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Status and Prospect of the Beauty and Personal Care Market in China

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China Detergent & Cosmetics 2016年第3期1卷 14-17页

作者： Xiaoying Liu chuanxin wang China Research Institute of Daily Chemical Industry

The Chinese beauty and personal care market has been mainly dominated by big foreign brands such as L＇Oreal and Maybelline, due to their good product reputation, high quality and other advantages. On the back of ＂Korean Wave＂ in China, the Korean cosmetics are expanding their presence in the Chinese market. Local companies must upgrade their brand image and enhance the competitiveness of their brands in the high-end market. In the future, with the increase of people＇s purchasing power, and the demand for high-end cosmetics, the competition in the Chinese cosmetic market will become fiercer.

关键词： cosmetics personal care products Chinese market development trend

The Application of Modified Oil Ethoxylates in Laundry Beads Formulation

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China Detergent & Cosmetics 2021年第1期6卷 74-77页

作者： wang chuanxin Zhang Wei wang Fengshou Shanghai Fine Chemical Co. Ltd.China

The flow ability,foam,and detergency performance of SOE-N-60 are introduced,the advantages of its application in the formulation of laundry beads are ***,the formulation of laundry beads based on SOE-N-60 was *** results showed that SOE-N-60 has low foaming performance and excellent flow ability at low temperature,and it can maintain good liquidity of the mixed system,the laundry beads formulation has low foaming performance and its detergency meets the industry standards.

关键词： laundry beads SOE-N-60 low temperature fluidity formulation stability low foaming property

Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer

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World Journal of Gastroenterology 2013年第27期19卷 4309-4315页

作者： Wen-Fei wang Juan Li Lu-Tao Du Li-Li wang Yong-Mei Yang Yi-Min Liu Hui Liu Xin Zhang Zhao-Gang Dong Gui-Xi Zheng chuanxin wang School of Biosciences University of NottinghamSutton Bonington Campus Department of Clinical Laboratory Qilu HospitalShandong University

AIM:To investigate Krüppel-like factor 8 (KLF8) expression in gastric cancer and its relationship with angiogenesis and prognosis of gastric cancer. METHODS:One hundred and fifty-four patients with gastric cancer who underwent successful curative resection were retrospectively enrolled in the study. Fifty tumor-adjacent healthy gastric tissues (≥ 5 cm from the tumor margin) obtained during the original resection were randomly selected for comparative analysis. In situ expression of KLF8 and CD34 proteins were examined by immunohistochemistry. The intratumoral microvessel density (MVD) was determined by manually counting the immunostained CD34-positive endothelial cells in three consecutive high-magnification fields (× 200). The relationship between differential KLF8 expression and MVD was assessed using Spearman's correlation coefficient test. χ2 test was performed to evaluate the effects of differential KLF8 expression on clinicopathologic factors. Kaplan-Meier and multivariate Cox survival analyses were used to assess the prognostic value of differential KLF8 expression in gastric cancer. RESULTS:Significantly higher levels of KLF8 protein were detected in gastric cancer tissues than in the adjacent non-cancerous tissues (54.5% vs 34.0%, P < 0.05). KLF8 expression was associated with tumor size (P < 0.001), local invasion (P = 0.005), regional lymph node metastasis (P = 0.029), distant metastasis (P = 0.023), and tumor node metastasis (TNM) stage (P = 0.002), as well as the MVD (r = 0.392, P < 0.001). Patients with KLF8 positive expression had poorer overall survival (P < 0.001) and cancer-specific survival (P < 0.001) than those with negative expression. Multivariate analysis demonstrated that KLF8 expression independently affected both overall and cancer-specific survival of gastric cancer patients (P = 0.035 and 0.042, respectively). CONCLUSION:KLF8 is closely associated with gastric tumor progression, angiogenesis and poor prognosis, suggesting it may represen

关键词： Gastric cancer Krüppel-like factor 8 Angiogenesis Prognosis

Peripheral blood mononuclear cell DNA methylation markers enables early non-invasive detection for breast cancer

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Peripheral blood mononuclear cell DNA methylation markers en...

β-catenin function affected by mutated adenomatous polyposis coli

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： tiantian wang chuanxin wang The Second Hospital of Shandong University

Background:The immune system can monitor the development of tumors,while DNA methylation is involved in the bodys immune response to *** blood mononuclear cell(PBMC) DNA carrying cancer-specific epigenetic aberrations may become a non-invasive approach for early detection of breast cancer(BC).Thus,we aimed:1) to analyze DNA methylation changes in PBMC of BC and identify candidate methylation markers,and 2) develop a new assay for the detection of BC by multiplex quantitative methylation-specific PCR assay(mBC-MSP) and evaluate its performance in the early diagnosis of ***:In this study,we examined the genome-wide methylation profile of PBMC from 50 BC and 30 normal controls using Infinium 850K BeadChips and identified specific DNA methylation changes in *** BC prediction diagnostic markers were then validated in a cohort(n=200) using pyrosequencing and MethylTarget sequencing.A m BC-MSP assay was established and the performance of this diagnostic method was analyzed in an independent cohort(n=522) and also compared with the traditional tumor markers CA153、CA125 and ***:We discovered a total of 282 differentially methylated CpG positions(DMPs) between BC and normal controls,including 171 hypo-methylated DMPs and 111 hyper-methylated DMPs,genes associated with DMPs were enriched in the pathways involved in immune monitoring *** significant DMPs markers were selected and further validated using pyrosequencing and MethylTarget sequencing,and finally four hyper-methylated DMPs passed the validation,and their methylation levels were higher in the early stage BC than in the late stage BC.A mBC-MSP assay was established based on the above four hyper-methylated DMPs,which is able to accurately distinguish BC from normal controls,yielded an area under the curve(AUC) of(0.925,0.918),sensitivity(83.1%,80.3%),and specificity(90.4%,89.1%) in both the training and validation *** importantly,compared with CA153、CA125 and CEA,the mBC-MSP

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β-catenin function affected by mutated adenomatous polyposi...

Direct RT-qPCR for serum circulating Bmi-1 mRNA and its clinical application in colorectal cancer

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Lili wang chuanxin wang Department of Clinical Laboratory Qilu HospitalShandong University The Second Hospital Shandong University

Objective: To study the role of mutated adenomatous polyposis coli(APC) on the regulation of β-catenin cellular transport kinetics in colorectal cancer. Methods: SW480, SW480 APC(cells expressing full length APC), and APC-depleted cells(APC-siRNA) were analyzed in this study. We transit transfected GFP, YFP-β-catenin plasmid into cells and also treated with LMB for 4 h and 8 h. The cellular transport of β-catenin were analyzed using fluorescence recovery after photobleaching(FRAP). Results: Compared with SW480 cells, the kinetics of β-catenin in SW480 APC cells in chronic recovery phase decreased, and the half-life time varied from 1 min to 5 min. We found that the expression of β-catenin was significantly higher than that of APC knockout cells, and the expression of β-catenin was significantly higher than that of APC knockout cells after 4 hours of LMB treatmen. Moreever, it did showed an effect on import of β-catenin with longer treatments(8 hrs). Conclusion: APC plays an important role in β-catenin cellular transportas a nuclear shuttle protein, which might have an effects on he nuclear function of β-catenin in tumor cells.

关键词： adenomatous polyposis coli β-catenin colorectal cancer

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Direct RT-qPCR for serum circulating Bmi-1 mRNA and its clin...

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Zhang Xin Zhang Yi wang chuanxin Department of Clinical Laboratory Qilu Hospital of Shandong University Department of Clinical Laboratory The Second Hospital of Shandong University

Purpose: Cell free Bmi-1 m RNA is stably detectable in the serum/plasma, and associated with development and progression of some tumors. Previous methods detecting extracellular Bmi-1 mRNA with RNA extraction are inefficient. This study developed a novel reverse transcription quantitative PCR(RTqPCR) approach directly applied in serum(RT-qPCR-D) to quantify Bmi-1 m RNA, and assessed its diagnostic and prognostic potential in colorectal cancer(CRC). Methods: The feasibility of RT-qPCR-D method was first analyzed in 50 serum samples. Then, using RT-qPCR-D method, Bmi-1 mRNA expression was validated in serum from an independent cohort of patients with 87 normal colonoscopy, 76 hyperplastic polyp, 82 inflammatory bowel disease, 68 adenoma and 158 CRC. Receiver operating characteristic(ROC) curves and Cox analyses were used to evaluate its diagnosis and prognosis value, respectively. Results: In pilot study, levels of Bmi-1 mRNA were increased in CRC serum samples detected by RT-qPCR-D, and significantly associated with results obtained by RT-qPCR. In validation cohort, serum Bmi-1 mRNA levels were significantly elevated in CRC group and adenoma group when compared with other groups. The area under ROC curve distinguishing CRC from benign colorectal diseases was 0.888 with 72.2% sensitivity and 94.9% specificity, which superior to CEA. Bmi-1 mRNA levels were significantly associated with survival. Cox analysis indicated Bmi-1 mRNA was an independent prognostic factor for overall survival. Conclusion: Detection of cell free Bmi-1 mRNA in serum by RT-qPCR-D is a simple and noninvasive approach, and may be used for CRC diagnosis and prognosis.

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新时代检验医学发展定位与思考

中华检验医学杂志 2022年第1期45卷 1-4页

作者：王传新山东大学第二医院检验医学中心济南250033

检验医学作为医学科学的重要支撑学科,在疾病早期诊断、病情监测、预后判断与风险评估等方面发挥着重要作用。21世纪是数字信息时代,高新检测技术、计算机科学及互联网大数据等,为检验医学的发展带来巨大的机遇与挑战,新时代下如何借助... 详细信息

检验医学作为医学科学的重要支撑学科,在疾病早期诊断、病情监测、预后判断与风险评估等方面发挥着重要作用。21世纪是数字信息时代,高新检测技术、计算机科学及互联网大数据等,为检验医学的发展带来巨大的机遇与挑战,新时代下如何借助信息科技革命实现检验医学新发展是检验工作者面临的重要课题。该文回顾检验医学的发展历程,重点关注检验医学在新时代的发展定位及未来发展方向,以求开创检验医学发展新局面。

关键词：检验医学支撑平台人工智能

Efficient Simultaneous Detection of Metabolites Based on Electroenzymatic Assembly Strategy

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Biomedical Engineering Frontiers 2023年第1期4卷 31-41页

作者： Anran Zheng Chao Li Shengkai Xu Zhen Guo Chuanyu Li Changsong Zhang Jia Yao Zhiqi Zhang Jinze Li Lutao Du Shasha Zhao chuanxin wang Wei Zhang Lianqun Zhou CAS Key Lab of Bio-Medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Suzhou Hospital Affiliated Hospital of Medical SchoolNanjing UniversitySuzhou 215153Jiangsu ProvinceChina Suzhou CASENS Co.Ltd. Suzhou 215163China Ji Hua Laboratory Foshan 528000China Department of Clinical Laboratory The Second Hospital of Shandong UniversityJinan 250033ShandongChina

Objective and Impact Statement:We describe an electroenzymatic mediator(EM)sensor based on an electroenzymatic assembly peak separation strategy,which can efficiently realize the simultaneous detection of 3 typical cardiovascular disease(CVD)metabolites in 5μl of plasma under one *** work has substantial implications toward improving the efficiency of chronic CVD ***:Monitoring CVD of metabolites is strongly associated with disease *** and time-consuming detection in hospitals is unfavorable for chronic CVD ***:The EM was flexibly designed by the cross-linking of electron mediators and enzymes,and 3 EM layers with different characteristics were assembled on one *** were transferred under tunable potential;3 metabolites were quantitatively detected by 3 peak currents that correlated with metabolite ***:In this study,the EM sensor showed high sensitivity for the simultaneous detection of 3 metabolites with a lower limit of 0.01 *** linear correlation between the sensor and clinical was greater than 0.980 for 242 patients,and the consistency of risk assessment was 94.6%.Conclusion:Metabolites could be expanded by the EM,and the sensor could be a promising candidate as a home healthcare tool for CVD risk assessment.

关键词： flex linking consuming

改良分段进水工艺处理低C/N城市污水流量优化控制

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化工学报 2015年第7期66卷 2686-2693页

作者：王伟陈强汪传新彭永臻黑龙江工程学院土木与建筑工程学院黑龙江哈尔滨150050 哈尔滨工业大学城市水资源与水环境国家重点实验室黑龙江哈尔滨150090 广州市市政工程设计研究院广东广州510060

采用改良分段进水工艺处理低碳氮比(C/N<3.5)生活污水,研究流量分配对系统处理性能的影响。在其他条件不变的情况下,以实际处理效果以及物料衡算结果为依据来逐步提高首段进水比例以寻求最优的流量运行工况,共确定4组不同的进水流量分... 详细信息

采用改良分段进水工艺处理低碳氮比(C/N<3.5)生活污水,研究流量分配对系统处理性能的影响。在其他条件不变的情况下,以实际处理效果以及物料衡算结果为依据来逐步提高首段进水比例以寻求最优的流量运行工况,共确定4组不同的进水流量分配。结果表明:在此碳氮比条件下,通过提高首段进水比例的方法并不能降低厌氧区氮氧化物的含量,甚至出现相反的情况;系统的同步硝化反硝化作用以及微生物同化作用强度对TN的去除起着至关重要的作用;首段进水比例的提高强化了厌氧区聚磷菌的释磷作用,提高了磷酸盐的去除率;综合考虑系统的脱氮除磷效能以及后续可优化空间,确定在进水流量分配比例为6:3:1的工况3为最优工况,系统出水COD、氨氮、总氮、磷酸盐浓度分别为45.98、0.04、17.47和2.43 mg·L-1。

关键词：分段进水废水流量分配沉降污染低碳氮比脱氮除磷