Wheat Quality LaboratoryWoosterOH 44691USA National Institute of Crop Science Rural Development AdministrationWanju 55365Korea

The purpose of this study is to identify major factors affecting the manufacture and quality of steamed bread,consumed in Southeast Asia including China,Japan,and ***,flours of 11 Korean wheat cultivars were used to evaluate quality attributes of two different styles of steamed bread,Korean style steamed bread(KSSB)and northern-style Chinese steamed bread(NSCSB).KSSB prepared more ingredients and higher optimum water absorption of dough than NSCSB because Korean consumers prefer white and glossy surface and soft *** showed lower height,larger diameter and volume of steamed bread,higher stress relaxation,and softer texture of crumb than *** correlation between flour characteristics and quality of steamed bread was different in KSSB and *** 90%of variability in the height and volume of KSSB could be predicted from protein content,mixing tolerance of Mixograph,average particle size of flour,final viscosity and solvent retention *** content and quality parameters also could explain the variation of steamed bread height in *** wheat carrying Glu-A3c allele produced higher volume of steamed bread(704.7 mL)than Glu-A3d allele(645.8 mL)in KSSB,although there was no significant difference in volume of NSCSB by glutenin ***-D1d and Glu-A3c alleles had softer texture of crumb than Glu-D1f and Glu-A3d alleles in KSSB,Glu-B3i allele also showed lower hardness of crumb than their counterpart allele in *** wheat showed higher height and volume of steamed bread,and lower stress relaxation and hardness of crumb than soft wheat in KSSB.

关键词： steamed bread quality wheat flour evaluation

Relationship between diversion colitis and quality of life in rectal cancer

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World Journal of Gastroenterology 2013年第4期19卷 542-549页

作者： Dong Nyoung Son Dong Jin Choi Si Uk woo Jin Kim Bo Ra Keom chul Hwan Kim Se Jin Baek Seon Hahn Kim Colorectal Division Department of SurgeryKorea University Anam Hospital Korea University College of Medicine Seoul 136-705South Korea Department of Surgery Sun General HospitalDaejeon 301-747South Korea Department of Surgery Gangseo Song-do HospitalSeoul 139-711South Korea Department of Gastroenterology Korea University Anam Hospital Department of Pathology Korea University Anam Hospital

AIM:To investigated the incidence of diversion colitis(DC) and impact of DC symptoms on quality of life(QoL) after ileostomy reversal in rectal ***:We performed a prospective study with 30 patients who underwent low anterior resection and the creation of a temporary ileostomy for the rectal cancer between January 2008 and July 2009 at the Department of Surgery,Korea University Anam *** participants totally underwent two rounds of the *** first examination,endoscopies,tissue biopsies,and questionnaire survey about the symptom were performed 3-4 mo after the ileostomy *** second examination,endoscopies,tissue biopsies,and questionnaire survey about the symptom and QoL were performed 5-6 mo after the ileostomy *** data were based on the histopathological reports and clinical records of the ***:At the first examination,all of the patients presented with inflammation,which was mild in 15(50%) patients,moderate in 11(36.7%) and severe in 4(13.3%) by endoscopy and mild in 14(46.7%) and moderate in 16(53.3%) by *** the second examination,only 11(36.7%) and 17(56.7%) patients had mild inflammation by endoscopy and histology,*** was no significant difference in DC grade between the endoscopic and the histological findings at first or second *** symptoms detected on the first and second questionnaires were mucous discharge in 12(40%) and 5(17%) patients,bloody discharge in 5(17%) and 3(10%) patients,abdominal pain in 4(13%) and 2(7%) patients and tenesmus in 9(30%) and 5(17%) patients,*** found no correlation between the endoscopic or histological findings and the symptoms such as mucous discharge,bleeding,abdominal pain and tenesmus in both time *** was detected in 9 patients at the second examination;this number correlated with the severity of DC(0%,0%,66.7%,33.3% vs 0%,71.4%,23.8%,4.8%,P = 0.001) and the symptom-related QoL(r =-0.791,P

关键词： Diversion colitis Quality of life Diarrhea Ileostomy Rectal cancer

Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive

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World Journal of Gastroenterology 2006年第41期12卷 6693-6698页

作者： Jung woo Shin Neung Hwa Park Seok Won Jung Byung chul Kim Sung Ho Kwon Jae Serk Park In Du Jeong Sung-Jo Bang Do Ha Kim Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of Medicine Ulsan University HospitalUlsanKorea

AIM： To determine the changes of quantitative hepatitis B e antigen （HBeAg） that predicts early detection of non-response or breakthrough to long-term lamivudine （LAM） therapy. METHODS： Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 too, we retrospectively analyzed 220 patients who had received LAM more than 24 too. RESULTS： The mean duration of LAM therapy was 36 （range, 24-72） mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 （24.1%） patients. Viral breakthrough was observed in 105 （47.7%） patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg： decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non-response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 （92.5%） of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four （7.5%） had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 too, 95.2% （negative predictive value） failed to achieve HBeAg seroconversion. CONCLUSION： Almost all patients who failed to show a continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough.

关键词： Hepatitis B e antigen positive chronic hepatitis B lamivudine Quantitative HBeAg levels Non- response Breakthrough

Seroprevalence of anti-HAV among patients with chronic viral liver disease

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World Journal of Gastroenterology 2011年第2期17卷 236-241页

作者： Hyun Chin Cho Seung woon Paik Yu Jin Kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung chul Yoo Hee Jung Son Seon woo Kim Division of Gastroenterology Samsung Medical CenterSungkyunkwan University School of Medicine Division of Gastroenterology Center for Health PromotionSamsung Medical CenterSungkyunkwan University School of Medicine Biostatics Team Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in *** also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December ***:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health *** anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver *** anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of *** analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus.

关键词： Chronic hepatitis B Chronic hepatitis C Hepatitis A virus Korea Seroprevalence

Evaluation of stability and simultaneous determination of fimasartan and amlodipine by a HPLC method in combination tablets

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Asian Journal of Pharmaceutical Sciences 2014年第3期9卷 123-128页

作者： Hyeon woo Moon Abid Mehmood Yousaf Kwan Hyung Cho chul Soon Yong Jong Oh Kim Han-Gon Choi College of Pharmacy Hanyang University1271Sa-3-DongAnsan 426-791South Korea College of Pharmacy Yeungnam University214-1Dae-DongGyongsan 712-749South Korea College of Pharmacy Inje UniversityInje-ro 197 Gimhae 621-749South Korea

A simple,rapid,accurate,precise and robust HPLC method was developed for the simultaneous determination of fimasartan and amlodipine in tablet dosage ***,stability of active ingredients was evaluated under normal and stress *** isocratic elution was accomplished by Nucleosil C18 column(250 mm×4.6 mm,5 mm)at 40℃.The mobile phase consisted of acetonitrile and 0.02 M monopotassium phosphate buffer(pH 2.2)in the ratio of 50:50(v/v)was eluted at 1.0 ml/*** eluent was monitored by the UV detector for fimasartan and amlodipine at 237 nm for 8 min,detection *** validation of HPLC method was carried out in accordance with the ICH guidelines.

关键词： Fimasartan Amlodipine Validation Stability HPLC Combination tablet

Preoperative colonoscopy through the colonic stent in patients with colorectal cancer obstruction

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World Journal of Gastroenterology 2014年第30期20卷 10570-10576页

作者： Jin Su Kim Kang Moon Lee Sang woo Kim Eun Jung Kim chul Hyun Lim Seong Taek Oh Myung Gyu Choi Kyu Yong Choi Division of Gastroenterology Department of Internal MedicineCatholic University of Korea College of MedicineSeoul 137-701South Korea Department of surgery Catholic University of Korea College of MedicineSeoul 137-701South Korea

AIM: To evaluate the feasibility of a preoperative colonoscopy through a self-expendable metallic stent (SEMS) and to identify the factors that affect complete colonoscopy.

关键词： Colon cancer Stent Preoperative colonoscopy Complete colonoscopy

RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering

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Regenerative Biomaterials 2017年第3期4卷 159-166页

作者： Yong Cheol Shin Jeonghyo Kim Sung Eun Kim Su-Jin Song SuckWon Hong Jin-woo Oh Jaebeom Lee Jong-chul Park Suong-Hyu Hyon Dong-wook Han Department of Cogno-Mechatronics Engineering Department of Optics and Mechatronics Engineering Department of Nanoenergy Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Korea Cellbiocontrol Laboratory Department of Medical EngineeringYonsei University College of MedicineSeoul 03722Korea and 5Center for Fiber and Textile Science Kyoto Institute of TechnologyMatsugasakiKyoto 606-8585Japan

In recent years,much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular *** our study,RGD peptide and graphene oxide(GO)co-functionalized poly(lactide-co-glycolide,PLGA)(RGD-GO-PLGA)nanofiber mats were fabricated via electrospinning,and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue *** electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of randomoriented electrospun nanofibers with average diameter of *** successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic ***,the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and *** was found that the mats were thermally stable under the cell culture ***,the initial attachment and proliferation of primarily cultured vascular smoothmuscle cells(VSMCs)on the RGD-GO-PLGA nanofibermats were *** was revealed that the RGD-GO-PLGA nanofibermats can effectively promote the growth of *** conclusion,our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle.

关键词： RGD peptide graphene oxide poly(lactic-co-glycolic acid) biofunctional scaffold vascular smooth muscle cell