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Mo-Ti系复合材料的特性波阻抗

武汉理工大学学报 2002年第5期24卷 1-4页

作者：窦金锋沈强王传彬张联盟武汉理工大学

采用放电等离子烧结技术 ,在相同的温度 (14 73K)及压力 (30 MPa)下 ,制备出不同配比的致密的 Mo- Ti系复合材料。采用高精度超声波脉冲回波重合法 ,精确测量了样品的横、纵波声速 ,并由此计算得到其特性波阻抗的实验值。对样品的相组... 详细信息

采用放电等离子烧结技术 ,在相同的温度 (14 73K)及压力 (30 MPa)下 ,制备出不同配比的致密的 Mo- Ti系复合材料。采用高精度超声波脉冲回波重合法 ,精确测量了样品的横、纵波声速 ,并由此计算得到其特性波阻抗的实验值。对样品的相组成分析及电子探针分析的结果表明 ,Mo- Ti系复合材料是通过 Mo和 Ti之间形成固溶体来实现烧结致密化的。选用混合物模型对其特性波阻抗值进行了理论预测 ,与实测值的比较表明该模型能对 Mo-

关键词： Mo-Ti系复合材料特性波阻抗混合物模型钼钛烧结致密化功能梯度材料梯度飞片

The effect of organic ligand modification on protein corona formation of nanoscale metal organic frameworks

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Chinese Chemical Letters 2022年第9期33卷 4185-4190页

作者： Wenhao wang Huihui Liu Zhengwei Huang Fangqin Fu Wenhua wang Linjing Wu Ying Huang chuanbin Wu Xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 511443China

Nanoscale metal organic frameworks(NMOFs)have been widely reported in biomedical field for their unique porous structure and tunable ***,when administrated in vivo,the protein corona will be formed on the surface of NMOFs,significantly affecting their biodistribution,pharmacokinetics and drug *** studies paid attention to the protein corona formation process and its influencing factors of *** a well-established strategy for altering structure features of NMOFs,the organic ligand modification may have effect on the protein corona formation process,which is to be *** this study,the zirconium(Zr)-based UIO66 was chosen as model NMOFs,the organic ligand of which was modified with amino group(-NH_(2))or carboxyl group(-COOH)to synthesize UIO66-NH_(2)and UIO66-2COOH,*** serum albumin(BSA)was chosen as model protein to investigate the protein corona formation process of *** current results showed that the-COOH modification remarkably enhanced the BSA adsorption on NMOFs while-NH_(2)slightly decreased the protein binding *** differences may be ascribed to the two different dominate protein corona formation modes,i.e.,surface coating mode and porous embedded *** protein corona formation did not affect the crystal phase of NMOFs but increased the content ofα-helix of ***,upon protein corona formation,the cellular uptake of NMOFs was significantly *** believe our study will provide a new research paradigm to the design and applications of NMOFs.

关键词： Protein corona NMOFs UIO66 Organic ligand modification BSA

禽白血病病毒抗原高敏荧光微球快速定量检测方法的建立

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中国动物检疫 2021年第5期38卷 96-103页

作者：孙雨刘亚涛王睿男蒋菲马英李秀梅王文原小燕顾小雪王传彬中国动物疫病预防控制中心北京102600 新疆维吾尔自治区动物疾病预防控制中心新疆乌鲁木齐830000 洛阳现代生物技术研究院有限公司河南洛阳471000

为建立快速定量检测家禽样本中禽白血病病毒抗原的方法,对禽白血病病毒p27蛋白单克隆抗体细胞株2E5和3D5进行复苏、鉴定,通过反应条件优化,建立了禽白血病病毒抗原高敏荧光微球快速检测方法。该方法能够快速定量检测家禽样本中禽白血病... 详细信息

为建立快速定量检测家禽样本中禽白血病病毒抗原的方法,对禽白血病病毒p27蛋白单克隆抗体细胞株2E5和3D5进行复苏、鉴定,通过反应条件优化,建立了禽白血病病毒抗原高敏荧光微球快速检测方法。该方法能够快速定量检测家禽样本中禽白血病病毒,敏感性高、特异性强,对其他家禽病原无交叉反应且具有良好的检测重复性。对采自全国的240份临床家禽样品进行检测,同时用美国IDEXX公司生产的ELISA抗原试剂盒开展比较,结果发现两种方法符合率达93.98%,其中阳性样品符合率为90.83%,阴性样品符合率为95.83%;组内与组间变异系数分别低于10%和15%。本研究建立的禽白血病病毒p27抗原高敏荧光微球快速检测方法,特异性高、敏感性强,操作简单、快速,具有较高的应用推广价值。

关键词：禽白血病 p27融合抗原单克隆抗体荧光微球快速定量检测

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徐氏肾炎灵胶囊抗大鼠肾炎的研究

中国中医药现代远程教育 2014年第19期12卷 155-157页

作者：徐海朱向军郑群朱爱平王传斌雷钧涛江苏盐城市第一人民医院财务科盐城224006 江苏盐城市第一人民医院肾内科盐城224006 江苏盐城市第一人民医院科教科盐城224006 吉林医药学院药学系吉林132013

目的观察徐氏肾炎灵胶囊抗大鼠肾炎的影响。方法给药组与模型对照组大鼠用Freund完全佐剂诱发大鼠肾炎,给药组分别给予徐氏肾炎灵、强的松,模型对照组与健康对照组给予同体积蒸馏水,观察尿、血生化指标以及肾脏病理学形态变化和体重。... 详细信息

目的观察徐氏肾炎灵胶囊抗大鼠肾炎的影响。方法给药组与模型对照组大鼠用Freund完全佐剂诱发大鼠肾炎,给药组分别给予徐氏肾炎灵、强的松,模型对照组与健康对照组给予同体积蒸馏水,观察尿、血生化指标以及肾脏病理学形态变化和体重。结果与模型对照组比较,徐氏肾炎灵组的血尿素氮、尿蛋白的含量与肾间质损伤程度均显著降低,体重改善。结论徐氏肾炎灵对抗大鼠肾炎治疗作用明显。

关键词：徐氏肾炎灵胶囊肾炎影响

Impact of particle size and pH on protein corona formation of solid lipid nanoparticles:A proof-of-concept study

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Acta Pharmaceutica Sinica B 2021年第4期11卷 1030-1046页

作者： Wenhao wang Zhengwei Huang Yanbei Li Wenhua wang Jiayu Shi Fangqin Fu Ying Huang Xin Pan chuanbin Wu School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 511443China

When nanoparticles were introduced into the biological media,the protein corona would be formed,which endowed the nanoparticles with new ***,controlling protein corona formation is critical to in vivo therapeutic *** the particle size is the most feasible method during design,and the infuence of media pH which varies with disease condition is quite *** impact of particle size and pH on bovine serum albumin(BSA)corona formation of solid lipid nanoparticles(SLNs)was studied *** BSA corona formation of SLNs with increasing particle size(120-480 nm)in pH 6.0 and 7.4 was *** techniques were employed for visualization study,conformational structure study and mechanism study,etc."BSA corona-caused aggregation"of SLN2-3 was revealed in pH 6.0 while the dispersed state of SLNs was maintained in pH 7.4,which signifcantly affected the secondary structure of BSA and cell uptake of *** main interaction was driven by van der Waals force plus hydrogen bonding in p H 7.4,while by electrostatic attraction in pH 6.0,and size-dependent adsorption was *** study provides a systematic insight to the understanding of protein corona formation of SLNs.

关键词： Protein corona Solid lipid nanoparticles BSA corona-Caused aggregation Nanoparticle-protein interaction Size effect Cell uptake Medium pH Conformational structure

离开大地的安泰——科利奥兰纳斯悲剧的当代启示

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语言与文化研究

语言与文化研究 2024年第5期32卷 228-231页

作者：陈传斌何环英江西理工大学赣州341000 赣州市黄金实验小学赣州341000

《科利奥兰纳斯》是莎士比亚创作的最后一部关于古罗马历史的悲剧。文章从戏剧文本入手,揭示科利奥兰纳斯悲剧结局的原因是他的脱离群众。离开民众的科利奥兰纳斯就如离开大地的安泰,失去了力量之源。随后,文章进一步分析指出他的名门... 详细信息

《科利奥兰纳斯》是莎士比亚创作的最后一部关于古罗马历史的悲剧。文章从戏剧文本入手,揭示科利奥兰纳斯悲剧结局的原因是他的脱离群众。离开民众的科利奥兰纳斯就如离开大地的安泰,失去了力量之源。随后,文章进一步分析指出他的名门贵族身世、母亲扭曲的家教、骄傲自大的性格、彪悍勇猛的才干又是导致他脱离群众的原因。由此启示:当代中国共产党人要吸取科利奥兰纳斯失败的教训,能否保持党同人民群众的血肉联系,决定着党的事业的成败。

关键词：安泰科利奥兰纳斯悲剧启示

Environmental efficiency and its determinants in the development of China's western regions in 2000-2014

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Chinese Journal of Population,Resources and Environment 2017年第2期15卷 157-166页

作者： chuanbin Yin School of Economics Sichuan UniversityChengduChina

In this study, we measure the environmental efficiency of western China in 2000-2014 by the super-efficiency slacks-based measure model which considers the undesirable outputs. The results show that the environmental efficiency of western China is low and rank behind in the national level. The environmental efficiency is lower than the traditional efficiency which reflects that the economic growth in 2000-2014 has paid high environmental costs. The difference between the traditional efficiency and environmental efficiency experienced "inverted U"-type trend change. The environmental efficiency of the western provinces presented differentiated developing trend and the differences between the western provinces were enlarging. The environmental efficiency of the western regions was not only lower than that in the eastern regions with a big gap but also lower than that in the central regions. Through the convergence test, we found that the environmental efficiency gap between the western and the eastern regions was gradually expanding; meanwhile, the environmental efficiency gap between the central and the western regions was narrowing. This paper also analyzes the determinants of environmental efficiency by the tobit model and then addresses.

关键词： Western China environmental efficiency super-efficiency SBM determinants

Bibliometric landscape of the researches on protein corona of nanoparticles

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Frontiers of Materials Science 2021年第4期15卷 477-493页

作者： Zhengwei HUANG Fangqin FU Linjing WU Wenhao wang Wenhua wang Chaonan SHI Ying HUANG Xin PAN chuanbin WU College of Pharmacy Jinan UniversityGuangzhou 510006China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

Unclear biological fate hampers the clinical translation of nanoparticles for biomedical *** recent years,it is documented that the formation of protein corona upon nanoparticles is a critical factor leading to the ambiguous biological *** have been made to explore the protein corona forming behaviors on nanoparticles,and rearrangement of the relevant studies will help to understand the current trend of such a *** this work,the publications about protein corona of nanoparticles in Science Citation Index Expanded database of Web of Science from 2007 to 2020(1417 in total)were analyzed in detail,and the bibliometrics landscape of them was *** basic bibliometrics characteristics were summarized to provide an overall *** analysis was performed to scrutinize the peer interests of these *** research hotspots in the field were evaluated,based on which some feasible topics for future studies were *** general,the results demonstrated that protein corona of nanoparticles was a prospective research area,and had attracted global research *** was believed that this work could comprehensively highlight the bibliometrics landscape,inspire further exploitation on protein corona of nanoparticles,and ultimately promote the clinical translation of nanoparticles.

关键词： protein corona nanoparticle bibliometrics Web of Science

Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10

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International Journal of Oral Science 2023年第4期15卷 718-728页

作者： Qingxiang Li Yuke Li Qiao Qiao Ning Zhao Yuanning Yang Lin wang Yifei wang chuanbin Guo Yuxing Guo Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina

Recent studies have suggested that long-term application of anti-angiogenic drugs may impair oral mucosal wound *** study investigated the effect of sunitinib on oral mucosal healing impairment in mice and the therapeutic potential of Bifidobacterium breve(***).A mouse hard palate mucosal defect model was used to investigate the influence of sunitinib and/or zoledronate on wound *** volume and density of the bone under the mucosal defect were assessed by micro-computed tomography(micro-CT).Inflammatory factors were detected by protein microarray analysis and enzyme-linked immunosorbent assay(ELISA).The senescence and biological functions were tested in oral mucosal stem cells(OMSCs)treated with *** loop experiments were used to investigate the effect of oral *** antibody for interleukin-10(IL-10)was used to prove the critical role of IL-10 in the pro-healing process derived from *** showed that sunitinib caused oral mucosal wound healing impairment in *** vitro,sunitinib induced cellular senescence in OMSCs and affected biological functions such as proliferation,migration,and *** administration of *** reduced oral mucosal inflammation and promoted wound healing via intestinal dendritic cells(DCs)-derived ***-10 reversed cellular senescence caused by sunitinib in OMSCs,and IL-10 neutralizing antibody blocked the ameliorative effect of *** on oral mucosal wound healing under sunitinib treatment *** conclusion,sunitinib induces cellular senescence in OMSCs and causes oral mucosal wound healing impairment and oral administration of *** could improve wound healing impairment via intestinal DCs-derived IL-10.

关键词： healing wound mucosal