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聚苯乙烯磺酸钠与季鏻盐表面活性剂复合物的结构调控及其抗菌性能

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应用化学 2024年第4期41卷 521-528页

作者：刘博睿牟倡骏班雨王磊闫秋艳石恒冲殷敬华栾世方中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022 中国科学技术大学应用化学与工程学院合肥230026 山东威高血液净化制品股份有限公司威海264200

发展非抗生素抗菌策略在减少医疗器械相关的细菌感染并降低对抗生素的过度依赖方面具有重大意义。对医疗器械表面进行功能化,赋予其抗菌性能是非抗生素抗菌所采用的常用方式。聚电解质-表面活性剂复合物的醇溶、水不溶的特点使其在构建... 详细信息

发展非抗生素抗菌策略在减少医疗器械相关的细菌感染并降低对抗生素的过度依赖方面具有重大意义。对医疗器械表面进行功能化,赋予其抗菌性能是非抗生素抗菌所采用的常用方式。聚电解质-表面活性剂复合物的醇溶、水不溶的特点使其在构建抗菌涂层方面具有操作简单、不受器械结构限制的优点,有望应用于各种医疗器械的表面功能化。本文通过构建不同烷基链长季鏻盐表面活性剂与聚苯乙烯磺酸钠聚阴离子复合物,系统研究了复合物在水溶液中的组装行为以及所制备复合物涂层的抗菌性能与表面活性剂组分疏水碳链长度之间的内在关联。通过浊度、等温滴定量热法等测试手段对聚苯乙烯磺酸钠与3种三丁基烷基季鏻盐表面活性剂在水中的组装过程进行了分析,结果表明增加表面活性剂烷基链长将促进聚电解质-表面活性剂复合物形成。通过在常用医疗器械材料表面构建复合物涂层,对比了3种复合物对两种模型菌种的抗菌性能。对于以金黄色葡萄球菌为代表的革兰氏阳性菌,所制备的3种复合物涂层的杀菌率分别为42.9%、99.97%和99.99%,随着表面活性剂烷基链越长而提高;对于大肠杆菌为代表的革兰氏阴性菌,随着表面活性剂烷基链长度增加,单独季鏻盐表面活性剂的抗菌性能增强,而其对应复合物涂层的抗菌性能有所下降,杀菌率分别为99.3%、92.3%和64.8%。以上结果表明,通过优化结构,此类聚电解质-表面活性剂复合物涂层有望用于减少医疗器械相关感染。

关键词：聚电解质-表面活性剂复合物聚苯乙烯磺酸钠季鏻盐表面活性剂涂层杀菌

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Fouling-resistant Behavior of Liquid-infused Porous Slippery Surfaces

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chinese Journal of polymer Science 2017年第7期35卷 887-896页

作者： Dan Zhao 徐晓冬袁帅帅 Shun-jie Yan Xiang-hong Wang 栾世方 jing-hua yin key laboratory of Superlight Materials & Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China state key laboratory of polymer physics and chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changckun 130022 China School of polymer Science and Engineering Qingdao University of Science and Technology Qingdao 266042 China

Marine economy is seriously affected by marine biofouling, which has plagued people for thousands of years. Although various strategies have been developed to protect artificial surfaces against marine biofouling, cost-effective biofouling-resistant coating is still a goal in pursue. Herein, a cost-effective liquid-infused porous slippery surface （LIPSS） was facilely prepared by using poly（styrene-b-（ethylene-co-butylene）-b-styrene）（SEBS） elastomer to form microsphere surfaces, followed by infusing fluorocarbon lubricants into the porous structure. The as-prepared slippery surfaces were characterized by static water contact angle, sliding velocity and sliding angle analysis. We also investigated the adhesion behavior of Escherichia coli （E. coli） and limnetic algae on different surfaces. It is confirmed that the slippery surfaces have better anti-biofouling properties than the porous SEBS reference. This cost-effective approach is feasible and easily produced, and may potentially be used as fouling-resistant surfaces.

关键词： Porous surfaces Slippery surfaces Antifouling Bacteria Algae

Oriented Antibody Immobilization and Immunoassay Based on Boronic Acid-containing polymer Brush

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chinese Journal of polymer Science 2018年第4期36卷 472-478页

作者： Jie Zhao Ru Mo Li-Mei Tian Ling-Jie Song Shi-Fang Luan jing-hua yin Lu-Quan Ren key laboratory of Bionic Engineering Ministry ofEdueationJilin UniversityChangchun 130022China state key laboratory of polymer physics and chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Jilin Province People's Hospital Changchun 130021China

High sensitive immunoassay platforms have gained intense attention due to their vital roles in early-stage disease diagnosis and therapeutic information feedback. Although random covalent-binding of antibody has been widely adopted in immunoassays due to its simplicity and effectiveness, it readily loses its activity and fails to exhibit high antigen-binding capacity. In this work, copolymer of zwitterionic sulfobetaine methacrylate（SBMA） and glycidyl methacrylate（GMA） brushes were immobilized onto inert polypropylene（PP） via surface-initiated atom transfer radical polymerization（ATRP） based on biomimetic dopamine pretreatment. Subsequently, boronic acid（BA） groups were covalently bonded via active GMA units, followed by the introduction of oriented immobilization of antibody. Owing to the oriented immobilization of antibody facilitated by BA groups in polymer brush, the bioactivity of antibody is well preserved, which endows the surface with significantly enhanced antigen-binding capacity. Moreover, the existence of SBMA segments in polymer brushes renders the surface high resistance to nonspecific protein adsorption, significantly alleviating the signal interference of antigen recognition. This strategy could find potential applications in developing high sensitive immunoassay platforms based on the different substrates.

关键词： Biomimetic dopamine Atom transfer radical polymerization (ATRP) Boronic acid (BA) Immunoassay Biomimetic

Surface Patterning of Self-healing P(MMA/nBA)Copolymer for Dynamic Control Cell Behaviors

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chinese Journal of polymer Science 2020年第7期38卷 696-703,I0005页

作者： Su-Su Liu Ze-Hong Xiang Zhi-Fang Ma Xue-Wen WU Qiang Shi Shing-Chung Wong jing-hua yin School of Chemical Engineering Xiangtan UniversityXiangtan 411105China state key laboratory of polymer physics and chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Mechanical Engineering University of AkronOhio 44323-3903USA

Cell behaviors are regulated by a dynamic and complex environment characterized by biophysical,mechanical and biochemical ***,most works regulate cell behaviors under static conditions or by external *** control cell adhesion and proliferation with a dynamic and mechanical environment,we pattern the surface on self-healing copolymer P(MMA/nBA).The copolymer P(MMA/nBA)with the composition of 48/52(MMA/nBA)recovers nearly 100%of its original tensile strains after 86 h of recovery from *** physical patterns on P(MMA/nBA)film are obtained over large areas and the size of the hole and the width of connecting bar are in line with the copper grid *** patterned surface tends to be fiat after 12 h with almost 75%-80%*** with cell incubation on polystyrene fiat and patterned surface of P(MMA/nBA)film without self-healing capability,the number and morphology of cells are well manipulated on the patterned surface of self-healing P(MMA/nBA)*** approach provides a convenient method for dynamically regulating the cell behaviors on the surface of self-healing materials without chemical or biological modifications.

关键词： Surface pattern Self-healing Cell behavior Dynamic

A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks

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chinese Journal of polymer Science 2018年第5期36卷 576-583页

作者： Ru-Jian Jiang Shun-Jie Yan Li-Mei Tian Shi-Ai Xu Zhi-Rong Xin Shi-Fang Luan jing-hua yin Lu-Quan Ren Jie Zhao key laboratory of Bionic Engineering Ministry of Education Jilin University School of chemistry and Chemical Engineering Yantai University state key laboratory of polymer physics and chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation, developing a stable, highly antibacterial and easily produced surface remains a technical challenge. As a crucial structural component of biofilm, extracellular DNA（eDNA） can facilitate initial bacterial adhesion, subsequent development, and final maturation. Inspired by the mechanistic pathways of natural enzymes（deoxyribonuclease）, here we report a novel antibacterial surface by employing cerium（Ce（Ⅳ）） ion to mimic theDNA-cleavage ability of natural enzymes. In this process, the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces. Tannic acid（TA） works as an essential scaffold and Ce（Ⅳ） ion acts as both a cross-linker and a destructor of eDNA. The Ce（Ⅳ）-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe（Ⅲ）-TA modified samples. Moreover, the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time. This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections.

关键词： Antibacterial surface Metal-phenolic coating DNA-cleavage Biomimetic surface

生物医用材料表面光引发活性接枝聚合研究新进展

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高分子学报 2021年第3期52卷 223-234页

作者：孙立伟宋凌杰栾世方殷敬华中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022 中国科学技术大学应用化学与工程学院合肥230026 威高集团有限公司医用植入器械国家工程实验室威海264210

表面接枝聚合改性已经成为提升生物医用材料性能的最重要方法之一.参比其他活性接枝聚合方法,光引发活性接枝聚合因其独特的优势已被越来越广泛地应用于生物医用材料表面改性.根据光引发剂的类型,目前应用最多的光引发活性接枝聚合的引... 详细信息

表面接枝聚合改性已经成为提升生物医用材料性能的最重要方法之一.参比其他活性接枝聚合方法,光引发活性接枝聚合因其独特的优势已被越来越广泛地应用于生物医用材料表面改性.根据光引发剂的类型,目前应用最多的光引发活性接枝聚合的引发体系主要有3种:光引发-转移-终止剂介导的聚合引发体系、二苯甲酮及其衍生物引发体系、硫杂蒽酮类引发体系.本文首先简要介绍了上述3种光引发活性接枝聚合体系的发展历程、接枝机理以及特点.同时结合本课题组相关研究工作,重点论述了光引发接枝聚合技术在3个不同生物医用领域的主要应用:(1)抗菌表面,利用光活性接枝的特点构建层状功能高分子刷,实现表面抗菌功能的阶段性需求.(2)免疫检测表面,使用光活性接枝方法构建层状功能高分子刷,解决检测灵敏度低以及蛋白干扰问题.(3)生物活性分子表面固定,利用可见光活性接枝聚合体系,实现酶在表面的固定化使用以及细胞表面修饰以提高细胞稳定性.最后展望了生物医用材料表面光引发活性接枝聚合研究的发展趋势.

关键词：光活性接枝聚合表面改性抗菌免疫检测生物活性分子

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua cai Wenyong cai Wujun cai Yijian cai Yizhou cai Yuchen cai Haiying cai huacheng cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui applied physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research institute Co. LtdBeijing Beijing institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise